Clinical trials: Drive, open to volunteers
Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome)
The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung Mechanics
The goal of this interventional study is to evaluate the effect of different positive end-expiratory pressures (PEEP) on lung and diaphragm function in patients mechanically ventilated with pressure support ventilation in the…
- Conditions
- Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome), Pneumonia, Respiratory Insufficiency
- Trial name
- INFLATE-ICU (NCT07188038)
- Testing
- Low positive end-expiratory pressure, Medium positive end-expiratory pressure, High positive end-expiratory pressure
- Where
- 2 sites in Sweden
- Volunteers
- 25 people
- Sponsor
- Vastra Gotaland Region
Transgender Persons, Health Services for Transgender Persons
THE GUIDE: Transforming Health for Young Adults Using Interventions to Drive Engagement
This is a randomized controlled trial to test the effectiveness of an interactive educational app-based digital intervention that provides knowledge and support to transgender and gender-diverse (TGD) young adults ages 18-29…
- Conditions
- Transgender Persons, Health Services for Transgender Persons, Gender Identity
- Trial name
- NCT06177600
- Testing
- Interactive educational digital platform for transgender and gender-diverse (TGD) young adults and caregivers
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Tobacco Use, Cigarette Smoking
RTMS Targets Neural Circuits for Smoking Cessation
Cigarette smoking is a significant public health concern. Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel…
- Trial name
- NCT04903028
- Testing
- Active rTMS 10 Hz DLPFC
- Where
- 2 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cardiac Resynchronization Therapy, Chronic Heart Failure
Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment
The objective of this prospective, multicenter controlled study is to assess the feasibility of a patient-tailored implantation by creating a cloud-based pre-procedural multimodality CRT-roadmap by integration of 3D images from…
- Conditions
- Cardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch Block
- Trial name
- CRT-DRIVE (NCT05327062)
- Testing
- CRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment
- Where
- 13 sites in United States, Austria and 5 more
- Volunteers
- 150 people
- Sponsor
- XSpline S.p.A.
OSA
Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA
Obstructive sleep apnea (OSA) is a highly prevalent disorder that has major consequences for cardiovascular health, neurocognitive function, risk of traffic accidents, daytime sleepiness, and quality of life.
- Trial name
- NCT06091085
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Brigham and Women's Hospital
Prediabetes
Pharmacist-Led Continuous Glucose Monitoring for Prediabetes
The goal of this observational study is to determine if a pharmacist-led program involving continuous glucose monitoring (CGM) improves glucose control and health behavior in people with prediabetes.
- Trial name
- NCT07529366
- Testing
- Dexcom Stelo CGM
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Sleep Apnea Syndrome, Obstructive
Treatment Failure of Continuous Positive Airway Pressure (CPAP) in Patients With Obstructive Sleep Apnea Syndrome (OSA): A Trial Comparing Polysomnography and the Sunrise Device to Drive Treatment-Adjustment Decisions.
The goal of this clinical trial is to determine whether treatment-adjustment decisions based on one night of home monitoring with the Sunrise device are comparable to decisions based on one night of in-laboratory polysomnography…
- Trial name
- SUNCPAP (NCT07530302)
- Testing
- Sunrise
- Where
- France
- Volunteers
- 105 people
- Sponsor
- University Hospital, Grenoble
Stroke, Stroke (CVA) or Transient Ischemic Attack
Optimized Recruitment to Drive Equitable Research in Stroke, Empowering Decision-making (ORDERed)
Stroke is a major health issue, especially for women, who are more likely than men to have worse outcomes and lower quality of life after a stroke.
- Trial name
- ORDERed (NCT07576647)
- Testing
- Supported, women-centred and aphasia-friendly recruitment process (ORDERed), Traditional recruitment processes (TRADITIONAL)
- Where
- 3 sites in Canada
- Volunteers
- 1,600 people
- Sponsor
- McMaster University
Patient Discharge, Neurocognition
PACU Discharge Readiness
The use of custom-created apps, neuropsychological testing, and clinical assessments will be evaluated as tools for determining the appropriateness of PACU discharge to home.
- Conditions
- Patient Discharge, Neurocognition, Baseline
- Trial name
- NCT07588542
- Testing
- custom-created apps, neuropsychological testing, and clinical assessments
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Illinois Chicago
Acute Respiratory Disease
Estimation of P0.1 Using Ultrasound Indexes of Diaphragm Function
Occlusion pressure at 100 ms (P0.1) is a reliable and non-invasive index of inspiratory drive that can be measured easily on most ventilator. Unfortunately, P0.1 cannot be measured reliably in non-intubated patients.
