Clinical trials: Driving Pressure, active
One-lung Ventilation (OLV), Video-assisted Thoracis Surgery (VATS)
Comparison of Different Ventilation Modes in Video-Assisted Thoracoscopic Lung Resection
One-lung ventilation (OLV) is required for video-assisted thoracoscopic surgery (VATS) lung resection, but it exposes the dependent lung to atelectasis, high driving pressures, and oxidative stress, and is associated with…
- Trial name
- OLV-VENT (NCT07866170)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Solid Tumor (Excluding CNS)
Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology
Tumor thermal ablation under Jet Ventilation is a procedure performed under general anesthesia that enables tumor ablation under radiological imaging guidance.
- Trial name
- Pulmojet 3 (NCT07408375)
- Testing
- High-Frequency Jet Ventilation (HFJV)
- Where
- 7 sites in France
- Volunteers
- 560 people
- Sponsor
- Nantes University Hospital
Dynamic Lung Compliance
Effects of Changes in Driving Pressure on Intraoperative Pulmonary Dynamic Compliance and PaO₂/FiO₂ Ratio in Laparoscopic Sleeve Gastrectomy
The goal of this prospective intervention study is to determine whether individualized positive end expiratory pressure (PEEP) titration targeting the minimum Driving pressure (ΔP) during LGS operation improves intraoperative…
- Trial name
- PEEP (NCT07494240)
- Testing
- incremental peep
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Beni-Suef University
One-lung Ventilation (OLV)
Correlation of Oxygenation and Saturation Indices in One-Lung Ventilation
One-lung ventilation is commonly used during thoracic surgery but is frequently associated with impaired oxygenation and altered respiratory mechanics.
- Trial name
- OLV-INDICES (NCT07381517)
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Acute Respiratory Distress Syndrome ARDS
Driving Pressure-guided Tidal Volume Ventilation in the Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is associated with high mortality, some of which can be attributed to ventilator-induced lung injury (VILI) when artificial ventilation is not customized to the severity of lung injury.
- Trial name
- DRIVENT (NCT06322758)
- Testing
- Tidal volume customization in the acute respiratory distress syndrome
- Volunteers
- 750 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Surgery, Mechanical Power
Individualized PEEP and Pulmonary Complications in On-Pump CABG
Postoperative pulmonary complications (PPCs) are an important cause of morbidity and mortality after major surgery and are frequently observed in cardiac surgery patients undergoing cardiopulmonary bypass (CPB).
- Conditions
- Cardiac Surgery, Mechanical Power, Postoperative Pulmonary Complications (PPCs)
- Trial name
- NCT07623109
- Testing
- Driving pressure-based personalized PEEP strategy, Conventional lung protective mechanical ventilation strategy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa City Hospital
Obese Patients With Bariatric Surgery, Lung Ultrasound Score
Comparison Between Individualized PEEP Ventilation Guided by Driving Pressure and Conventional Lung Protective Strategy in Obese Patients Undergoing Laparoscopic Bariatric Surgery
this study to compare the ventilation in obese patients either using Driving pressure ventilation technique or conventional protective lung strategy all by using Lung ultrasound score
- Trial name
- NCT06950112
- Testing
- lung ultrasound
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mahmoud Gamal Ahmed Arakeeb
Peep Titration in Lung Protective Ventilation
Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery
Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery.
- Trial name
- NCT07044089
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Intra-Abdominal Hypertension, Respiratory Mechanics
Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
This prospective observational cohort study aims to investigate the relationship between intra-abdominal pressure (IAP), respiratory system mechanics, and successful liberation from invasive mechanical ventilation in adult…
- Conditions
- Intra-Abdominal Hypertension, Respiratory Mechanics, Mechanical Ventilation
- Trial name
- IAP-VENT (NCT07889609)
- Testing
- Serial Intra-Abdominal Pressure and Respiratory Mechanics Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Lumbar Disc Herniation, Spinal Surgery
Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery
This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in…
- Conditions
- Lumbar Disc Herniation, Spinal Surgery, Prone Position, General Anesthesia
- Trial name
- PROPEEP (NCT07545733)
- Testing
- Mechanical Ventilation (PEEP)
- Volunteers
- 60 people
- Sponsor
- Harran University
Cerebral Hemodynamics, Mechanical Ventilation Strategies
Cerebral Hemodynamic Effects of Individualized PEEP During Robotic Prostatectomy
This randomized clinical trial will compare two approaches to setting positive end-expiratory pressure (PEEP) during robot-assisted radical prostatectomy performed in the Trendelenburg position.
