Clinical trials: Diverticular Diseases
Diverticulitis
Natural History of Sigmoid Diverticulitis: The Geneva Cohort Study
Aim: This is a longitudinal cohort study to assess long-term clinical outcome of patients who were admitted in our institution for a first episode of uncomplicated sigmoid diverticulitis.
- Trial name
- NCT01015378
- Testing
- laparoscopid sigmoid resection
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- University Hospital, Geneva
Diverticulitis
Hospitalization or Ambulatory Treatment of Acute Diverticulitis
The purpose of 01DIVER is to evaluate efficacy and safety of a home treatment protocol for non complicated diverticulitis compared with management in the hospital.
- Trial name
- 01DIVER (NCT01081054)
- Testing
- Ambulatory versus hospitalisation
- Where
- 5 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Hospital Universitari de Bellvitge
Zenker Diverticulum, Diverticulum, Esophago-Pharyngeal
Comparison of Zenker's Diverticulum Treatment Using Peroral Endoscopic Myotomy and Flexible Endoscopy Septotomy.
The Zenker's or pharyngo-esophageal diverticulum is an acquired sac-like outpouching of the mucosa and submucosa layers located dorsally at the pharyngoesophageal junction through Killian's dehiscence.
- Conditions
- Zenker Diverticulum, Diverticulum, Esophago-Pharyngeal, Diverticulum, Esophageal, Dysphagia
- Trial name
- ZIPPY (NCT04514042)
- Testing
- Peroral endoscopic myotomy, Flexible endoscopic septotomy
- Where
- Poland
- Volunteers
- 165 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Achalasia, Paraesophageal Hernia
Minimally Invasive Surgery of the Gastro-esophageal Junction
This study will assess short and long term outcomes of individuals undergoing minimally invasive surgery of the gastro-esophageal junction (MISGEJ).
- Conditions
- Achalasia, Paraesophageal Hernia, GERD, Epiphrenic Diverticula
- Trial name
- MISGEJ (NCT01799967)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Uncomplicated Diverticulitis
Non-antibiotic Management in Acute Uncomplicated Diverticulitis
Diverticulitis is a common condition that causes swelling and pain in part of the colon (the large intestine). Doctors classify it as "mild" when there are no serious complications.
- Trial name
- NAMAD (NCT07625267)
- Testing
- Symptomatic treatment (ibuprofen and acetaminophen), Amoxicillin-clavulanate, Ciprofloxacin plus metronidazole
- Sponsor
- Montefiore Medical Center
Diverticulitis
Investigation of Medical Management to Prevent Episodes of Diverticulitis Trial
This is a randomized trial (n=75) of a Mediterranean style Food Pattern and versus standardized guidance on fiber intake for patients with diverticulitis to evaluate the feasibility of this dietary intervention including…
- Trial name
- IMPEDE (NCT05681559)
- Testing
- Medi for All, Standard Fiber Supplementation
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Washington
Colorectal Surgery, Colorectal Neoplasms
Follow-Up Phone Calls After Colorectal Surgery
The purpose of this study is to assess if follow-up telephone calls after colorectal surgery affects a patient's satisfaction, the outcome of their surgery, and their quality of life.
- Conditions
- Colorectal Surgery, Colorectal Neoplasms, Colitis, Ulcerative, Diverticulitis
- Trial name
- NCT00474097
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University Hospitals Cleveland Medical Center
Colonic Diverticuar Disease, Defecatory Functions
Effects of Inferior Mesenteric Artery Preservation in Laparoscopic Colorectal Resection for Diverticular Disease.
This is a prospective randomized study aimed to verifying the short and long-term results of inferior mesenteric artery preservation following colorectal resection for diverticular disease
- Conditions
- Colonic Diverticuar Disease, Defecatory Functions, Fecal Incontinence, Constipation
- Trial name
- EIMAP (NCT06506552)
- Testing
- IMA preserving, IMA sectioning
- Volunteers
- 300 people
- Sponsor
- University of Roma La Sapienza
Colovesical Fistula
Early Foley Catheter Removal After Diverticular Colovesical Fistula Repair
Patients undergoing surgical repair of colovesical fistula will have have "early" (post-operative day 3) cystogram and removal of bladder catheter.
- Trial name
- NCT05235204
- Testing
- Removal of Foley Catheter 2 to 3 days post Colovesical Fistula (CVF) repair surgery
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Karim Alavi
Sexual Function Disturbances
Preservation of Inferior Mesenteric Artery Could Improve Sexual Function After Laparoscopic Colorectal Resection for Diverticular Disease
This study aims to evaluate whether IMA sparing may represent an advantage in terms of reduced incidence and severity of sexual dysfunctions after colorectal resections for diverticular disease (DD).
- Trial name
- IMAPSEX (NCT04752241)
- Testing
- Inferior Mesenteric Artery Preservation, Inferior Mesenteric Artery Ligation
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Roma La Sapienza
Appendicitis, Cholecystitis
Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection
This is a phase 3b/4 randomized, open-label, comparative, multicenter study of the safety and efficacy of tigecycline to ceftriaxone sodium plus metronidazole in hospitalized subjects with cIAI (Complicated Intra-Abdominal…
- Conditions
- Appendicitis, Cholecystitis, Cross Infection, Diverticulitis
- Trial name
- NCT00195351
- Testing
- tigecycline, ceftriaxone sodium + metronidazole
- Where
- 66 sites in United States, Argentina and 4 more
- Volunteers
- 467 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Inflammatory Bowel Diseases, Colon Cancer
Pre-Habilitation Exercise Intervention
The purpose of this study is to see whether exercise can improve the health and well-being of patients scheduled to undergo surgery for a bowel related condition.
- Conditions
- Inflammatory Bowel Diseases, Colon Cancer, Rectal Cancer, Diverticular Disease
- Trial name
- NCT02849717
- Testing
- Exercise for Cancer Patients
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Rochester
Colonic Diverticula, Angiodysplasia
Study of Hemospray for Lower Gastrointestinal Hemorrhage
This study is to evaluate the performance of Hemospray for the teatment of nonvariceal lower gastrointestinal bleeding.
- Conditions
- Colonic Diverticula, Angiodysplasia, Colonic Polyp
- Trial name
- NCT02099435
- Testing
- Hemospray
- Where
- 4 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Cook Group Incorporated
Colostomy, Colorectal Neoplasm
A Randomized Trial on the Technical Aspects of Stoma Construction.
An investigation on the difference in stoma hernia frequency related to surgical technique when incising the fascia. All patients planned for elective colostomy formation are to be included.
- Conditions
- Colostomy, Colorectal Neoplasm, Diverticulitis
- Trial name
- NCT01694238
- Testing
- Cruciate incision, Circular incision, Mesh enforced cruciate incision
- Where
- Sweden
- Volunteers
- 209 people
- Sponsor
- Sahlgrenska University Hospital
Zenker Diverticulum, Progressive Dysphagia
Cricopharyngeal Dysfunction and Esophageal Diverticulum
Patients undergoing open transcervical or endoscopic approach in which a laser or stapler is used to divide the common wall between the diverticulum and esophagus, or who are not surgical candidates but agree to follow-up.
- Conditions
- Zenker Diverticulum, Progressive Dysphagia, Pharyngoesophageal Diverticulum
- Trial name
- NCT03187925
- Testing
- open, transcervical versus rigid endoscopic treatment
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Cincinnati
Colon Cancer, Inflammatory Bowel Diseases
Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine
Patients receiving perioperative intravenous lidocaine, post operative restoration of bowel movement will be faster and decrease pain intensity, opioid consumption and side effects, length of hospital stay; probably as a result…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT01155440
- Testing
- Lidocaine, Thoracic epidural block
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Rectal Neoplasms, Colon Neoplasms
Fluorescent Evaluation of Colorectal Anastamoses
Bowel removal is indicated for various types of colon and rectal disease, including colon cancer, rectal cancer, diverticulitis, and inflammatory bowel disease among others.
- Conditions
- Rectal Neoplasms, Colon Neoplasms, Diverticulitis
- Trial name
- NCT01424293
- Testing
- Indocyanine Green, The SPY® Intraoperative Imaging System
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Maimonides Medical Center
Diverticulitis
Asacol Acute Diverticulitis(DIVA)Study
The purpose of this study is to determine whether Asacol® 2.4 g/day (400 mg Mesalamine) is safe and effective in the treatment of diverticulitis.
- Trial name
- NCT00554099
- Testing
- Mesalamine, Probiotic, Dietary Advice
- Where
- 36 sites in United States
- Volunteers
- 117 people
- Sponsor
- Warner Chilcott
Colorectal Neoplasms, Diverticulitis
Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery
This randomized clinical trial studies how well neomycin and metronidazole hydrochloride with or without polyethylene glycol work in reducing infection in patients undergoing elective colorectal surgery.
- Conditions
- Colorectal Neoplasms, Diverticulitis, Inflammatory Bowel Diseases, Surgical Site Infection
- Trial name
- NCT03042091
- Testing
- Polyethylene Glycol, Neomycin, Metronidazole Hydrochloride
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Thomas Jefferson University
Diverticular Disease
Prophylactic Endoscopic Clipping of Diverticula (PECoD)
This study will evaluate the effect of endoscopic clipping of colonic diverticula in treatment of symptoms related to diverticular disease.
- Trial name
- PECoD (NCT03935100)
- Testing
- Endoscopic clipping
- Where
- United Kingdom
- Volunteers
- 84 people
- Sponsor
- King's College Hospital NHS Trust