- Trial name
- PoccUS (NCT07564258)
- Testing
- Spontaneous breathing trial
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Amyotrophic Lateral Sclerosis (ALS)
Developing New Ways to Detect Respiratory Impairment Early in ALS
The goal of this observational study is to develop new ways to detect early changes associated with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
- Trial name
- NCT07844590
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Peripheral Nerve Injuries
Non-invasive Therapy to Drive Nerve Regeneration
Peripheral nerve injuries are common and often associated with poor outcomes including incomplete repair, debilitating pain states and compromised function.
- Trial name
- NCT05848778
- Testing
- Acute Intermittent Hypoxia, Normoxia
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Alberta
Pleural Effusion
Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion
The aim of this study is to better understand the relationship between pleural effusions and breathlessness in patients with unilateral pleural effusions and breathlessness who require pleural fluid removal for its management.
- Trial name
- COSINE (NCT05945043)
- Testing
- Surface parasternal eletromyogram, Surface diaphragm electromyogram, Parasternal muscle ultrasound
- Where
- United Kingdom
- Volunteers
- 124 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Respiratory Failure, Critical Illness
The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
This clinical trial aims to assess the efficacy of sedation protocol targeting optimal respiratory drive using P0.1 and arousal level compared with conventional sedation strategy (targeting arousal level alone) in patients…
- Conditions
- Respiratory Failure, Critical Illness, Respiratory Distress Syndrome, Adult, Lung Injury
- Trial name
- NCT06203405
- Testing
- Titrating sedation targeting both optimal P0.1 and appropriate arousal level, Fentanyl, Midazolam
- Where
- Thailand
- Volunteers
- 214 people
- Sponsor
- Siriraj Hospital
Autism Spectrum Disorders
A Comparative Study of Driving Performance Among Adolescents With Autism Spectrum Disorder and Neurotypical Adolescents
The primary objective of this study is to compare the number of driving errors made by novice adolescents (0-5 hours of driving instruction) with ASD to those made by neurotypical adolescents during a standardized driving…
- Trial name
- Perf-TSA (NCT07630298)
- Testing
- Assessment of executive functions and attention, Evaluation on a driving simulator, Evaluation on-road
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Hopital La Musse
Palliative Therapy, Implementation Science
Clinical Surveillance Tool to Screen for Unmet Palliative Needs Among Patients in the Final Year of Life
One of the most important obstacles to improving end-of-life care is the inability of clinicians to reliably identify those who are approaching the end-of-life.
- Conditions
- Palliative Therapy, Implementation Science, Screening, Terminal Care
- Trial name
- HOMR (NCT04171830)
- Testing
- modified Hospital One-year Mortality Risk (mHOMR)
- Where
- 13 sites in Canada
- Volunteers
- 3,536 people
- Sponsor
- Ottawa Hospital Research Institute
Cancer
Precision Care Initiative: Integrating Precision Oncology Into Clinical Programs
The purpose of this study is to drive integration of precision medicine into routine oncology healthcare. It is hoped that this research will not only optimise the newly established Precision Care Clinic within the Prince of…
- Trial name
- NCT06077110
- Testing
- Precision Care Clinic services
- Volunteers
- 300 people
- Sponsor
- The University of New South Wales
Cerebral Palsy
Dynamic, Real-world Learning, Innovative Mobility, and Versatile Exploration (DRIVE): Evaluating a Dose-matched Developmental Powered Mobility Intervention for Young Children With Cerebral Palsy
The goal of this clinical trial is to understand the effects of developmental powered mobility intervention on global development, gross motor function, and activity performance outcomes in 48 young children (ages 1-2 years) with…
- Trial name
- DRIVE (NCT07876219)
- Testing
- Permobil Explorer Mini, MORE-PT
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of Washington
Chronic Knee Pain, Fibromyalgia
Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive
Background: pain lasting for 12 weeks or beyond, which is often referred to as chronic pain, is common for people living with musculoskeletal conditions (e.g. arthritis, low back pain and fibromyalgia).
- Trial name
- Pain-Drive (NCT07281651)
- Testing
- Central Pain Hypersensitivity
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Invasive Mechanical Ventilation, Extubation Time
Measurement of Efferent Neural Drive From Respiratory Centers to Upper Airways Using Electromyography (EMG) of Genioglossus (GG) in Patients Dependent on Invasive Mechanical Ventilation
Muscle activity in the upper airway is influenced by specific states such as anesthesia, sleep, wakefulness, and the phases of respiration.
- Trial name
- NCT07842484
- Testing
- electromyography (EMG) of genioglossus (GG)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia