Clinical trials: Drug Distribution
Child, Only, Joint Laxity
Effects of Textured Insoles and Exercise in Children With Joint Hypermobility
Joint hypermobility is the condition that the joints have a greater range of motion than normal and can be observed frequently in children.
- Conditions
- Child, Only, Joint Laxity, Exercise, Textured Insoles
- Trial name
- NCT06350240
- Testing
- Exercise, Exercise+texture insoles
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Cervical Cancer, HPV Infection
Feasibility of HPV Self-Collection Kits for Cervical Cancer Screening
This study is testing and implementing an equity-focused, community-based intervention that improves women's access to cervical cancer screening and adherence to follow up after an abnormal result.
- Trial name
- NCT07453459
- Testing
- Qualitative Interview, Virtual Visit Standard Instructions, Virtual Visit Standard Instructions + In-Person Registration Navigation
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pain, Postoperative
Ultrasound-guided Dual TAP Block: Magnetic Resonance (MR) Evaluation of the Distribution of Local Anesthetic
Using Magnetic resonance (MR) scanning and ultrasonography the investigators wish to investigate, in what way a known volume of local anesthetic injectate will be distributed in the transverse abdominis plane (TAP) in young…
- Trial name
- NCT01305603
- Testing
- Bupivacaine, Injection
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Obesity, Metabolic Syndrome
Cellular Dynamics of Subcutaneous Fat Distribution in Obese Women
The body shape of obese women varies between having the majority of fat either above the waist ("apple" shape) or below the waist ("pear" shape).
- Trial name
- Apple/Pear (NCT01748994)
- Testing
- Pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Asthma
Sensitivity of Pharmacokinetics to Differences in Aerodynamic Particle Size Distribution
When a drug company first develops a drug, the company has to show the Food and Drug Administration (FDA) that the drug is safe and effective. If FDA concludes that the drug is safe and effective, FDA approves the drug.
- Trial name
- NCT01966692
- Testing
- Fluticasone Propionate Formulation 1, Fluticasone Propionate Formulation 2, Fluticasone Propionate Formulation 3
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Florida
Overweight and Obesity, Weight Loss
PRE-Pregnancy Weight Loss And the Reducing Effect on CHILDhood Overweight - Aarhus
The study is a single site parallel randomized controlled study. The study will be assessing the effect of a 10% pre-conceptional weight loss intervention vs a control group among healthy couples where the prospective mother is…
- Conditions
- Overweight and Obesity, Weight Loss, Pregnancy Related, Child Nutrition Sciences
- Trial name
- PREPARE CHILD (NCT05798494)
- Testing
- Weight loss intervention
- Where
- Denmark
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ulla Kampmann Opstrup
Sedentary Behavior
Weekend Warrior Exercise in Sedentary Female University Students
This single-center, single-blind, three-arm randomized controlled trial aims to compare the effects of weekend-concentrated exercise, regularly distributed exercise, and usual lifestyle on aerobic capacity and skeletal muscle…
- Trial name
- NCT07693504
- Testing
- Weekend Warrior Exercise, Regularly Distributed Exercise
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chongqing Normal University
Healthy
A Study in Healthy Men to Test How BI 1584862 is Processed in the Body
The goal of this study is to find out how BI 1584862 moves through and exits the body of healthy men. To do this, BI 1584862 is labelled using radioactive carbon (C-14) and using a non-radioactive, naturally occurring, stable…
- Trial name
- NCT07336758
- Testing
- [13C]-labeled BI 1584862, Unlabeled BI 1584862 mixed with [14C]-labeled BI 1584862
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Volunteer
A Study to Investigate the Absolute Bioavailability, Absorption, Metabolism, Distribution and Excretion of [14C]AZD5363 (Capivasertib)
The Sponsor is developing the test medicine, Capivasertib, for the potential treatment of primary breast and prostate cancer. This two-part healthy volunteer study will try to identify the absolute bioavailability (amount of the…
- Trial name
- NCT05419401
- Testing
- Capivasertib film-coated tablet, 200 mg, [14C]AZD5363 (Capivasertib)
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
HIV
HIV Self-Testing Africa Zambia
This study consists of a Cluster Randomised Trial (CRT) of community and facility-based HIVST distribution by the Society for Family Health (SFH) in multiple rural and peri-urban settings.