- Conditions
- Cerebral Hemodynamics, Mechanical Ventilation Strategies, Robotic Prostatectomy
- Trial name
- NCT07784010
- Testing
- Individualized PEEP Titration, Standard PEEP Group
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University
Atelectasis
Lung Ultrasound Evaluation of Individualized Versus Standard PEEP on Postoperative Atelectasis in Gynecological Laparoscopy
The purpose of this study is to compare two different airway pressure (PEEP) strategies during gynecological laparoscopic surgery to see which one better prevents lung collapse (atelectasis).
- Trial name
- NCT07602543
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ankara Etlik City Hospital
Postoperative Pulmonary Complications
Mechanical Power and Driving Pressure Exposure in Laparoscopic Surgery
Postoperative pulmonary complications (PPCs) remain an important cause of morbidity after abdominal surgery. Intraoperative mechanical ventilation may contribute to lung injury through the mechanical load applied to the…
- Trial name
- NCT07431242
- Testing
- Intraoperative Ventilatory Load Exposure (Mechanical Power and Driving Pressure)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istinye University
Hypoxemia, Ventilator Lung
Driving Pressure-guided Lung Protective Ventilation
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving…
- Trial name
- DPV (NCT06361420)
- Testing
- Driving pressure-guided positive end expiratory pressure, Optimal oxygenation-guided positive end expiratory pressure, Ventilation strategy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Yong Lin, PhD
Hypoxemia, Ards
Effectiveness of Low Volume and Low Pressure in Severe Hypoxemic Patients
The present study set up to answer two questions: (a) "how low tidal volume must be to provide protective ventilatory settings able to minimize the risk of death due to Ventilator-Induced Lung Injury (VILI)?"; (b) "if protection…
- Trial name
- avengARDS (NCT06513299)
- Testing
- low tidal volume, high tidal volume, low driving pressure
- Where
- Italy
- Volunteers
- 4,300 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Pulmonary Resection Surgery, One Lung Ventillation (OLV)
BMI-Adjusted PEEP During One-Lung Ventilation in Thoracic Surgery
One-lung ventilation (OLV) is required during many thoracic surgical procedures and is associated with reduced functional residual capacity, atelectasis, ventilation-perfusion mismatch, hypoxemia, and potentially…
- Conditions
- Pulmonary Resection Surgery, One Lung Ventillation (OLV), General Anesthetic
- Trial name
- SIMPLE-PEEP (NCT07851740)
- Testing
- Fixed PEEP, BMI-adjusted PEEP
- Where
- 4 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Jesús Manuel Nieves Alonso
Postoperative Complications, Surgery
Driving Pressure During General Anesthesia for Minimally Invasive Abdominal Surgery (GENERATOR)
The purpose of this international multicenter, patient and outcome-assessor blinded randomized controlled trial is to determine whether the application of an individualized high Positive End Expiratory Pressure (PEEP) strategy…
- Trial name
- GENERATOR (NCT06101511)
- Testing
- Intraoperative ventilation with individualized high PEEP titrated to the lowest ΔP with RMs
- Where
- Netherlands
- Volunteers
- 1,806 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mechanical Ventilation Complication, Ventilator Induced Lung Injury
Mechanical Power and Mortality in Mechanically Ventilated Adults
This prospective observational cohort study aims to investigate the relationship between mechanical power during the first 72 hours of invasive mechanical ventilation and 28-day mortality in mechanically ventilated adult patients…
- Conditions
- Mechanical Ventilation Complication, Ventilator Induced Lung Injury, ARDS, ICU Mortality (Survival Rate)
- Trial name
- NCT07836153
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Zagazig University
Acute Respiratory Distress Syndrome
Association Between Driving Transpulmonary Pressure and Extravascular Lung Water in Patients with ARDS
Intubated patients with the acute respiratory distress syndrome (ARDS) are usually treated with protective ventilation limiting plateau pressure below 30 centimeter of water (cmH2O) and, if possible, a driving pressure under 15…
- Trial name
- NCT05474196
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Bicetre Hospital
Acute Kidney Failure, Mechanical Ventilation Strategies
Driving Pressure Optimization, RV-PA Coupling, and AKI in Mechanically Ventilated Critically Ill Patients
This study evaluates the effect of driving pressure optimization on right ventricular-pulmonary artery (RV-PA) coupling, assessed by TAPSE/PASP ratio, and its association with acute kidney injury (AKI) progression in mechanically…
- Conditions
- Acute Kidney Failure, Mechanical Ventilation Strategies, Right Ventricular (RV) Dysfunction, Critical Illness
- Trial name
- NCT07836387
- Testing
- Driving Pressure-Guided Ventilator Optimization
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Nardin Aymn Boshra