Clinical trials: Donor
Living Donor Liver Transplantation Recipients, Deceased Donor Liver Transplantation Recipients
Longitudinal Follow-up and Health-Related Outcomes in Liver Transplant Recipients and Living Donors
This prospective cohort study aims to identify risk factors for postoperative adverse events in liver transplant recipients and living donors.
- Conditions
- Living Donor Liver Transplantation Recipients, Deceased Donor Liver Transplantation Recipients, Living Liver Donor
- Trial name
- NCT07301853
- Testing
- liver transplantation, Living Donor Hepatectomy
- Where
- China
- Volunteers
- 9,999 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Leukemia, High Risk, Myelodysplastic Syndromes, High Risk
A Study Testing an Improved Dose of UM171 to Help Make Cord Blood Transplants More Effective and Safe.
This clinical study is testing a new way to improve stem cell transplants for adults with high-risk blood cancers, such as leukemia or myelodysplasia, who do not have a suitable donor.
- Conditions
- Acute Leukemia, High Risk, Myelodysplastic Syndromes, High Risk, Hematologic Malignancy Requiring an Allogeneic Hematopoietic Stem Cell Transplant Lacking a Donor
- Trial name
- ECT-001-CB-013 (NCT07301866)
- Testing
- ECT-001-CB
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Transplantation, Kidney, Living Donors
Paired Marrow Aspirations to Assess Assays in Sensitized Renal Allograft Recipients
The aim of this study is to determine a comprehensive immune profile of transplant donors and recipients through assessment of immune cell compositions in bone marrow, and lymph nodes.
- Conditions
- Transplantation, Kidney, Living Donors, Kidney Transplant Recipients
- Trial name
- NCT01150487
- Testing
- bone marrow aspirations, lymph node collection
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- Mayo Clinic
Living Donors, Nephrectomy
Pilot Study of an mHealth Intervention for Living Donor Follow-up
The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of follow-up compliance among living kidney donors.
- Conditions
- Living Donors, Nephrectomy, Kidney
- Trial name
- mHealth (NCT03400085)
- Testing
- mHealth application
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Johns Hopkins University
Living Donor Liver Transplantation
Steatosis Assessment Pre-LDLT
There is a major shortage of donor livers in the Netherlands. Living donor liver transplantation (LDLT) is a good solution to this shortage. Donor screening is extensive to minimalize risks for donors and recipients.
- Trial name
- SILDLT (NCT07015723)
- Testing
- Living liver donors
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Erasmus Medical Center
Prone Position, Donors
Prone vs Supine Position in Potential Organ Donors: Multicenter Clinical Trial
Background and justification: In Argentina, 9,650 people are on the organ transplant waiting list, including 290 who require a lung transplant.
- Conditions
- Prone Position, Donors, Lung Procurement, Tissue Donors
- Trial name
- PRODONAR (NCT07251777)
- Testing
- Prone position
- Where
- Argentina
- Volunteers
- 254 people
- Sponsor
- Hospital de Alta Complejidad del Bicentenario Esteban Echeverría
Skin Graft Wounds, Donor Site Complication
Aloe Vera vs Paraffin Tulle Dressings for Pain Management in Split Thickness Skin Graft Donor Sites
The goal of this clinical trial is to learn if Aloe Vera gel dressing helps reduce pain better than traditional paraffin-based tulle dressing at the donor site of split-thickness skin grafts in adult patients aged 18 to 60.
- Conditions
- Skin Graft Wounds, Donor Site Complication, Pain, Postoperative, Skin Transplantation
- Trial name
- AloePaTu (NCT07057557)
- Testing
- Aloe Vera Gel Dressing, Paraffin-Based Tulle Dressing
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- King Edward Medical University
Living Donor Liver Transplantation
DCreg in Living Donor Liver Transplantation
Phase I/II, single center, prospective, open-label, non-controlled, non-randomized, interventional, cohort study in which low risk living donor liver transplant (LDLT) recipients will receive a single infusion of donor-derived…
- Trial name
- NCT03164265
- Testing
- Regulatory Donor-Derived Dendritic Cell infusion
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Angus W. Thomson PhD DSc
To Assess the Safety and Tolerability of Intranasal Administration of a Male Donor Memory T Lymphocyte Solution
A Phase I, Single-Center, Open-Label, Dose-Escalation Clinical Trial to Assess the Safety and Tolerability of an Intranasal Memory T Lymphocytes Solution in Adult Females: vRELEASE I. (vRELEASE I)
Proof-of-concept trial to assess the safety and tolerability of intranasal administration of a male donor memory T lymphocyte solution in females aged between 18 - 55 years of age.
- Trial name
- vRELEASE I (NCT06699758)
- Testing
- CD45RA- memory T lymphocytes cells sourced from healthy peripheral blood mononuclear cells male donors.
