Clinical trials: Drug Drug Interaction Study
Healthy
The Study is to Evaluate the Effect of Multiple Doses PF-06751979 on the Pharmacokinetics of Midazolam in Healthy Adults
This is a drug interaction study to evaluate the PF-06751979 at steady state on the pharmacokinetics of oral midazolam single doses in fixed sequences including single dose midazolam alone in period 1 followed by multiple doses…
- Trial name
- NCT03126721
- Testing
- midazolam, PF-06751979
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Study Investigating the Pharmacokinetic Interaction Between INX-08189 and Verapamil HCL ER in Healthy Volunteers
The purpose of this study is to evaluate the potential for a pharmacokinetic (PK) drug-drug interaction between INX-08189 and extended release verapamil hydrochloride (verapamil HCL ER).
- Trial name
- INX-189-005 (NCT01471704)
- Testing
- INX-08189 50 mg, 240 mg verapamil HCL ER, 50 mg dose of INX-08189 and 240 mg verapamil HCL ER
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Healthy Subjects, Drug Interactions
Pharmacokinetic Interaction Study to Assess the Effect of ASP015K on Mycophenolate Mofetil in Healthy Volunteers
This study characterizes the pharmacokinetic effect of ASP015K on mycophenolate mofetil in healthy volunteers.
- Conditions
- Healthy Subjects, Drug Interactions, Pharmacokinetics of ASP015K
- Trial name
- NCT01364987
- Testing
- ASP015K, Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy Volunteers
Drug-drug Interaction Study of CTP-543 and Itraconazole in Healthy Adult Subjects
This is a Phase 1 open-label study of the effect of itraconazole on the pharmacokinetics of CTP-543 in healthy subjects.
- Trial name
- NCT04743414
- Testing
- CTP-543
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Concert Pharmaceuticals
Prostatic Neoplasms
Drug-drug-interaction Study to Assess the Effect of Darolutamide on the Pharmacokinetics of Probe Substrates of CYP3A4 and P-gp in Healthy Male Volunteers
Evaluate the effect of darolutamide on the pharmacokinetics of a probe CYP3A4 substrate and Pgp substrate
- Trial name
- NCT03237416
- Testing
- Dabigatran etexilate, Midazolam, BAY1841788 (darolutamide)
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Bayer
Healthy Participants
A Study to Assess the Effect of Food Intake and Drug-drug Interactions of E7090 When Co-administered With Rabeprazole or Rifampin in Healthy Participants
This study will have three parts: Part A, Part B, and Part C. The primary purpose of Part A is to evaluate the effect of food on the rate and extent of E7090 absorption following single oral doses of E7090 in healthy…
- Trial name
- NCT04565574
- Testing
- E7090, Rabeprazole 20 mg, Rifampin 600 mg
- Where
- Japan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Eisai Co., Ltd.
Drug Interaction
Drug-Drug Interaction Study to Evaluate the Effect of Inhibition of UGTs on the PK of Ecopipam and Its Active Metabolite
This is a single center, open-label, fixed sequence, drug-drug interaction (DDI) study in healthy subjects.
- Trial name
- NCT04902105
- Testing
- ecopipam HCL, Mefenamic acid, Divalproex Sodium ER
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Emalex Biosciences Inc.
Healthy
Assess the Influence of Cenobamate on the PK of Cytochrome P450 (CYP) Probe Drugs As a Means of Predicting Drug-drug Interactions
This study is aimed to investigate the influence of cenobamate on the activity of CYP3A4/5, CYP2B6, CYP2C19, and CYP2C9 by using drugs recommended by both the FDA and EMA as in vivo probes.
- Trial name
- NCT03234699
- Testing
- Cenobamate, midazolam, Warfarin Pill
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- SK Life Science, Inc.
Healthy
Effect Of Itraconazole On The Pharmacokinetics Of Palbociclib
This study is designed to evaluate the potential effect of itraconazole on the pharmacokinetics of palbociclib.
- Trial name
- NCT02131298
- Testing
- Palbociclib Alone, Palbociclib plus itraconazole
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Type 2 Diabetes
The Drug -Drug Interaction of SP2086 and Glyburide
The purpose of the study is to investigate the potential interaction between SP2086 and Glyburide after the singe and multiple oral doses treatment in healthy adult volunteers respectively.
