Clinical trials: Drinking, Alcohol
Acute Alcoholic Hepatitis, Chemical and Drug Induced Liver Injury
Digoxin In Treatment of Alcohol Associated Hepatitis
Prospective, single center, open label, randomized controlled trial to explore whether digoxin treatment affects cytokine levels as biomarkers of inflammation in patients with acute alcohol associated hepatitis, digoxin…
- Conditions
- Acute Alcoholic Hepatitis, Chemical and Drug Induced Liver Injury, Alcohol-Induced Disorders, Steatohepatitis Caused by Ingestible Alcohol
- Trial name
- DIGIT-AlcHep (NCT05014087)
- Testing
- Intravenous digoxin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Yale University
Bariatric Surgery Candidate, Alcohol Drinking
Reducing Alcohol Use Post-Bariatric Surgery
Despite bariatric surgery being the most effective weight loss intervention for patients who are severely obese, as many as 1 in 5 patients will develop an alcohol use disorder after their surgery.
- Trial name
- NCT04788316
- Testing
- CBI and Text messaging
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Henry Ford Health System
Alcohol Drinking, Marijuana
Brief Interventions With Text Messaging to Reduce Adolescent Alcohol and Marijuana Use
This study tests the feasibility of an intervention to prevent risky alcohol or marijuana use that adds a 4-week course of tailored text messaging to a brief motivational intervention for 13-18-year-old adolescents.
- Trial name
- STAR (NCT03401333)
- Testing
- Text Messaging and Brief Negotiation Interview
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yale University
Adolescent Alcohol Use
Hybrid Type 1 Trial of a Parent-Based Intervention Addressing Social Media and Adolescent Alcohol Use
The central goal of this application is to conduct a Hybrid Type 1 effectiveness-implementation randomized controlled trial to test the comparative effectiveness of an alcohol and social media parent-based intervention (PBI)…
- Trial name
- NCT07664644
- Testing
- Combined Alcohol and Social Media PBI and PFI, Alcohol and Social Media PBI, Power of Parents
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Cannabis Use, Alcohol Use
Alcohol and Cannabis Co-Use and the Gut-Brain Axis
This observational study aims to improve our understanding of how legal market cannabis use impacts acute and long-term alcohol use, the microbiota-gut-brain-axis (MGBA), and neurobehavioral alcohol use phenotypes such as…
- Conditions
- Cannabis Use, Alcohol Use, Inflammation
- Trial name
- FRACTAL (NCT04998006)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alcohol Drinking, Alcohol Use Disorder
Alcohol Misuse Intervention in Active Duty US Navy Personnel
A pilot trial among ship-board US Navy personnel surrounding a holiday weekend tested an evidence-based video on responsible drinking.
- Trial name
- NCT04893044
- Testing
- Video
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Binge Drinking, Alcohol Abuse
Cognitive Behavioral Treatment to Reduce Alcohol Use Among HIV-Infected Kenyans
This study will determine whether a cognitive behavioral intervention that demonstrates strong evidence in the U.S. of reducing alcohol use is effective when delivered by paraprofessionals in Kenya and compared against a usual…
- Conditions
- Binge Drinking, Alcohol Abuse, Alcohol Dependence, HIV Infections
- Trial name
- KHBS (NCT00792519)
- Testing
- HIV support group, CBT
- Where
- Kenya
- Volunteers
- 75 people
- Sponsor
- Brown University
Alcohol Drinking
High Schools- High on Life: an Intervention to Reduce Excessive Drinking in Danish High Schools
High schools High on life' intervention is a high school-based, multi-component intervention guided by theory, evidence, and empirical findings to reduce excessive drinking among Danish high school students.
- Trial name
- NCT03906500
- Testing
- High schools High on Life
- Where
- Denmark
- Volunteers
- 3,682 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Alcohol Use Disorder
Intranasal Insulin for Treatment of Alcohol Use Disorder
This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo.
- Trial name
- ITA (NCT05988632)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brown University
Post Traumatic Stress Disorder, Alcohol Abuse
Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD
Objective: Evaluate the efficacy and physiological effects of sublingual buprenorphine (SL-BUP; Subutex) combined with extended-release injectable naltrexone (XR-NTX; Vivitrol) in the treatment alcohol use disorder of comorbid…
- Trial name
- NCT03852628
- Testing
- 2mg Buprenex and 380mg Vivitrol
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
HIV, Partner Violence
Improving South African Government Workers' Capacities to Deliver HIV Interventions
The purpose of this study is to address the United States Office of AIDS Research highest priorities: improving the workforce, reducing health disparities, and addressing HIV comorbidities.
- Conditions
- HIV, Partner Violence, Malnutrition, Alcohol Use/Abuse
- Trial name
- NCT02957799
- Testing
- Accountable Condition, Control Condition
- Where
- 2 sites in South Africa
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Psychological Stress, Alcohol Intoxication
Stress-motivated Alcohol Use as a Value-based Decision-making Process
The goal of this experimental study is to improve our understanding of the effects of stress on the decision to consume (more) alcohol in regular drinkers.
- Trial name
- NCT06264791
- Testing
- Stress, Alcohol
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Washington
Drinking Behavior
BC179 Relieves Discomfort After Drinking
To assess the effectiveness and safety of probiotic strain BC179 in reducing alcohol absorption in the gut, thereby lowering health risks.
- Trial name
- NCT06899620
- Testing
- Probiotic group
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Alcohol Metabolism Modifier Adverse Reaction, Bariatric Surgery Candidate
Alcohol Metabolism After Sleeve Gastrectomy
This prospective study aimed to determine the alcohol intake symptoms and alcohol metabolism before and 12 months after sleeve gastrectomy (SG) by evaluating blood alcohol content (BAC) and urinary alcohol metabolite levels…
- Trial name
- NCT04079023
- Testing
- Sleeve Gastrectomy
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Roma La Sapienza
Alcohol Drinking
Validation in Humans of Genes Involved in Alcohol Drinking, Stress-Induced Alcohol Drinking and Relapse
Aim of the project is to validate and functionally characterize the combined impact of candidate genes and stress exposure on drinking in adolescents.
- Trial name
- NCT00326742
- Testing
- Trier Social Stress Test
- Where
- Germany
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Heavy Drinking, Alcohol Abuse
Effects of Long-term Exercise on Various Parameters in Heavy Drinkers
The purpose of this research is to examine the effects of long-term aerobic exercise of moderate intensity on psychological, physiological, biochemical, physiological and alcohol-related parameters in heavy drinkers, in order to…
- Conditions
- Heavy Drinking, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- NCT02664766
- Testing
- Exercise training program
- Volunteers
- 13 people
- Sponsor
- University of Thessaly
Alcohol Use, Cannabis Use
MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education
The MATAspire intervention is a web-app designed to promote substance misuse prevention education and bolster protective coping skills whereby students complete six weekly interactive modules using a smart device or computer.
- Conditions
- Alcohol Use, Cannabis Use, Nicotine Use, Illicit Drug Use
- Trial name
- MATAspire (NCT06553196)
- Testing
- MATAspire Web-app
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Alcohol Drinking, Sexual Assault
Integrated Alcohol and Sexual Assault Intervention for College Men
This research will evaluate a new intervention that integrates evidence-based alcohol intervention strategies and promising sexual assault prevention strategies with the goal of decreasing sexual aggression among men who report…
- Trial name
- NCT05773027
- Testing
- SAFE, Mindfulness-Based Control Condition
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Lifespan
Hazardous Behavior, Alcohol Consequences
Bystander Intervention for Hazardous Drinking
The objective of this treatment development grant is to create an innovative and efficacious alcohol intervention for emerging adults using features from three theoretically sound and empirically supported approaches.
- Trial name
- DISH (NCT06543342)
- Testing
- Bystander Brief Motivational Intervention
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Drinking, Drug Abuse
Enhancing Housing First Programs With a Social Network Substance Use Intervention
Housing First programs are promising approaches to transitioning substance using chronically homeless adults to affordable housing.
- Conditions
- Alcohol Drinking, Drug Abuse, HIV
- Trial name
- NCT02140359
- Testing
- Motivational Network Interview
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- RAND