Clinical trials: Dobutamine
Myocardial Blood Flow Reserve, Mechanical Dyssynchrony
Mechanical Dyssynchrony and Microvascular Dysfunction by SPECT
The project is aimed at studying the feasibility of mechanical dyssynchrony of the left ventricle of the heart, determined by SPECT (gated MPI), as well as its stress-induced dynamics, in the evaluation of patients with coronary…
- Conditions
- Myocardial Blood Flow Reserve, Mechanical Dyssynchrony, Coronary Arterial Disease (CAD)
- Trial name
- MD&MD (NCT06969547)
- Testing
- dynamic SPECT (two-day rest/stress protocol), gated myocardial perfusion imaging, blood sampling
- Where
- Russia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Ischemic Heart Disease
DSE vs. FFR in SCAD and BYSTANDER Lesions
Enrollment: Patients with stable coronary artery disease (SCAD) and moderate coronary artery stenoses (30-70 %) Patients with acute myocardial infarction and moderate stenosis of non-culprit arteries (NCL; BYSTANDER LESION) Aims…
- Trial name
- DSE-vs-FFR (NCT03383718)
- Testing
- Revascularisation, Optimal Medical Treatment/OMT
- Volunteers
- 200 people
- Sponsor
- Bajcsy-Zsilinszky Hospital
Heart Failure
Right Ventricular Contractile Reserve in HF
Right ventricle dysfunction and pulmonary hypertension are related to a worse prognosis in patients with heart failure with reduced left ventricular ejection fraction (HFrEF) or with normal left ventricular ejection fraction…
- Trial name
- RISE-HF (NCT05797584)
- Testing
- Dobutamine, Passive leg raising
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Kidney Transplantation, Pancreas Transplantation
Pre-operative Evaluation of Kidney & Pancreas Transplant Patients
Examine the clinical utility of the dobutamine stress contrast echoes and angiograms obtained routinely in the evaluation of patients prior to kidney or pancreas transplantation.
- Trial name
- NCT00580437
- Testing
- Dobutamine Stress Echocardiogram
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Nebraska
SCI - Spinal Cord Injury
Cardiocentric Inotropic Optimization in Spinal Cord Injury
The first hours-to-day following acute traumatic cervical SCI represent a critical period of time to optimize hemodynamic management. After a spinal cord injury, cardiovascular function is affected.
- Trial name
- CARDIO-SCI (NCT07871643)
- Testing
- Dobutamine crossover
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of British Columbia
General Anesthesia
Effect of Dobutamine on Hepatic Blood Flow During Goal-directed Hemodynamic Therapy
Maintaining adequate perfusion pressure and oxygen supply is essential for organ survival. Splanchnic hypoperfusion during the perioperative period in abdominal surgery may result in mucosal ischemia with increased permeability…
- Trial name
- DOBU whipple (NCT04893655)
- Testing
- Dobutamine Hydrochloride
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- University Hospital, Ghent
Coronary Artery Disease, Echocardiography, Stress
New Three-dimensional Methods of Analysis for the Detection of Coronary Artery Disease by Dobutamine Stress Echocardiography
The investigators are going to recruit patients who have a scheduled elective coronary angiography and going to do a dobutamin stress echography (DSE) before the coronary examination.
- Trial name
- 3-DSE (NCT02240745)
- Testing
- Stress-echocardiography
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Lung Cancer, Surgery
CMR Right Ventricular Contractile Reserve Following Lung Resection
Feasibility study investigating CMR dobutamine stress testing before and after lung resection
- Conditions
- Lung Cancer, Surgery, Anesthesia
- Trial name
- NCT06465277
- Testing
- Dobutamine stress CMR, Cardiac biomarker sample
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Cardiac Output, Low, Coronary Disease
Liberal Versus Restrictive Use of Dobutamine in Cardiac Surgery
Inotropic agents are usually administered in the postoperative period after cardiac surgery. In most cases, dobutamine is administered routinely, for the probable occurrence of myocardial dysfunction after cardiopulmonary bypass…
- Trial name
- DOBUTACS (NCT02361801)
- Testing
- Liberal dobutamine protocol, Restrictive dobutamine protocol
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- University of Sao Paulo
Myocardial Infarction
Timing of Complete Revascularization for Multivessel Coronary Artery Disease in STEMI
The study will compare clinical outcomes between complete revascularization during hospitalization for ST elevation myocardial infarction (STEMI) and intervention after 30 days and intervention based on outpatient non-invasive…
- Trial name
- MVD (NCT02756000)
- Testing
- PCI, dobutamine stress echocardiography
- Where
- 4 sites in Serbia
- Volunteers
- 120 people
- Sponsor
- Clinical Hospital Center Zemun
End-Stage Renal Disease, Cardiovascular Diseases
Myocardial Perfusion and Contractile Reserve in End-stage Renal Disease
The investigators prospectively recruited a total of 377 ESRD patients evaluated for kidney transplantation between January 2010 and July 2013 in our centre.
- Trial name
- NCT04172064
- Testing
- Myocardial perfusion scintigraphy
- Volunteers
- 377 people
- Sponsor
- University Hospital Muenster
Nfuence of Vasoactive Medication on Spinal Oxygenation
Influence of Continuous Administration of Phenylephrine Versus Dobutamine on Spinal Oxygen Saturation, Measured With Near-infrared Spectroscopy (NIRS).
To assess the effect of hemodynamic supportive medication on spinal vasculature, patients scheduled for arterial dilation of the lower limb were chosen as our study population.
- Trial name
- NIRS continu (NCT03846765)
- Testing
- Phenylephrine, Dobutamine
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- University Hospital, Ghent
Hemodynamic Instability
Hemodynamic Optimalization in Pediatric Patients
Hemodynamic unstability, defined by macrocirculation and/or microcirculation dysfunction or alteration is common in critically ill pediatric patients.
- Trial name
- HOPED (NCT04227821)
- Testing
- Vasopressor and/inotrope therapy
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Acute Decompensated Heart Failure
A Comparison of Recombinant Human Brain Natriuretic Peptide and Dobutamine
To compare the therapeutic efficacy of recombinant human brain natriuretic peptide (rhBNP) with dobutamine on acute decompensated heart failure patients with different blood BNP levels
- Trial name
- NCT01837849
- Volunteers
- 104 people
- Sponsor
- Nantong University
Cirrhosis, Cirrhotic Cardiomyopathy
DOCICAR: Cardiac Dysfunction in Cirrhosis
Patients with cirrhosis have a altered cardiac response to stress. This study evaluate the cardiac response by MRI during dobutamine stress. Hypothesis: impared increase in cardiac output, cardiac index, ejection fraction.
- Trial name
- NCT00250315
- Testing
- Dobutamine
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Coronary Disease
Myocardial Perfusion, Coronary Flow Reserve and Kinetic Analysis During Dobutamine Stress Echocardiography
Stress echocardiography is a screening test for coronary heart disease that already has good sensitivity and specificity (both around 70%).
- Trial name
- TRIPLESTRESS (NCT03996499)
- Testing
- Stress echocardiography
- Where
- France
- Volunteers
- 201 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Arterial Hypotension
Dopamine Versus Dobutamine for Treatment of Arterial Hypotension in Term and Preterm Neonates
The purpose of this study is to examine the effects of Dobutamine as compared to Dopamine in term and preterm neonates with arterial hypotension on cerebral and renal oxygenation, fractional tissue oxygen extraction, mean…
- Trial name
- NCT01427686
- Testing
- Dobutamine, Dopamine
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Ulm
Heart Failure
Outcome and Safety of Intermittent Dobutamine Infusion at a Day-Care Center in Advanced Heart Failure Patients
Heart failure (HF) is a prevalent disease reaching 1-2% of adult population in developed countries, and 10% in patients over 70 years.
- Trial name
- DoBHF (NCT01930734)
- Testing
- Dobutamine, Normal Saline
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Coronary Artery Disease
Hemodynamic Forces at Rest and Stress vs. Adenosine and Dobutamine Stress Cardiac Magnetic Resonance
Stress perfusion CMR has recently considered as one of the methods of choice for establishing the diagnosis of CAD based on its high diagnostic accuracy, lack of ionizing radiation as well as its ability to simultaneously assess…
- Trial name
- CMR (NCT04247698)
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Assiut University
Coronary Artery Disease
Evaluation of Safety and Efficacy of Lumason/SonoVue in Subjects Undergoing Pharmacologic Stress BR1-141
The purpose of this study was to assess the safety and efficacy of Lumason-enhanced dobutamine stress echo (CE-DSE) in subjects having a suboptimal left ventricular endocardial border delineation (LV EBD) at rest and who were…
- Trial name
- NCT02522481
- Testing
- Lumason
- Where
- 17 sites in United States, Canada and 2 more
- Volunteers
- 175 people
- Sponsor
- Bracco Diagnostics, Inc