Clinical trials: Diuretics
Ureteropelvic Junction Obstruction
CTT on Renogram as an Early Marker of Significant Obstruction in Uretero-pelvic Junction Syndrome
Cortical transit time on diuretic renogram as an early marker of significant obstruction in antenatally detected uretero-pelvic junction syndrome
- Trial name
- JUMP (NCT02812212)
- Testing
- ultrasonography, diuretic renography
- Where
- 5 sites in France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Cardiorenal Syndrome Type 1
Ultrasound Guided Diuretic Therapy in Type 1 Cardiorenal Syndrome
A double-blind, randomized, controlled trial was conducted with the main objective of evaluating if patients with clinical assessment and VExUS reach decongestion faster within a maximum period of 7 days during the hospital stay.
- Trial name
- NEEDED (NCT06065163)
- Testing
- Diuretic de/escalation based on ultrasound findings (VExUS Score), Diuretic de/escalation based on clinical findings (CCS Score)
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Heart Failure
Effectiveness of a Diuretic Algorithm in Clinical Stability in Heart Failure Patients
One of the challenges in treating patients with heart failure (HF) is achieving clinical stability and reducing the hospital readmission rate.
- Trial name
- NCT02068937
- Testing
- Furosemide and Phone contact, Furosemide
- Where
- Brazil
- Volunteers
- 206 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Congestive Heart Failure
Study to Evaluate Cardiac Hemodynamics and Safety of SLV320 in Subjects With Congestive Heart Failure
The study is a randomized, placebo controlled, multi-center, single dose study to evaluate cardiac hemodynamics and safety of iv SLV320 in 110 subjects with congestive heart failure requiring diuretic treatment.
- Trial name
- NCT00160134
- Testing
- SLV320
- Where
- Germany
- Sponsor
- Solvay Pharmaceuticals
Diabetes Mellitus, Type 2, Hypertension
Short-term Effects of Perindopril-amlodipine Versus Perindopril-indapamide in Type 2 Diabetes
This was a double-blinded randomized controlled trial of 24-hour blood pressure control in sub Saharan type 2 diabetes patients, newly diagnosed for hypertension.
- Trial name
- NCT03747978
- Testing
- Perindopril and Amlodipine, Perindopril-indapamide
- Where
- Cameroon
- Volunteers
- 30 people
- Sponsor
- Yaounde Central Hospital
Acute Heart Failure (AHF), Congestion, Venous
Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart Failure
The aim of this study is to evaluate the effectiveness of loop diuretic adaptative algorithm that is based on machine learning, urine output prediction tool, in decongestion of acute heart failure patients.
- Trial name
- SAFER-DHF (NCT07099885)
- Testing
- Standard of Care (SOC), Algorithhm-based decongestion
- Where
- 2 sites in Poland
- Volunteers
- 90 people
- Sponsor
- Wroclaw Medical University
Secondary Hyperparathyroidism, Chronic Kidney Disease
The Effect of Diuretics on Mineral and Bone Disorder in Chronic Kidney Disease Patients
Chronic kidney disease (CKD) patients often have associated systemic hypertension due to volume retention, as one of the mechanisms, therefore the use of diuretics is widespread in this population.
- Trial name
- NCT03082742
- Testing
- Hydrochlorothiazide, Furosemide
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Decompensated Heart Failure
Furosemide-induced Diuresis With Matched Dehydration Compared to Standard Diuretic Therapy in Patients With Acute Heart Failure and Overt Fluid Overload
Acute decompensated heart failure (ADHF) is a complex clinical syndrome caused by cardiac abnormalities compromising the ability of the heart to provide a blood supply adequate to the metabolic needs of peripheral tissues.
- Trial name
- MYTHOS-HF (NCT05807152)
- Testing
- RenalGuard device
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Centro Cardiologico Monzino
Heart Failure
Weight-Based Torsemide Dosing in Subjects With Heart Failure
This study will be a randomized open-label pilot study. The purpose of the study is to compare standard of care outpatient heart failure management versus a weight based torsemide regimen.
