Clinical trials: Drug Induced Sleep Disorder
Opioid-use Disorder, Sleep
Dual-Orexin Antagonism As a Mechanism for Improving Sleep and Drug Abstinence in Opioid Use Disorder
Summary of Study Protocol. This project is designed to test neurobehavioral mechanisms underlying effects of the dual orexin-1/2 receptor antagonist suvorexant on sleep efficiency and opioid abstinence, and whether these outcomes…
- Trial name
- NCT04262193
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Wayne State University
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Opioid Use Disorder, Pregnancy
Technology-Enhanced Therapy vs. Medication Monitoring for Buprenorphine Retention in Pregnant Persons
This study involves testing how useful a technology-enhanced therapy is for pregnant people prescribed buprenorphine for the treatment of opioid use disorder, compared to medication monitoring.
- Trial name
- NCT06999811
- Testing
- Empowering Pregnant Women and People Receiving medications for opioid use disorder (EMPWR), Medication monitoring (control)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Medical University of South Carolina
Obstructive Sleep Apnea
DISE: Phenotyping Obstruction Patterns
Drug-induced sleep endoscopy (DISE) represents an opportunity to evaluate the upper airway in sleep-like conditions. In its current clinical form, however, DISE does not routinely determine the functional impact of anatomic and…
- Trial name
- DISE-PhOP (NCT05050383)
- Testing
- Pharyngeal Manometry
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea
Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
This research study is designed to learn, first, whether two anesthetics have different effects on collapse seen within the upper airway during sleep endoscopy.
- Trial name
- NCT05303987
- Testing
- Propofol sedation, Dexmedetomidine sedation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Erin Kirkham
Alcohol Dependence, Insomnia
Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
Insomnia and other sleep abnormalities are common, persistent, and associated with relapse in alcohol-dependent patients. The overall, long-term objectives of the proposed research are to investigate the neurophysiologic…
- Trial name
- MA (NCT01014533)
- Testing
- Gabapentin dispensed to subject.
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Dr. Kirk Brower
Leukemia
Sleep, Fatigue, and Dexamethosone in Children With Leukemia
The purpose of this study is to determine the relationship between dexamethosone (steroid) and children's sleep and fatigue.
- Trial name
- NCT00075101
- Testing
- Dexamethosone
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- National Institute of Nursing Research (NINR)
Obstructive Sleep Apnea
Assessment of the Effect of Hypoglossal Nerve Stimulation Therapy on Upper Airway Collapsibility During Drug-induced Sleep Endoscopy
This clinical trial will evaluate the effect of treatment with hypoglossal nerve stimulation on the underlying mechanisms of obstructive sleep apnea.
- Trial name
- HNS-CoDSE (NCT07337239)
- Testing
- Additional measurements during clinical standard follow-up drug-induced sleep endoscopy (DISE)
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Antwerp
Alcohol Use Disorder With Insomnia
CBT-I Augmentation of Medication for Drinking in AUD
Alcohol Use Disorder (AUD) and insomnia are more prevalent in Veterans than in the general community. Furthermore, insomnia is comorbid in 36-91% of individuals with AUD and jeopardizes recovery by increasing their risk for…
- Trial name
- NCT04581603
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene Education
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea of Child
Surgical Treatment of Children With OSA and Small Tonsils or Down Syndrome
The purpose of this study is to prospectively compare the effectiveness of a novel personalized approach to the surgical treatment of obstructive sleep apnea (OSA) in children, drug induced sleep endoscopy (DISE) directed surgery…
- Trial name
- NCT05154214
- Testing
- Adenotonsillectomy, Drug-induced sleep endoscopy directed surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Sleep Apnea Syndrome
Upper Airway Collapse in Patients With Obstructive Sleep Apnea Syndrome by Drug Induced Sleep Endoscopy
This is a prospective, interventional cohort study of drug-induced sleep endoscopy (DISE). The goal is to evaluate the upper airway in a cohort of patients with obstructive sleep apnea hypopnea syndrome (OSAHS) diagnosed in a…
- Trial name
- NCT02588300
- Testing
- Drug induced sleep endoscopy
- Where
- Germany
- Volunteers
- 43 people
- Sponsor
- Technical University of Munich
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Drug Induce Sleep Endoscopy, Hypnosis
Feasibility Study of Sleep Endoscopy Under Hypnosis in a Sleep Center
It is proposed to induce in a obstructive sleep apnea syndrome patient, a hypnotic trance leading to intense muscle relaxation, capable of reproducing in the upper airways (VAS) the muscle relaxation observed in sleep, at the…
- Conditions
- Drug Induce Sleep Endoscopy, Hypnosis, Obstructive Sleep Apnea Syndrome
- Trial name
- DISE (NCT05091164)
- Testing
- Drug induce sleep endoscopy of upper aerodigestive tract under hypnosis
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Elsan
Sleep Disordered Breathing, Drug Induced Sleep Disorder
DISE in Pediatric Sleep Disordered Breathing
Adenotonsillar hypertrophy is the most common reason for children to have sleep disordered breathing (SDB). Even though adenotonsillectomy improves sleep apnea in children, 20-40% of children will still have persistent SDB.
- Trial name
- NCT06756971
- Testing
- Propofol, Dexmedetomidine
- Sponsor
- University of Iowa
Obstructive Sleep Apnea
Mechanisms of Upper Airway Obstruction
The current study is designed to examine underlying mechanisms of action of lingual muscles in the maintenance of airway patency during sleep.
- Trial name
- DISE-CAD (NCT04322097)
- Testing
- Hypoglossal Nerve Stimulation
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid Use Disorder, Sleep Disturbance
Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment
Opioid use disorder (OUD) is a treatable medical illness with three medications FDA approved for treatment. However, persons with OUD report significant sleep disturbance, even when treated with medications for opioid use…
- Trial name
- MOUD (NCT06104280)
- Testing
- Post-Illumination Pupillary Response (PIPR), Polysomnography, Multiple Sleep Latency Test
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Sedative Effect During Drug-induced Sleep Endoscopy, Obstructive Sleep Apnea (OSA)
Combination of Remimazolam and Propofol During Drug-induced Sleep Endoscopy
This study helps patients find the optimal sedation regimen in drug-induced sleep endoscopy
- Trial name
- NCT06784479
- Testing
- Remimazolam and Propofol, Propofol, Midazolam and propofol
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Dan Liu
Attention Deficit Disorder, Attention Deficit Disorder (ADD)
The Primary Objective of This Study is to Determine Whether Positively Framed Information (PFI) on Side Effects, Compared to Negatively Framed and Extensive Information (NFI) Can Reduce the Number and Severity of Reported Adverse Events Caused by ADHD Medication in Children Aged 7 to 17 Years.
The goal of this randomized controlled care evaluation is to determine whether positively framed and concise information (PFI), compared to negatively framed and extensive information (NFI) about adverse events can reduce the…
- Conditions
- Attention Deficit Disorder, Attention Deficit Disorder (ADD), Attention Deficit Disorder with Hyperactivity, ADHD
- Trial name
- NOVA (NCT06797570)
- Testing
- Communication Strategy for Side Effect Counseling in ADHD Treatment
- Volunteers
- 130 people
- Sponsor
- St. Antonius Hospital
Opioid Use Disorder, Pregnancy Related
Open Trial of Technology-Enhanced Behavioral Intervention for Buprenorphine Retention in Pregnant and Postpartum People
This study involves testing how useful a technology-enhanced intervention is for pregnant people prescribed buprenorphine for the management of opioid use disorder.
- Trial name
- NCT06496230
- Testing
- Empowering Pregnant Women and People Receiving Medications for Opioid Use Disorder
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
Neurobehavioral Manifestations, Drug Related Sleep Disturbance
Acute and Residual Effects of Caffeinated Beer
The aim of this study is to develop information about the acute and residual effects of a new product being targeted to young adults.
- Conditions
- Neurobehavioral Manifestations, Drug Related Sleep Disturbance, Alcohol Intoxication
- Trial name
- NCT00515294
- Testing
- Caffeinated Alcoholic Beer, Non-Caffeinated Alcoholic Beer, Caffeinated Non-Alcoholic Beer
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Boston University