Clinical trials: Drug Interaction Study
Healthy
Study of Pharmacokinetic Interaction Between Combivir® (ZDV+3TC) and BILR 355 BS Plus Ritonavir in Healthy Subjects
Study to determine the effect of BILR 355/r on Combivir® pharmacokinetics and the effect of Combivir® on BILR 355 BS pharmacokinetics.
- Trial name
- NCT02256774
- Testing
- BILR 355 BS, Combivir®, Ritonavir
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Solid Tumor
IMP4297 DDI (Drug-Drug Interaction)Trial in Healthy Male Volunteers
A Phase I, Open-label, Fixed-Sequence Study to Evaluate the Effect of Multiple-dose Itraconazole or Rifampicin Capsules on the Single-dose PK Profiles of IMP4297 Capsules in Healthy Subjects
- Trial name
- NCT04584515
- Testing
- IMP4297 40 mg, IMP4297 100 mg
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Impact Therapeutics, Inc.
Fetal Growth, Obstetric Ultrasonography
Clinicians' Trust in AI-Based Fetal Growth Estimates
This study examines how clinicians trust and use artificial intelligence (AI) when estimating fetal weight during pregnancy. Accurate assessment of fetal growth is important for identifying growth problems that may affect…
- Conditions
- Fetal Growth, Obstetric Ultrasonography, Pregnancy, Clinical Decision-making
- Trial name
- NCT07401368
- Testing
- Intervention - AI Performance Information
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Exercise Training, Neurocognitive Function
Exercise and Neurocognition in Adults Relative to ApoE Genotype
The current project is a single-blinded, double-arm, 6-month randomized controlled trial aiming to assess the effects of a integrated intervention program on neurocognitive function with respect to event-related potential in…
- Conditions
- Exercise Training, Neurocognitive Function, Aging
- Trial name
- NCT05101174
- Testing
- Integrated Intervention Group (IIG), Control Group
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Healthy Volunteers
A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin
The purpose of this study is to evaluate the effects of KarXT administration on the drug levels of midazolam, fexofenadine, and digoxin in healthy adult participants.
- Trial name
- NCT07118215
- Testing
- KarXT, Midazolam, Fexofenadine
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Cardiovascular Diseases
Interaction of Cocoa Methylxanthines With Cocoa Flavanol Related Vascular Effects
Epidemiological studies suggest that certain foods rich in flavanols, including cocoa products, red wine, and tea, are associated with decreased cardiovascular mortality and morbidity.
- Trial name
- New Drink (NCT02149238)
- Testing
- flavanol, methylxanthine, flavanol + methylxanthine
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Type 2 Diabetes Mellitus
Drug-drug Interaction Study (CKD-501, Ketoconazole)
The purpose of this study is to assess the effect of Ketoconazole on the pharmacokinetic characteristics of CKD-501 in healthy subject.
- Trial name
- NCT01330563
- Testing
- CKD-501, Ketoconazole
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Healthy Volunteer
A Study to Learn if Taking BIIB141 (Omaveloxolone) Affects How Omeprazole is Processed in the Body and About BIIB141's Safety in Healthy Adults Aged 18 to 55
In this study, researchers will learn more about BIIB141, also known as omaveloxolone or SKYCLARYS®. This drug has been approved, or made available for doctors to prescribe, for people with Friedrich's Ataxia (FA) who are at…
- Trial name
- NCT07149415
- Testing
- Omaveloxolone, Omeprazole
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Biogen
Drug Interactions
A Drug Interaction Study of BIIB074 and an Oral Contraceptive Regimen
The primary objective of this study is to evaluate the effect of multiple doses of a uridine diphosphate glucuronosyltransferases (UGT)-inducing oral contraceptive (OC) regimen (ethinyl estradiol and levonorgestrel) on the PK of…
- Trial name
- NCT03324685
- Testing
- BIIB074, OC (ethinyl estradiol and levonorgestrel)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Biogen
Drug Interaction Potentiation
Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin
This is a Phase 1, three-part, open-label study to evaluate vadadustat as a perpetrator in drug-drug interactions with rosuvastatin, sulfasalazine, pravastatin, atorvastatin and simvastatin in healthy male and female subjects.
- Trial name
- NCT03801733
- Testing
- Vadadustat, Simvastatin, Rosuvastatin
- Where
- Canada
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Akebia Therapeutics
Drug Drug Interaction
Drug-drug Interaction Study of SPH3127
A single center, open-label, fixed sequence Phase 1, drug-drug interaction (DDI) study in male healthy subjects.
- Trial name
- NCT05359055
- Testing
- SPH3127 tablet, Itraconazole, Rifampin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Bacterial Infections
VNRX-5133 Drug-Drug Interaction in Healthy Adult Volunteers
This is a 2-part, drug-drug interaction study to evaluate potential PK interactions after single doses in Part 1 and multiple doses in Part 2.
- Trial name
- NCT03332732
- Testing
- VNRX-5133, VNRX-5022, Metronidazole
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Venatorx Pharmaceuticals, Inc.
Adult, Drug Interactions
Effect of Multiple Doses of Modafinil on the Pharmacokinetics of Single Dose Lorlatinib in Healthy Participants
The primary purpose of the study is to characterize the safety profile of lorlatinib in the presence of a moderate CYP3A4/5 inducer, modafinil.
- Conditions
- Adult, Drug Interactions, Healthy Volunteers, Humans
- Trial name
- NCT03961997
- Testing
- Lorlatinib 50 mg, Lorlatinib 75 mg, Lorlatinib 100 mg
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cholesterol
MD Ezetimibe Cyclosporine Interaction (0653-057)
Study to determine the effect of multiple oral doses of ezetimibe on the pharmacokinetics of a single oral dose cyclosporine in young healthy males and females.
- Trial name
- NCT00653276
- Testing
- ezetimibe, Comparator: cyclosporine
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Infections, Bacterial
Relative Bioavailability Study in Healthy Subjects
Part 1 of this study will assess the relative bioavailability of GSK1322322 administered as one of three investigational tablets compared to powder in a bottle formulation.
- Trial name
- PDF112034 (NCT00924911)
- Testing
- GSK1322322
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cognitive Disorders
Safety, Blood Levels, Drug Interaction and Effects of Repeated Doses of GSK1034702
GSK1034702 is being developed for improving cognitive impairment in diseases such as Alzheimer's disease and schizophrenia. This study will be done in healthy men and women of no child beading potential to investigate repeated…
- Trial name
- NCT00950586
- Testing
- GSK1043702, Dextromethorphan
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Drug-Drug Interaction Study Between Colchicine and Atorvastatin
Colchicine is a substrate for cytochrome P450 3A4 (CYP3A4). In-vitro studies have indicated that the ortho-and para-hydroxylated metabolites of atorvastatin may be CYP3A4/5 competitive and mechanism-based inhibitors (MBI).
- Trial name
- NCT00960323
- Testing
- Colchicine, Atorvastatin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mutual Pharmaceutical Company, Inc.
Healthy, Pharmacokinetics of ASP015K and Tacrolimus
A Study to Evaluate the Drug Interaction of ASP015K and Tacrolimus
The objective of the study is to characterize the effect of multiple doses of ASP015K on the pharmacokinetics of a single oral dose or a single intravenous (IV) dose of tacrolimus.
- Trial name
- NCT01190670
- Testing
- Tacrolimus, ASP015K
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy
A Drug-Drug Interaction Study of Lanabecestat (LY3314814) in Healthy Participants
The purpose of this study is to study the effect of lanabecestat on how the body absorbs and processes 3 other medications, midazolam, simvastatin and donepezil and how these 3 medications affect lanabecestat when they are taken…
- Trial name
- NCT02406261
- Testing
- Lanabecestat, Simvastatin, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pregnancy
Prenatal Exposure Effects Psychophysiology Study
The purpose of the study is to understand the biology and behavior of early mother-infant attachment, and to investigate how it may be affected by prenatal substance exposures.
- Trial name
- PEEPS (NCT01134770)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
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