Clinical trials: Drug Effect
Lymphoma, Physical Exercise
Effects of Exercise Training in Survivors of Lymphoma
This study aims to compare the effects of aerobic exercise with or without addition of resistance exercise to usual care in individuals treated with anthracyclines for lymphomas and to compare exercise effects to age- and…
- Conditions
- Lymphoma, Physical Exercise, Cardiotoxicity, Cardiovascular Diseases
- Trial name
- LYMfit (NCT06270667)
- Testing
- Aerobic Exercise, Combined Aerobic and Resistance Exercise
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Health Participants
A Study to Evaluate the Safety, Tolerability, Drug Levels and Drug Effects of Single and Multiple Doses of BMS-986209 in Healthy Participants
The purpose of this study is to investigate the safety and tolerability of BMS-986209 in healthy participants. The first-in-human study is designed in 3 parts that vary based on duration and food effect.
- Trial name
- NCT04154800
- Testing
- BMS-986209, Itraconazole, Diltiazem
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Healthy Volunteers
Understanding The Effect Of A Strong CYP3A4 Inducer On Glasdegib Pharmacokinetics
The study also aims to determine the effect of a strong enzyme (CYP3A4) inducer-rifampin- on drug exposure of Glasdegib. This study will be conducted in healthy subjects given a single dose of glasdegib in each period.
- Trial name
- NCT02430545
- Testing
- Glasdegib, Rifampin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Participants
PF-07321332/Ritonavir and Ritonavir on Dabigatran Study in Healthy Participants
This is a drug-drug interaction study to assess the effects of PF-07321332/ritonavir and ritonavir on the Pharmacokinetic (PK) of dabigatran in healthy volunteers. PK will be evaluated for PF-07321332 and ritonavir.
- Trial name
- NCT05064800
- Testing
- Dabigatran, PF-07321332/ritonavir + Dabigatran, Ritonavir + Dabigatran
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cognitive Function
Fenfluramine and Cognition
In this study, the investigators will investigate the cognitive effects of fenfluramine, a drug that directly stimulates the release of serotonin in the brain and positively modulates σ1 function.
- Trial name
- FEN&Cognition (NCT05026398)
- Testing
- Fenfluramine
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Drug Interaction Research
Clinical Study on Drug Interactions of Flonoltinib Maleate Tablets
This study is a single center, open label, fixed sequence drug interaction study to evaluate the effects of CYP3A4 inhibitor itraconazole and CYP3A4 inducer rifampicin on the pharmacokinetic characteristics of a single oral dose…
- Trial name
- NCT07768111
- Testing
- 75mg Flonoltinib, 100mg Flonoltinib
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chengdu Zenitar Biomedical Technology Co., Ltd
Healthy, Obese
A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants
The main purpose of this study is to determine effect of orforglipron capsule formulation on the amount of digoxin, rosuvastatin, acetaminophen, midazolam, and simvastatin (each given alone and together with orforglipron) that…
- Conditions
- Healthy, Obese, Overweight
- Trial name
- NCT06186622
- Testing
- Orforglipron, Simvastatin, Digoxin
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
This Study Will Evaluate Whether TXA Reduces Pain
Effect of Tranexamic Acid (TXA) Administered Prior to Shoulder Arthroscopy on Postoperative Pain Medication Usage: A Randomized Controlled Trial
To our knowledge, no studies examining the use of TXA after shoulder arthroscopy in an outpatient setting have been published. This study will evaluate whether TXA reduces pain as measured by opioid consumption and a visual…
- Trial name
- NCT06920264
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Louis Joint Replacement Institute
Healthy
Effect of Aspirin Pretreatment or Slow Dose Titration on Flushing and Gastrointestinal Events in Healthy Volunteers Receiving Delayed-release Dimethyl Fumarate
The primary objective of the study is to evaluate whether premedication with 325 mg microcoated aspirin (ASA) tablet or a slow-titration dosing schedule of BG00012 reduces the incidence and severity of flushing and GI events…
- Trial name
- NCT01568112
- Testing
- BG00012 (dimethyl fumarate), ASA
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Biogen
Obesity
Effect and Safety of TCM-FMD in Phlegm-Dampness Type Overweight/Obesity Patients(EASTAR)
The primary aim of this study is to is to determine if a diet (TCM-FMD) which combine fasting-mimicking diet (FMD) with "dispelling dampness" meal replacement (a meal replacement made up of traditional Chinese medicine) is the…
- Trial name
- NCT04029571
- Testing
- TCM-FMD, FMD
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Gout
Food Effect Study of Febuxostat XR in Healthy Participants
The purpose of this study is to assess the effect of food on the bioavailability of febuxostat after a single oral dose of 80 mg febuxostat XR and to evaluate the pharmacokinetics (PK) of febuxostat after single oral doses of 40…
- Trial name
- NCT02374164
- Testing
- Febuxostat XR
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Takeda
Drug Absorption
Effect of Gamma-cyclodextrin on the Bioavailability of Ginsenosides
This study will evaluate the relative bioavailability of ginsenosides Rg5, Rk1, and Ck of Red ginseng HRG80 preparations containing gamma-cyclodextrin (GCD) in the blood plasma of healthy subjects after oral administration of two…
- Trial name
- NCT04932265
- Testing
- HRG80™ Red Ginseng, HRG80™ Red Ginseng + gamma cyclodextrin
- Where
- 4 sites in Armenia, Sweden
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- EuroPharma, Inc.
Atherosclerosis
Study to Determine the Effect of Repeated Administration of Diltiazem on the Pharmacokinetics of Darapladib (Sb-480848).
Darapladib (SB-480848) is a novel, selective, orally active inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2) currently under clinical development by GlaxoSmithKline as a potential anti-atherosclerosis agent for…
- Trial name
- NCT01852565
- Testing
- Darapladib, Diltiazem
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
MUSIC THERAPY, Premenstrual Syndrome
Music and Premenstrual Symptoms and Quality of Life
Premenstrual syndrome is an important health problem affecting women of childbearing age. This study is a prospective, single-blinded randomized controlled trial. Participants were randomized into music, and control groups.
- Trial name
- NCT04955912
- Testing
- music medicine
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Kırklareli University
Healthy
Drug Interaction Study To Investigate The Potential Effect Of Proton Pump Inhibitor On The Pharmacokinetics Of Palbociclib (PD-0332991)
Fixed sequence, 2-period crossover study to compare the pharmacokinetic profiles of Palbociclib in absence and presence of prior administration of proton pump inhibitor Rabeprazole.
- Trial name
- NCT01918176
- Testing
- Palbociclib alone, Palbociclib + Rabeprazole
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pharmacokinetics, Drug Interactions
A Study to Evaluate the Pharmacokinetic Drug Interaction Between Multiple Doses of JNJ-31001074 and a Single Dose of an Oral Contraceptive Containing Ethinyl Estradiol and Levonorgestrel in Women
The main purpose of this research study is to evaluate the effect of multiple doses of an investigational drug known as JNJ-31001074 on the single dose of combination oral contraceptive Ovral-L containing ethinyl estradiol and…
- Conditions
- Pharmacokinetics, Drug Interactions, Healthy
- Trial name
- NCT00915668
- Testing
- JNJ-31001074
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Dietary Supplements, Heart Rate/Drug Effects
Caffeine and Sodium Citrate Ingestion
A positive ergogenic effect of sodium citrate and caffeine ingestion in a short-term, high-intensity exercise task was shown by several studies. These studies were conducted with healthy, able-bodied subjects.
- Conditions
- Dietary Supplements, Heart Rate/Drug Effects, Lactic Acid/Metabolism, Physical Education and Training/Methods
- Trial name
- NCT01591226
- Testing
- Caffeine, Sodium Citrate, Mannitol
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Hepatitis C, Chronic Hepatitis C
Drug Interaction Study to Assess the Effect of Co-Administered Miravirsen and Telaprevir in Healthy Subjects
The purpose of this study is to assess the safety, tolerability, and affect on blood levels of miravirsen and telaprevir when administered together.
- Trial name
- NCT01646489
- Testing
- Miravirsen sodium, Telaprevir
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Santaris Pharma A/S
Narcotic Abuse
Aprepitant Effects on Oxycodone Response
Addressing the issue of opioid dependence and tolerance has public health implications for the treatment of opioid abuse (both heroin as well as pharmaceutical opioids) and for the treatment of pain.
- Trial name
- NCT00999544
- Testing
- Aprepitant 0mg, Aprepitant 40mg, Aprepitant 200mg
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Sharon Walsh
Psychiatric Disorder
Using Pharmacogenetics to Identify Patients With Polypharmacy at Risk of Medication Adverse Effects
The Researchers are trying to learn more about how individuals break down and process medications based on their genes. The Researchers want to find out whether subjects will have fewer side effects if they take different…
- Trial name
- NCT03748355
- Testing
- Pharmacogentic Analysis
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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