Clinical trials: Drug Users
Opiate Abuse, Opiate Overdose
FAVOR Opioid Recovery Coaching Evaluation
The Emergency Department (ED) is an ideal location to identify patients in need of treatment for opioid addiction. A local non-profit community-based addiction recovery program, Faces and Voices of Recovery (FAVOR) utilizes a…
- Conditions
- Opiate Abuse, Opiate Overdose, Opioid-use Disorder
- Trial name
- FORCE (NCT03798470)
- Testing
- Peer Addiction Counseling
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Prisma Health-Upstate
Nitrous Oxide, Drug Abuse
Nitrous Oxyde Misuse Among Teenagers Consulting in an Addictology Center Dedicated to Young Drug Users in Montpellier
Nitrous oxide gas is used in several application areas : medical as an anesthetic drug ; in food industry as a foaming and a mixing agent ; industrial to speed combustion.
- Trial name
- NC (NCT04301024)
- Testing
- assessing the nitrous oxide misuse
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Drug Overdose, Metformin
Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning
This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both…
- Conditions
- Drug Overdose, Metformin, Dapagliflozin, Lactic Acidosis
- Trial name
- NCT07193069
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Tobacco Use Disorder, Oral Nicotine Pouch Use
Switching to Potential Reduced Exposure Products in Adult Smokers
This study aims to assess the feasibility, acceptability, and the potential harm reduction of switching to potentially lower risk, oral nicotine pouches in adult smokers.
- Conditions
- Tobacco Use Disorder, Oral Nicotine Pouch Use, Smoking Behaviors, Harm Reduction
- Trial name
- ZYN (NCT04250727)
- Testing
- ZYN
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Drug Dependence
CB1R in Synthetic Psychoactive Cannabinoids
The purpose of this research study is to determine whether the CB1R availability is lower in synthetic psychoactive cannabinoid subjects using the most widely available synthetic psychoactive cannabinoids at the time the study is…
- Trial name
- CB1R in Spice (NCT03539575)
- Testing
- [11-C]OMAR
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Yale University
Hepatitis B Infection, Hepatitis C Infection
An Hepatitis B Vaccine Model for HIV Vaccine Trials in Drug Users
The goal of the proposed study is to use the HBV vaccine as a model for a future HIV vaccine trial, examining the efficacy of community-based outreach intervention as well as an accelerated vaccine schedule as a method for…
- Conditions
- Hepatitis B Infection, Hepatitis C Infection, HIV Infection
- Trial name
- NCT00841477
- Testing
- hepatitis B vaccine 3 dose schedule (0,1,2 month), HBV Vaccination Self-Efficacy Intervention
- Where
- United States
- Volunteers
- 1,260 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Hepatitis C, Liver Diseases
Improving Hepatitis C Treatment in Injection Drug Users
The overall goal of the research project is to improve the outcome of medical care for injection drug users (IDUs) with Hepatitis C viral (HCV) infection.
- Conditions
- Hepatitis C, Liver Diseases, Drug Abuse, Alcoholism
- Trial name
- NCT00148031
- Testing
- Pegylated Interferon and Ribavirin, Psychosocial, On-site (MMT Clinic) HCV evaluation and treatment
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- State University of New York - Upstate Medical University
Drug Overdose
Bioavailability of Nasal Naloxone and Injected Naloxone Compared
Opioid overdoses have in the last decade counted for about 230 untimely deaths annually in Norway. The government is currently implementing a strategy for combating this epidemic.
- Trial name
- OPI-15-002 (NCT02598856)
- Testing
- Intranasal (IN) naloxone 1x, Intranasal (IN) naloxone 2, Intravenous (IV) naloxone
- Where
- Norway
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Suicide, Firearm Injury
Home Safety Intervention
Access to lethal methods of self-harm such as firearms and medications increases risk for suicide. As such, VA/DoD guidelines for the care of individuals with elevated suicide risk include recommendations that clinicians deliver…
- Conditions
- Suicide, Firearm Injury, Overdose
- Trial name
- HSI (NCT06216327)
- Testing
- household safety intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Depression, Dual Diagnosis
A Randomized Double-Blind Controlled Trial of Creatine in Female Methamphetamine Users
Methamphetamine (MA) addiction is a public health concern that causes substantial harm to individual users, and imposes an economic burden in the U.S. totaling up to $48.3 billion annually.
- Conditions
- Depression, Dual Diagnosis, Drug Addiction
- Trial name
- NCT02192931
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Perry Renshaw
Substance-related Disorders
Brief Intervention for Prescription Drug Misuse in General Hospital
In a randomized controlled trial, patients recruited in a general hospital and fulfilling criteria for regular consumption (more than 60 days within the last three months), dependence or abuse of prescription drugs will be…
- Trial name
- MIMIK (NCT00514839)
- Testing
- Motivational Interviewing
- Volunteers
- 126 people
- Sponsor
- University of Luebeck
Substance Use Disorder, Drug Dependence,
Impact of Prevention Awareness Group (PAG) on Treatment Attendance and Drug Abstinence Among Substance User
Substance Use Disorder has been showing a rising trend all over the world including India. The project tested whether a Integrated community wide effort of Prevention and Awareness Groups (PAG) to manage substance use would have…
- Conditions
- Substance Use Disorder, Drug Dependence,, Alcohol Dependence
- Trial name
- NCT02173041
- Testing
- Prevention Awareness Groups (PAG), Standard Care
- Where
- India
- Volunteers
- 152 people
- Sponsor
- Macmillan Research Group UK
Opioid Use Disorder (OUD)
HEALing Communities Study
This study will test the impact of implementing the Communities That Helping to End Addiction Long-term (HEAL) intervention on opioid overdose deaths within 67 highly affected communities with the goal of reducing opioid overdose…
- Trial name
- NCT04111939
- Testing
- Communities That HEAL, Wait-list control
- Where
- 4 sites in United States
- Volunteers
- 67 people
- Sponsor
- RTI International
Drug Dependency
Clinician-patient Interaction During Addiction Consultation
Accurately predicting the risk factors of patients' suffering a drug overdose plays a crucial role in effective prevention of drug overdose.
- Trial name
- CLiPID (NCT01769651)
- Testing
- methadone replacement therapy
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of St Andrews
Anxiety
Anxiety Sensitivity Treatment for Heroin Users
Anxiety Sensitivity Treatment for Heroin Users is a development project targeting mild and above levels of anxiety sensitivity that will involve the testing of a specialized protocol for improving treatment retention and outcomes…
- Trial name
- ASTH-HR (NCT01196312)
- Testing
- Anxiety sensitivity therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, College Park
Microbicide Delivery System Perceptibility and Acceptability
Developing Rectal USPE Measures
The purpose of this study is to: (a) adapt existing vaginal USPE items/instruments for evaluation of similar elements of rectal compartment use; (b) develop these scales using 3 distinct semi-solid formulations that represent a…
- Trial name
- Project DRUM (NCT02102867)
- Testing
- Gel, Cream, Liquid
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Opioid Use, Pain, Musculoskeletal
Naloxone Education in Total Joint Patients
This study examines the efficacy of a brief pre-hospital naloxone education module added to the standard "Total Joint Class" curriculum on patient safety and experience.
- Conditions
- Opioid Use, Pain, Musculoskeletal, Surgery, Overdose of Opiate
- Trial name
- NCT04868552
- Testing
- Pre-hospital naloxone education
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Carilion Clinic
Adult Patients Drug Users, Substituted / Weaned or Not
Non-vaccination Factors Against Hepatitis B Virus in Drug Users
Hepatitis B is one of the major public health problems in the world. According to World Health Organization (WHO) data, about 2 billion people have been in contact with the hepatitis B virus (HBV), and 257 million have chronic…
- Trial name
- ANOVAC B (NCT03817697)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 137 people
- Sponsor
- Hospices Civils de Lyon
Abuse Potential
An Abuse Potential Study of Orally Administered HORIZANT in Healthy, Non-dependent, Recreational Drug Users
The purpose of this study is to assess the abuse potential of gabapentin enacarbil in healthy adult, non-dependent, recreational drug users.
- Trial name
- NCT06097676
- Testing
- Alprazolam 2 mg, Gabapentin Enacarbil Immediate Release (GE-IR) 200 mg, Gabapentin Enacarbil Immediate Release (GE-IR) 450 mg
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Arbor Pharmaceuticals, Inc.
Depression, Substance Use
Behavioral Depression Treatment for African American HIV-infected Substance Users
The objective of the current study is to test a novel, behavioral approach to treat depressive symptoms and improve HIV medication adherence and subsequent physical health outcomes among African American HIV-infected substance…
- Trial name
- NCT01351454
- Testing
- ACT HEALTHY, Nondirective Therapy (NDT)
- Where
- 2 sites in United States
- Volunteers
- 61 people
- Sponsor
- University of North Carolina, Chapel Hill