Clinical trials: Drug Use Disorders
Substance Use (Drugs, Alcohol), Substance Use Risk
Options for Navigating Talking About Risk and Adolescent Choices
This study will examine the effectiveness of ON-TRAC (Options for Navigating Talking about Risk and Adolescent Choices), which is an online substance use prevention program that also teaches emotion regulation skills.
- Conditions
- Substance Use (Drugs, Alcohol), Substance Use Risk, Substance Use, Emotion Regulation
- Trial name
- ON-TRAC (NCT06754527)
- Testing
- ON-TRAC
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Dementia, Potentially Inappropriate Medication Use
e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most
The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational…
- Conditions
- Dementia, Potentially Inappropriate Medication Use, Mild Cognitive Impairment (MCI)
- Trial name
- e-ALIGN (NCT07454824)
- Testing
- e-ALIGN Patient-Portal Deprescribing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cardiac Arrest, Cardiopulmonary Arrest
Use of a Feedback Device to Limit Too Shallow Compressions Associated With the Use of an I-gel® Device
Airway management in out-of-hospital cardiac arrest is still debated. Several options exist: bag-valve-mask ventilation, supraglottic devices and endotracheal intubation.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Resuscitation, Emergency Medicine
- Trial name
- NCT05709613
- Testing
- Use of a chest compressions' feedback device
- Where
- 4 sites in Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Geneve TEAM Ambulances
Contraceptive Usage, HIV Infections
Effect of Dolutegravir on Etonogestrel Levels in HIV-infected Women in Botswana
The primary aim is to assess if etonogestrel (ENG) implant users taking dolutegravir (DTG) have a 20% or greater change in their ENG plasma levels, compared to women taking no antiretroviral therapy (ART).
- Conditions
- Contraceptive Usage, HIV Infections, Drug Interaction
- Trial name
- NCT03336346
- Testing
- dolutegravir, ENG implant, Efavirenz
- Where
- Botswana
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Columbia University
Unhealthy Alcohol Use, Alcohol Use Disorder
Relational Agent for Alcohol Screening and Treatment
This project will involve the development and initial evaluation of a promising computer-based intervention to improve the primary care management of risky alcohol use among Veterans.
- Conditions
- Unhealthy Alcohol Use, Alcohol Use Disorder, Alcohol Disorders
- Trial name
- RAAST (NCT02030288)
- Testing
- Relational Agent Intervention
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Alzheimer Disease
Use of a Cannabinoids as a Treatment Strategy for Alzheimer's Disease
Brief Summary: The objective of the study is to evaluate the effect of cannabinoids on Alzheimer's Disease. This is a double-blind, randomized, placebo-controlled clinical trial.
- Trial name
- DAZACANN (NCT06570928)
- Testing
- Cannabis
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Federal University of Latin American Integration
Cocaine Use Disorders
Lorcaserin Intra Venous Cocaine Effects
This is a randomized, cross-over, single-blind, placebo-controlled, single-center, multiple-panel evaluation of the potential for oral lorcaserin to modify cocaine self-administration in a laboratory setting.
- Trial name
- LIVE (NCT02680288)
- Testing
- Lorcaserin, 10 mg, Lorcaserin, 20 mg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Drug Use, HCV Infection
A Community-based Intervention Among Active Drug Users in Montpellier
The study aims to assess the effectiveness of a community-based model of HCV mass screening associated with an immediate HCV treatment on the cascade of care among active drug users (DUs) in the city of Montpellier, France.
- Trial name
- ICONE (NCT04008927)
- Testing
- HCV screening, Diagnosis of hepatitis C, HCV treatment
- Where
- France
- Volunteers
- 554 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Opioid Use Disorder, Substance Use Disorders
Minds and Mentors Program- R33
The proposed research effort will: The purpose of this study is as follows: 1. Test the effectiveness of the Minds and Mentors Program in a group treatment trial in which individuals using medications for opioid use disorder…
- Conditions
- Opioid Use Disorder, Substance Use Disorders, Medication Assisted Treatment
- Trial name
- MiMP (NCT05363371)
- Testing
- Minds and Mentors, Twelve Step Intervention Group
- Where
- 4 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Anxiety, Chronic Pain
Controlled Substance Treatment Agreements in an Internal Medicine Residents' Clinic
The purpose of this study is to characterize and improve controlled substance, carisoprodol and tramadol use in an internal medicine residents' clinic.
- Conditions
- Anxiety, Chronic Pain, Opioid Use, Unspecified
- Trial name
- NCT02244099
- Testing
- Controlled Substance
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Smoking Cessation, Genetic Predisposition
Efficacy of the Use of Genetic Markers in the Choice of the Pharmacological Treatment of Smoking (GENTSMOKING)
Smoking is the leading cause of avoidable death in the world. Smoking is associated with the development of cardiovascular and respiratory diseases, as well as being considered a leading cause of cancer death.
- Trial name
- GENTSMOKING (NCT03362099)
- Testing
- Varenicline Tartrate or bupropion
- Where
- Brazil
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Alcohol Related Disorders, Alcohol Drug Interactions
Healthy Living as You Age
Older persons who drink can be vulnerable to negative consequences of drinking. This trial aims to prevent harm from alcohol use in older adults through a program of screening and brief advice followed up with several health…
- Trial name
- HLAYA (NCT00379093)
- Testing
- Brief advice
- Where
- United States
- Volunteers
- 631 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Adherence, Medication, Risk Reduction
Prevention and Risk: Treatment With a New Emphasis on Relationships
This research examines the efficacy of an individually-delivered intervention tailored for YMSM in relationships. The intervention - termed PARTNER - utilizes a brief (4 session) motivational interviewing format to target…
- Conditions
- Adherence, Medication, Risk Reduction, Drug Use, Sex, Anal
- Trial name
- PARTNER (NCT03396367)
- Testing
- PARTNER, Education Intervention
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Acne Vulgaris
Drug Utilization Study on Diane-35 (and Generics) in Three European Healthcare Databases
The study objectives are to characterize new users of Cyproterone Acetate / Ethinylestradiol (CPA/EE) in 2011/2012 and in 2014 according to demographics, treatment characteristics, previous diagnosis of acne, hirsutism or other…
- Trial name
- NCT02349399
- Testing
- Cyproterone / Ethinylestradiol (Diane-35, BAY86-5264) and its Generics
- Where
- 3 sites in Italy, Netherlands and 1 more
- Volunteers
- 26,065 people, healthy volunteers welcome
- Sponsor
- Bayer
the Study Focus on the Uses of Telephone and Other New Technology in Medicine, Diagnosis and Treatment
Pros and Cons of Telemedicine in Diagnosis and Management
Telemedicine "healing at a distance" Telemedicine has many advantages especially in time of pandemics for both doctors and patients, low cost and easily accessibility.
- Trial name
- NCT04752553
- Where
- Egypt
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Heba A Yassa
Periodontitis, Surgery
Metronidazole vs Azithromycin in Periodontal Surgery for Patients Positive to Porphyromonas Gingivalis
The objective of this study is to determine whether, in patients with non treated periodontitis (stage III and IV) positive to Porphyromonas gingivalis, the use of systemic antimicrobials (metronidazole versus azithromycin) as an…
- Trial name
- NCT03862456
- Testing
- Azithromycin, Metronidazole
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Opioid-use Disorder
Tailoring a Mindful Intervention to Enhance Opioid Treatment
The main aim of this study is to better understand whether yoga can be blended with mindfulness as an additional intervention for people receiving medication assisted treatment at a Hartford-based community agency.
- Trial name
- BEING (NCT04879238)
- Testing
- BEING
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Non-Prescription Drug Misuse, Antibiotic Use
Intervention on Non-prescription Antibiotic Use Among the Public
The purpose of this study is to test the effectiveness of health education int led by community health workers for non-prescription antibiotic use among the public.
- Trial name
- NCT06317415
- Testing
- WeChat-based health education on antibiotic use, Regular public health education
- Where
- China
- Volunteers
- 1,550 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Delinquency, HIV Risk
The ProGirls Study
Girls in the juvenile justice system who have high rates of delinquency, drug abuse, and trauma are particularly at risk for engaging in risky sexual behavior and for contracting HIV/AIDS or other sexually transmitted infections…
- Conditions
- Delinquency, HIV Risk, Substance Use, Trauma Exposure
- Trial name
- NCT02112201
- Testing
- Integrated intervention for parents and adolescent girls
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Drug Abuse, Genotoxicity
Effect of Folic Acid on the Presentation of Nuclear Abnormalities in People With a History Drug Abuse
Background: Multiple studies have pointed to the harmful potential of licit and illicit drugs. as agents associated with neoplastic processes and other non-communicable diseases, for which reason It has become a problem of global…
- Trial name
- NCT05712044
- Testing
- Folic Acid 5 MG
- Where
- Mexico
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centro Universitario de Tonalá