Clinical trials: Drowsiness, open to volunteers
Obstructive Sleep Apnea, Sleepiness
Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness
Obstructive sleep apnea (OSA) is a sleep disorder that is commonly treated using positive airway pressure, yet 50% of patients still experience residual sleepiness after successful therapy.
- Trial name
- STIL TIRED (NCT06698809)
- Testing
- Active tPBM
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- NYU Langone Health
Insomnia Chronic, Narcolepsy
The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders
Carry out precise and effective neuromodulation interventions, and develop new neuromodulation technologies for sleep disorders.
- Conditions
- Insomnia Chronic, Narcolepsy, REM Sleep Behavior Disorder
- Trial name
- NCT06797284
- Testing
- Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Apnea, Sleep Disorders
A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Do Not Use a Breathing Machine (PAP) (VESPER-OSA 2)
This study is being done to learn about the safety and effects of a study medicine called berobenatide (bear-oh-BEN-uh-tide). The study will see if berobenatide can help adults with breathing problems during sleep (obstructive…
- Conditions
- Apnea, Sleep Disorders, Overweight and/or Obesity
- Trial name
- VESPER-OSA 2 (NCT07881757)
- Testing
- Berobenatide
- Where
- 4 sites in United States
- Volunteers
- 258 people
- Sponsor
- Pfizer
Mental Fatigue, Cognitive Performance
Predicting Declines in Attention and Memory During a Prolonged Mental Task
This study will investigate whether heart activity and changes in the skin's ability to conduct electricity can help predict performance during a demanding computer task.
- Trial name
- COG-PRED (NCT07877389)
- Testing
- Individually Calibrated Time Load Dual-back Task With Seated Rest
- Where
- Poland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- DSW Ideis University
End Stage Renal Failure, Hemodialysis, Fatigue
Reflexology Versus Progressive Muscle Relaxation for Fatigue in Hemodialysis Patients
The goal of this clinical trial is to compare the effects of reflexology and progressive muscle relaxation in reducing fatigue among hemodialysis patients and to determine which intervention provides greater relief from fatigue.
- Trial name
- PMR-HD (NCT07575607)
- Testing
- reflexology, progressive muscle relaxation, Control
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Idiopathic Hypersomnia, POTS - Postural Orthostatic Tachycardia Syndrome
Effect of Low Sodium Oxybate (LXB) on Autonomic Symptom Burden in Idiopathic Hypersomnia Patients With Postural Tachycardia Syndrome
The investigators hope to learn if low sodium oxybate (LXB) is an effective treatment for symptoms of idiopathic hypersomnia (IH) and postural tachycardia syndrome (POTS).
- Trial name
- NCT07077278
- Testing
- Low sodium oxybate (LXB)
- Volunteers
- 25 people
- Sponsor
- Stanford University
Narcolepsy
Proteomics and Metabolomics of Body Fluid in Patients With Narcolepsy
Narcolepsy (NRL) is a rare chronic central nervous system dysfunction disease, which is more common in children and adolescents, and less common in adults.
- Trial name
- NCT06279247
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Narcolepsy, Social Cognition
Evaluation of Social Cognition in Patient With Type 1 or Type 2 Narcolepsy Versus Patients With Idiopathic Hypersomnia
Narcolepsy is a chronic disabling neurologic disorder mainly characterised by excessive daytime sleepiness. Type 1 narcolepsy is associated with a deficit of hypocretin in the cerebrospinal fluid responsible for the cataplexy…
- Trial name
- COGNAR (NCT05773872)
- Testing
- Questionary
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Narcolepsy
A Phase 3 Study to Evaluate the Efficacy and Safety of Samelisant in Patients With Narcolepsy (AWAKE)
The primary objective of this study is to evaluate the effect of Samelisant on excessive daytime sleepiness (EDS) after 12 weeks of treatment.
- Trial name
- NCT07540364
- Testing
- Samelisant
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Suven Life Sciences Limited
Shift Work
Effects of Operational Naps on Blood Pressure and Performance Among Night Shift Workers
Night shift work schedules disrupt sleep and have a negative impact on cardiovascular health. Most who work in public safety occupations and in healthcare work night shifts.
