Clinical trials: Donor
Vitrification, Egg Donor
Validation of Donor Oocytes Semi-automated Vitrification
Oocyte vitrification is an effective method of freezing which has been authorized in France since 2011. The arrival of this technique has led to real improvements in the survival rate of oocytes after warming compared to that…
- Conditions
- Vitrification, Egg Donor, Fertility, Assisted Reproductive Technology
- Trial name
- GAVIDO (NCT06238570)
- Testing
- Gavi, Merck® (automated vitrification instrument), Vitrolife system
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Normothermic Machine Perfusion (NMP) of Deceased Donor Kidneys
Registry Analysis of Deceased Donor Kidney Transplant Outcomes
This study uses existing transplant data obtained from a national public donor registry operated by the Organ Procurement and Transplant Network (OPTN) under Health Resources and Services Agency (HRSA) to evaluate outcomes…
- Trial name
- NCT07530991
- Where
- United States
- Volunteers
- 3,500 people
- Sponsor
- Chris Jaynes
Increase Repeat Blood Donation Attempts Among First-time Donors
Community-based Communication for Blood Donation in Ghana
A randomized controlled trial to evaluate the effectiveness of the WhatsApp groups or docudrama compared to a control group (usual engagement with blood services) on repeat blood donation attempts among first-time blood donors in…
- Trial name
- C-CAD (NCT05973890)
- Testing
- WhatsApp, docudrama
- Where
- United States
- Volunteers
- 882 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Donor Site Complication, Burn
Blue Light for Donor Site Healing in Burn Patients
The goal of this clinical trial is to learn whether blue light (BL) photobiomodulation can improve the healing of donor site (DS) wounds in patients with burn injuries who are treated surgically.
- Conditions
- Donor Site Complication, Burn, Photobiomodulation Therapy, Blue Light
- Trial name
- CGU01_BL (NCT07453927)
- Testing
- Photobiomodulation with blue light
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- AUSL Romagna Rimini
Lung Transplantation, Donor-specific Anti-human Leukocyte Antigen(HLA) Antibodies
Monitoring of Donor-specific Antibodies After Treatment With Immunoglobulins, Plasmapheresis and Rituximab in Lung Transplantation
Single-arm, prospective observational study
- Trial name
- NCT03798860
- Testing
- blood samples
- Where
- Germany
- Volunteers
- 340 people
- Sponsor
- Hannover Medical School
Solid Tumor, Adult, Healthy Donors
A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.
Primary Objective: This is a study to investigate the feasibility of harvesting, expanding, and selecting T lymphocytes from cancer patients and healthy volunteers.
- Conditions
- Solid Tumor, Adult, Healthy Donors, COVID-19 Donors
- Trial name
- NCT00571389
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- BioCytics, Inc.
Lactating Women - Human Milk Donors
Single-center Evaluation of Human Milk Quantity and Quality Over Five Years
This single-center retrospective observational study includes all human milk donors collaborating with the milk bank at České Budějovice Hospital between 2021 and 2025.
- Trial name
- HUMBLE (NCT07309146)
- Testing
- No Interventions
- Where
- Czechia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Living Donor Liver Transplantation
PRehab tO PreparE Living Liver Donors for Enhanced Recovery
1. to determine if a Phase III RCT of prehab vs usual care for LLDs is feasible (including rates of recruitment, adherence, adverse events, and attrition); 2.
- Trial name
- PROPELLER (NCT05431361)
- Testing
- Prehabilitation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Palatal Donor Site Wound Healing, Palatal Wound
Influence of Hyaluronic Acid in the Healing of Palatal Donor Sites During Free Gingival Graft Procedures
The goal of this study is to evaluate the use of a gel containing cross-linked hyaluronic acid (xHyA) at the palatal donor site following soft tissue harvesting procedures.
