Clinical trials: Doxycycline
Cystic Fibrosis
Doxycycline Effects on Inflammation in Cystic Fibrosis
Doxycycline is known to exhibit immune modulatory activities beyond its antibacterial effects. In particular, doxycycline is a potent inhibitor of matrix metalloproteinase 9, which is a protease derived largely from neutrophils.
- Trial name
- NCT01323101
- Testing
- Doxycycline, No doxycycline
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Southern California
COVID-19 Patients
Efficacy and Safety of Ivermectin and Doxycycline in Combination or IVE Alone in Patients With COVID-19 Infection.
Burden: Initial outbreak of corona virus disease 2019 (COVID-19) was reported from Wuhan, China in early December 2019.Presently known to be caused by a novel beta-corona virus, named as Severe acute respiratory syndrome corona…
- Trial name
- NCT04407130
- Where
- Bangladesh
- Volunteers
- 72 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Neurofibromatosis Type 2
Doxycycline in Cutaneous Schwannoma (NF2)
In this research study the investigators want to learn more about an alternate, local treatment for skin schwannomas. Specifically, local doxycycline intra-tumoral injection will be performed as a potential treatment for…
- Trial name
- NCT05521048
- Testing
- Doxycycline Injection [Doxy]
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Lymphogranuloma Venereum, no Anorectal Symptoms
Multicentre Study Evaluating the Efficacy of a 7-day Course of Doxycycline for the Treatment of Asymptomatic Anal Lymphogranuloma Venereum.
Lymphogranuloma venereum (LGV) is a sexually transmitted infection (STI) caused by the L genotypes of C. trachomatis. Proctitis is the main clinical manifestation of infection in the current LGV epidemic.
- Conditions
- Lymphogranuloma Venereum, no Anorectal Symptoms, Doxycycline
- Trial name
- SHORT-LGV (NCT07767422)
- Testing
- Doxycline
- Where
- 14 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Bordeaux
Metastatic Cancer
Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions
RATIONALE: Some drugs such as bleomycin or doxycycline, or other compounds like talc, may help to control fluid in the chest caused by cancer.
- Trial name
- NCT00002872
- Testing
- bleomycin sulfate, doxycycline, talc
- Volunteers
- 480 people
- Sponsor
- Eastern Cooperative Oncology Group
Mycoplasma Genitalium Infection
Lefamulin for M. Genitalium Treatment Failures
The purpose of this drug study is to find out whether the antibiotic lefamulin (trade name Xenleta) will cure Mycoplasma genitalium infections that have not been cured by prior antibiotics while finding out whether it is more…
- Trial name
- NCT05111002
- Testing
- Lefamulin, Doxycycline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Washington
Advanced Cancers, Malignant Pleural Effusions
Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis
The goal of this clinical research study is to compare indwelling pleural catheters (IPC) in combination with saline (the current standard of care) versus IPC in combination with doxycycline as treatment for pleural effusions.
- Trial name
- NCT02623959
- Testing
- Questionnaires, Fentanyl Patch, Fentanyl (IV)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Leptospirosis, Chemoprophylaxis
These Studies That Evaluated the Efficacy of Antibiotics for Leptospirosis Treatment.
The goal of this randomized controlled trial is to study antibiotic chemoprophylaxis to prevent leptospirosis of high-risk populations.
- Trial name
- NCT07865156
- Testing
- Doxycycline
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Endometritis
Doxycycline Prophylaxis at Vacuum Aspiration Trial
This study is a randomized, double-blinded, controlled trial comparing two regimens of doxycycline for the prevention of infection after surgical abortion.
- Trial name
- Tu Du Doxy (NCT00547170)
- Testing
- Doxycycline pre-operatively, Doxycycline post-operatively
- Where
- Vietnam
- Volunteers
- 1,000 people
- Sponsor
- University of Pittsburgh
Aggressive Periodontitis
Doxycycline in the Treatment of Aggressive Periodontitis
The aim of the study was to compare the clinical effects of systemic use of doxycycline to amoxicillin plus metronidazole as adjunctive treatment in nonsurgical debridement of aggressive periodontitis (AgP).
- Trial name
- NCT03727620
- Testing
- amoxicillin plus metronidazole, Doxycycline
- Where
- Morocco
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mohammed V Souissi University
Gonorrhea, Chlamydia
Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men
The purpose of this study is to understand if taking an antibiotic called doxycycline by mouth as soon as possible after sexual contact without a condom can reduce the risk of sexually transmitted infections (STIs), including…
- Conditions
- Gonorrhea, Chlamydia, Syphilis
- Trial name
- NCT03980223
- Testing
- Doxycycline Hyclate Delayed-Release 200 mg
- Where
- 3 sites in United States
- Volunteers
- 641 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acne
Efficacy & Safety Comparison of Epiduo With Doxycycline Versus Vehicle With Isotretinoin in the Treatment of Severe Acne
Non-inferiority, randomized, controlled, multi-center, investigator-blind, parallel-group comparison study in subjects with severe acne vulgaris on the face.
- Trial name
- POWER (NCT01474590)
- Testing
- Epiduo/Tactuo, vehicle gel, doxycycline 200mg
- Where
- 25 sites in Canada
- Volunteers
- 266 people
- Sponsor
- Galderma R&D
To Determine Bioequivalence Under Fed Conditions
Bioequivalence Study of Doxycycline Monohydrate Tablets Under Fed Conditions
The purpose of this study is to compare the single-dose bioequivalence of Par and Oclassen doxycycline monohydrate 100 mg.
- Trial name
- NCT01380496
- Testing
- doxycycline monohydrate
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.