Clinical trials: Drug Effect (Glaucoma Drugs)
Glaucoma, Ocular Hypertension
Comparison of the Effects of Two Glaucoma Drugs Over 24 Hours (0507A-137)(COMPLETED)
This study is comparing 2 medications for glaucoma and how effective they are at controlling glaucoma over the course of an entire day.
- Trial name
- NCT00108017
- Testing
- MK0507A, dorzolamide hydrochloride (+) timolol maleate, Comparator: timolol maleate, Duration of Treatment: Part 1) 6 wk timolol maleate run in
- Volunteers
- 330 people
- Sponsor
- Merck Sharp & Dohme LLC
Glaucoma, OHT - Ocular Hypertension
Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance
Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments.
- Trial name
- NCT04412096
- Testing
- Timolol 0.5% ophthalmic solution, Latanoprost 0.005% Ophthalmic Solution
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- Ohio State University
Graft vs Host Disease, Congenital Aniridia
Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation
The ARGOS-IO pressure sensor is intended to be implanted in the human eye in combination with Boston Keratoprosthesis (BKPro) surgery and to remain in place indefinitely.
- Conditions
- Graft vs Host Disease, Congenital Aniridia, Chemical Burns, Stevens-Johnson Syndrome
- Trial name
- NCT02945176
- Testing
- ARGOS-IO system
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Implandata Ophthalmic Products GmbH
Glaucoma, Ocular Hypertension
Continuous Intraocular Pressure (IOP) Measurement and Ability to Detect Treatment Effect
Continuous intraocular pressure (IOP) measurement with a contact lens sensor may provide more information on the drug-related IOP change than 24-hour IOP measurement with Goldmann applanation tonometry (GAT.
- Trial name
- NCT01491867
- Testing
- travoprost 0.003%
- Where
- 2 sites in Hungary
- Volunteers
- 9 people
- Sponsor
- Semmelweis University
Healthy
Effect of Topical Glaucoma Therapy on Tear Film Stability in Healthy Subjects
Long term treatment with anti-glaucomatous drugs has been shown to increase the incidence of dry eye syndrome with all known consequences such as ocular discomfort and epithelial keratitis.
- Trial name
- NCT01746602
- Testing
- Timoptic® 0.5%, Timophtal sine® 0.5%, Genteal HA®
- Where
- Austria
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Effect of Drug
Comparison of Preserved and Preservative-free Latanoprost 0.005% in Primary Open Angle Glaucoma and Ocular Hypertensive Patients, at Guinness Eye Centre, Lagos.
It is a randomised, double-blinded clinical trial in which consenting participants who meet the inclusion criteria would be randomised into 2 groups.
- Trial name
- NCT05606796
- Testing
- Latanoprost 0.005% Ophthalmic Solution
- Where
- Nigeria
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Uzoma Chinyei Joan
Primary Open Angle Glaucoma, Drug Effect
Effect of Ginkgo Biloba Capsule on Visual Function of Primary Open-angle Glaucoma With Blood Stasis Syndrome
Primary Open Angle Glaucoma (POAG) is an eye disease that causes optic nerve damage, visual field defect, and blindness caused by increased intraocular pressure.
- Trial name
- NCT04334564
- Testing
- Ginkgo biloba capsule
- Where
- China
- Volunteers
- 512 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Hypertension
The Effect of Antihypertensive Medication Timing on Morbidity and Mortality
High blood pressure is common and its presence increases the risk of cardiovascular mortality and morbidity (most notably stroke, myocardial infarction, and congestive heart failure).
- Trial name
- NCT02990663
- Testing
- Use of blood pressure lowering medication at bedtime, Use of blood pressure lowering medication in the morning
- Where
- 5 sites in Canada
- Volunteers
- 3,357 people
- Sponsor
- University of Alberta
Healthy
The Pharmacokinetics of D565 and the Drug Effect of D565 on Pharmacokinetic Characteristics of D930
This study is a single sequence, 3-period, multiple-dose study to evaluate the pharmacokinetics of D565 and the drug effect of D565 on pharmacokinetic characteristics of D930 in healthy male volunteers.
