Clinical trials: Drug Interaction Study
HIV Infection, HIV Infections
Buprenorphine/Raltegravir Pharmacokinetic Interaction Study
The main purpose of this protocol is to study the effect of an HIV medication known as Raltegravir on Buprenorphine in people who have been receiving the same dose of Buprenorphine for at least 3 weeks before study entry.
- Trial name
- NCT00858962
- Testing
- Raltegravir
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Yale University
Drug Interaction Potentiation
Drug-Drug Interaction Study of Vadadustat With Digoxin, Adefovir and Furosemide
This is a Phase 1, open-label, 3-arm, fixed sequence, study to evaluate vadadustat as a perpetrator of drug-drug interactions (DDIs) with digoxin, adefovir and furosemide in healthy male and female subjects.
- Trial name
- NCT03801759
- Testing
- Vadadustat, Furosemide, Adefovir
- Where
- Canada
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Akebia Therapeutics
Anthrax
Ph1 Study of Valortim and Ciprofloxacin in Humans
The purpose of this study is to evaluate the safety and tolerability of short-term dosing of IV ciprofloxacin when administered concomitantly with IV Valortim in healthy normal human subjects.
- Trial name
- NCT00964561
- Testing
- Ciprofloxacin and Valortim
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- PharmAthene, Inc.
Healthy Subjects
Pharmacokinetic Interaction Between Diltiazem and ACT-541468 in Healthy Subjects
The main objective of this study is to investigate whether repeated administration of a cardiac medication (diltiazem) can affect the pharmacokinetics (i.e., amount and time of presence in the blood) of ACT-541468
- Trial name
- NCT02526888
- Testing
- ACT-541468, Diltiazem
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
HIV Infections
Drug-drug Interaction (DDI) Study of GSK3640254 With Darunavir/Ritonavir (DRV/RTV) and Etravirine (ETR)
This is an open-label, single-sequence, multiple-dose, 3 cohort study to investigate the effects of DRV/RTV and/or ETR on the pharmacokinetics (PK) of GSK3640254 and the effects of GSK3640254 on the PK of DRV/RTV and/or ETR.
- Trial name
- NCT04630002
- Testing
- GSK3640254, Darunavir/Ritonavir (DRV/RTV), Etravirine (ETR)
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Respiratory Syncytial Virus Infections
A Study to Learn About the Drug-drug Interactions of Sisunatovir in Healthy Adult Participants
The purpose of this clinical trial is to learn about the interaction of sisunatovir with four medications (midazolam, itraconazole, rifampicin, and verapamil).
- Trial name
- NCT03782662
- Testing
- Itraconazole, Verapamil, Rifampicin
- Where
- United Kingdom
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pharmacokinetics, Pharmacodynamics
A Drug-Drug Interaction Study Between AZD9668 and Warfarin to Study the Effect of AZD9668 on the Metabolism and Effect of Warfarin
The primary purpose of this study is to determine whether the treatment with AZD9668 will affect the metabolism and effect of Warfarin.
- Trial name
- NCT01214122
- Testing
- AZD9668, Warfarin
- Where
- 2 sites in Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
An Interaction Study of Ketoconazole/Verapamil Versus AZD1305
The purpose is to study whether ketoconazole or verapamil have an effect on how AZD1305 is handled by the body, i.e the absorption, distribution, metabolism and excretion, when administered in combination with AZD1305.
- Trial name
- NCT00707551
- Testing
- Ketoconazole, Verapamil, AZD1305
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Investigation of Pharmacokinetic Drug-drug Interaction of BI 409306 and Donepezil in Healthy Male and Female Subjects
Part I: To investigate whether and to what extent donepezil affects single dose pharmacokinetics of BI 409306 Part II: To investigate whether and to what extent BI 409306 affects the single dose pharmacokinetics of donepezil
- Trial name
- NCT02635750
- Testing
- BI 409306, Donepezil
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Volunteers
Clinical Trial to Evaluate the PK Interactions of YHR2402 Monotherapy and YHR2402 and YHR2403 Co-Administration in Healthy Volunteers
An open-label, randomized, single-dose, crossover study to evaluate the pharmacokinetic interactions and safety after co-administration of YHR2402 and YHR2403 compared to the administration of YHR2402 independently in healthy…
- Trial name
- NCT06623526
- Testing
- YHR2402, YHR2402+YHR2403
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Healthy Volunteers
A Study to Assess the Effect of Cefiderocol on the Pharmacokinetics (PK) of Midazolam in Healthy Participants
The purpose of this study is to determine the effect of repeated doses of cefiderocol on the PK of midazolam.
- Trial name
- NCT05395104
- Testing
- Midazolam, Cefiderocol
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Shionogi
Healthy Volunteers
Vyvanse and Adderall XR Given Alone and in Combination With Prilosec OTC
The purpose of this study is to determine if taking Vyvanse with Prilosec OTC or Adderall XR with Prilosec OTC changes how quickly the drug is absorbed into the body and/or changes how much of the drug is absorbed into the body.
- Trial name
- NCT00746733
- Testing
- Lisdexamfetamine Dimesylate, Adderall XR (mixed salts amphetamine)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Shire
Healthy
Drug-drug Interaction Study Between UIC201601 and UIC201602
An open-label, multiple-dosing, two-arms, one-sequence study to evaluate the safety and pharmacokinetics after co-administration of UIC201601 and UIC201602 in healthy male volunteers.
- Trial name
- NCT05190133
- Testing
- UIC201602 and co-administration of UIC201601 and UIC201602, UIC201601 and co-administration of UIC201601 and UIC201602
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Infection, Human Immunodeficiency Virus, HIV Infections
Effect of Rifabutin on the Pharmacokinetics of Oral Cabotegravir in Healthy Subjects
This is a Phase I, single-center, open-label, fixed-sequence, 2-period crossover study in healthy adults to evaluate the effect of oral rifabutin (RBT) 300 milligram (mg) on the pharmacokinetics of oral cabotegravir (CAB) 30…
- Trial name
- NCT03149848
- Testing
- Cabotegravir, Rifabutin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Diseases of the Circulatory System, Essential Hypertension
To Evaluate the Drug-drug Interaction Between Telmisartan and Atorvastatin in Healthy Male Volunteers
The study design was composed of 2 parts, 2-way crossover and multiple-dose. There are having 2 groups in each part that have divided period 1 and period 2, and wash-out period is 16 days between periods.
- Trial name
- NCT02579356
- Testing
- Telmisartan, Atorvastatin
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Samil Pharmaceutical Co., Ltd.
Drug Interactions
A Study to Evaluate the Interaction Between Vicodin® CR and Ethanol in Healthy Male and Female Moderate Alcohol Drinkers
The purpose of this research study is to determine if varying strengths of ethanol affect the drug level and safety profile of Vicodin® CR.
- Trial name
- NCT00429468
- Testing
- Vicodin® CR (extended-release hydrocodone/acetaminophen)
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Abbott
Drug Interactions, Healthy
A Drug Interaction Study of Folic Acid and Oral Contraceptive Tablets Containing Norgestimate (NGM) /Ethinyl Estradiol (EE) in Healthy Women.
The purpose of the study is to assess the effect of folic acid administration on the blood level and the breakdown products of OC study drug (250 mcg norgestimate[NGM]/35 mcg Ethinyl Estradiol [EE]) tablets.
- Conditions
- Drug Interactions, Healthy, Pharmacokinetics
- Trial name
- NCT00709982
- Testing
- Norgestimate; Ethinyl Estradiol; Folic acid
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Interaction
The Effect of Itraconazole on BCT197 Exposure in Healthy Male Participants
An Open-label, 2-period, Single-sequence, Crossover Study to Evaluate the Effect of Multiple Oral Dosing of Itraconazole on BCT197 Systemic Exposure in Healthy Male Participants.
- Trial name
- NCT03498170
- Testing
- BCT197, Itraconazole 200 mg
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mereo BioPharma
Healthy
Drug Interaction Study of MGL-3196 With Rosuvastatin and Simvastatin
The purpose of this study is to determine whether MGL-3196 alters the pharmacokinetics of rosuvastatin and/or simvastatin in healthy male subjects and female subjects not of child-bearing potential.
- Trial name
- NCT02542969
- Testing
- Simvastatin, Rosuvastatin, MGL-3196
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Madrigal Pharmaceuticals, Inc.
Pharmakokinetic
A Drug-Drug Interaction Study to Study the Effect of AZD1981 on Warfarin
The primary purpose of this study is to determine whether the treatment with AZD1981 affect the exposure of Warfarin.
- Trial name
- NCT01199341
- Testing
- AZD1981, Warfarin
- Where
- Sweden
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.