- Trial name
- STAR Zambia (NCT02793804)
- Testing
- Oraquick (made in Thailand)
- Where
- Zambia
- Volunteers
- 5,005 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Weightlessness, Cerebral Blood Flow
Cerebral Blood Flow Distribution During Parabolic Flight-induced Microgravity
When astronauts return from space flight, they manifest a set of symptoms, the most striking of which is orthostatic intolerance, that is, the inability to stay upright.
- Trial name
- GraCer (NCT03986788)
- Testing
- Weightlessness
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy
Open Label, Healthy Volunteers, ADME Study With Single Oral Administration of [14C] AZD5069
This is a phase I, open label, healthy volunteers, ADME study with single oral administration of [14C] AZD5069.
- Trial name
- NCT01332903
- Testing
- [14C] AZD5069
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pain
Off-set Analgesia Induced by Cold Temperature
In this study, it will be investigated if the phenomenon of offset analgesia, usually associated with painful heat stimulation, could also be induced using cold painful temperatures.
- Trial name
- NCT07395869
- Testing
- Heat off-set analgesia, Cold off-set analgesia
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Arthritis, Psoriatic, Healthy
A Study of Guselkumab and Risankizumab in Healthy Participants and Participants With Psoriatic Arthritis
The purpose of this study is to assess the tissue distribution of guselkumab and risankizumab in healthy participants (Part 1) and psoriatic arthritis (PsA) participants (Part 2 and Part 3).
- Trial name
- NCT05083078
- Testing
- Guselkumab, Risankizumab
- Where
- Austria
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy Volunteers
Optimal Low B-value in Intravoxel Incoherent Motion Diffusion-weighted MR Imaging of the Brain
Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.
- Trial name
- NCT02411864
- Testing
- different low b-values distribution
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Obesity
Shifting and Distribution of Foot Pressure Among Obese Subjects
Background: The foot is considered a sensitive structure of musculoskeletal system that bears significant loads of the body weight during walking.
- Trial name
- NCT03441763
- Testing
- Emed foot device
- Where
- Saudi Arabia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Myofascial Pain
Distribution of Trigger Points in Patient Who Have Myofascial Pain Disorder
Myofascial pain alone covers 45.3% of the diagnosis of TMJ. It is defined as palpation sensitivity and regional muscle pain. Clinically muscle pain connects to myofascial trigger points.These trigger points are hypersensitive…
- Trial name
- NCT03962556
- Testing
- bimanual palpation
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Glucose Metabolism
Macronutrient Distribution and Plasma Metabolites to Model Meals Composition
Continuous glucose monitors (CGMs) measure plasma glucose concentration continually and thus they are a key tool in the management of diabetes, including type 2 diabetes (T2D).
- Trial name
- NCT04928872
- Testing
- Predefined meal
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Opioid Use, Opioid-Related Disorders
Surviving Opioid Overdose With Naloxone Education and Resuscitation Trial (SOONER)
Among people at risk of opioid overdose and receiving care in an academic emergency department, family practice, opioid substitution clinic or general inpatient units, does brief opioid overdose resuscitation training and…
- Conditions
- Opioid Use, Opioid-Related Disorders, Opioid Withdrawal, Opioid Overdose
- Trial name
- SOONER (NCT04740099)
- Testing
- SOONER Video & Kit, Standard of Care
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Extracorporeal Shock Wave Therapy, Kinaesthesia
Extracorporeal Shock Wave Therapy Applied to the Plantar Region in Individuals With Hemiplegia
Sensory and balance losses occur in hemiplegic patients. In some patients, sensory and balance rehabilitations may vary depending on the treatment they receive, depending on the treatment.
- Conditions
- Extracorporeal Shock Wave Therapy, Kinaesthesia, Sensory Disorders
- Trial name
- NCT05360316
- Testing
- ESWT
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Firat University