- Trial name
- NCT03034486
- Testing
- D930, D565
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Glaucoma and Ocular Hypertension, Diabetic Macular Edema
Effect of Dexamethasone Implant on Optic Disc
This study evaluates the effect of dexamethasone implant which is an intraocular corticosteroid on the optic nerve fibers. Retinal nerve fiber thicknesses and optic nerve head pitting rates were measured before and 6 months after…
- Conditions
- Glaucoma and Ocular Hypertension, Diabetic Macular Edema, Intravenous Drug Usage, Optic Disk Disorders
- Trial name
- NCT03927118
- Testing
- intravitreal dexamethasone implant application
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Glaucoma
Aqueous Suppressant Versus Aqueous Outflow on Ocular Blood Flow
The purpose of this study will be to compare the aqueous production suppressant to aqueous outflow drugs in terms of the response to known vascular parameters.
- Trial name
- NCT01308788
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Indiana University
Glaucoma
Effect of Antihypertensive Drugs on Glaucoma Patients
It has been reported that among Asian non-glaucomatous, antihypertensive medications were associated with retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness.
- Trial name
- NCT04943107
- Testing
- no intervention
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Glaucoma
This Study Examines Whether Personality Traits Influence the Frequency or Severity of Ocular Adverse Effects Reported by Patients Using Glaucoma Medications. The Findings May Identify Patients at Greater Risk of Intolerance and Support More Personalized Treatment and Counselling.
The goal of this observational study is to learn whether personality traits are related to eye side effects from glaucoma medications in adults who currently use or previously used these medications.
- Trial name
- Adverse Events (NCT07739784)
- Testing
- No Interventions
- Where
- Canada
- Volunteers
- 352 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Glaucoma
Effects of Anti-Glaucoma Medications on the Ocular Surface
The purpose of the study is to compare the efficacy of FDA-approved Travoprost (Travatan Z) and Latanoprost (Xalatan)as anti-glaucoma treatment.
- Trial name
- BAK (NCT01315574)
- Testing
- Travoprost, Latanoprost
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Glaucoma, Glaucoma, Open-Angle
The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients
Glaucoma represents a group of conditions that cause damage to the optic nerve and can lead to irreversible vision loss. Current treatments are aimed at lowering intraocular pressure while minimizing medication side effects.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma; Drugs, Droopy Eyelid
- Trial name
- NCT04007276
- Testing
- brimonidine tartrate ophthalmic solution 0.025%, sterile balanced saline solution
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tulane University
Glaucoma
The Effect of Education on Patient Compliance
With patient education, the compliance with glaucoma medications will increase.
- Trial name
- NCT00376974
- Testing
- American Academy of Ophthalmology Glaucoma Educational Tape
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Glaucoma, Primary Open Angle, Ocular Hypertension
Generic Travoprost Versus Brand Name Travoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
The purpose of this study is to compare the efficacy and tolerance of generic travoprost with its brand name formulation. In this open label, randomized, crossover study, the primary outcome will be intraocular pressure and the…
- Trial name
- NCT02796560
- Testing
- Brand name travoprost, Generic travoprost
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Université de Sherbrooke
Primary Open-Angle Glaucoma, Mild Stage, Glaucoma, Suspect
Effects of Prostaglandin Analogue Washout Following Long-term Therapy in Adults With Primary Open Angle Glaucoma
A target for glaucoma treatment is the intra-ocular pressure (IOP) which is lowered with medications, laser, or surgical intervention.
- Conditions
- Primary Open-Angle Glaucoma, Mild Stage, Glaucoma, Suspect, Ocular Hypertension
- Trial name
- NCT03534882
- Testing
- Discontinuation of topical prostaglandin analogue therapy
- Where
- Canada
- Volunteers
- 87 people
- Sponsor
- Cindy Hutnik
Ocular Surface Disease
Amelioration of Adverse Ocular Side Effects of Glaucoma Medications in Glaucoma Patients Using Topical GL101
To evaluate the safety and efficacy of 0.5% GL101 topical gel administered twice daily for 28 days in ameliorating adverse ocular side effects in patients under ongoing treatment with glaucoma medications.
- Trial name
- NCT02656394
- Testing
- GL101
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Glia, LLC
Drug Effect (Glaucoma Drugs)
Pupillary Response After Glaucoma Medication
Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.
- Trial name
- pupil (NCT02522039)
- Testing
- Latanoprost, Timolol, Dorzolamide
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen