Clinical trials: Diuretics
Acute Decompensated Heart Failure
DORAYA-HF Early Feasibility Study
The study objective is to evaluate the feasibility of the Doraya Catheter and measure clinical performance and safety endpoints, in ADHF patients deemed to have insufficient diuretic response.
- Trial name
- NCT05206422
- Testing
- Doraya Catheter
- Where
- 14 sites in United States
- Volunteers
- 21 people
- Sponsor
- Revamp Medical Inc.
Heart Failure Acute
Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients
Acutely decompensated heart failure (ADHF) is highly prevalent and has a high (financial) burden on the health care system. Treatment often consists of the administration of IV decongestive agents.
- Trial name
- TAILOR-AHF (NCT06092437)
- Testing
- Urine sodium guided diuretic algorithm, Usual care
- Where
- 2 sites in Netherlands
- Volunteers
- 556 people
- Sponsor
- Zuyderland Medisch Centrum
Hypernatraemia
Hydrochloorthiazide and Hypernatriaemie
Acquired hypernatremia appears to be associated with mortallity in ICU. To reduce hypernatremia and shorten the time of hypernatremia, we investigate the effect of hydrochloorthiazide compared to a placebo
- Trial name
- NCT01974739
- Testing
- Hydrochloorthiazide
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Frisius Medisch Centrum
Hypertension, Peritoneal Dialysis
Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients
To evaluate the blood pressure lowering effects of thiazide diuretics in patients on peritoneal dialysis
- Conditions
- Hypertension, Peritoneal Dialysis, End Stage Kidney Disease (ESRD)
- Trial name
- NCT07271420
- Testing
- Hydrochlorothiazide 25mg once per day
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Acute Kidney Injury
Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill Adults
The goal of this RCT is to compare the effectiveness of aminophylline and furosemide combination vs furosemide alone in producing effective diuresis in critically ill adults in ICU.
- Trial name
- NCT05933642
- Testing
- Aminophylline, Frusemide
- Where
- Malaysia
- Volunteers
- 132 people
- Sponsor
- University of Malaya
End Stage Renal Disease on Dialysis
Diuretic Use in Hemodialysis Patients With Residual Renal Function
This pilot trial will evaluate the use of diuretic medications (furosemide and chlorthalidone) in participants on dialysis to see if these medications work to preserve existing kidney function, increase urine output, and reduce…
- Trial name
- DIURESED (NCT05915286)
- Testing
- Furosemide, Chlorthalidone
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta
Hypertension
Implementing Evidence Based Treatment of Hypertension
This study examines the use of patient initiated discussions of blood pressure medication in the primary care setting. Additionally, this study examines different levels of patient incentive(s) to initiate discussions with…
- Trial name
- NCT00265538
- Testing
- Patient educational letter to engage provider in hypertension rx discussion, Financial incentive (Arms B and C) and health educator phone call (Arm C)
- Where
- 2 sites in United States
- Volunteers
- 834 people
- Sponsor
- VA Office of Research and Development
Acute Heart Failure, Chronic Kidney Diseases
Natriuresis-Guided Diuretic Therapy in Patients With Acute Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease
To investigate the effectiveness and feasibility of natriuresis-guided diuretic therapy as a personalized approach to managing acute heart failure in patients with underlying chronic kidney disease and its effect on short term…
- Trial name
- NCT06203236
- Testing
- Furosemide 20 MG, diuretic therapy
- Volunteers
- 300 people
- Sponsor
- Assiut University
Heart Failure; With Decompensation
A Study of Ultra High Dose Diuretics to Treat Heart Failure
The purpose of this study is to determine the safety and effectiveness of ultrahigh dose diuretics compared to standard dose diuretics over 24 hours in patients with decompensated heart failure.
- Trial name
- NCT06036914
- Testing
- Bumetanide, Furosemide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Renal Insufficiency, Chronic Hypertension
Spironolactone in CKD Enabled by Chlorthalidone: PILOT
Highly prevalent among patients with chronic kidney disease (CKD) and poorly controlled blood pressure (BP), is a modifiable risk factor to abrogate both kidney failure progression and cardiovascular (CV) disease.
- Trial name
- SPICE PILOT (NCT05222191)
- Testing
- Spironolactone, Chlorthalidone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Indiana Institute for Medical Research
Preeclampsia, Preeclampsia Postpartum
Optimizing Preeclampsia Postpartum With Point-of-care Ultrasound
This study explores a novel approach to improving care for postpartum patients with preeclampsia, a pregnancy-related condition characterized by high blood pressure, protein in the urine, and organ dysfunction.
