Clinical trials: Donor
Free Gingival Graft
A-PRF and CGF in Palatal Donor Site Healing
The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort…
- Trial name
- FGG (NCT07439068)
- Testing
- Advanced platelet-rich fibrin, Concentrated growth factor, Sterile gelatin sponge
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ordu University
Living Kidney Donors Undergoing VAMS-nephrectomy
Effect of Oral Pregabalin on Hyperalgesia and Post-operative Pain in Patients Undergoing Nephrectomy Surgery: Sex Differential Study
Hyperalgesia is known to be caused by the excitatory amino acid through NMDA receptor. GABA, an inhibitory amino acid, alters the opioid receptor sensitivity against pain resulting hyperalgesia.
- Trial name
- NCT02340455
- Testing
- Pregabalin_male, Pregabalin_female
- Where
- South Korea
- Sponsor
- Yonsei University
Kidney Transplant Rejection, End Stage Renal Disease
Safety & Tolerability Study of Chimeric Antigen Receptor T-Reg Cell Therapy in Living Donor Renal Transplant Recipients
The purpose of this study is to evaluate the safety and tolerability of TX200-TR101 and its effects on the donated kidney in living donor kidney transplant recipients.
- Trial name
- STEADFAST (NCT04817774)
- Testing
- TX200-TR101
- Where
- 5 sites in Belgium, Netherlands and 1 more
- Volunteers
- 26 people
- Sponsor
- Sangamo Therapeutics
Pediatric Acute Respiratory Distress Syndrome, Desflurane
Effect of Desflurane on Pediatric Acute Respiratory Distress Syndrome After Living Donor Liver Transplant Recipients
Biliary atresia is a serious congenital anomaly characterized by persistent and progressive cholestatic jaundice. The incidence of biliary atresia is more common in East Asia, especially China, with an incidence of 2 per 10,000…
- Conditions
- Pediatric Acute Respiratory Distress Syndrome, Desflurane, Biliary Atresia
- Trial name
- EDPARDSLDLTR (NCT05783518)
- Testing
- desflurane, propofol
- Where
- 2 sites in China
- Volunteers
- 165 people
- Sponsor
- Tianjin First Central Hospital
Idiopathic Aplastic Anemia, Severe Aplastic Anemia
Up-front Matched Unrelated Donor Transplantation in Pediatric Patients With Idiopathic Aplastic Anemia
Pediatric patients with idiopathic aplastic anemia (AA) respond better than adults to immunosuppressive therapy (IST) but the long-term risks of relapse, ciclosporine dependence, and clonal evolution are high.
- Conditions
- Idiopathic Aplastic Anemia, Severe Aplastic Anemia, Moderate Aplastic Anemia Requiring Transfusions
- Trial name
- UPFRONT-MUD (NCT05419843)
- Testing
- HSCT Arm group
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Clonal Hematopoiesis
Donor CHIP and Allogeneic HSCT Outcome
Current data on the impact of donor CHIP on long-term recipient outcome remain largely speculative. Data on the impact of donor CHIP including on allograft function, immunologic dysfunction, graft versus host disease (GVHD)…
- Trial name
- NCT04689750
- Testing
- Next generation sequencing
- Where
- Hong Kong
- Volunteers
- 850 people
- Sponsor
- The University of Hong Kong
Late Complication From Skin Graft, Infection of Skin Donor Site
Efficacy and Safety of Silk Fibroin With Bioactive Coating Layer Dressing
A split-thickness skin graft (STSG) is used for a large wounds or wounds that cannot be closed by primary and secondary wound closure.
- Conditions
- Late Complication From Skin Graft, Infection of Skin Donor Site, Impaired Wound Healing, Pain, Intractable
- Trial name
- NCT02091076
- Testing
- Silk fibroin with bioactive coating layer dressing, Bactigras wound dressing
- Where
- Thailand
- Volunteers
- 29 people
- Sponsor
- Chulalongkorn University
Cutaneous T-Cell Non-Hodgkin Lymphoma, Recurrent Mycosis Fungoides and Sezary Syndrome
Reduced Intensity Conditioning Before Partially Matched Donor Stem Cell Transplant in Treating Patients With Advanced Cutaneous T Cell Lymphoma
This phase I trial studies the side effects and the best dose of donor lymphocyte infusion when given together with reduced intensity conditioning regimen before partially matched donor stem cell transplant in treating patients…
- Conditions
- Cutaneous T-Cell Non-Hodgkin Lymphoma, Recurrent Mycosis Fungoides and Sezary Syndrome, Stage IIB Mycosis Fungoides and Sezary Syndrome, Stage IIIA Mycosis Fungoides and Sezary Syndrome
- Trial name
- NCT02548468
- Testing
- Fludarabine, Total-Body Irradiation, T Cell-Depleted Donor Lymphocyte Infusion
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Infection, Precancerous/Nonmalignant Condition
Emergency Use of Adoptive Immunotherapy With CMV-Specific T Cells After Donor Bone Marrow Transplant of an Infant With Immunodeficiency Syndrome and CMV Infection
RATIONALE: Collecting the T cells from a donor and transplanting them into a patient may be effective treatment for immunodeficiency syndrome and CMV infection.
- Trial name
- NCT00547235
- Testing
- therapeutic allogeneic lymphocytes, allogeneic bone marrow transplantation, total-body irradiation
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Donor Hepatectomy
Drain vs No Drain After Live Donor Hepatectomy
Prophylactic abdominal drain placement after donor hepatectomy has been a common or even mandatory practice in most transplant centers.
- Trial name
- NCT06769776
- Testing
- No Drain i.e. Omission of abdominal drain placement
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Marengo Asia Hospitals
Graft Versus Host Disease, Leukemia
Clofarabine, Melphalan, and Thiotepa Followed By a Donor Stem Cell Transplant in Treating Patients With High-Risk and/or Advanced Hematologic Cancer or Other Disease
RATIONALE: Giving chemotherapy, such as clofarabine, melphalan, and thiotepa, before a donor stem cell transplant helps stop the growth of cancer or abnormal cells.
- Conditions
- Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT00423514
- Testing
- filgrastim, clofarabine, melphalan
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Adenosine Deaminase Deficiency, Autosomal Recessive Disorder
Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant
This pilot clinical trial studies total-body irradiation followed by cyclosporine and mycophenolate mofetil in treating patients with severe combined immunodeficiency (SCID) undergoing donor bone marrow transplant.
- Conditions
- Adenosine Deaminase Deficiency, Autosomal Recessive Disorder, Immune System Disorder, Purine-Nucleoside Phosphorylase Deficiency
- Trial name
- NCT00008450
- Testing
- Allogeneic Bone Marrow Transplantation, Cyclosporine, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Fred Hutchinson Cancer Center
Kidney Transplantation
Effect of Privigen Against Graft Loss
The principal objective of this pilot study is to determine whether the progression of chronic antibody-mediated rejection (ABMR) could be minimized by the post-transplant administration of high dose of Intravenous…
- Trial name
- InAuGuRAL (NCT02374736)
- Testing
- Privigen (Human normal immunoglobulin G (IgG > 98 % purity))
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Immunodeficiency Syndrome, Non-Cancer Diagnosis
Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by a Donor Stem Cell Transplant in Treating Patients With Immunodeficiency or Other Nonmalignant Inherited Disorders
This phase II trial studies fludarabine phosphate and total-body irradiation with or without alemtuzumab followed by donor stem cell transplant to see how well it works in treating patients with immunodeficiency or other…
- Trial name
- NCT00553098
- Testing
- Alemtuzumab, Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation
- Where
- 6 sites in United States
- Volunteers
- 29 people
- Sponsor
- Fred Hutchinson Cancer Center
Clostridium Difficile
Fresh Versus Frozen Stool for Fecal Transplant in Children
The primary goal of this study will be to assess whether stool collected and frozen from anonymous screened unrelated donors can be as effective as stool freshly collected from recipient's parents when used in Fecal Microbial…
- Trial name
- NCT02423967
- Testing
- Transplant uses frozen anonymous stool, Transplant uses fresh familial stool
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma
RATIONALE: Giving high doses of chemotherapy drugs, such as busulfan and cyclophosphamide, before a donor bone marrow transplant helps stop the growth of cancer cells.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a)
- Trial name
- NCT01177371
- Testing
- busulfan, cyclophosphamide, allogeneic bone marrow transplantation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Kidney Transplant
Clinical Study on Thymus-Kidney Transplantation From Neonatal Donors for the Induction of Immune Tolerance
Thymus transplantation for the induction of immune tolerance in kidney transplantation: This study aims to understand how thymus transplantation can induce immune tolerance in recipients of allogeneic kidney transplants to…
- Trial name
- NCT06715865
- Testing
- Thymus Transplantation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Alveolar Ridge Augmentation, Tissue Transplantation
Peri-implant Tissue Stability Following Tissue Augmentation Harvested From Deep Palate or Tuberosity
This study will compare peri implant tissue stability following connective tissue graft harvested fromLateral Palate or the Tuberosity Area.
- Conditions
- Alveolar Ridge Augmentation, Tissue Transplantation, Tissue Donors
- Trial name
- NCT05014763
- Testing
- connective tissue graft
- Where
- Iran
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Cell-Free Nucleic Acids
Study for Detection of Donor-derived Cell-free DNA After Renal Transplantation Using Devysers NGS-based Chimerism Assay.
The aim of this study is to evaluate highly sensitive quantitative tests for early molecular detection of graft rejection and associated immune response from liquid biopsies in the blood from patients undergoing renal…
- Trial name
- NCT05226936
- Testing
- Cell free DNA analysis
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
End Stage Chronic Renal Failure, Renal Transplant
Microvasculature Ultrasound Super-resolution in Transplant Delayed Graft Function
This pilot study is testing a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow and tiny blood vessels in transplanted kidneys in very detailed images after kidney transplant surgery.
- Conditions
- End Stage Chronic Renal Failure, Renal Transplant, Microvascular Changes, Microvascular Circulation
- Trial name
- MUST-D (NCT07645599)
- Testing
- Ultrasound contrast agent (Contrast-enhanced ultrasound), Optison (Perflutren Protein-Type A Microspheres Injectable Suspension), Lumason® contrast agent
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Roderick Tan
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