Clinical trials: Drug Interaction
Depression, Anxiety
SALSA (Health, Food and Sociability): Community Networks for Healthy Eating, Autonomy, and Social Interaction
Antecedents: Unwanted loneliness is associated with an increased risk of anxiety, depression, social isolation, and malnutrition.
- Conditions
- Depression, Anxiety, Social Support (Formal and Informal), Quality of Life (QOL)
- Trial name
- SALSA (NCT06800027)
- Testing
- SALSA group intervention: Going to lunch at the restaurant in a group and attending healthy eating workshops.
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
COPD, Emphysema
Right Ventricular Diastolic Dysfunction
Heart-lung interactions remain misunderstood whereas pulmonary and cardiac pathologies are very commonly associated. Emphysema by increasing intrathoracic pressure appears to affect cardiac function.
- Conditions
- COPD, Emphysema, Right Heart Dysfunction
- Trial name
- RVDD (NCT04467242)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Neuromuscular Block, Residual, Pain
Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults
This randomized controlled trial aims to compare the effects of intravenous methylprednisolone and dexamethasone on the reversal time of rocuronium by sugammadex in adult patients undergoing elective septoplasty or rhinoplasty.
- Conditions
- Neuromuscular Block, Residual, Pain, Postoperative Nausea
- Trial name
- NCT07187037
- Testing
- Methylprednisolone (MP), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Mood Disorder, Substance-Related Disorders
Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA)
The purpose of this study is to determinate the effect of a pre-treatment with doxazosin, a alpha1-adrenergic receptor blocker, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").
- Conditions
- Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
- Trial name
- NCT01386177
- Testing
- 3,4-Methylenedioxymethamphetamine, Doxazosin
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Overweight, Obesity
Influence of HDM1005 on Gastric Emptying and Pharmacokinetics of Metformin, Atorvastatin, Warfarin, and Digoxin
The purpose of this study is to characterize the Influence of HDM1005 on gastric emptying and drug-drug interaction of HDM1005 and metformin, atorvastatin, warfarin, and digoxin in overweight/obese adult subjects.
- Trial name
- NCT07502001
- Testing
- Acetaminophen, Metformin, Warfarin
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Candidiasis, HIV Infections
A Study to Assess the Effect of Concomitant Administration of Fluconazole on the Clinical Pharmacokinetics of Methadone
To evaluate the pharmacokinetics and safety of concomitant administration of methadone and fluconazole. Injection drug users constitute the second largest subset of the U.S.
- Trial name
- NCT00000788
- Testing
- Methadone hydrochloride, Fluconazole
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COPD
Personalised Exercise Training in COPD
Exercise training as part of Pulmonary Rehabilitation (PR) has been shown conclusively to improve breathlessness,quality of life and exercise capacity for people with COPD.
- Trial name
- NCT03817294
- Testing
- Comparison of exercise training modalities
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Loughborough University
Influenza
The Interaction Between Mucosal Microbiota Colonization and the Immune Response to an Intranasal Influenza Live Attenuated Vaccine
This is a single-center, randomized, open-label trial designed to explore the interaction between mucosal microbiota colonization in the nasal cavity and gut and the immune response to an intranasal live attenuated influenza…
- Trial name
- NCT06609811
- Testing
- Intranasal Influenza Live Attenuated Vaccine
- Where
- China
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Healthy
Pharmacokinetic Interaction and Safety Between NVP-1203-R1 and NVP-1203-R2
The purpose of this study is to compare the pharmacokinetics and safety between NVP-1203-R1 and NVP-1203-R2
- Trial name
- Navipharm (NCT04181437)
- Testing
- NVP-1203-R1, NVP-1203-R2, NVP-1203-R1 and NVP-1203-R2
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NVP Healthcare
Cognitive Decline
Cognitive Training and Social Interaction Effects on Cognitive Performance of Older Adults
Aging is associated with a decline in almost all aspects of cognitive functions, particularly memory. Recent research suggests that combining cognitive training with ongoing social interaction may aid in improving cognitive…
- Trial name
- NCT05016336
- Testing
- Social interaction combined with cognitive training based on mnemonic strategies., Social interaction group
- Where
- Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bar-Ilan University, Israel
BCG Infection, Reaction - Vaccine
A Study of the Interaction Between BCG And MenC Immunisation: BAM
The Bacille Calmette-Guérin (BCG) vaccine is the only vaccine licenced to prevent tuberculosis (TB). The stimulus it gives to the immune system allows it to respond more effectively to a subsequent infection with TB.
