Clinical trials: Drug Resistant Epilepsy
Focal Epilepsy
A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy.
- Trial name
- RISE 2 (NCT06132893)
- Testing
- BHV-7000
- Where
- 104 sites in United States, Argentina and 10 more
- Volunteers
- 390 people
- Sponsor
- Biohaven Therapeutics Ltd.
Epilepsy
Dietary Therapy in Children With Refractory Epilepsy
In children aged 1yr -18 years with refractory epilepsy Modified Atkins diet as add on to ongoing AED therapy would not be inferior compared to ketogenic diet ** in terms of seizure reduction from baseline seizure frequency at 6…
- Trial name
- NCT01983163
- Testing
- Ketogenic diet (2.5 to 4:1), Modified Atkin's diet
- Where
- India
- Volunteers
- 30 people
- Sponsor
- All India Institute of Medical Sciences
Drug Resistant Epilepsy
A First in hUman Study for Resistant Epilepsy With the Vagus Nerve stimulatiOn Device by syneRgia medicAl
This is an open label, single arm, interventional, prospective first in human study, designed to evaluate the safety of the NAO.VNS SYSTEM.
- Trial name
- AURORA (NCT06340802)
- Testing
- VNS Treatment
- Where
- 2 sites in Belgium
- Volunteers
- 5 people
- Sponsor
- Synergia Medical
Intellectual Disability, Developmental Delay
Biomarker for Creatine Deficiency Syndromes (BioCDS)
Development of a new mass spectrometry-based biomarker for the ear-ly and sensitive diagnosis of the Creatine Deficiency Syndromes from dry-blood-spot sample
- Conditions
- Intellectual Disability, Developmental Delay, Movement Disorder, Behavioral Disorder
- Trial name
- BioCDS (NCT02934854)
- Where
- 4 sites in Egypt, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Tuberous Sclerosis Complex (TSC)
Treatment With Full-spectrum Cannabis Extract of Refractory Epilepsy Associated With Tuberous Sclerosis Complex (TSC)
1. To assess treatment efficacy with YCJ-01 by changes in the number of epileptic seizures in patients with refractory epilepsy secondary to Tuberous Sclerosis Complex. 2.
- Trial name
- Spectrum (NCT07403266)
- Testing
- YCJ-01 Full Spectrum cannbis Extract
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Oils4Cure
Epilepsy, Focal Epilepsy
Cognitive Impairment in Drug-resistant and Drug-responsive Focal Cryptogenic Epilepsy
This is a national monocentric (San Raffaele Hospital - OSR, Via Olgettina, 60, 20132 Milan, Italy) observational low-risk-intervention study, prospective and multiparametric (clinical, EEG, neuropsychological evaluations) study.
- Trial name
- NCT06210022
- Testing
- Neuropsychological Assessment
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- IRCCS San Raffaele
Epilepsy, Seizure
Predictors of Drug Resistant Epilepsy Among Pediatric Patients
1. This study aims to determine the main predictors of drug resistance in pediatric epilepsy by examining clinical data, EEG abnormalities, and neuroimaging results, in order to support early identification of resistant cases and…
- Conditions
- Epilepsy, Seizure, Resistance
- Trial name
- NCT07241754
- Volunteers
- 200 people
- Sponsor
- Assiut University
Epilepsy Intractable, Epilepsy in Children
The Mosaic Brain: a New Diagnostic Approach in Focal Epilepsies
Overall, this observational cohort study aims to: 1. Improve our understanding of the genetic architecture of childhood focal epilepsies. 2.
- Trial name
- NCT06602570
- Volunteers
- 40 people
- Sponsor
- Institute of Child Health
Advanced Parkinson's Disease, Refractory Epilepsy
An Automated Navigation System for Deep Brain Electrode Implantation
1. Analysis of the correlation between imaging and electrophysiological signals. 2. Real time analysis method for optimal implantation position. 3. Simultaneous Imaging and electrophysiology navigation. 4.
- Conditions
- Advanced Parkinson's Disease, Refractory Epilepsy, Obsessive-compulsive Disorder
- Trial name
- NCT06396494
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Epilepsy
Pediatric Language and Memory Mapping in Refractory Epilepsy Using Magnetoencephalography
This is a pilot research study where language and working memory tasks will be used to study brain activities from children with epilepsy.
- Trial name
- NCT04888637
- Testing
- Baseline MEG Test, Receptive Language Task, Memory Task
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arkansas
Refractory Epilepsy
Comparative Study of Dietary and Immunological Management of Refractory Epilepsy in Children
1. Comparison of the efficacy of Rituximab and ketogenic diet in controlling refractory seizures versus the traditional lines as corticosteroid and trace elements. 2. Improving the management of children with refractory seizures
- Trial name
- NCT04542629
- Testing
- RiTUXimab Injection [Rituxan]
- Volunteers
- 140 people
- Sponsor
- Assiut University
Drug Resistant Epilepsy, Autism Spectrum Disorder
Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients
The goal of this observational study is to learn about the clinical and nutritional effectiveness of ketogenic diet (KD) in pediatric patients with genetic, neurological or metabolic conditions requiring KD.
- Conditions
- Drug Resistant Epilepsy, Autism Spectrum Disorder, Chronic Migraine, Brain Tumor, Pediatric
- Trial name
- NCT06309251
- Testing
- ketogenic diet (as per clinical practice)
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Danone Nutricia SpA Società Benefit
Refractory Epilepsy, Focal Seizure
Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy
This is a multiple site, randomized, double blinded parallel-group controlled study. The purpose of this study is to evaluate efficacy, safety, and tolerability of repeated, daily sessions with the STARSTIM device, which delivers…
- Conditions
- Refractory Epilepsy, Focal Seizure, Seizures, Focal, Seizures
- Trial name
- NCT04770337
- Testing
- STARSTIM device
- Where
- 32 sites in United States, Belgium and 2 more
- Volunteers
- 127 people
- Sponsor
- Neuroelectrics Corporation
Drug Resistant Epilepsy
Fluorescence Guided Focal Cortical Dysplasia Surgery
Epilepsy is one of the most common neurological disorders, with one of the highest morbidity rates of all diseases. Despite the development of new anticonvulsant drugs, around a third of patients suffer from drug-resistant…
- Trial name
- FLUOFOCODYS (NCT07657975)
- Testing
- 5-ALA (Gliolan)
- Where
- 2 sites in France
- Volunteers
- 5 people
- Sponsor
- Hospices Civils de Lyon
Epilepsy Intractable, Glucose Transporter Type 1 Deficiency Syndrome
Evaluation of Ketoflo
For 28 days, 30 participants aged 3 to 18 years of age (inclusive) with a condition requiring a ketogenic diet will incorporate Ketoflo into their usual dietary regime.
- Conditions
- Epilepsy Intractable, Glucose Transporter Type 1 Deficiency Syndrome, Ketogenic Dieting
- Trial name
- Ketoflo (NCT04399954)
- Testing
- Ketoflo
- Where
- 5 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- Vitaflo International, Ltd
Epilepsy in Children, Focal Epilepsy
Novel Network Analysis of Intracranial Stereoelectroencephalography
Epilepsy is a disorder of the brain which is associated with disabling seizures and affects 100,000 people under 25. Many children with epilepsy also have a learning disability or problems with development.
- Conditions
- Epilepsy in Children, Focal Epilepsy, Epilepsy Intractable, Epilepsy, Focal
- Trial name
- NNAIS (NCT03916848)
- Testing
- Combined Micro-Macro SEEG Electrodes
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Epilepsy Menstrual
Interest of a Specific Care Pathway for the Management of Catamenial Epilepsy
This is a study of patients with catamenial epilepsy. Catamenial epilepsies are defined as epileptic seizures during the menstrual cycle. Today, there are no recommendations and no care pathway for these patients.
- Trial name
- EPICAT (NCT05898152)
- Testing
- Data collection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Refractory Epilepsy
Efficacy and Safety of Perampanel in Combination in Glioma-refractory Epilepsy
Gliomas are primitive brain tumors frequently associated with epilepsy. In a significant number of these patients epilepsy is resistant to antiepileptic drugs.
- Trial name
- NCT03636958
- Testing
- Perampanel, conventional antiepileptic treatment
- Where
- 2 sites in France
- Sponsor
- Assistance Publique Hopitaux De Marseille
Refractory Epilepsy
Evaluation of the Modified Atkins Diet in Young Children With Refractory Epilepsy
The modified Atkins diet is a non-pharmacologic therapy for intractable childhood epilepsy that was designed to be a less restrictive alternative to the traditional ketogenic diet.
- Trial name
- NCT01880333
- Testing
- Modified Atkin Diet
- Where
- India
- Volunteers
- 31 people
- Sponsor
- Lady Hardinge Medical College
Epilepsy
Study of the Intracerebral Electrophysiological Signature in the Epileptic Patient
As part of the clinical management of certain severe, drug-resistant forms of epilepsy, it is necessary to implant electrodes in the brain to identify the epileptic network prior to potential neurosurgical resection of the source…
- Trial name
- ACTELIN 2 (NCT07796984)
- Testing
- Cognitive tasks in the form of questionnaires
- Where
- France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Toulouse