- Trial name
- NCT03187509
- Testing
- Torsemide, Standard Outpatient Heart Failure Management
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Chronic Pain, Hypertension
Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure Reduction
The purpose of this study (PASSION study) is to monitor symptoms of chronic pain before and after 2 weeks of a standard drug commonly used to treat elevated blood pressure compared with 2 weeks of placebo (crossover design) so…
- Conditions
- Chronic Pain, Hypertension, Diuretics Drug Reactions, SCS
- Trial name
- PASSION (NCT04676399)
- Testing
- Hydrochlorothiazide 12.5mg
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Kansas Medical Center
Congestive Heart Failure
A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)
To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients
- Trial name
- NCT02047422
- Testing
- Furosemide, metolazone, furosemid/spironolactone
- Sponsor
- Yonsei University
Heart Failure, Chronic Systolic Heart Failure
SCD for CRS in Congestive Heart Failure (CHF) (No Left Ventricular Assist Device)
The purpose of this clinical trial is to see if a new device (SCD) is safe and if it can reduce damage to the kidney enough to allow medications to work to improve heart and kidney function for use in patients that have moderate…
- Conditions
- Heart Failure, Chronic Systolic Heart Failure, Renal Failure, Cardiorenal Syndrome
- Trial name
- NCT04589065
- Testing
- Selective Cytopheretic Device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Lenar Yessayan
Eustachian Tube Dysfunction, Endolymphatic Hydrops
Refractory Eustachian Tube Dysfunction: Are the Symptoms Related to Endolymphatic Hydrops
The purpose of this study is to evaluate the benefit of treatment of refractory Eustachian tube dysfunction with standard treatment for endolymphatic hydrops.
- Trial name
- NCT01661777
- Testing
- Nasal steroid, Myringotomy tube placement, Diuretic
- Where
- United States
- Sponsor
- Vanderbilt University
Congestive Heart Failure, Renal Insufficiency
Concentrated Saline Infusions and Increased Dietary Sodium With Diuretics for Heart Failure With Kidney Dysfunction
At present the standard management of fluid overload in patients with congestive heart failure (CHF) involves limiting the intake of salt and water while administering high dose diuretics, often at the cost of deteriorating…
- Trial name
- NCT00575484
- Testing
- Hypertonic saline, then oral sodium chloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Barnes-Jewish Hospital
Delayed Graft Function, Kidney Transplantation
The Impact of Intraoperative Diuretic Use on Delayed Graft Function Following Deceased Donor Renal Transplantation
Delayed graft function, defined as the need for dialysis within seven days of kidney transplantation, is a common complication affecting deceased-donor kidney transplant recipients.
- Trial name
- NCT07726134
- Testing
- Furosemide, Mannitol
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Heart Failure, Congestive Heart Failure
Oral dIuretics in Very Intensive Treatment, an Early Intervention in Outpatients With Heart Failure
In the present study, consecutive patients, older than 18 years, of both genders will be included. The diagnosis of reduced Heart Failure (HfrEF) according to: Clinical pattern, laboratories and Cardiac imaging (ESC criteria).
- Trial name
- DIVINE (NCT03709160)
- Testing
- Bumetanide 1 MG
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Centro en Insuficiencia Cardiaca, Mexico
Acute Heart Failure, Acute Kidney Injury
Early Sequential Nephron Blockade in Acute Heart Failure Patients: A Randomised, Controlled Study
This study aims to demonstrate the efficacy of sequential nephron blockade by adding hydrochlorothiazide or spironolactone on intravenous furosemide compared to intravenous furosemide alone in the treatments of volume overload in…
- Trial name
- NEB-HF (NCT04465123)
- Testing
- Spironolactone or hydrochlorothiazide
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Chiang Mai University
Acute Heart Failure
Sequential Nephron Blockade in Acute Heart Failure
Background - Volume overload is an important clinical target in acute heart failure management (AHF), typically addressed using loop diuretics.
- Trial name
- NCT04163588
- Testing
- Metolazone, Loop Diuretics
- Where
- Italy
- Volunteers
- 310 people
- Sponsor
- Policlinico Casilino ASL RMB
Cirrhosis, Ascites Hepatic
PEriToneal Catheter Versus Repeated Paracentesis for Ascites in Cirrhosis
Insertion of a tunnelated peritoneal catheter (PleurX) allows repeated intermittent small volume fluid drainage at home. The treatment may improve the management of ascites and have a beneficial effect on the quality of life.
- Conditions
- Cirrhosis, Ascites Hepatic, Ascites (Non-Malignant)
- Trial name
- PETRA (NCT03027635)
- Testing
- PleurX, peritoneal tunnelated catheter, Large Volume Paracentesis, Ciprofloxacin 500Mg Tablet
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Nina Kimer
Chronic Kidney Disease(CKD), Uncontrolled Hypertension
Intensification of Blood Pressure Lowering Therapeutics Based on Diuretics Versus Usual Management for Uncontrolled Hypertension IN Patients With Moderate to Severe Chronic Kidney Disease
Chronic kidney disease (CKD) is a major public health issue worldwide. Hypertension is the first risk factor in patients with CKD for mortality, cardiovascular disease and end-stage renal disease.
- Trial name
- THINK (NCT05732727)
- Testing
- Antihypertensive algorithm, Standard of care
- Where
- 40 sites in France
- Volunteers
- 720 people
- Sponsor
- University Hospital, Tours