- Conditions
- BCG Infection, Reaction - Vaccine, Immune Response
- Trial name
- BAM (NCT02002156)
- Testing
- BCG, NeisVac-C®, Pediacel®, Infanrix™, Prevenar-13®, Menitorix®, Priorix®, Rotarix®, NeisVac-C®, Pediacel®, Infanrix™, Prevenar-13®, Menitorix®, Priorix®, Rotarix®
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Type 2 Diabetes Mellitus
Drug-Drug Interaction Study of Mitiglinide and Gemfibrozil
The primary objective of this study is to determine the extent of effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of mitiglinide.
- Trial name
- NCT00566865
- Testing
- gemfibrozil
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Elixir Pharmaceuticals
Depression, History of Suicide Attempt
Behavioral Adaptation to Negative Social Cues in Depressed Patients According to Personal History of Suicide Attempt- COMPASS
Social interactions are part of daily life. To decide to interact with someone or not is a routine for humans. To ensure the quality of interpersonal relationships, emotional cues must be taken into account to adapt optimally the…
- Trial name
- COMPASS (NCT03898648)
- Testing
- Waiting room task
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Montpellier
Drug-drug Interactions
A Clinical Trial to Evaluate the Drug-drug Interactions of Co-administered 'HUC2-744-A' and 'HUC2-744-B' in Healthy Adult Volunteers
This study aims to evaluate the pharmacokinetic interactions between HUC2-744-A and HUC2-744-B following monotherapy or co-administration under multiple-dose conditions.
- Trial name
- DDI (NCT07784608)
- Testing
- Atorvastatin Calcium, Telmisartan
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Huons Co., Ltd.
Major Depressive Disorder
A Study of LY2216684 in Healthy Participants
This study will evaluate the pharmacodynamic and pharmacokinetic interaction of LY2216684 with alcohol in healthy participants. This study will run approximately for 34 days.
- Trial name
- NCT01380691
- Testing
- LY2216684, Alcoholic beverage
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy Participants
A Study to Evaluate the Drug-drug Interaction Effect of Itraconazole on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
The primary objective of the study is to evaluate the pharmacokinetic (PK) profile of AMG 510 administered alone and in combination with itraconazole in healthy participants.
- Trial name
- NCT05568082
- Testing
- AMG 510, Itraconazole
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Amgen
Healthy
Study for Investigate the Pharmacokinetic Drug Interactions Between Gemigliptin and Rosuvastatin
Investigate the pharmacokinetic drug interactions between gemigliptin and rosuvastatin in healthy subjects
- Trial name
- NCT01823133
- Testing
- gemigliptin only, rosuvastatin only, gemigliptin and rosuvastatin
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Gastrointestinal Neoplasms, Genitourinary Cancer
Immune Checkpoint Inhibitor (ICI)-Drug-Drug Interaction (DDI) Study
Immune checkpoint inhibitors (ICIs) (also called "immunotherapy") are an effective family of anti-cancer drugs, but they can cause serious side effects.
- Conditions
- Gastrointestinal Neoplasms, Genitourinary Cancer, Thoracic Cancer, Sarcoma
- Trial name
- NCT07389525
- Testing
- ICI Therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Healthy
Effects of Garlic Supplements on Drug Metabolism
This study will determine whether garlic supplements affect the way certain drugs are processed in the body.
- Trial name
- NCT00122889
- Testing
- Garlic powder with high allicin content, Garlic powder with low allicin content, Garlic oil
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Healthy
A Study to Investigate the Interaction Between JNJ-64155806 and Ethinylestradiol/Drospirenone in Healthy Females
The primary purpose of this study is to evaluate the effect of single and multiple doses of JNJ-64155806 on the steady-state pharmacokinetics (PK) of ethinylestradiol and drospirenone and vice versa in healthy female participants.
- Trial name
- NCT03126097
- Testing
- JNJ-64155806 150 mg, Ethinylestradiol/drospirenone 0.02 mg/3 mg
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC