Clinical trials: Drug Interaction
Chronic Hepatitis B
A Drug-drug Interaction (DDI) Study of Morphothiadine Mesilate/Ritonavir in Healthy Subjects
The purpose of this study is to evaluate the drug-drug-interaction (DDI), pharmacokinetics (PK) and tolerability of Morphothiadine Mesilate/Ritonavir combined with Entecavir or Tenofovir Disoproxil Fumarate in healthy subjects
- Trial name
- NCT03662568
- Testing
- GLS4, RTV, ETV
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Healthy
Study of Pharmacokinetic Interaction Between Combivir® (ZDV+3TC) and BILR 355 BS Plus Ritonavir in Healthy Subjects
Study to determine the effect of BILR 355/r on Combivir® pharmacokinetics and the effect of Combivir® on BILR 355 BS pharmacokinetics.
- Trial name
- NCT02256774
- Testing
- BILR 355 BS, Combivir®, Ritonavir
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Male Subjects
A Study to Assess the Effects of Savolitinib on the Pharmacokinetics of Digoxin, Rosuvastatin, Metformin, and Furosemide in Healthy Male Subjects
This study will assess the effects of savolitinib on the pharmacokinetics (PK) of substrates of human transporters digoxin (P-gp), rosuvastatin (OATP1B1/3), metformin (OCT2, MATE1/2K), and furosemide (OAT1/3) in healthy male…
- Trial name
- NCT05768360
- Testing
- Savolitinib, Digoxin, Metformin Hydrochloride
- Where
- Germany
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Mother-Infant Interaction
The Effect of the Newborn Behavioral Observations System on Maternal Sensitivity
The study evaluates if the Newborn Behavioral Observation system, a relationship building tool, delivered to at risk mothers will have, on one site, an effect on maternal sensitivity and the other site on Childs responsiveness…
- Trial name
- NCT04739332
- Testing
- The Newborn behavioral observations system
- Where
- Iceland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Center for Parents and Infants, Iceland
Healthy
Drug Interaction Study Between Bosutinib And Dabigatran
The study evaluates the effect of a single oral dose of bosutinib on the single dose pharmacokinetics of dabigatran, a p-glycoprotein substrate, in healthy subjects.
- Trial name
- NCT02102633
- Testing
- Dabigatran, Bosutinib
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Pfizer
Drug Interaction Study
Rivaroxaban Hypericum Trial
Single-center, open-label, sequential treatment study to investigate the influence of the combined P-glycoprotein and CYP3A4 inducer hypericum perforatum on the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy…
- Trial name
- NCT03796377
- Testing
- St Johns Wort Extract, Rivaroxaban
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Emotional Intelligence, Social Interaction
Efficacy of iMentalize and MISC-SA to Foster Parents' Mentalization and Children Mental Health in General Population.
OBJECTIVES: The goal of this parallel randomized controlled trial is to test the efficacy of the iMentalize program and the Mediational Intervention for Sensitizing Caregivers - Self Administered version (MISC-SA) to foster…
- Conditions
- Emotional Intelligence, Social Interaction, Mental Health Wellness 1, Well-Being, Psychological
- Trial name
- iMentalize (NCT06270732)
- Testing
- iMentalize Program (iMentalize), Mediational Intervention for Sensitizing Caregivers, Self-Administered version (MISC-SA), Mediational Intervention for Sensitizing Caregivers - Readings version (MISC-R): Treatment as Usual (TAU)
- Where
- 2 sites in Spain
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universitat Autonoma de Barcelona
Healthy
Interaction Study of Clopidogrel 600/150 mg Given Alone or Concomitantly With Omeprazole 80 mg in Healthy Subjects
Primary objective: Assess the effects of clopidogrel (600 mg loading dose followed by 4 days 150 mg/day) on Adenosine diphosphate (ADP)-induced platelet aggregation when given concomitantly with omeprazole 80 mg/day compared to…
- Trial name
- NCT01129414
- Testing
- Clopidogrel, Omeprazole
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sanofi
Infection, Human Immunodeficiency Virus
Drug-drug Interaction (DDI) Rifabutin
The purpose of this study is to provide dosing recommendations for the coadministration of BMS-663068 and Rifabutin with and without Ritonavir in upcoming Phase 3 studies and for prescribing information purposes
- Trial name
- NCT02138084
- Testing
- BMS-663068, Rifabutin, Ritonavir
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
N/A - Healthy Subjects
Phase 1 Drug Interaction Study of Apixaban and Atenolol in Healthy Subjects
The purpose of this study is to assess the effect of Atenolol 100 mg on the Pharmacokinetics (PK) of Apixaban and the effect of Apixaban 10 mg on the PK of Atenolol in Healthy subjects.
- Trial name
- NCT02262533
- Testing
- Apixaban, Atenolol
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Healthy
A Study to Evaluate the Effect of Rifampicin on the Pharmacokinetics of Abiraterone in Healthy Male Participants
The purpose of this study is to assess the effects of repeated daily administration of rifampicin on the pharmacokinetics (what the body does to the medication) of abiraterone following single-dose administration of abiraterone…
- Trial name
- NCT01655147
- Testing
- Abiraterone acetate, Rifampicin
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Influence of Genotype of Drug Metabolizing Enzyme or Transporter on the Pharmacokinetics/Pharmacodynamics of Clopidogrel, Influence of Aspirin on the Pharmacokinetics/Pharmacodynamics of Clopidogrel
Clinical Trial to Evaluate the Influence of Genotype on the Pharmacokinetics/Pharmacodynamics of Clopidogrel
This study has an open-label, five-period, single-sequence design. The purpose of this study is as follows; 1. Primary To evaluate the influence of genotype of drug metabolizing enzyme or transporter on the…
- Trial name
- NCT01503658
- Testing
- Clopidogrel+Aspirin
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Postpartum Depression
Interaction Between Genetic Factors and Maternal Stressors During Pregnancy in the Risk of Postpartum Depression
"The prevalence of postpartum depression (PPD) is approximately 13%. PPD is associated with a higher maternal morbidity and mortality, and also with pervasive effects on the emotional, cognitive and behavioral development of the…
- Trial name
- IGEDEPP (NCT01648816)
- Where
- France
- Volunteers
- 3,338 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pharmacokinetics, Cytochrome P-450 CYP2D6
Open Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Aripiprazole When Coadministered To Healthy Subjects
The goal of this study is to evaluate the effect of multiple doses of Desvenlafaxine Sustained Release (SR) on the pharmacokinetics of Aripiprazole when coadministered to healthy adult subjects.
- Conditions
- Pharmacokinetics, Cytochrome P-450 CYP2D6, CYP3A4 Protein, Human
- Trial name
- NCT01188668
- Testing
- Aripiprazole, Aripiprazole + desvenlafaxine succinate sustained release
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Pfizer
Artificial Intelligence (AI), Clinical Reasoning
Teaching Doctors in Training to Reason With Artificial Intelligence
The purpose of the TEACH-AI study is to assess whether a brief, structured workshop on artificial intelligence can improve the performance of medicine doctors in training (i.e.
- Conditions
- Artificial Intelligence (AI), Clinical Reasoning, Clinical Decision-making, Medical Education
- Trial name
- TEACH-AI (NCT07813754)
- Testing
- Workshop-First
- Where
- 4 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Healthy
Drug-Drug Interaction Study to Evaluate the Effect of DWC202511 or DWC202512 With DWP16001 in Healthy Adults
Drug-Drug Interaction Study to Evaluate the Effect of DWC202511 or DWC202512 With DWP16001 in Healthy Adults
- Trial name
- NCT07213310
- Testing
- DWP16001, DWC202511, DWC202512
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Healthy Participants
Potential Drug Interaction Study Between Vemircopan and Rosuvastatin, Metformin, Levonorgestrel/Ethinyl Estradiol-containing Oral Contraceptives, and Carbamazepine
This study will investigate the potential drug interactions between vemircopan and metformin, rosuvastatin, levonorgestrel/ ethinyl estradiol (LNG/EE)-containing oral contraceptive(s) (OCs), and carbamazepine in healthy…
- Trial name
- NCT06071442
- Testing
- Vemircopan, Rosuvastatin, Metformin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Healthy Adult Participants
A Trial in Healthy Participants to Assess Drug Interaction Potential of BGB-43395
This study will enroll healthy participants to evaluate whether BGB-43395 interacts with other drugs, including midazolam, celecoxib, dabigatran, and rosuvastatin.
- Trial name
- NCT07820891
- Testing
- BGB-43395, Midazolam, Celecoxib
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- BeOne Medicines
Healthy
AV650 Drug-Drug Interaction Study
The purpose of this study is to evaluate the effects that paroxetine and fluvoxamine have on the way the body distributes, breakdowns and eliminates AV650.
- Trial name
- NCT00456560
- Testing
- AV650, Fluvoxamine, Paroxetine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Avigen
Postpartum Depression, Psychoeducation
Psychoeducational Intervention to Reduce Depressive Symptoms and Strengthen Mother-Infant Bonding
The study aims to evaluate the effectiveness of a psychoeducational intervention designed within the framework of the Watson Human Caring Model in reducing postpartum depressive symptoms and creating a stronger mother-infant…
- Conditions
- Postpartum Depression, Psychoeducation, Mother-Infant Interaction
- Trial name
- NCT07062159
- Testing
- the psychoeducation intervention program, routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Yasemin Ozhuner
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