- Trial name
- EONN (NCT07217769)
- Testing
- No-nap, 15-min nap, 30-min nap
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Sleep Apnea Syndrome, Obstructive Sleep Apnea
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population.
- Conditions
- Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome
- Trial name
- NCT04179981
- Testing
- Positive airway pressure, Conservative care (control arm)
- Where
- United States
- Volunteers
- 668 people
- Sponsor
- VA Office of Research and Development
Sleep Apnea, Insomnia
Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.
Rural communities in the southern U.S. suffer a disproportionate burden of morbidity and mortality from cardiometabolic disease, with traditional risk factors explaining only a modest proportion of the excess burden of disease.
- Conditions
- Sleep Apnea, Insomnia, Sleep Deprivation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT06336525
- Where
- United States
- Volunteers
- 3,680 people
- Sponsor
- Brigham and Women's Hospital
Narcolepsy Type 1, Hypersomnolence
Mind-wandering and Predictive Processes in Narcolepsy: a Putative Mechanism Through Covert REM Intrusions
Mind wandering is a state in which attention turns away from the external environment or current task to focus on internal thoughts (past experiences, future events, planned actions...).
- Conditions
- Narcolepsy Type 1, Hypersomnolence, Idiopathic Hypersomnia
- Trial name
- NARCOWANDERING (NCT06457945)
- Testing
- ASRT, Questionnaires, Electrophysiological recordings
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Post Acute Sequelae of SARS CoV 2 Infection, Obstructive Sleep Apnea
Predictors of Post-COVID-19 Clinical and Cognitive Consequences
The CDC describes Post-acute sequelae of SARS-COV-2 infection (PASC) for the wide range of physical and mental health consequences experienced by some patients.
- Trial name
- SCLC (NCT06291870)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Chronic Insomnia, Sleep Deprivation
Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
This clinical trial aims to evaluate the safety and efficacy of PROSOMNIA Sleep Therapy (PSTx) for individuals suffering from chronic insomnia, sleep deprivation, and REM sleep disorders.
- Conditions
- Chronic Insomnia, Sleep Deprivation, REM Behavior Disorder, REM Sleep Behavior Disorder
- Trial name
- PSHW (NCT06644573)
- Testing
- PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nyree Penn
Narcolepsy Type 1, Narcolepsy Type 2
A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence
Narcolepsy Type 1 (NT1) and Narcolepsy Type 2 (NT2) are rare conditions that make people feel very sleepy during the day (often referred to as excessive daytime sleepiness [EDS]).
- Trial name
- NCT07598708
- Testing
- cleminorexton
- Where
- 26 sites in United States
- Volunteers
- 222 people
- Sponsor
- Centessa Pharmaceuticals (UK) Limited
Idiopathic Hypersomnia
Efficacy and Tolerance of Solriamfetol in Patients Affected with Idiopathic Hypersomnia.
This Phase II clinical trial is a monocenter, double-blind, randomized, placebo-controlled study aimed at evaluate the efficacy and safety of solriamfetol from 75 to 300 mg per day in IH patients.
- Trial name
- SOLR-IH (NCT06590662)
- Testing
- Solriamfetol
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Obstructive Sleep Apnea
Bright Light Therapy for OSA
Persistent daytime symptoms of sleepiness in individuals with obstructive sleep apnea (OSA) who are using Continuous Positive Airway Pressure (CPAP) are associated with adverse long term medical and functional outcomes.
- Trial name
- BrightDaysII (NCT05917119)
- Testing
- BLT, s-BLT
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Excessive Daytime Sleepiness
A Study of ORX142 in Healthy Adult Subjects, Including Subjects 18 to 80 Years of Age
Characterize the safety, tolerability and pharmacokinetics of ORX142 following single and multiple doses.
- Trial name
- NCT07082829
- Testing
- ORX142 Tablets
- Where
- 3 sites in United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Centessa Pharmaceuticals (UK) Limited