- Trial name
- HA Palate (NCT07458685)
- Testing
- Test - xHyA, Negative control
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Milan
Brain-dead Organ Donors
Anesthesia sTrategy foR Organ Procurement In braiN dEath
The optimal anesthetic strategy during organ procurement in brain-dead donors remains unknown. The administration of anesthetic drugs in this setting aims to preserve hemodynamic stability in the face of reflex responses mediated…
- Trial name
- ATROPINE (NCT07166991)
- Testing
- Volatile anesthetic, Opioid Anesthesia, Intraoperative brain-dead donor management
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Grenoble
Transplant Patients, Organ Failure, Multiple
Controlled Terminal Reperfusion With Cold Preservation Solution in the cDCD III Donor
The goal of this observational study is to describe the details of a controlled administration strategy of cold preservation solution or oxygenated cold preservation solution at the end of Abdominal Normothermic Regional…
- Conditions
- Transplant Patients, Organ Failure, Multiple, Organ Donor Registration
- Trial name
- PERFEND (NCT07421726)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Living Donor Nephrectomy
Scrotal Surgery After Laparoscopic Donor Nephrectomy
This study will examine whether laparoscopic nephrectomy is associated with a higher long-term risk of receiving scrotal surgery in male living kidney donors compared to male nondonors from the general population who have similar…
- Trial name
- NCT06716723
- Testing
- Nephrectomy
- Where
- Canada
- Volunteers
- 9,878 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Living Donor Liver Transplantation
Prediction Models for LDLT Outcomes
Rationale: Living donor liver transplantation (LDLT) has emerged as an important option for patients with end-stage liver disease.
- Trial name
- PREDICTLDLT (NCT07383194)
- Testing
- Living donor liver transplantation
- Where
- Netherlands
- Volunteers
- 3,000 people
- Sponsor
- Erasmus Medical Center
Living Liver and Kidney Donors
Living Organ Donor Recovery Enhancement Program
The purpose of the study is to test if using these living donor-specific pre-transplant resources would lead to a better and faster recovery post-transplant.
- Trial name
- NCT03865264
- Testing
- Recovery Enhancement Program
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Wound Healing, Palatal Wound
The Effectiveness of Nano Bio Fusion Gingival Gel (NBF) on Wound Healing at the Palate (Donor Site) After Soft Tissue Graft Surgery Compared to Placebo Gel.
The goal of this clinical trial is to assess the effect of Nano-biofusion gingival gel (NBF) on wound healing at the palatal donor site following soft tissue graft surgery and compare it to placebo gel.
- Conditions
- Wound Healing, Palatal Wound, Donor Site Complication, Inflammatory Cytokines
- Trial name
- NCT07330154
- Testing
- Application of NBF gel after soft tissue graft surgery
- Where
- Jordan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Kidney Failure, Kidney Transplant
Worldwide Assessment of Deceased Donor Kidney Utilization
The persistent imbalance between kidney transplant demand and organ availability remains a major global challenge. Optimizing the utilization of kidneys from deceased donors is a critical strategy to expand the donor pool and…
- Conditions
- Kidney Failure, Kidney Transplant, Deceased Donor Kidney Transplant
- Trial name
- NCT07341516
- Where
- 2 sites in United States, France
- Volunteers
- 300,000 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Living Donor Liver Transplantation
The Regenerative Capacity of the Donor Liver After Living Donor Liver Transplantation: an Ambidirectional Cohort Study
Rationale: Living donor liver transplantation (LDLT) offers a promising solution to the organ shortage. During living liver donation, a substantial portion of the donor's liver is resected.
- Trial name
- LRLDLT (NCT07329296)
- Testing
- Living liver donation
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Erasmus Medical Center
Living Donor Kidney Transplantation
Multidisciplinary Support To Access Living Donor Kidney Transplant-Pilot
For patients with kidney failure the two treatment options are kidney transplantation or dialysis. Transplantation offers longer survival, better quality of life and provides cost savings for the health system (>$60,000/year per…
- Trial name
- MuST AKT (NCT04666545)
- Testing
- MuST AKT
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta
Living Donor Kidney Transplantation
Multidisciplinary Support to Access Living Donor Kidney Transplant (MuST AKT)
For people living with kidney failure, the two active treatment options are dialysis or kidney transplantation. Transplantation is optimal, and especially from a living donor - offering patients longer survival, a better quality…
- Trial name
- MuST AKT (NCT05459337)
- Testing
- MuST AKT
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University of Alberta
Graft Rejection, Kidney Transplantation
TRAnscriptional Profile of Peripheral Blood Cells in Patient With Chronic Kidney and Lung Rejection: Correlation With Response to Extracorporeal Photo-aphereSiS
With this project, the research team aims to identify the molecular pathways associated with the response to extracorporeal photonchemioapheresis (ECP) in kidney or lung transplant patients suffering from chronic rejection, by…
- Conditions
- Graft Rejection, Kidney Transplantation, Lung Transplantation, Antibody-Mediated Rejection
- Trial name
- TRACKLESS (NCT07316829)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia