Clinical trials: Drug Eluting Stents
Angioplasty, Chronic Coronary Occlusion
XIENCE V Everolimus Eluting Coronary Stent System (EECSS) China: Post-Approval, Single-Arm Study
This is a prospective, observational, single-arm, open-label, multicenter, postapproval registry study in China. The purpose of this study is to: Evaluate the continued safety and effectiveness of the XIENCE V EECSS in a cohort…
- Conditions
- Angioplasty, Chronic Coronary Occlusion, Stent Thrombosis, Vascular Disease
- Trial name
- XV CHINA SAS (NCT01249027)
- Testing
- XIENCE V® Everolimus Eluting Coronary Stent System (EECSS)
- Where
- United States
- Volunteers
- 2,605 people
- Sponsor
- Abbott Medical Devices
Coronary Heart Disease
Optical Coherence Tomography Assessment of Intimal Tissue and Malapposition
The purpose of this study is to use a high-resolution intracoronary imaging modality, called optical coherence tomography (OCT) to examine two different types of coronary artery stents used to treat patients with coronary artery…
- Trial name
- OPTIMA (NCT01137019)
- Testing
- Biolimus-eluting stent, Everolimus-eluting coronary stent
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- Dr Peter Barlis
Coronary Artery Disease
Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents
Prospective, multicenter, registry of at least 11,000 (and up to 15,000) consecutive patients with coronary artery disease undergoing stent-assisted percutaneous coronary intervention (PCI) using DES without major procedural…
- Trial name
- ADAPT-DES (NCT00638794)
- Testing
- Drug -Eluting Stent (Taxus™, Cypher®, Endeavor™, Xience V™)
- Where
- 8 sites in United States
- Volunteers
- 8,575 people
- Sponsor
- Cardiovascular Research Foundation, New York
Coronary Artery Disease
Intravascular Ultrasound Guided Drug Eluting Stents Implantation in "All-comers" Coronary Lesions （ULTIMATE Trial）
A number of 1448 patients scheduled for elective percutaneous coronary intervention (PCI) with a native coronary stenosis suitable for DES implantation and IVUS imaging are openly randomized 1:1 to either IVUS guidance or…
- Trial name
- ULTIMATE (NCT02215915)
- Testing
- Angiography, IVUS, DES implantation
- Where
- China
- Volunteers
- 1,448 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Left Main Coronary Artery Stenosis
Ultrathin-strut Biodegradable Polymer Sirolimus-eluting Stents With P2Y12 Inhibitor-based Single Antiplatelet Therapy vs. Conventional DAPT for Unprotected Left Main Coronary Artery Disease (ULTIMATE-LM)
The management of patients with unprotected left main coronary artery (LMCA) disease undergoing percutaneous coronary intervention (PCI) in contemporary interventional cardiology practice remains matter of intense debate.
- Trial name
- ULTIMATE-LM (NCT05650411)
- Testing
- LMCA PCI with Supraflex Cruz ultrathin-strut biodegradable polymer sirolimus-eluting stent (Sahajanand Medical Technologies Ltd., Surat, India)., P2Y12 inhibitor-based SAPT after short DAPT, Conventional DAPT
- Where
- Switzerland
- Volunteers
- 828 people
- Sponsor
- IGLESIAS Juan Fernando
Coronary Artery Disease
Medtronic RevElution Trial
The purpose of this trial is to evaluate the clinical safety and efficacy of the Polymer-Free Drug-Eluting coronary stent system for the treatment of de novo lesions in native coronary arteries with a reference vessel diameter…
- Trial name
- RevElution (NCT02480348)
- Testing
- Polymer-free DES (Drug Eluting Stent)
- Where
- 15 sites in Australia, Brazil and 1 more
- Volunteers
- 109 people
- Sponsor
- Medtronic Vascular
Coronary Artery Disease
COmparison and Modification in Neointimal Pattern Assessed by Optical Coherence Tomography With High Versus Moderate Efficacy Statin Treatment After Drug Eluting Stent Implantation: COMPASS Trial
This study is a prospective randomized trial to evaluate and compare the quantitative and qualitative characteristics of neointimal formation between high and low efficacy statin treatment after drug eluting stent (DES)…
- Trial name
- NCT02155530
- Testing
- Atorvastatin 40mg, pravastatin 20 mg
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Antiplatelet Drugs
Perioperative Antiplatelet Therapy in Patients With Drug-eluting Stent Undergoing Noncardiac Surgery
The purpose of this study is to evaluate the safety and effectiveness of perioperative antiplatelet therapy in patients with drug-eluting stent undergoing non-cardiac surgery.
- Trial name
- ASSURE-DES (NCT02797548)
- Testing
- Aspirin only, No antiplatelet therapy
- Where
- 35 sites in India, South Korea and 1 more
- Volunteers
- 1,010 people
- Sponsor
- Jung-min Ahn
Coronary Restenosis
Drug-eluting Stents vs. Drug-coated Balloon for Preventing Recurrent In-stent Restenosis
The purpose of this study is to establish the safety and effectiveness of paclitaxel eluting balloon (SeQuent Please) compared to coronary stenting with the Everolimus-eluting balloon expandable stent (Xience Prime or Xience…
- Trial name
- RESTORE (NCT01967199)
- Testing
- Everolimus-eluting balloon expandable stent, paclitaxel eluting balloon
- Where
- 11 sites in South Korea
- Volunteers
- 175 people
- Sponsor
- Seung-Jung Park
Myocardial Infarction, Coronary Artery Disease
Safety and Efficacy Study of CYPHER® Sirolimus Stent and ENDEAVOR® Zotarolimus Stent in Patients With Acute ST Elevation Myocardial Infarction (STEMI) and Analysis of Current Status of Emergency PCI Green Channel for STEMI Patients in China
This study is to compare the clinical effect of CYPHER® stent and ENDEAVOR® stent in patients with acute ST elevation myocardial infarction.
- Trial name
- CREST-MI (NCT00781716)
- Testing
- Drug eluting coronary stent system
- Where
- China
- Volunteers
- 1,020 people
- Sponsor
- Beijing Chao Yang Hospital
Coronary Artery Disease, Atheroscleroses, Coronary
Long Term Follow-up of Comparison of Clopidogrel vs. Aspirin Monotherapy After Drug-eluting Stent Implantation
This is an retrospective extended study of a randomized clinical trial (The HOST-EXAM trial ClinicalTrials.gov Identifier: NCT02044250).
- Trial name
- HOST-EXAM-EX (NCT05567536)
- Testing
- Antiplatelet Agents
- Volunteers
- 5,530 people
- Sponsor
- Seoul National University Hospital
Drug-eluting Stent, Coronary Artery Disease
Efficacy of OSFIT Drug-Eluting Stent in Coronary Ostial Artery Stenosis
The purpose of this observational study is to evaluate the long-term effectiveness and safety of the OSFIT drug-eluting stent designed to facilitate procedures in coronary artery lesions.
- Trial name
- NCT06066450
- Testing
- Genoss® DES system, Genoss® Osfit system
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Genoss Co., Ltd.
Coronary Artery Disease
DES Versus BiOSS LIM - POLBOS II Study
Coronary bifurcation lesions pose therapeutic problems during percutaneous coronary interventions (PCI) and are associated with higher rates of periprocedural complications as well as higher rates of in-stent restenosis and stent…
- Trial name
- POLBOS II (NCT02198300)
- Testing
- Coronary angioplasty with stent implantation, Dual antipletlet therapy (DAPT)
- Where
- Poland
- Volunteers
- 202 people
- Sponsor
- Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Patients With de Novo Coronary Artery Lesions
A Prospective, Multicenter, Randomized Controlled Clinical Study on the Safety and Efficacy of Biolimus Drug-Coated Balloon (DCB) Versus Drug-Eluting Stent (DES) in the Treatment of De Novo Coronary Artery Lesions
To compare the safety and efficacy of Biolimus drug-coated balloon (DCB) versus drug-eluting stent (DES) in the treatment of de novo coronary artery lesions.
- Trial name
- NCT07582250
- Testing
- Biolimus-Coated Coronary Artery Balloon Dilatation Catheter, Xinyue Drug-Coated Stent System
- Volunteers
- 1,548 people
- Sponsor
- JW Medical Systems Ltd
Coronary Artery Disease
Dynamic Change of Coronary Artery Curvature
The novolimus-eluting DynamX bioadaptor system is composed of 71 µm cobalt-chromium sinusoidal rings connected to each other axially by three S-links Each ring contains three uncaging elements that are positioned at equal…
- Trial name
- DC3 (NCT04936191)
- Testing
- DynamX Bioadaptor
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Sweden Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- NCT01667003
- Where
- 8 sites in Sweden
- Volunteers
- 406 people
- Sponsor
- Biotronik ApS
Coronary Artery Disease
In Stent ELUTES Study
This trial will compare the long term safety and effectiveness of the V Flex Plus PTX Drug Eluting coronary stent with conventional treatment for in-stent restenosis for coronary arteries.
- Trial name
- ELUTES II (NCT00225680)
- Testing
- drug eluting coronary stent
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Cook Group Incorporated
Coronary Artery Disease, Myocardial Infarction
Randomized Study to Assess the Effect of ThRombus Aspiration on Flow Area in STEMI Patients
The purpose of the study it to evaluate whether primary percutaneous coronary intervention (primary PCI) with a new thrombectomy device as compared to primary PCI without thrombectomy increases minimal flow area after stenting…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, STEMI
- Trial name
- TROFI (NCT01271361)
- Testing
- primary PCI with thrombectomy, primary PCI without thrombectomy
- Where
- 5 sites in Denmark, France and 2 more
- Volunteers
- 140 people
- Sponsor
- Terumo Europe N.V.
CHD - Coronary Heart Disease, Percutaneous Coronary Intervention
Optical Coherence Tomography Guided Percutaneous Coronary Intervention for Drug-eluting In-stent Restenosis
This study is a prospective, registry trial aimed to compare the clinical and angiographic outcomes of OCT-guided and angiography-guided PCI in patients with coronary DES-ISR.
- Conditions
- CHD - Coronary Heart Disease, Percutaneous Coronary Intervention, In-stent Restenosis
- Trial name
- NCT03809754
- Testing
- Percutaneous Coronary Intervention under OCT, Percutaneous Coronary Intervention under Angiography
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
In-stent Arterial Restenosis
Paclitaxel Eluting Balloon for SFA In-stent Restenosis
The purpose of the study is to evaluate the safety and efficacy on the use of drug eluting balloon (DEB) with paclitaxel to treat in-stent restenosis in femoropopliteal arteries.
- Trial name
- NCT01616888
- Testing
- PTA with drug eluting balloon with paclitaxel
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto