Clinical trials: Drug Use Disorders
Substance Use
Rapid Adaptation to Prevent Drug Use
Using a 2-group, mixed method cluster randomized trial design, this study will compare standard implementation versus RAPD implementation strategy in Michigan Middle Schools
- Trial name
- RAPD (NCT05806840)
- Testing
- Rapid Adaptation to Prevent Drug Use (RAPD), Standard Implementation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Obstetric Anesthesia Problems, Placenta Accreta
Fibrinogen Concentrate and Placenta Acreta Spectrum
The aim of this study is to evaluate the relationship between fibrinogen use and bleeding in patients who underwent cesarean section with a prediagnosis of PAS.
- Trial name
- NCT05938062
- Testing
- the group without fibrinogen concentrate (GNF) , the group with fibrinogen concentrate (GF)
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Alcohol Consumption, Drug Abuse
Brief Youth Substance Use Intervention for Primary Care
Over the past decade, many new programs intended to prevent substance use among adolescents have been developed and evaluated. There has been a recent shift towards brief interventions for youth in school (Brown, 2001; D'Amico…
- Trial name
- NCT00292240
- Testing
- Brief motivational substance use intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- RAND
Bipolar Disorder, Pregnancy
Antimanic Drug Use in Pregnancy
The purpose of this study is to learn about the effects of bipolar disorder or the use of antimanic medications on the mother's health and wellbeing during pregnancy and for the first postpartum year.
- Trial name
- AMUP (NCT00585702)
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alcohol Abuse, Drug Use
The Weaving Healthy Families Program
Alcohol and other drug (AOD) abuse and violence in families are co-occurring risk factors that drive health disparities and mortality among Native Americans (NA), making the long-term goal of this research is to promote health…
- Conditions
- Alcohol Abuse, Drug Use, Violence, Domestic, Child Abuse
- Trial name
- NCT03924167
- Testing
- Weaving Healthy Families Program
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tulane University
Dermatologic Disorders
Use of Alternative Medicine Among Outpatients in Dermatology and Primary Care Clinics
This study is to assess the practice of complementary and alternative medicine (CAM) for skin related conditions among patients in the Primary Care and Dermatology clinics.
- Trial name
- NCT01660139
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Opioid Overdose, Opioid Use Disorder
Safety, Tolerability, and Pharmacokinetics of CSX-1004
This is a Phase 1a, randomized, double-blind, single ascending dose study, designed to assess the safety, tolerability, and PK of a single CSX-1004 injection, administered by IV infusion across a range of doses in healthy adult…
- Trial name
- NCT06005402
- Testing
- CSX-1004
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cessation Therapeutics, Inc.
Substance Use (Drugs, Alcohol), Tobacco Use
The ICEC Cluster Trial: Integrated Community Engagement Collaborative for Youth Substance Use Prevention in Rural America
This study will evaluate whether the Integrated Community Engagement (ICE) Collaborative can help prevent alcohol, tobacco, and other drug use among youth living in rural communities.
- Conditions
- Substance Use (Drugs, Alcohol), Tobacco Use, Adolescent Substance Use
- Trial name
- NCT07843576
- Testing
- Integrated Community Engagement Collaborative, School-Based Data Collection and Reporting without Network Coordinator Support
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Marijuana Use
Project Chill: Tailored Youth Drug Intervention In Primary Care
This study examines the impact of tailored computer-delivered and therapist-delivered brief motivations prevention/interventions both for adolescents who have not initiated marijuana use (prevention), and those who use marijuana…
- Trial name
- NCT01329315
- Testing
- BMI-T, BMI-C
- Volunteers
- 1,141 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diarrhea
Impact of Bismuth Subsalicylate on Antimicrobial Use Among Adult Diarrhea Outpatients--Pakistan
The purpose of this study is to learn whether bismuth subsalicylate can reduce use of antibiotics among adults with diarrhea in Pakistan.
- Trial name
- NCT02047162
- Testing
- Bismuth subsalicylate
- Where
- Pakistan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Alcohol Use Disorder, Depression
The Network Study: Soldiers Connecting for Work and Health
This study will examine the efficacy of an internet-based brief intervention designed to reduce risky behavior in Soldiers as they transition from Active Duty into the civilian workforce as a Veteran.
- Trial name
- NCT04463225
- Testing
- Internet-Delivered Brief Intervention
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Cornell University
Scrub Typhus
Clinical Effectiveness of Tigecycline for Scrub Typhus.
This multicenter, randomized, open-label clinical trial evaluated the efficacy and tolerability of intravenous tigecycline compared with oral doxycycline in adults hospitalized with scrub typhus.
- Trial name
- NCT07513103
- Testing
- doxycycline, Tigecycline (Tygacil)
- Where
- 3 sites in South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Jin Soo Lee
HIV Infections, Sexually Transmitted Diseases
Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention
The purpose of this study is to compare the effectiveness of two mobile health technologies (text messaging or a mobile app) designed to help people take HIV pre-exposure prophylaxis (PrEP) as directed by the clinic.
- Trial name
- PCORI PrEP (NCT04855773)
- Testing
- PrEPmate, Dot Diary
- Where
- 4 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Human Immunodeficiency Virus, Substance Use
Harm Reduction in HIV Primary Care for PLWH Who Use Drugs
People living with HIV (PLWH) who use drugs experience significant health disparities including lower rates of retention in HIV care and higher rates of unsuppressed viral load, resulting in secondary infections and increased…
- Conditions
- Human Immunodeficiency Virus, Substance Use, Stigma, Social
- Trial name
- NCT05404750
- Testing
- Harm Reduction
- Where
- 3 sites in United States
- Volunteers
- 641 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Substance Abuse
Preventing Drug Abuse Among Sexual Minority Youth
The planned randomized clinical trial will longitudinally test a tailored, web-based drug abuse prevention program with a nationwide sample of 15- to 17-year-old sexual minority youth (youth who identify as gay, lesbian…
- Trial name
- NCT03954535
- Testing
- Free2b
- Where
- United States
- Volunteers
- 1,216 people, healthy volunteers welcome
- Sponsor
- Columbia University
Depression, Anxiety
Latent Structure of Multi-level Assessments and Predictors of Outcomes in Psychiatric Disorders
In this study the investigators will seek to improve our understanding of how positive and negative valence systems, cognition, and arousal/interoception are inter-related in disorders of mood, substance use, and eating behavior.
- Conditions
- Depression, Anxiety, Eating Disorders, Drug Use Disorders
- Trial name
- NCT02450240
- Testing
- standardized diagnostic assessment, self-report questionnaires, behavioral tasks
- Where
- United States
- Volunteers
- 1,271 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Methamphetamine Use Disorder, Drug Interaction
Mirtazapine and Methamphetamine Drug-drug Interaction Study
This is a drug-drug interaction (DDI) study of mirtazapine for methamphetamine (MA) use disorder (MUD) to ensure the safety of this medication in the presence of a relevant dose of MA for people actively-using MA.
- Conditions
- Methamphetamine Use Disorder, Drug Interaction, Cardiovascular Abnormalities
- Trial name
- NCT04614584
- Testing
- Mirtazapine, Methamphetamine
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- San Francisco Department of Public Health
Substance Use
Unidos Against ATOD Use Intervention Trial
Adolescent alcohol tobacco and drug (ATOD) use is a major public health concern, with rates for Latino middle school youth higher than other ethnic groups.
- Trial name
- TWC (NCT03642106)
- Testing
- Unidos Se Puede
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Irritable Bowel Syndrome, Microbial Colonization
Panaceo "MED" for IBS (Irritable Bowel Syndrome)
Zeolite clinoptilolite is a volcanic mineral from the group of zeolites. The porous structure is associated with a large inner surface. Due to the anionic framework charge, ions (e.g., Pb^2+) can be absorbed or exchanged.
- Conditions
- Irritable Bowel Syndrome, Microbial Colonization, Intestinal Disease
- Trial name
- PCeo-17 (NCT03817645)
- Testing
- Zeolite
- Where
- Austria
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Scigenia GmbH
Asthma
Observational Study Regarding Adherence, Drug Use, Will to Take Part in Shared Decisioning in Asthma Outpatients
In a private practice setting typical for ambulatory medicine in Germany, asthma staging according to the GINA guidelines will be correlated with "real life" treatment and self management of adult outpatients suffering from…
- Trial name
- NCT00557141
- Where
- 2 sites in Germany
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Heidelberg Metasystems GmbH