Clinical trials: Drug Refractory Epilepsy
Epilepsy, Refractory
Using Micro-filaments to Detect "fast Ripples" and Improve the Identification of the Epileptogenic Zone
record fast ripples with novel intracranial electrodes with micro-tetrodes to improve the identification of epileptogenic zone (EZ) and investigate the neuronal circuits underlying brain dynamics associated with epilepsy
- Trial name
- NeuroSeizure (NCT05254730)
- Testing
- macro-micro tetrodes for intracranial recording
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Adrien Peyrache
Advanced Parkinson's Disease, Refractory Epilepsy
An Automated Navigation System for Deep Brain Electrode Implantation
1. Analysis of the correlation between imaging and electrophysiological signals. 2. Real time analysis method for optimal implantation position. 3. Simultaneous Imaging and electrophysiology navigation. 4.
- Conditions
- Advanced Parkinson's Disease, Refractory Epilepsy, Obsessive-compulsive Disorder
- Trial name
- NCT06396494
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Refractory Epilepsy, Focal Epilepsy
Atlas of Human Cognition by SEEG (MAPCOG-SEEG)
The main objective of MAPCOG_SEEG is to create a database including brain recordings of cognition performed in clinical routine in patients during the pre-surgical SEEG assessment.
- Trial name
- MAPCOG-SEEG (NCT03644732)
- Testing
- SEEG Group
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Grenoble
Refractory Epilepsy
Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 in Subjects With Focal Seizures, With Temporal Lobe Onset With or Without Secondary Generalization
This is a Phase 2 double-blind, randomized, placebo-controlled study to assess the safety and efficacy of ICV delivery of CT-010 via an implantable pump and a cranial port and dual lumen catheter (CIC) in subjects with focal…
- Trial name
- NCT04153175
- Testing
- ICV delivery of CT-010 via an implantable pump and a cranial port and dual lumen catheter (CIC)
- Where
- 11 sites in Australia, Israel
- Volunteers
- 30 people
- Sponsor
- Cerebral Therapeutics LLC
Transcranial Direct Current Stimulation, EEG
High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Refractory Epilepsy
To observe the clinical effect and safety of transcranial electrical stimulation on patients with refractory epilepsy before and after treatment and analyze its therapeutic mechanism.
- Conditions
- Transcranial Direct Current Stimulation, EEG, Functional Magnetic Resonance Imaging, Refractory Epilepsy
- Trial name
- NCT06241963
- Testing
- Active Comparator: Unilateral real High definition transcranial direct current stimulation, Active Comparator: Bilateral real High definition transcranial direct current stimulation
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Anhui Medical University
Refractory Epilepsy
Expanded Use of Cannabidiol Oral Solution
To allow subjects who have completed Insys 030 extension study to continue to take Cannabidiol oral solution.
- Trial name
- NCT03196934
- Testing
- Cannabidiol oral solution
- Sponsor
- MultiCare Health System Research Institute
Electroencephalography, Refractory Epilepsy
Clinical Utility of Automated Electric Source Imaging in Presurgical Evaluation
Electrical source imaging is part of the presurgical evaluation of patients with drug-resistant focal epilepsy. The software packages that will be used in this study have Declaration of Conformity within the European Economic…
- Conditions
- Electroencephalography, Refractory Epilepsy, Brain Imaging, Surgery
- Trial name
- PROMAESIS (NCT04218812)
- Testing
- No electrical source imaging (ESI), Automated electrical source imaging (ESI)
- Where
- 12 sites in Austria, Czechia and 6 more
- Volunteers
- 250 people
- Sponsor
- Sándor Beniczky
Refractory Epilepsy
Localization of the Reward Positivity to ACC
The exact function of the anterior cingulate cortex (ACC) is one of the largest riddles in cognitive neuroscience and a major challenge in mental health research.
- Trial name
- NCT04684797
- Testing
- Virtual T-maze task
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Refractory Epilepsy, Development Delay
European Non-interventional Study on Refractory Epilepsy With Developmental Delay
This is a multinational, multicentre, non-interventional, retrospective data collection (manual Medical Chart Review).
- Trial name
- NCT04398667
- Where
- 19 sites in France, Germany and 2 more
- Volunteers
- 93 people
- Sponsor
- Zogenix, Inc.
Drug-Refractory Epilepsy
Rechargeable Implantable Vagus Nerve Stimulation System for Drug-Refractory Epilepsy
To evaluate the performance of automatic stimulation mode of a new rechargeable implantable vagus nerve stimulation system for drug-refractory epilepsy
- Trial name
- NCT05993117
- Testing
- G114R VNS system
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Refractory Epilepsy
Acute and Long Term Effects of VNS on Memory in Patients With Refractory Epilepsy
Refractory epilepsy patients implanted with a vagus nerve stimulator perform a memory test at baseline in three conditions: invasive vagus nerve stimulation (VNS), transcutaneous vagus nerve stimulation (taVNS) and sham…
- Trial name
- NCT05031208
- Testing
- Memory task
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University Hospital, Ghent
Drug Refractory Epilepsy
cTBS Targeting Cerebellum for Drug-refractory Epilepsy
This study aims to observe the effect and safety of cerebellar continuous θ burst stimulation (cTBS) for drug-refractory epilepsy(DRE), in order to provide a new treatment for DRE and improve the quality of life of those…
- Trial name
- NCT05042726
- Testing
- cTBS First, Pseudo-stimulation First
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Xijing Hospital
Refractory Epilepsy, Epilepsy
Exercise as Adjunctive Treatment for Refractory Epilepsy
The purpose of this research study is to determine whether a 12-week telehealth aerobic exercise intervention is feasible in people with epilepsy.
- Trial name
- NCT04607317
- Testing
- Exercise program, Health Coach, Health Information
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Refractory Epilepsy
A Study to Evaluate fMRI of Active DBS Stimulation in Epilepsy
The purpose of this study is to use functional imaging to study the mechanisms of the anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS).
- Trial name
- NCT04753983
- Testing
- Functional magnetic resonance imaging (fMRI)
- Sponsor
- Mayo Clinic
Epilepsy in Children, Epilepsy in Youth
The Potential of a Low Glutamate Diet as a Treatment for Pediatric Epilepsy
The study is investigating if following the low glutamate diet for 1 month, as compared to care as usual, can improve seizure frequency, severity, and duration; cognitive functioning; and/or quality of life in children with…
- Conditions
- Epilepsy in Children, Epilepsy in Youth, Randomized Controlled Trial, Refractory Epilepsy
- Trial name
- NCT04545346
- Testing
- Low Glutamate diet
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- American University
Refractory Epilepsy
Efficacy and Safety of Perampanel in Combination in Glioma-refractory Epilepsy
Gliomas are primitive brain tumors frequently associated with epilepsy. In a significant number of these patients epilepsy is resistant to antiepileptic drugs.
- Trial name
- NCT03636958
- Testing
- Perampanel, conventional antiepileptic treatment
- Where
- 2 sites in France
- Sponsor
- Assistance Publique Hopitaux De Marseille
Epilepsy, Epileptic Encephalopathy
Tele-epic (Telemedicine for Epilepsy Care)
Epilepsy is a chronic condition that requires consistent follow-up aimed at seizure control, surveillance of comorbidities, monitoring of antiepileptic drugs (AED) levels and side effects.
- Conditions
- Epilepsy, Epileptic Encephalopathy, Refractory Epilepsy
- Trial name
- Tele-epic (NCT04496310)
- Testing
- Telemedicine
- Where
- 2 sites in Italy
- Volunteers
- 600 people
- Sponsor
- Azienda Usl di Bologna
Epilepsy in Children, Focal Epilepsy
Novel Network Analysis of Intracranial Stereoelectroencephalography
Epilepsy is a disorder of the brain which is associated with disabling seizures and affects 100,000 people under 25. Many children with epilepsy also have a learning disability or problems with development.
- Conditions
- Epilepsy in Children, Focal Epilepsy, Epilepsy Intractable, Epilepsy, Focal
- Trial name
- NNAIS (NCT03916848)
- Testing
- Combined Micro-Macro SEEG Electrodes
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Epilepsy, Epilepsy, Focal
MELD as an Adjunct for SEEG Trajectories
Epilepsy is a disorder of the brain which is associated with disabling seizures and affects 100,000 people under 25. Many children with epilepsy also have a learning disability or problems with development.
- Conditions
- Epilepsy, Epilepsy, Focal, Epilepsy, Refractory
- Trial name
- MAST (NCT04383028)
- Testing
- MELD algorithm use to aid in the planning of SEEG electrode trajectories
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Refractory Epilepsy
Randomized Controlled Trial on Cardiovascular Exercise in Uncontrolled Epilepsy:
This is an open-label randomized controlled tria testing if an improvement in cardiovascular fitness can improve quality of Life and reduce seizure frequency in patients with refractory epilepsy..
- Trial name
- Epilepsy (NCT03570489)
- Testing
- Exercise, Relaxation
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Vastra Gotaland Region