Clinical trials: Drug Use Disorders
Substance Use
Unplugged, a Drug Use Prevention Program: Adaptation and Evaluation of Effectiveness Among Students in Chile
Substance use and drug related disorders are important public health problems. Alcohol and illicit drug use account for 5.4% of the total burden of disease and the peak has been found in early adulthood (between ages 20 and 30…
- Trial name
- YSLQQ (NCT04236999)
- Testing
- Yo Sé Lo Que Quiero (YSLQQ)
- Where
- Chile
- Volunteers
- 8,880 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Overdose Risk, Opioid Use Disorder
Kentucky Women's Justice Community Overdose Innovation Network - Phase II
This project continues our work with women in the Kentucky Women's Justice Community Overdose Innovation Network Phase II (WJCOIN-II) with the overall aim of reducing overdose risk during the transition from jail to rural…
- Conditions
- Overdose Risk, Opioid Use Disorder, Stimulant Use Disorders
- Trial name
- WJCOIN-II (NCT07179614)
- Testing
- Overdose Prevention Intervention Package (OPIP)
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Michele Staton
Photoaging, Actinic Keratosis
5fluorouracil for Advanced Photoaging
It is well known the efficacy of 5% 5-fluoruracil for multiple and superficial actinic keratosis (AKs)treatment. Recently its additional benefit for advanced and severe photoaging while treating Aks was reported.
- Trial name
- NCT01405144
- Testing
- 5-fluoruracil
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Tobacco Use, Nicotine Dependence, Other Tobacco Product
A Study to Characterize Puff Topography With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers
A Study to Characterize Puff Topography with Use of a JUUL 5% Electronic Nicotine Delivery Systems (ENDS) in Adult Smokers
- Conditions
- Tobacco Use, Nicotine Dependence, Other Tobacco Product, Tobacco Smoking
- Trial name
- NCT03596034
- Testing
- JUUL 5%, Virginia Tobacco, ENDS product
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
HIV Infections
Reduction of Drug Use and HIV Risk Among Out-of-Treatment Methamphetamine Users
There is a need to identify and test effective strategies to reduce meth use and human immunodeficiency virus (HIV) risk behaviors in heterosexuals.
- Trial name
- NCT01161485
- Testing
- HIV Testing and Counseling, Contingency Management, Strengths-based case management
- Where
- United States
- Volunteers
- 502 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Psychoactive Substance Use Disorder
Psychoactive Drug Uses Among Medical and Pharmacy Students
Drug addiction to psychoactive substances, widely consumed in France, represents a major public health issue. The three main motivations identified for the consumption of psychostimulants would be self-medication, the party…
- Trial name
- PSYCHO'ACT (NCT05115981)
- Where
- France
- Volunteers
- 1,930 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Tooth Whitening, Tooth Discoloration
Clinical Research Study to Evaluate Stain Removal and Whitening Improvement
The objective of this clinical research study is to evaluate the stain removal and whitening improvement of a toothpaste containing Vitamin C and 1100 ppm F as sodium fluoride as compared to a matching placebo toothpaste…
- Trial name
- NCT07870018
- Testing
- Vitamin C toothpaste
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
HIV-1-infection, Pneumocystis Pneumonia
Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria
Cotrimoxazole preventive therapy (CPT) is recommended for prevention of morbidity and mortality due to Pneumocystis pneumonia and other infections in HIV positive patients with low immunity.
- Conditions
- HIV-1-infection, Pneumocystis Pneumonia, Opportunistic Infections, Preventive Therapy
- Trial name
- CoTrimResist (NCT03087890)
- Testing
- Cotrimoxazole
- Where
- 6 sites in Tanzania
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Opioids; Harmful Use
Piloting a Naloxone Intervention in Philadelphia
The escalating opioid overdose epidemic is one of the most serious public health problems confronting the U.S. Death due to drug overdose is a significant and rising cause of mortality and morbidity in Philadelphia.
- Trial name
- NCT03305497
- Testing
- Mobile Phone Application
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Drexel University
Fatty Acids, Alpha-Linolenic Acid
The ALA, DHA and EPA Esters in the Prevention of Cardiovascular Diseases.
Essential polyunsaturated fatty acids (EFAs) have a significant impact on human health, even before birth. Their supplementation is recommended at all ages, especially in people with cardiolovascular risks.
- Conditions
- Fatty Acids, Alpha-Linolenic Acid, Docosahexaenoic Acids, Eicosapentaenoic Acid
- Trial name
- OMEGA (NCT04743050)
- Testing
- Fatty Acids, Unsaturated, Diagnostic Tests
- Where
- 3 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Atopic Dermatitis
A Non-Drug Study Detecting And Quantifying Nocturnal Scratch Behaviors From Wrist Actigraphy Data In Adult Healthy Volunteers And Participants With Atopic Dermatitis (AD)
Sleep disturbance is very common in patients with atopic dermatitis (AD) and is a major factor leading to impaired quality of life. Nocturnal scratching is one of the factors causing sleep disturbance in AD patients.
- Trial name
- NCT04262791
- Testing
- Wrist Actigraphy Device, Sleep Headband
- Where
- 3 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AbbVie
Contraceptive Usage
A Prospective Observational Study of the Performance of Zarin in Kenya
This will be a non-comparative prospective observational study of women using Zarin as a primary method of contraception in Kenya.
- Trial name
- NCT01334190
- Where
- Kenya
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- FHI 360
Nicotine Withdrawal, Nicotine Addiction
Acute Pharmacokinetic and Pharmacodynamic Effects of "Tobacco-Free" Oral Nicotine Pouches in Smokers
The purpose of the present study is to examine the pharmacokinetics and pharmacodynamics of "tobacco-free" oral nicotine pouches, at various doses and flavors, in healthy adult smokers.
- Conditions
- Nicotine Withdrawal, Nicotine Addiction, Drug Effect
- Trial name
- NCT05335915
- Testing
- Nicotine, Cigarette
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
LGBTQ, Racial Disparities
Family Acceptance Project Online (Pilot RCT)
Research shows that sexual and gender minority youth (SGMY) experience high rates of mental health problems and other challenges (e.g., social, academic).
- Conditions
- LGBTQ, Racial Disparities, Family Relationships, Minority Stress
- Trial name
- FAP-O (NCT06839859)
- Testing
- Family Acceptance Project - Online
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Schizophrenia, Dual Diagnosis
Cannabis and Schizophrenia: Self-Medication and Agonist Treatment
The first aim of this study is to determine whether a brain reward center (BRC) deficiency in patients with schizophrenia (SCZ) and cannabis use disorder (CUD) will be normalized when patients are given cannabis or dronabinol.
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00946348
- Testing
- Dronabinol, Cannabis
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Substance Use Disorder (SUD)
A Study of a Mobile Phone Application Measuring the Eyes Before and After Medication
This is a post-market clinical follow-up study on an approved CE-marked eHealth system where a mobile phone application is used to measure the pupils and eye measurements to monitor the use of different drug substances.
- Trial name
- NCT06629740
- Testing
- Measurements with a eHealth system
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Kontigo Care AB
Arthritis, Diabetes Mellitus
Use of Complementary and Alternative Medicine Among Older Mexican Americans
The purpose of this study is to examine complementary and alternative medicine use among older Mexican Americans and to determine how this use influences physical, functional, and mental health.
- Conditions
- Arthritis, Diabetes Mellitus, Fractures, Hypertension
- Trial name
- NCT00084110
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Mental Health Conditions, Allergic
Impact of Help-Seeking Behaviors on Allergic Rhinitis and Mental Health: A Longitudinal Study
This study explores how help-seeking behaviors for both emotional well-being and allergies impact the management of allergic rhinitis, asthma, and mental health symptoms, including anxiety and depression.
- Trial name
- NCT06623799
- Where
- United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- QHSLab, Inc.
Cocaine Use Disorder
Cocaine and Zolmitriptan
Cocaine potently inhibits the reuptake of serotonin (5-HT). Increased synaptic 5-HT resulting from this reuptake inhibition activates multiple 5-HT receptor subtypes.
- Trial name
- NCT05019430
- Testing
- Cocaine, Zolmitriptan
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- William Stoops
Psoriasis
Study of a New Dressing for Use With Topical Medications
The purpose of this study is to determine if a new dressing designed to be used with topical medications will enhance the effects of these topical medications.
- Trial name
- NCT00234728
- Testing
- Occlusive dressing
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Teikoku Pharma USA, Inc.