Clinical trials: Drug Distribution
Human Immunodeficiency Virus
Secondary Distribution of HIV Self-tests: an Innovative Strategy for Promoting Partner Testing and Reducing HIV Risk
This cluster randomized trial will assess whether the provision of multiple oral-fluid based HIV self-test kits to HIV-negative women at high risk of acquiring HIV in western Kenya is an approach that promotes HIV testing among…
- Trial name
- NCT03135067
- Testing
- Provision of multiple self-tests
- Where
- Kenya
- Volunteers
- 2,102 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Android Obesity, Metabolic Parameters and Adipose Tissue (AT) Gene Expression
Effect of Hula Hooping as Compared to Walking on Adipose Tissue Distribution, Metabolic Parameters and Adipose Tissue Gene Expression
o determine effects of hula-hooping on android obesity, metabolic parameters and adipose tissue (AT) gene expression.
- Trial name
- NCT01913171
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Parkinson's Disease
Absorption, Distribution, Metabolism and Excretion of [14C]-Labelled BIA 3-202 and Metabolites
The purpose of this study is: To determine the rate and routes of excretion of BIA 3-202 and the mass balance in urine and faeces To determine the kinetics of total radioactivity in blood To determine the kinetics of total…
- Trial name
- NCT02772614
- Testing
- BIA 3-202 (200 mg)
- Where
- Switzerland
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Chronic Obstructive Pulmonary Disease, Healthy
Ventilation Distribution in COPD Patients During Breathing Exercises
ELTGOL (Slow Expiration with the Opened Glottis in the Lateral posture) is an airway clearance technique performed in the lateral decubitus position.
- Trial name
- NCT06381973
- Testing
- ELTGOL_Physio, ELTGOL_Auto, PEP
- Where
- Belgium
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- William Poncin, PT, PhD
Menopause
Healthy Transitions: Menopause Effect on Obesity, Energy Balance, and Insulin
The purpose of this study is to determine the effect of menopause on obesity, energy balance, and insulin in postmenopausal, obese women.
- Trial name
- NCT00412269
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Partially Edentulous Mandible
Evaluation of Occlusal Contact Distribution in Digitally Fabricated Implant-Retained Fixed Partial Dentures in Mandibular Kennedy Class II Patients Following Artificial Intelligence Bite Optimization: A Quasi-Experimental Study
The aim of the study is to evaluate the occlusal contact distribution in digitally fabricated implant-retained fixed partial dentures in mandibular Kennedy Class II patients before and after artificial intelligence bite…
- Trial name
- Quasi (NCT07657910)
- Testing
- After, Before
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cairo University
Absorption
Study of Tocotrienol Absorption and Distribution Under Different Fat Status
Despite the emerging interest in tocotrienols, the absorption of tocotrienols in humans remains unclear especially with different fat diets.This study aimed at evaluating the absorption and distribution of tocotrienols in plasma…
- Trial name
- NCT01185769
- Testing
- Tocotrienol
- Where
- Malaysia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Malaysia Palm Oil Board
Healthy
A Study to Investigate the Whole Body Distribution and Radiation Dosimetry of the Positron Emission Tomography Ligand Fluoride-18 (18F)-JNJ-64326067 in Healthy Participants
The purpose of this study is to measure the whole-body distribution and radiation dosimetry of 18F-JNJ-64326067 in healthy participants.
- Trial name
- NCT03581916
- Testing
- 18F-JNJ-64326067
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
This Study Highlights Differences in Baropodometry Between Genders
Evaluation of the Effect of a Clinical Exercise Programme on Plantar Distribution and Correction of Postural Asymmetries
The aim of this study was to identify significant variables that contribute to the association between postural problems, plantar pressure distribution and levels of bodily pain in middle-aged and elderly adults.
- Trial name
- NCT06647355
- Testing
- Effectiveness of physical exercise in preventing pain and improving plantar pressure distribution
- Where
- Portugal
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Beira Interior
Endurance Exercise, Exercise Physiology
Comparison of Training Intensity Distribution Models in Recreational Distance Runners
This study aims to compare the effects of three different training intensity distribution (TID) models-polarized, threshold, and pyramidal-on physiological and performance adaptations in recreational distance runners.