- Trial name
- NCT02815787
- Testing
- SP2086, Glyburide
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy
Safinamide Steady State Interaction With Rosuvastatin
To evaluate if safinamide at the steady state, obtained after multiple 100 mg once a day administrations, has an effect on the pharmacokinetics of rosuvastatin, concomitantly administered as a single 20 mg dose, with respect to…
- Trial name
- NCT03216304
- Testing
- 100 mg safinamide, 20 mg rosuvastatin calcium period 1, 20 mg rosuvastatin calcium period 2
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cross Research S.A.
Pulmonary Disease, Chronic Obstructive
A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics (PK) of Nemiralisib
Nemiralisib is a potent anti-inflammatory agent for the treatment of chronic obstructive pulmonary disease (COPD) and other inflammatory lung diseases.
- Trial name
- NCT03398421
- Testing
- Nemiralisib, Itraconazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Sjogren Syndrome, Dry Eye Syndrome
Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops
Aqueous deficiency dry eye is mainly caused by Sjogren syndrome (SS), an autoimmune, chronic, inflammatory and systemic disease which affects most commonly the lacrimal and salivary glands.The ocular treatment is focused in…
- Trial name
- NCT01850979
- Testing
- Tacrolimus, Olive Oil
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo General Hospital
Glaucoma, Eye Diseases
KJ-TFC-004 Drug-drug Interaction Study
To assess the pharmacokinetic Interaction between Dorzolamide and Brimonidine in healthy male subjects.
- Conditions
- Glaucoma, Eye Diseases, Ocular Hypertension
- Trial name
- NCT02967614
- Testing
- [A], [B], [A]+[B](1)
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Kukje Pharma
Healthy
AV650 Drug-Drug Interaction Study
The purpose of this study is to evaluate the effects that paroxetine and fluvoxamine have on the way the body distributes, breakdowns and eliminates AV650.
- Trial name
- NCT00456560
- Testing
- AV650, Fluvoxamine, Paroxetine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Avigen
Healthy
Drug-Drug Interaction Study With Pravastatin and Cyclosporine
This study will address the following question: Does cyclosporine affect the pharmacokinetics of pravastatin in healthy volunteers? Studies have shown that cyclosporine inhibits the organic anion transporter required for…
- Trial name
- NCT01497483
- Testing
- Pravastatin alone, Pravastatin and Cyclosporine
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Epilepsy
Standardized Educational Plan for Epilepsy Patients With Comorbidities
Epilepsy requires long-term drug treatment and is frequently associated with other clinical conditions. Combinations of antiepileptic drugs and other compounds are fairly common and increase with age.
- Trial name
- EDU-COM (NCT01804322)
- Testing
- Standardized educational plan, usual care
- Where
- Italy
- Volunteers
- 187 people
- Sponsor
- San Gerardo Hospital
Healthy Volunteers
A Study of the Interaction of Other Drugs With TAK-279 in Healthy Adults
The main aim of this study is to find out how several doses of TAK-279 affects the body of healthy adults and processes midazolam and repaglinide (pharmacokinetics or PK).
- Trial name
- NCT06290050
- Testing
- Midazolam, Repaglinide, TAK-279
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Takeda
Healthy
Pharmacokinetic Drug Interaction Study Between Gemigliptin and Irbesartan After Oral Administration in Healthy Male Subjects
The objective of the study is to investigate the drug interaction between Gemigliptin and Irbesartan by comparing pharmacokinetics of Gemigliptin and Irbesartan administered concomitantly and each alone in healthy male subjects.
- Trial name
- NCT01825850
- Testing
- Gemigliptin, Irbesartan
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Healthy
A Pharmacokinetic Interaction Study Between Odalasvir, Given as a Single Agent or in Combination With Simeprevir, and Dabigatran Etexilate Mesylate in Healthy Participants
The purpose of this study is to evaluate the effect of steady-state concentrations of odalasvir (ODV), as a single agent or in combination with simeprevir (SMV), on the single-dose pharmacokinetics of dabigatran etexilate in…
- Trial name
- NCT02945020
- Testing
- Dabigatran etexilate mesylate, Odalasvir (ODV), Simeprevir (SMV)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
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