- Conditions
- Preeclampsia, Preeclampsia Postpartum, Preeclampsia Severe or Mild
- Trial name
- PPPOCUS (NCT07167862)
- Testing
- Butterfly iQ3 ultrasound system for determination of postpartum volume status, Oral furosemide, Intravenous furosemide
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of California, Irvine
Pre-hypertension, Pre-diabetes
Losartan Versus Hydrochlorothiazide in Reversing Remodeling of Small Arteries in Pre-Hypertensive Pre-Diabetic Subjects
This randomized, double-blind, parallel group, two-centre pilot study will test the hypothesis that subjects who are otherwise healthy but fulfill the criteria for a diagnosis of pre-hypertension and pre-diabetes will have…
- Trial name
- NCT00388388
- Testing
- losartan, hydrochlorothiazide
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Diabetes Mellitus
Examining the Effect of Different Diuretics on Fluid Retention in Diabetics Treated With Rosiglitazone.
Study examining the effect of different diuretics on fluid retention in diabetics treated with rosiglitazone.
- Trial name
- NCT00306696
- Testing
- Rosiglitazone, spironolactone, hydrochlorothiazide
- Where
- 46 sites in Belgium, Canada and 12 more
- Volunteers
- 388 people
- Sponsor
- GlaxoSmithKline
Thiazide Diuretics Induced Hyponatremia
Polymorphisms of the Thiazide's Receptor Gene SLC12A3 and Development of Hyponatremia
The purpose of this study is to detect if there are any differences in the coding region of SLC12A3 gene in individuals who have had hyponatremia associated to the use of thiazides, and those thiazides consumers without…
- Trial name
- NCT01346891
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Hospital Italiano de Buenos Aires
Cardiac Failure, Renal Failure
Protocolized Diuretic Strategy in Cardiorenal Failure
This research study is a randomized clinical trial to evaluate if taking diuretics (medications that increase urine production and help with fluid removal from the body) in a standardized fashion (using a guideline for adjusting…
- Conditions
- Cardiac Failure, Renal Failure, Kidney Failure
- Trial name
- ProDiuS (NCT01921829)
- Testing
- Protocolized Diuretic Strategy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Kelly V. Liang, MD
Acute Decompensated Heart Failure
Assessment of Coronary Flow Reserve in Heart Failure Patients After Ultrafiltration Versus Diuretics
The purpose of this research study is to compare the effects (good and bad) of ultrafiltration treatment with standard intravenous (in your vein) diuretic therapy (furosemide, torsemide, bumetanide) on your heart function and…
- Trial name
- NCT01457053
- Testing
- Loop diuretics (furosemide, torsemide, bumetanide), Ultrafiltration
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of Cincinnati
Heart Failure, Congestive
Diuretic Efficacy of Dexamethasone in Heart Failure
The purpose of this study is to determine whether glucocorticoids have potent diuretic effects in patients with congestive heart failure.
- Trial name
- NCT00263302
- Testing
- dexamethasone
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Hebei Medical University
Acute Decompensated Heart Failure, Diuretics Resistance
Exploring Diuretics Effective Management in Acute Decompensated Heart Failure, EDEMA Trial
1. Evaluate efficacy and safety of continuous infusion of IV Frusemide compared to IV shots in acute decompensated heart failure ADHF 2.
- Trial name
- EDEMA (NCT03863626)
- Testing
- Frusemide IV shots, Frusemide IV infusion
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Cairo University
Heart Failure, Heart Failure - NYHA II - IV
Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared…
- Conditions
- Heart Failure, Heart Failure - NYHA II - IV, Heart Failure Acute, Acute Heart Failure (AHF)
- Trial name
- US-DASH (NCT07263035)
- Testing
- Furosemide intravenous solution
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Lakeland Regional Health Systems, Inc.
Heart Failure Acute, Heart Failure，Congestive
Effects of Empagliflozin on Clinical Outcomes in Patients With Acute Decompensated Heart Failure
Acute decompensated heart failure is the fastest growing disease in the world and the leading cause of hospital admissions worldwide.
- Conditions
- Heart Failure Acute, Heart Failure，Congestive, Heart Failure; With Decompensation
- Trial name
- EMPA-RESPONSE (NCT03200860)
- Testing
- Empagliflozin 10 MG
- Where
- 5 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- University Medical Center Groningen