- Conditions
- Endurance Exercise, Exercise Physiology, Running Performance
- Trial name
- NCT07565168
- Testing
- Polarided training intensity distribution, Threshold Training Intensity Distribution, Pyramidal Training Intensity Distribution
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Intrauterine Adhesions
Treatment of Intrauterine Adhesions and Its Distribution of Genital Tract Flora
This study aims to investigate the treatment of intrauterine adhesion and the factors influencing its prognosis.
- Trial name
- NCT03731689
- Testing
- Intrauterine lavage therapy, Intrauterine gel-injection therapy
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Sleep Disorder, Body Fat Distribution
Relationship Between Normal-weight Central Obesity and Obstructive Sleep Apnea
Comparison of the prevalence of obstructive sleep apnea (OSA), measured by polysomnography in normal weight patients with central obesity by body mass index (BMI) and waist hip ratio (WHR), with normal weight patients without…
- Trial name
- NCT04061226
- Testing
- Overnight polysomnography
- Where
- Czechia
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
HIV
Targeting Interventions at Venues Where Risk of HIV Transmission is High
The aim of this study is to investigate whether distribution of condoms and condom demonstrations by youth peer educators in venues where people meet new sexual partners in Livingstone, Zambia, leads to increased condom use among…
- Trial name
- PLACE (NCT01423357)
- Testing
- Condom distribution and peer education
- Where
- 2 sites in Zambia
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- University of Zambia
HCV
Radiolabel ADME (Absorption, Distribution, Metabolism, and Excretion) Study Of [14C] PF-00868554 In Healthy Adult Male Subjects
This is a phase 1 study to assess the routes of elimination of a single oral dose of [14C] PF-00868554 and to characterize the metabolic profile following single dose administration.
- Trial name
- NCT00823745
- Testing
- [14C]-PF-00868554
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
A Study to Understand How a Study Medicine Called PF-07328948 is Absorbed and Processed in the Body of Healthy Male Adults
The purpose of this study is to learn how a certain amount of [14C] PF-07320948 is taken up into the bloodstream and removed from the body.
- Trial name
- NCT07508228
- Testing
- Oral [14C]PF-07328948, Oral Unlabeled PF-07328948, IV [14C]PF-07328948
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tobacco Use Disorder, Smoking
Distribution of Bupropion and Varenicline to Increase Smoking Cessation Attempts
Bupropion and varenicline are indicated for smoking cessation. The objectives of this study are two-fold: (1) to explore the logistic feasibility of distributing bupropion and varenicline free of charge to treatment-seeking…
- Conditions
- Tobacco Use Disorder, Smoking, Smoking Cessation
- Trial name
- NCT01023659
- Testing
- bupropion, varenicline, motivational emails
- Where
- Canada
- Volunteers
- 893 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Healthy Volunteers
TAK-385 Phase I Absorption, Distribution, Metabolism, Excretion and Absolute Bioavailability Study
The purpose of this 2 part study is to look at how TAK-385 is taken up, broken down and removed from the body when given as a radiolabelled oral solution (by mouth) or as an oral tablet (by mouth) followed by a radiolabelled…
- Trial name
- NCT02252354
- Testing
- [14C]-TAK-385 Oral Solution, TAK-385 Tablets, [14C]-TAK-385 Solution for Intravenous Infusion
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Takeda
Healthy Volunteers Only
A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults
This study investigates how body fat distribution affects airway closure and lung mechanics in healthy adults. Using Electrical Impedance Tomography (EIT), esophageal manometry, and computed tomography (CT), we aim to…
- Trial name
- NCT07019831
- Testing
- Body positioning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maurizio F. Cereda, MD
Pulmonary Disease, Chronic Obstructive
A Single Dose Study to Determine the Excretion, Balance and Metabolic Disposition of Radiolabelled GW642444.
The purpose of this study is to characterise the metabolic disposition of radiolabelled GW642444 when administered orally.
- Trial name
- NCT01286831
- Testing
- [14C]GW642444
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Intestinal Disorders, Bowel Diseases, Inflammatory
TD-1473 Absorption, Distribution, Metabolism and Excretion (ADME) Study in Healthy Male Subjects
This is an open-label, 2-cohort study to evaluate the absolute bioavailability, absorption, distribution, metabolism and excretion of TD-1473 in healthy male subjects.
- Trial name
- NCT03408470
- Testing
- TD-1473 oral capsule, [14C]-TD-1473 IV bolus, [14C]-TD-1473 Oral Capsule
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma