Clinical trials: Drug Monitoring
Tuberculosis, Latent Tuberculosis Infection
VDOT for Monitoring Adherence to LTBI Treatment
The three-month short-course treatment with isoniazid [H] and rifapentine [P] (3HP) recently recommended by the Centers for Disease Control and Prevention could dramatically increase the number of persons starting and completing…
- Trial name
- VMALT (NCT02641106)
- Testing
- Video Directly Observed Therapy, In-Person DOT
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Lymphatic Filariasis Elimination by Mass Drug Administration, Monitoring and Evaluation of Mass Drug Administration for Lymphatic Filariasis
East New Britain Province Monitoring & Evaluation
While tremendous progress towards elimination of lymphatic filariasis (LF) has been made in the 20 years since the 1997 Fiftieth World Health Assembly, it is unlikely the goal of eliminating LF as a public health problem by 2020…
- Conditions
- Lymphatic Filariasis Elimination by Mass Drug Administration, Monitoring and Evaluation of Mass Drug Administration for Lymphatic Filariasis, Acceptability of Mass Drug Administration for Lymphatic Filariasis
- Trial name
- ENBP M&E (NCT04124250)
- Testing
- Observational
- Where
- Papua New Guinea
- Volunteers
- 12,930 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Drug Use
mHealth to Enhance & Sustain Drug Use Reduction of the QUIT BI in Primary Care
The QUIT-Mobile study proposes to use mobile phone self-monitoring and feedback to enhance and sustain over 12-months the impacts of the Quit Using Drugs Intervention Trial (QUIT), an effective screening and brief intervention…
- Trial name
- QUIT-Mobile (NCT04935606)
- Testing
- Usual Care, QUIT Intervention (doctor brief advice, video doctor, health coaching sessions at 2- and 6-weeks), QUIT-Mobile (QUIT Intervention plus weekly mobile-web app or text message weekly self-monitoring, automated feedback over 12 months)
- Where
- 5 sites in United States
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV
Male Engagement in PMTCT Services
The study employs a quasi-experimental design in 8 public health centers in southwest Uganda offering care and treatment (C\&T) services.
- Trial name
- NCT01903889
- Testing
- clinic based intervention, clinic and community based intervention
- Where
- 7 sites in Uganda
- Volunteers
- 3,806 people, healthy volunteers welcome
- Sponsor
- FHI 360
Glaucoma
Real-time Glaucoma Medication Adherence
This study will evaluate the effectiveness of real-time data collected on patients taking topical medication to treat glaucoma. Patients will be randomized to two groups, the first of which will only use the study device to take…
- Trial name
- NCT03194828
- Testing
- Medication reminder, Medication monitoring only
- Where
- 8 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Soil-transmitted Helminth Infections
Validating Egg-based Diagnostics and Molecular Markers for the Spread of Anthelmintic Resistance
Soil-transmitted helminths (STHs) are a group of parasitic worms that infect millions of children in sub-tropical and tropical countries, resulting in malnutrition, growth stunting, intellectual retardation and cognitive…
- Trial name
- StarwormsWP1 (NCT03465488)
- Testing
- Albendazole Pill 400mg (GSK)
- Where
- 4 sites in Brazil, Ethiopia and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Ghent
Adherence, Medication, Risk Behavior
DOT Diary Optimization Pilot: A Pilot Study to Optimize the DOT Diary App to Measure PrEP Adherence
The researchers are working with a technology company, AiCure, to develop a smartphone app, DOT Diary, which combines two drug adherence strategies.
- Conditions
- Adherence, Medication, Risk Behavior, Pre-Exposure Prophylaxis, HIV Prevention
- Trial name
- NCT03387462
- Testing
- Emtricitabine / Tenofovir Disoproxil Oral Tablet, DOT Diary mobile app
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Emergencies
The Greek Acute Dance Injuries Registry
Dance is a highly demanded physical activity with a high rate of acute and emergent events (AEE). No systematic prospective study has been conducted in any Greek population of dance students for the registration of the AEE and…
- Trial name
- GrADIR (NCT06220916)
- Testing
- Dance training in Classical Ballet and Contemporary Dance
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Stroke, Medication Adherence
Adherence to Medical Treatments for Telemedicine Patients
This study will test the feasibility of MedRem, a novel medication reminder and tracking system on wearable wrist devices, specifically with the Apple Watch 4.
- Trial name
- NCT04180475
- Testing
- MedRem application
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Virginia
HIV Infections, Adherence, Medication
Testing a Real-time Electronic Antiretroviral Adherence Monitoring Intervention
The investigators propose using an electronic adherence device that is basically a pill container that can alert when it is not opened at a scheduled time.
- Trial name
- A-TEAM (NCT06550804)
- Testing
- A-TEAM
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Healthy Volunteers
Evaluation of the Bioavailability of Amino Acids From Purple Bacteria
This interventional clinical study aims to evaluate the bioavailability of amino acids derived from purple bacteria in healthy adults.
- Trial name
- PROTEBOOST_1 (NCT07613983)
- Testing
- Purple Bacteria-Enriched Dairy Product, Protein-Enriched Dairy Product
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Cytotoxicity
Study Evaluating Occupational Exposure to Antineoplastic Drugs
The multicenter study involves comparing two groups (an exposed group and a control group). The exposed group is selected from workers who perform their activities in drug handling areas (DH) or units for antineoplastic…
- Trial name
- BRIC (NCT06343103)
- Testing
- Workers exposed, Workers not exposed
- Where
- 5 sites in Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Thyroidectomy
Optimal Concentration of Remifentanil for NIM Tube Intubation With Low-dose NMBA
During thyroid surgery, Intraoperative Neuromonitoring (IONM) plays a crucial role in preventing serious complications such as bilateral vocal cord paralysis.
- Trial name
- NCT06162390
- Testing
- Remifentanil
- Where
- South Korea
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Kyungpook National University Chilgok Hospital
Term Labour
Accuracy and Reliability of Novii: Fetal Heart Rate (FHR), Maternal Heart Rate (MHR) and Uterine Contraction (UA) Compared With Doppler, Scalp Fetal Scalp Electrode (FSE), Tocodynamometer (TOCO) and Intra Uterine Pressure Catheter (IUPC)
Accuracy and Reliability of the Novii device (fetal heart rate, maternal heart rate and uterine activity) compared with Food and Drug Administration (FDA) approved techniques
- Trial name
- NCT03409146
- Testing
- Monica Novii Wireless Patch System
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Lymphatic Filariasis
Optimization of MDA With Existing Drug Regimens for LF: Monitoring Efficacy of Ongoing Treatment Programs in PNG
The standard regimen for elimination of lymphatic filariasis (LF) in PNG is annual administration of two drugs at the same time.
- Trial name
- MDA (NCT03268252)
- Where
- Papua New Guinea
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Inflammatory Bowel Diseases
Comparison of the Performance of SB2-Infliximab With Originator Infliximab in the Measure of Serum Concentrations in Serum
The measurement of serum concentrations of infliximab (IFX)has now become a routine part of optimal use of that drug. Trough values are used in two situations: (a) reactively where there is loss of response to infliximab …
- Trial name
- NCT03308357
- Testing
- Drug assays to measure infliximab
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Alfred
Hypertension
Hypertension Control Program in Argentina (HCPIA)
The objective of this cluster randomized trial is to test whether a comprehensive intervention program within a national public primary care system will improve hypertension control among uninsured hypertensive patients and their…
- Trial name
- NCT01834131
- Testing
- Comprehensive Intervention
- Where
- Argentina
- Volunteers
- 1,954 people, healthy volunteers welcome
- Sponsor
- Tulane University
Healthy Volunteer Study
Smart Blister Packaging and Mobile Application to Monitor and Support Medication Adherence: a Two-arm Usability Study
Many people struggle to take their medications as prescribed, which can lead to poor health outcomes and increased healthcare costs.
- Trial name
- SMART-BLISTER (NCT07099612)
- Testing
- MEMS® Mobile smartphone application, Cere®Pak smart blister pack
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Digital Health Intervention, Remote Consultation, Teleconsultation
Evaluation and Implementation of Digital Health Ecosystem in Academic Health Center
Mobile health technologies, such as smartwatches, wearable sensors, and digital applications, have the potential to support healthier lifestyles and improve the management of health conditions.
- Conditions
- Digital Health Intervention, Remote Consultation, Teleconsultation, Lifestyle Factors, Stress
- Trial name
- e-IDEA (NCT07831837)
- Testing
- Integrated Digital Health Ecosystem, Usual Primary Care
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Depression
Evaluation of Use of Brain Activity Monitoring for Evaluation of Depression Treatment
This study evaluates the use of brain activity monitoring for early identification of pharmaceutical treatment efficacy and development of depression deterioration events.
- Trial name
- NCT02523105
- Testing
- EEG monitoring
- Where
- 2 sites in Israel
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Brainmarc Ltd.