Clinical trials: Drug Interaction Study
Healthy
Study of the Effects of ITCA 650 on Gastric Emptying and Interaction of ITCA 650 on 4 Commonly Studied Drugs
A Phase 1, Fixed-Sequence, Open-label Study in Healthy Subjects to Estimate the Effects of ITCA 650 on Gastric Emptying and on the Absorption Pharmacokinetics of Each of 4 Commonly Studied DDI Probe Compounds.
- Trial name
- NCT02641899
- Testing
- ITCA 650 20/60 mcg/day, Acetaminophen, Atorvastatin
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Intarcia Therapeutics
Healthy Volunteers
A Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b)
The purpose of this healthy volunteers drug-drug interaction study is to assess the CYP1A2 and CYP3A4 perpetrator interaction potential and CYP1A2 victim potential of TEV-56286 (anle138b).
- Trial name
- NCT05532358
- Testing
- anle138b (TEV-56286), Fluvoxamine 100 mg QD for 5 days
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- MODAG GmbH
Healthy
Study of Potential for Drug Interactions Mediated by CYP3A4 Inhibition With Aramchol in Healthy Volunteers
The trial is an open-label, 2-period, single-sequence assessment of CYP3A4 inhibition by aramchol using the probe substrates midazolam and atorvastatin to assess CYP3A4 activity.
- Trial name
- NCT03760848
- Testing
- Aramchol, Midazolam, Atorvastatin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Galmed Pharmaceuticals Ltd
Type2 Diabetes
Pharmacokinetic and Pharmacodynamic Drug-Drug Interaction of Evogliptin and Empagliflozin or Dapagliflozin in Healthy Male Adults
A Randomized, Open-label, Multiple-dose, Crossover Study to Investigate the Pharmacokinetic and Pharmacodynamic Drug-Drug Interaction of Evogliptin 5 mg and Empagliflozin 25 mg or Dapagliflozin 10 mg after Oral Administration in…
- Trial name
- NCT03766724
- Testing
- Evogliptin→Evogliptin+Empagliflozin→Empagliflozin, Empagliflozin→Evogliptin→Evogliptin+Empagliflozin, Evogliptin→Evogliptin+Dapagliflozin→Dapagliflozin
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
HCV Infections, Gastric Acid-related Disorders
Pharmacokinetic Study of the HCV Protease Inhibitor Bo-cePRevir and the Proton Pump Inhibitor OMeprazOle (PROMO)
The objective of this study is to determine the effect of multiple dose omeprazole on the pharmacokinetics of boceprevir and vice versa.
- Trial name
- PROMO (NCT01470690)
- Testing
- boceprevir, Omeprazole
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus
Effect of Rifampicin on the Pharmacokinetics and Pharmacodynamics of Sotagliflozin
Primary Objective: To evaluate the effects of rifampicin on the pharmacokinetics (PK) of sotagliflozin and its metabolite in healthy male and female subjects.
- Trial name
- NCT03063580
- Testing
- Sotagliflozin (SAR439954), Rifampicin
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sanofi
Neuroscience, Neuromodulation
Study of the Dynamics of Verbal and Non-verbal Interaction in Healthy Subjects, Through the Recording of Body Movements and Non-invasive Neurophysiological Techniques
Based on study literature, the investigators can say that our study aims to give an explanation not only from a behavioral point of view but also with respect to what are the neuronal mechanisms underlying our ability to perceive…
- Trial name
- OMNIBUS2023 (NCT06251479)
- Testing
- behavioral 1, behavioral 2, neuromodulation 1
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Dengue Fever
Investigation of the Immuno-regulation and Viral Hepatitis Among Patients With or After Dengue Fever Infection
The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.
- Trial name
- NCT00688389
- Testing
- case/control
- Where
- Taiwan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Healthy Volunteer
A Phase 1 Study to Examine the Effects of Itraconazole After Single Dose Administration of Varegacestat (AL102) to Healthy Participants
This is an open label, fixed sequence, 1-way crossover drug-drug interaction (DDI) study in healthy participants.
- Trial name
- NCT06677996
- Testing
- varegacestat, Itraconazole (200 mg)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Immunome, Inc.
Intracranial Aneurysm, CT Angiography
IDEAL Study: Blinded RCT for the Impact of AI Model for Cerebral Aneurysms Detection on Patients' Diagnosis and Outcomes
This study (IEDAL study) intends to prospectively enroll more than 6450 patients who will undergo head CT angiography (CTA) scanning in the outpatient clinic.
- Conditions
- Intracranial Aneurysm, CT Angiography, Deep Learning, Double Bind Interaction
- Trial name
- IDEAL (NCT06118840)
- Testing
- True-AI-integrated intracranial aneurysms diagnosis strategy
- Where
- 21 sites in China
- Volunteers
- 6,450 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Healthy
Pharmacokinetic Drug-Drug Interaction Study Between K-877 and CSG452 in Healthy Adult Volunteers
A study to compare the pharmacokinetic(s) of K-877 and CSG452 when each drug is administered alone and when both are administered together.
- Trial name
- NCT04237597
- Testing
- K-877, CSG452
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kowa Research Institute, Inc.
Type 2 Diabetes Mellitus
A Drug to Drug Interaction Study of Sotagliflozin With Midazolam and Metoprolol
Primary Objective: To assess the effect of repeated once-daily oral doses of sotagliflozin on CYP2D6 and CYP3A activities using a CYP probe cocktail of metoprolol and midazolam.
- Trial name
- NCT02940379
- Testing
- sotagliflozin (SAR439954), midazolam, metoprolol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sanofi
Patient-Ventilator Interaction, Asynchrony, Patient-Ventilator
Standardising Terminology, Classification, Diagnostic Recognition and Reporting of Patient-ventilator Interactions: Protocol for an International Delphi Consensus Study
Patient-ventilator interaction describes how a mechanically ventilated patient's breathing effort aligns with ventilator support.
- Trial name
- INTERACT (NCT07638540)
- Testing
- Modified Delphi consensus survey
- Where
- Kuwait
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al Adan Hospital Kuwait
Healthy
A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics, Pharmacodynamics, and Safety of Glyburide in Healthy Volunteers
The purpose of this study is to determine how multiple doses of canagliflozin (JNJ-28431754) affect the pharmacokinetics (ie, how the body affects the drug) and pharmacodynamics (ie, how the drug affects the body) of a single…
- Trial name
- NCT01733108
- Testing
- Glyburide, Canagliflozin (JNJ-28431754)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Healthy
Evaluating a Pharmacokinetic Drug Interaction Between Amlodipine/Losartan and Rosuvastatin
The purpose of this study is to evaluate the drug-drug interaction between amlodipine/losartan and rosuvastatin in healthy male volunteers.
- Trial name
- NCT02140489
- Testing
- amosartan, rosuvastatin, amosartan and rosuvastatin
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Hypertension
Study to Evaluate the Pharmacokinetic Interaction Between Fimasartan and Atorvastatin in Healthy Male Volunteers
A phase I clinical trial to compare the pharmacokinetics and safety of fimasartan/Atorvastatin combination tablet and coadministration of fimasartan and Atorvastatin in healthy male volunteers.
- Trial name
- NCT02397590
- Testing
- Fimasartan, Atorvastatin
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Healthy
A Study of the Relative Bioavailability of ASC18 Tablets vs Reference Tablets in Healthy Volunteers
The objective of this study is to evaluate potential drug interaction between RDV and SOF in ASC18 tablets (RDV/SOF compound tablets) and the influence of food effect on the pharmacokinetics of ASC18 tablets were evaluated in…
- Trial name
- NCT04358523
- Testing
- ASC18, ravidasvir and sofosbuvir
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ascletis Pharmaceuticals Co., Ltd.
Stroke Sequelae, Stroke
Multiple Dose Study to Evaluate Drug-drug Interactions, Safety and Tolerability of NDC-002 in Healthy Volunteers
An Open-label, One-sequence, Three-period, Multiple-dose Study to Evaluate Drug-drug Interactions, Safety and Tolerability between NDC-002A/NDC-002B and NDC-002C in Healthy Volunteers
- Trial name
- NCT06090474
- Testing
- NDC-002
- Where
- South Korea
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Dr. Noah Biotech Inc.
Healthy Adults
A Drug-Drug Interaction (DDI) Study of ADC189 With Itraconazole in Healthy, Adult Subjects
This study aims to answer how repeat doses of itraconazole impact the pharmacokinetics, safety, and tolerability of single doses of ADC189 in healthy adults.
- Trial name
- NCT06589635
- Testing
- ADC-189 and Itraconazole
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jiaxing AnDiCon Biotech Co.,Ltd
Healthy Male Volunteer
The Pharmacokinetic Drug-drug Interaction and Safety of Telmisartan/Amlodipine and Rosuvastatin in Healthy Male Volunteers
To investigate the pharmacokinetic Drug-drug interaction
- Trial name
- NCT02233218
- Testing
- Telmisartan, Amlodipine, Rosuvastatin
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
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