Clinical trials: Donor
Donor Hepatectomy, Central Venous Catheter
Spectral Analysis of Central Venous Pressure Waveform
The use of central venous pressure has been abandoned for the assessment of intravascular volume status. The dynamic fluctuation of central venous pressure according to heart rate is quantitatively measured by spectral analysis…
- Conditions
- Donor Hepatectomy, Central Venous Catheter, Hypovolemia
- Trial name
- NCT04733547
- Testing
- Placement of a central venous catheter, Monitoring of central venous pressure, Furosemide-induced hypovolemia before graft procurement
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- JongHae Kim
Burns
A Randomized Comparison Study of Aquacel Ag and Glucan II as Donor Site Dressings
The research will be looking at patient outcomes for healing of donor sites after a split-thickness skin graft procedure for a burn or skin tissue loss.
- Trial name
- NCT00581217
- Testing
- Aquacel Ag, Glucan II
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Irvine
Burns
CONTINUED ACCESS PROTOCOL: Demonstration of the Safety and Effectiveness of ReCell® Combined With Meshed Skin Graft for Reduction of Donor Area in the Treatment of Acute Burn Injuries
The overall purpose of this is study to provide continued access to the ReCell device following completion of protocol CTP001-6, and allow for collection of supplementary clinical outcome data for the ReCell device when used as…
- Trial name
- NCT02994654
- Testing
- ReCell
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- Avita Medical
Idiopathic Pulmonary Fibrosis, Emphysema or COPD
Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure
The purpose of this study is to determine whether a lung transplantation prior to bone marrow transplantation (BMT) would allow for restoration of pulmonary function prior to BMT, allowing to proceed to BMT, to restore…
- Trial name
- NCT03500731
- Testing
- CD3/CD19 negative hematopoietic stem cells, Rituximab, Alemtuzumab
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Paul Szabolcs
Kidney Diseases
Comparative Renal Function of Young (18-45 Years) and Ageing (55 Years and Above) Kidney Donors
It is our purpose in this study to compare the kidney structure and function of older patients to that of young patients before and after removal of a single kidney for transplant donation and to examine the remaining kidney's…
- Trial name
- NCT00846729
- Testing
- CT angiogram of the remaining kidney., Kidney Function study using Iothalamate & PAH as clearance markers
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Stanford University
Hypertension, Cardiovascular Diseases
Effect of Sublingually Generated S-nitroso-N-acetylcysteine on Systemic Blood Pressure.
The purpose of the study is to increase the in vivo levels of nitric oxide by generating nitric oxide donor compound S-nitrosoacetylcysteine (SNOAC) using the mixture of sodium nitrite and N-acetylcysteine crystals in the…
- Trial name
- NCT05798481
- Testing
- Mixture of Sodium Nitrite and N-acetylcysteine (NAC) crytals.
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
aGVHD
Efficacy and Safety Study of ATG for Prophylaxis of aGVHD in Matched Sibling Donor PBSCT
The purpose of this study is to determine the efficacy and safety of combined ATG （antithymocyte globulin ） regimen for aGVHD(acute graft-versus-host disease ) prophylaxis in matched sibling donor peripheral blood stem cell…
- Trial name
- NCT02677181
- Testing
- ATG, CsA, mycophenolate mofetil
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Hepatic Transplantation
Clamp-crush Technique Versus Harmonic Scalpel in Living Donor Hepatectomy
The purpose of this study is to determine whether clamp-crush technique for liver parenchymal transection is as safe as Harmonic scalpel device.
- Trial name
- KK_HS (NCT02853981)
- Testing
- Harmonic scalpel, Kelly clamp crush technique
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Leukemia, Lymphoma
Total-Body Irradiation and Chemotherapy Followed By Donor Bone Marrow Transplant in Treating Young Patients With Hematologic Cancer
RATIONALE: Giving chemotherapy and total body irradiation before a donor bone marrow transplant helps stop the growth of cancer and abnormal cells and helps stop the patient's immune system from rejecting the donor's stem cells.
- Conditions
- Leukemia, Lymphoma, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
- Trial name
- NCT00028730
- Testing
- anti-thymocyte globulin, filgrastim, cyclophosphamide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Leukemia, Lymphoma
Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Cancer
RATIONALE: Giving low doses of chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells.
- Conditions
- Leukemia, Lymphoma, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
- Trial name
- NCT00818961
- Testing
- alemtuzumab, graft-versus-tumor induction therapy, rituximab
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Northside Hospital, Inc.
Gingival Recession, Mucogingival Surgery
Role of Manuka Honey in Lowering Pain and Boosting Healing After Gum Graft Surgery.
The goal of this clinical trial is to learn if medical grade Manuka Honey works to lower pain and improve healing sites after gum grafting surgery.
- Trial name
- NCT07016373
- Testing
- Palatal Plate without Manuka Honey, Palatal plate with Manuka Honey
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Nancy Mouradian
Irritable Bowel Syndrome With Diarrhea, Irritable Bowel Syndrome Mixed
Faecal Microbiota Transplantation in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is the most common functional bowel disorder, being present in approximately 10% of adult Europoid population. The etiology of IBS is elusive.