- Where
- Spain
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Cristina Calvo Rey
Prostate Cancer, Healthy Donors
Comparative Study of Diagnostic and Prognosis Biomarkers of Prostate Cancer in Liquid Biopsy (HOPE)
Constitution of a biological collection within the framework of the establishment of a diagnostic, prognostic and active surveillance test for prostate cancer from long non-coding RNA biomarkers, in 3 cohorts of patients, with…
- Trial name
- HOPE (NCT05141383)
- Testing
- Urine sampling
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Institut Curie
Kidney Failure, Presence of Donor Specific Antibodies
Nanoparticle for DSA Removal
Magnetic nanoparticles, coated with human leukocyte antigens (HLA) to capture anti-HLA antibodies with donor specificity (donor-specific antibodies, DSA), will be tested ex-vivo.
- Trial name
- NCT04277377
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Hypertension, Living Kidney Donor
Dietary Sodium Intake and Blood Pressure in Living Kidney Donors
This is a pilot study to determine the feasibility of the study design and examine the main outcome whether low dietary sodium intake is superior to high dietary sodium intake in controlling blood pressure to be within the…
- Conditions
- Hypertension, Living Kidney Donor, Dietary Sodium Intake
- Trial name
- SPLID (NCT05041829)
- Testing
- Dietary sodium
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Donor Corneas Preservation
In Vitro Study on Donor Corneas Preservation in IRESTORE Storage Medium. A Post Marketing Interventional Study on Device
Donor corneas are harvested and then stored in the Eye Bank to maintain their viability until analysis and subsequent release for transplantation.
- Trial name
- IRESTORE (NCT07134946)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Blood Donation, Blood Platelets
grouP O wholE blooD : storagE leSion impacT And infLammation
"Etablissement Français du Sang" (EFS) prepares labile blood products from blood donations that are separated by type (red blood cells, plasma and platelets).
- Conditions
- Blood Donation, Blood Platelets, Blood Donors, Inflammation
- Trial name
- PEDESTAL EFS (NCT06809010)
- Testing
- Whole blood donation, Apheresis donation
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Etablissement Français du Sang
Antiplatelet Therapy, Healthy Donors
T-TAS® wS Method Comparison
This study involves the collection of blood samples and measurement with the T-TAS PL assay to compare the performance of the T-TAS wS instrument to the T-TAS 01 instrument
- Conditions
- Antiplatelet Therapy, Healthy Donors, Von Willebrand Disease (VWD)
- Trial name
- NCT06710262
- Testing
- T-TAS PL Assay
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- Hikari Dx, Inc.
Hydrocele, Hydrocele of Tunica Vaginalis
Hydrocelectomies in Male Donors
This is a population-based matched cohort study to examine whether male living kidney donors are at increased risk of undergoing hydrocelectomy compared to similar males in the general population.
- Conditions
- Hydrocele, Hydrocele of Tunica Vaginalis, Hydrocelectomy, Living Kidney Donor
- Trial name
- NCT07078123
- Testing
- Laparoscopic Donor Nephrectomy
- Volunteers
- 2,750 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Healthy Blood Donor
Comparison of the Impact of Different Suspension Mediums on ABO Antibody Titres.
Accurate estimation of ABO antibody titres is vital in Transfusion Medicine due to their involvement in hemolytic transfusion reactions, hemolytic disease of the fetus and newborn, and solid-organ transplant rejection.
- Trial name
- NCT07054372
- Testing
- Titres on conventional test tube method with different diluent
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Brain-dead Organ Donors
Potassium Canrenoate in Brain-dead Organ Donors: Randomized Controlled Clinical Trial
Given the current organ shortage, improving the quality/efficacy of harvested grafts from expanded criteria donors is essential to substantially increase the number of potential donors.
- Trial name
- CANREO-PMO (NCT04714710)
- Testing
- IV Potassium Canrenoate, IV Sodium Chloride 0.9 %
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Pr. Nicolas GIRERD
Healthy, Healthy Donors
Bioequivalence Study of Revolade® Eltrombopag 50 mg
Bioequivalence Study
- Trial name
- Eltrombopag (NCT06834451)
- Testing
- Revolade®, Eltrombopag (EPAG)
- Where
- Colombia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centro de Atencion e Investigacion Medica
Oral Cancer, Oral Cavity Cancer
Radial Forearm Donor Site Closure
The radial forearm free flap (RFFF) is widely used in head and neck reconstruction. Its thinness, pliability, pedicle length, and vessel size are particularly suited for oropharyngeal and oral cavity reconstruction.
- Conditions
- Oral Cancer, Oral Cavity Cancer, Donor Site Complication
- Trial name
- NCT05740033
- Testing
- Split-Thickness Skin Graft for Radial Forearm Donor Site Closure, Hatchet Flap for Radial Forearm Donor Site Closure
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of British Columbia