Clinical trials: Drug Use Disorders
HIV, AIDS
Project RETAIN: Providing Integrated Care for HIV-Infected Crack Cocaine Users
This study will evaluate the efficacy of an integrated "Retention Clinic" in achieving virologic suppression among HIV-infected cocaine (including crack) users by using a two-group randomized, prospective trial.
- Conditions
- HIV, AIDS, Substance Abuse
- Trial name
- NCT01614106
- Testing
- Retention Clinic
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hirsutism, Androgenetic Alopecia
DUS on the Prescribing Indications for CPA/EE in 5 European Countries
This study was designed to compile the reasons and specific indications for the prescription of Cyproterone Acetate combined with Ethinyl Estradiol by Health Care Providers.
- Conditions
- Hirsutism, Androgenetic Alopecia, Severe Anemia, Seborrhea
- Trial name
- NCT02494297
- Where
- Germany
- Volunteers
- 1,597 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Opioids; Harmful Use
Piloting a Naloxone Intervention in Philadelphia
The escalating opioid overdose epidemic is one of the most serious public health problems confronting the U.S. Death due to drug overdose is a significant and rising cause of mortality and morbidity in Philadelphia.
- Trial name
- NCT03305497
- Testing
- Mobile Phone Application
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Drexel University
Drug Abuse, Nicotine Dependence
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
Background: Functional and structural magnetic resonance imaging (MRI) techniques have allowed researchers to map and study how the brain works when at rest and when engaged in specific tasks.
- Trial name
- NCT01036581
- Testing
- MagPro X100 Magnetic Stimulator, Transcranial Rotating Magnetic Stimulator, Magnetom Prisma Fit 3T Scanner
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use
Unplugged, a Drug Use Prevention Program: Adaptation and Evaluation of Effectiveness Among Students in Chile
Substance use and drug related disorders are important public health problems. Alcohol and illicit drug use account for 5.4% of the total burden of disease and the peak has been found in early adulthood (between ages 20 and 30…
- Trial name
- YSLQQ (NCT04236999)
- Testing
- Yo Sé Lo Que Quiero (YSLQQ)
- Where
- Chile
- Volunteers
- 8,880 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Nicotine Dependence
GABA (Gamma Amino Butyric Acid) Medication for Tobacco
The goal of this study is to examine the effects of a GABA (gamma amino butyric acid)-enhancing medication, pregabalin (300 mg/day), on smoking behavior, tobacco withdrawal and cigarette craving in smokers.
- Trial name
- NCT00644137
- Testing
- pregabalin, cigarettes
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yale University
Smoking Cessation, Genetic Predisposition
Efficacy of the Use of Genetic Markers in the Choice of the Pharmacological Treatment of Smoking (GENTSMOKING)
Smoking is the leading cause of avoidable death in the world. Smoking is associated with the development of cardiovascular and respiratory diseases, as well as being considered a leading cause of cancer death.
- Trial name
- GENTSMOKING (NCT03362099)
- Testing
- Varenicline Tartrate or bupropion
- Where
- Brazil
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Tachycardia, Hypertension
To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU.
The goal of this clinical trial is to to observe the haemodynamic parameters including Heart Rate Blood pressure Respiratory rate and Oxygen Saturation with or without giving reversal agent on extubation in patients receiving…
- Conditions
- Tachycardia, Hypertension, Hypoxia, Hyperventilation
- Trial name
- NCT07097441
- Testing
- neostigmine (reversal agent)
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ziauddin University
Cirrhosis, Sepsis
Cohort Study of Chronic Liver Disease Complicated by Sepsis
Study population: Patients with liver cirrhosis complicated by sepsis Observation indicators: Fluid resuscitation strategy, early dynamic indicators such as MAP Observation endpoint: 28-day all-cause mortality Study design…
- Trial name
- NCT07465003
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Alcohol Use Disorder
Developing a Novel Human Laboratory Paradigm for AUD Medication Screening
The intent of the study is to develop two versions of the 'ability to resist' drinking model designed to screen Alcohol Use Disorder (AUD) medications.
- Trial name
- NCT06489782
- Testing
- Model 1, Model 2
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yale University
Behavior Therapy, Cocaine
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1
Although LAAM, a derivative of methadone, has been successfully used as an alternative to methadone maintenance in opioid addicts, its effect on concurrent opioid and cocaine abuse has not been ascertained.
- Conditions
- Behavior Therapy, Cocaine, Contingency Management, Heroin Dependence
- Trial name
- NCT00158288
- Testing
- LAAM
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Human Immunodeficiency Virus, Opioid Use Disorder
Combined Injectable Treatment for HIV and OUD
This is study seeks to evaluate perspectives of a combined injectable treatment for HIV and OUD. Specifically, with the development of new long-acting medications such as cabotegravir co-administered with rilpivirine (CAB/RPV)…
- Trial name
- CHOICE (NCT05991622)
- Testing
- Combined LAI Treatment: Cabenuva and Sublocade
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Substance Abuse Disorder
Machine Learning Technology in Predicting Relapse and Implementing Peer Recovery Intervention Before Drug Use Occurs
The goal of this clinical trial is to study the relationship between substance cravings, cognitive performance, behaviors, and physiological markers in individuals with substance use disorder, as well as the effects of peer…
- Trial name
- NCT05976672
- Testing
- PRSS (Peer Recovery Support Specialist)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Opioid Abuse (Disorder)
Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes
This project tests a training strategy to help rural jails start or increase their use of medications to treat opioid use disorder (MOUD - methadone, buprenorphine, naltrexone).
- Trial name
- J-ECHO OPS (NCT07637994)
- Testing
- Project ECHO
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Tobacco Use Disorder, Opioid-use Disorder
A Trial of Directly Observed and Long-term Varenicline
This 2 x 2 factorial, randomized, double-blind, placebo-controlled trial will test two interventions: directly observed medication therapy, and long-term therapy with varenicline among smokers with opioid use disorder recruited…
- Trial name
- NCT03365362
- Testing
- Long-Term Varenicline, Short-Term Varenicline, Directly Observed Therapy
- Where
- United States
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
A Brief Negotiation Interview Chatbot to Improve Buprenorphine Engagement Among Justice-Involved Individuals
Primary Objective: Conduct pilot study to assess effects of brief negotiation interview (BNI) Chatbot among individuals involved in the Connecticut criminal justice system with opioid use disorder (OUD).
- Conditions
- Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe, Criminal Behavior
- Trial name
- BNICHAT (NCT04982627)
- Testing
- BNI Chatbot, OUD Education & Treatment Resources
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Center for Progressive Recovery, LLC
Covid19, Personal Protective Equipment
Rational Use of Personal Protective Equipment During COVID-19 Pandemic
This study aims to improve the personal protective equipment (PPE) used while treating patients with COVID-19, to protect staff and avoid cross-infection of patients.
- Trial name
- RUPERT (NCT04712045)
- Testing
- New PPE, Old PPE
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Eye Tracking, Gambling Disorder
RCT for Gambling and Naltrexone, Using Use Eye-tracking Analysis to Predict Treatment Response
The primary objective of this study is to determine whether favorable response to naltrexone orally taken in treatment of GD can be predicted by patterns of visual scanning, assessed by eye-tracking technology before, at the…
- Conditions
- Eye Tracking, Gambling Disorder, Naltrexone
- Trial name
- NCT04738773
- Testing
- Naltrexone
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Alcohol and Other Drug Use Disorders
Texas Family Health Patterns: A Study Across Generations
The researchers are studying factors that may increase the risk for alcohol and drug use in individuals who do not have any problems with these substances.
- Trial name
- NCT02438254
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Performance Enhancing Product Use, Change, Body Weight
Effects of Acute Glycerol Ingestion on Performance, Metabolic and Biochemical Markers in International Athletes
This clinical study evaluates the acute effect of glycerol ingestion on performance (power output), weight, urine specific gravity, biochemical (antioxidants and lactate) and metabolic (indirect calorimetry) markers in…
- Conditions
- Performance Enhancing Product Use, Change, Body Weight, Change, Body Temperature, Antioxidative Stress
- Trial name
- NCT05295836
- Testing
- GLYCEROL
- Where
- Spain
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera