Clinical trials: Drug/Agent Toxicity by Tissue/Organ
Drug Toxicity
Antidote for Valproic Acid Toxicity: a New Indication for Meropenem Antibiotic.
Acute Valproic acid (VPA) toxicity is an emergency condition which may commonly present with central nervous system (CNS) depression(5).
- Trial name
- NCT04671589
- Testing
- Meropenem Injection
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Mabaret Al-Asafara Hospitals
Drug Toxicity
Real World Asparaginase Therapy Toxicity
This research study is being done to learn more about the short term and long term side effects of treatment with asparaginase drugs, which are commonly used in acute lymphoblastic leukemia (ALL) or acute lymphoblastic lymphoma…
- Trial name
- NCT07008027
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- St. Jude Children's Research Hospital
Drug/Agent Toxicity by Tissue/Organ, Head and Neck Cancer
Amifostine to Treat Side Effects of Treatment in Patients Receiving Radiation Therapy and Cisplatin for Advanced Head and Neck Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Head and Neck Cancer, Oral Complications, Radiation Toxicity
- Trial name
- NCT00003580
- Testing
- amifostine trihydrate, cisplatin, radiation therapy
- Where
- United States
- Sponsor
- University of Tennessee
Covid19, Ivermectin Poisoning
Adverse Effects of Ivermectin Used in Egypt During COVID-19
retrograde study of common and rare adverse effects of multiple doses of ivermectin used during the coivd 19 pandemic in egypt
- Conditions
- Covid19, Ivermectin Poisoning, Drug Toxicity, Drug Side Effect
- Trial name
- NCT04747678
- Testing
- Ivermectin
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Menoufia University
Methadone Toxicity, Methadone Overdose
Assessment of Methadone Dose Taken
Proof of concept: Pilot Study A Pilot, proof of concept, observational study with a long-term goal to develop a minimally invasive wearable Remote Medication Monitor (RMM) that provides continuous, real-time data on methadone…
- Conditions
- Methadone Toxicity, Methadone Overdose, Pain, Chronic, Drug Metabolism, Poor, CYP2D6-Related
- Trial name
- NCT05981573
- Testing
- Measurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo, Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo, ISF Extraction Device 2
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Cari Health Inc.
Breast Cancer, Drug/Agent Toxicity by Tissue/Organ
High-Dose Chemotherapy and Autologous Blood Cell Transplantation in Treating Patients With Primary, Locally Advanced, or Stage IV Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003068
- Testing
- amifostine trihydrate, cyclophosphamide, mitoxantrone hydrochloride
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Arizona
Sepsis, Critical Illness
Optimizing Vancomycin Therapy in Children
The purpose of Opt Vanc is to evaluate the feasibility of Bayesian dose adaptation, based on a previously-developed population pharmacokinetic (PK) model and a single optimally timed PK sample, to predict vancomycin area under…
- Conditions
- Sepsis, Critical Illness, Infections, Drug Toxicity
- Trial name
- Opt Vanc (NCT05691309)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Children's Hospital of Philadelphia
Melanoma, Neoplasm Metastasis
PegIntron Versus IntronA in CMAJCC Stage II (EADO 2001/CMII Trial)
Melanoma with a tumor thickness >= 1.5mm without clinically detectable nodes represents an increasing population with relapse rate of more than 50%.
- Trial name
- EADO (NCT00221702)
- Testing
- PegIntron, intron A
- Where
- France
- Volunteers
- 898 people
- Sponsor
- University Hospital, Bordeaux
Acute Kidney Injury, Drug Use
A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs (NeoAKI STOP)
This observational retrospective study aims to learn about the incidence of acute kidney (AKI) injury in newborns in infants exposed to nephrotoxic drugs with a big data approach.
- Conditions
- Acute Kidney Injury, Drug Use, Drug Interaction, Drug Toxicity
- Trial name
- NeoAKISTOP (NCT05851222)
- Where
- Italy
- Volunteers
- 4,200 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Immunosuppression, Kidney Transplant Rejection
The New LC-MS/MS Method for Determination of Unbound Tacrolimus in Plasma
Tacrolimus (TAC) is characterized by a narrow therapeutic window, as well as high inter- and intra-individual variability in pharmacokinetics. Both under- and overexposure may lead to severe adverse effects.
- Conditions
- Immunosuppression, Kidney Transplant Rejection, Kidney Transplant; Complications, Liver Transplant Rejection
- Trial name
- FreeTAC (NCT04657562)
- Testing
- Tacrolimus, Unbound tacrolimus measurement, CYP3A4 and CYP3A5 genotyping
- Where
- Poland
- Volunteers
- 380 people
- Sponsor
- National Science Centre, Poland
Drug Toxicity
Regional Data Exchange to Improve Medication Safety
Medication reconciliation, a process by which a provider obtains and documents a thorough medication history with specific attention to comparing current and previous medication use, can prevent medication-related errors and…
- Trial name
- NCT01239121
- Testing
- HIE-Enhanced Medication Reconciliation, Optimal Medication Reconciliation without HIE
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- VA Office of Research and Development
Mesenchymal Stromal Cells, Psoriasis
Efficacy and Safety of Expanded UCMSCs On Patients With Moderate to Severe Psoriasis
The purpose of this study is to evaluate the efficacy and safety of Expanded Umbilical Cord Mesenchymal Stem Cells on patients with moderate to severe psoriasis.
- Conditions
- Mesenchymal Stromal Cells, Psoriasis, Drug Effect, Drug Toxicity
- Trial name
- UCMSCs (NCT03745417)
- Testing
- Umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Bone Marrow Suppression, Brain and Central Nervous System Tumors
Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, etoposide phosphate, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Bone Marrow Suppression, Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ, Long-term Effects Secondary to Cancer Therapy in Children
- Trial name
- NCT00238173
- Testing
- filgrastim, acetylcysteine, carboplatin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- OHSU Knight Cancer Institute
Ankylosing Spondylitis, Therapeutic Agent Toxicity
A Randomized Open-labeled Study for Comparing Methods of Using Imrecoxib to Treat AS
The selective cox-2 inhibitor has been widely used in the treatment of Ankylosing spondylitis (AS). The Imrecoxib is a new cox-2 inhibitor. But the treatment strategy has not been decided yet.
- Trial name
- NCT04400786
- Testing
- intermittent treatment, continuous treatment
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Shanghai Zhongshan Hospital
Drug/Agent Toxicity by Tissue/Organ, Unspecified Adult Solid Tumor, Protocol Specific
Amifostine in Treating Patients With Cancer Who Have Neurological Changes Caused by Chemotherapy
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as amifostine, may protect normal cells from the side effects of chemotherapy.
- Trial name
- NCT00003252
- Testing
- amifostine trihydrate
- Where
- United States
- Sponsor
- Rush North Shore Medical Center
Drug Toxicity Psychotropic Agents Psychostimulants
Efficacy and Safety Study of Ryanodex as Adjuvant Treatment in Subjects With Psychostimulant Drug-Induced Toxicity (PDIT)
Ryanodex is being investigated as a potential adjuvant treatment for people suffering from psychostimulant drug-induced toxicity (PDIT), a life-threatening medical condition that results mainly from the abuse of certain illicit…
- Trial name
- NCT03189433
- Testing
- Ryanodex (dantrolene sodium) for injectable suspension
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Eagle Pharmaceuticals, Inc.
Drug/Agent Toxicity by Tissue/Organ, Lung Cancer
Amifostine to Prevent Side Effects in Patients Who Are Receiving Chemotherapy and Radiation Therapy for Limited-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Drugs such as amifostine may protect normal cells from the side effects of chemotherapy and radiation…
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Lung Cancer, Radiation Toxicity
- Trial name
- NCT00003583
- Testing
- amifostine trihydrate, cisplatin, etoposide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Drug Toxicity
Double-Blind Randomized Crossover Trial to Access Electrocardiogram Effects of HPN-100
Arm 1: Primary Objective: To determine the safety and tolerability of multiple ascending, supratherapeutic doses of HPN-100. Arm 2: Primary Objective: To assess the effects of steady-state levels of HPN-100 metabolites (4…
- Trial name
- NCT01135680
- Testing
- HPN-100, Moxifloxacin
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Amgen
Drug/Agent Toxicity by Tissue/Organ, Lymphoma
Irinotecan Plus Cyclosporine and Phenobarbital in Treating Patients With Solid Tumors or Lymphoma
Phase I trial to study the effectiveness of irinotecan plus cyclosporine and phenobarbital in treating patients who have solid tumors or lymphoma that is refractory to standard therapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Lymphoma, Neutropenia, Small Intestine Cancer
- Trial name
- NCT00002759
- Testing
- cyclosporine, irinotecan hydrochloride, phenobarbital
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Cancer Institute (NCI)
Cardiac Arrest, Respiratory Distress Syndrome
Pre Hospital Evaluation of Video Laryngoscopy
The objective of this work is to compare standard intubation with video laryngoscope (Glide scope Ranger ) in French pre hospital multicentric study.
- Conditions
- Cardiac Arrest, Respiratory Distress Syndrome, Shock, Acute Post-trauma Stress State
- Trial name
- EVE (NCT01374061)
- Testing
- Classical intubation, GLIDESCOPE
- Sponsor
- Assistance Publique - Hôpitaux de Paris