- Trial name
- MISCEAT (NCT04899869)
- Testing
- Faecal microbiota transplantation with active study microbiota first, Faecal microbiota transplantation with inactive autoclaved study microbiota first, Faecal microbiota transplantation with inactive autoclaved study microbiota only
- Where
- Czechia
- Volunteers
- 61 people
- Sponsor
- Thomayer University Hospital
Accelerating the Epithelialization of Split Thickness Skin Graft
Trial to Compare Intra-individually the Efficacy and Tolerance of Oleogel-S10 Versus Moist Wound Healing Dressing Alone in Accelerating the Epithelialization of Split Thickness Skin Graft Donor Sites
In this study the wound reepithelialization of that part of the skin graft donor site, which is treated with Oleogel-S10 compared to that part of the wound, which is covered by moist wound healing dressing alone will be…
- Trial name
- OleoSplit (NCT01294254)
- Testing
- Oleogel-S10, Moist wound healing dressings alone (Mepilex) on the other half of the skin graft donor site
- Where
- 2 sites in Germany
- Volunteers
- 24 people
- Sponsor
- Birken AG
Kidney Failure, Surgery
Effect of Lost Wage Reimbursement to Kidney Donors on Living Donation Rates
The study is designed as a randomized controlled trial. The investigators hypothesize that kidney transplant recipient candidates whose donors are offered reimbursement of lost wages (treatment arm) will have a higher probability…
- Conditions
- Kidney Failure, Surgery, Renal Failure
- Trial name
- NCT03350269
- Testing
- Information provision
- Where
- 6 sites in United States
- Volunteers
- 1,310 people
- Sponsor
- Arbor Research Collaborative for Health
Pediatric Sarcoma, Refractory, Pediatric Sarcoma, Relapsed
A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue
The purpose of this study is to determine if the addition of infusions of a type of immune cell called a "natural killer", or NK cell to the sarcoma chemotherapy regimen GEM/DOX (gemcitabine and docetaxel) can improve outcomes in…
- Trial name
- TINKS (NCT05634369)
- Testing
- GEM/DOX + TGFBi expanded NK cells
- Where
- 22 sites in United States
- Volunteers
- 50 people
- Sponsor
- Nationwide Children's Hospital
Transfusion Related Complication, Liver Transplant
Utilization of Donor Whole Blood for Blood Transfusion in Deceased Donor Liver Transplantation
We will study 40 matched patients. 20 patients will receive leukoreduced whole blood from the solid organ donor. These 20 patients will be compared to 20 historical matched controls with regards to allogenic blood product usage…
- Trial name
- NCT04383756
- Testing
- Donor Blood, Banked Blood
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Healthy Hematopoietic Stem Cell Donor, Healthy Allogeneic Hematopoietic Stem Cell Donor
Single-Dose vs. Divided-Dose G-CSF for Stem Cell Mobilization in Healthy Allogeneic Donors
National and international guidelines/consensus recommend G-CSF (granulocyte colony-stimulating factor) at 10 μg/kg/day as a single daily dose or divided into two daily doses for mobilization in healthy donors for allogeneic…
- Trial name
- NCT07692841
- Testing
- Single-dose Granulocyte colony-stimulating factor (G-CSF), Divided-dose Granulocyte colony-stimulating factor (G-CSF)
- Where
- 8 sites in China
- Volunteers
- 560 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Liver Transplantation, Reperfusion
A Study of Retrograde rEperfusion in Dbd Donor LIver Transplantation
To evaluate whether retrograde caval reperfusion of liver graft could be superior over antegrade portal reperfusion in regard of incidence and severity of early allograft liver dysfunction.
- Conditions
- Liver Transplantation, Reperfusion, Delayed Graft Function
- Trial name
- REDLIT (NCT02423941)
- Testing
- Retrogade reperfusion, Antegrade reperfusion
- Where
- Belarus
- Volunteers
- 90 people
- Sponsor
- Republican Scientific and Practical Center for Organ and Tissue Transplantation
MicroRNA Profile, Liver Transplant
MicroRNA Profile As a Biomarker of Liver Damage in Different Types of Liver Donors.
The goal of this observational study is to analyze the expression of liver-derived miRNAs in different types of liver donors to gain in depth knowledge about distinctive physiologic features within donors and find potential…
- Conditions
- MicroRNA Profile, Liver Transplant, Organ Donor
- Trial name
- NCT06611046
- Testing
- organ donor
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mar Dalmau
Anaplastic Ependymoma, Atypical Teratoid/Rhabdoid Tumor
Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer
This phase I trial investigates the side effects and effectiveness of chemotherapy followed by a donor (allogeneic) stem cell transplant when given to patients with high grade brain cancer.
- Conditions
- Anaplastic Ependymoma, Atypical Teratoid/Rhabdoid Tumor, Central Nervous System Germ Cell Tumor, Choroid Plexus Carcinoma
- Trial name
- NCT04521946
- Testing
- Etoposide, Fludarabine Phosphate, Hematopoietic Cell Transplantation
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
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