Clinical trials: Drug Utilization Review
Epilepsy With Uncontrolled Focal-onset Seizures
REACH: RWE Retrospective Study to Evaluate Cenobamate Impact on Health Care Resource Utilization
The Study is an observational, retrospective study which aim is to assess cenobamate's healthcare resources utilization (HCRU) in the management of uncontrolled focal onset seizures.
- Trial name
- NCT06922175
- Where
- 10 sites in Germany, Netherlands and 3 more
- Volunteers
- 200 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Deprescribing, Antidepressant
General Practitioner & Pharmacist Support for Discontinuing Long-term Antidepressants in Clinically Stable Patients
In Belgium, many adults who have suffered from depression keep using antidepressants on a daily basis for years afterwards, sometimes longer than guidelines recommend.
- Conditions
- Deprescribing, Antidepressant, Depression Disorder, Discontinuation
- Trial name
- GPS-AD (NCT07398053)
- Testing
- GPS-AD intervention
- Volunteers
- 324 people
- Sponsor
- University Ghent
Severe Mental Illness, Substance Use Disorder (SUD)
A Study to Investigate Health Related Quality of Life With a Pharmacist Intervention Compared to Treatment as Usual in Participants With Severe Mental Illness and Substance Use Disorder Receiving Treatment From FACT Teams.
The study aims to evaluate the impact of integrating a clinical pharmacist into Flexible Assertive Community (FACT) teams on health-related quality of life and pharmacotherapy for individuals with severe mental illness and…
- Trial name
- pharmaFACT (NCT07597863)
- Testing
- Clinical Pharmacist Intervention
- Where
- Norway
- Volunteers
- 160 people
- Sponsor
- Sykehuset Innlandet HF
Disabilities, Intellectual, Disability, Developmental
Appropriate Medication Use for Individuals With Intellectual Disabilities - A Matter of Life
The innovation idea is to develop valuable new knowledge about safe drug use in people with intellectual and/or developmental disabilities (IDDs).
- Trial name
- NCT06160102
- Testing
- Develop and implement the Framework for safe drug use in people with intellectual and/or developmental disabilities
- Where
- Norway
- Volunteers
- 110 people
- Sponsor
- Vestvagoy Municipality
Opioid Use, Opioid-Related Disorders
Comparing State Payer Strategies to Prevent Unsafe Opioid Prescribing
This study examines the comparative effectiveness of opioid review programs in reducing unsafe opioid prescribing in two states: prospective prior authorization (PA) with hard stops in Washington and retrospective review (RR)…
- Trial name
- NCT03932799
- Testing
- Prospective prior authorization (PA) with hard stops in Washington, Retrospective review (RR) with prescriber notification in Ohio
- Where
- 2 sites in United States
- Volunteers
- 5,411 people
- Sponsor
- University of Washington
Pregnancy Prevention
Continuous Use of COCs
The primary objective is to determine if continuous COC use leads to higher continuation rates over 12 months of follow up than use of the standard 28-day COC regimen.
- Trial name
- NCT00570440
- Testing
- Oral contraceptives--ethinyl estradiol, levonorgestrel
- Where
- 2 sites in Dominican Republic, Nicaragua
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- FHI 360
Medication Adherence, Patient Compliance
Individual Education on Rational Drug Use in Primary Healthcare for Patients on Long-Term Medication
Irrational medication use is a common problem in Turkiye and worldwide. Educational interventions are essential to promote rational drug use.
- Conditions
- Medication Adherence, Patient Compliance, Drug Utilization Review
- Trial name
- NCT06700642
- Testing
- Educational intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- Gülşah Onur
Medicines Use Review Service, Multiple Medication
Evaluation of Medicines Use Review in Slovenia
Medicines Use Review service (PUZ) has been officially introduced in Slovenian pharmacy practice in 2015 and has been offered to pharmacy customers by pharmacist, certified to provide the service.
- Conditions
- Medicines Use Review Service, Multiple Medication, Adherence, Medication
- Trial name
- SLOPUZ (NCT04417400)
- Testing
- medicines use review
- Where
- 14 sites in Slovenia
- Volunteers
- 169 people
- Sponsor
- Mitja Kos
Polypharmacy
Polymedication Check - a Randomised Controlled Trial
Since October 2010, Swiss community pharmacies can offer a 'Polymedication Check' (PMC) to patients on ≥4 prescribed drugs taken over ≥3 months.
- Trial name
- evalPMC (NCT01739816)
- Testing
- Medication review
- Where
- Switzerland
- Volunteers
- 450 people
- Sponsor
- Kurt Hersberger
3 or More Chronic Conditions for 6 Months or Longer, 5 or More Regular Drugs
Health Economic Evaluation Alongside the OPERAM Trial
The objective of the health economic evaluation is to perform a state-of-the-art economic analysis of the STRIP intervention, alongside the OPERAM Randomised Controlled Trial (RCT).
- Trial name
- NCT03108092
- Testing
- STRIP intervention, Control
- Where
- 4 sites in Belgium, Ireland and 2 more
- Volunteers
- 2,009 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Obsessive-Compulsive Disorder
Study of Memantine Augmentation in Severe Obsessive-Compulsive Disorder
Memantine is a glutamate receptor antagonist that has been reported to reduce Obsessive-Compulsive Disorder (OCD) symptoms in case studies of treatment-resistant individuals.
- Trial name
- NCT00869505
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Polypharmacy, Adverse Drug Reaction
Educational Intervention to Reduce Drug-related Hospitalizations in Elderly Primary Health Care Patients
The purpose of this study is to determine whether an educational intervention given towards health care providers working in primary health care centers can reduce inappropriate prescribing in the elderly patient and thus reduce…
- Trial name
- NCT01732302
- Testing
- Educational intervention
- Where
- Sweden
- Volunteers
- 69 people
- Sponsor
- Karolinska Institutet
Elderly
Effect of Systematic Medication Review in Elderly Patients Admitted to an Orthopedic Department
Elderly patients have a higher risk of experiencing adverse drug events due to an age related increase in morbidity and medication use.
- Trial name
- NCT00738816
- Testing
- Systematic medication review and advisory notes
- Where
- Denmark
- Volunteers
- 108 people
- Sponsor
- Aarhus University Hospital
Non-Small Cell Lung Cancer
Neutropenic Sepsis in Patients With Non-Small Cell Lung Cancer Treated With Single-Agent Docetaxel and Associated Resource Use in the UK
This is a multi-center retrospective observational research study collecting data for participants initiated on docetaxel for the treatment of relapsed non-small cell lung cancer (NSCLC) up to 6 years before start of data…
- Trial name
- NCT02658747
- Testing
- No intervention
- Where
- 7 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- Hoffmann-La Roche
3 or More Chronic Conditions for 6 Months or Longer, 5 or More Regular Drugs
OPtimising thERapy to Prevent Avoidable Hospital Admissions in the Multimorbid Older People
The objective of this Randomised Controlled Trial (RCT) is to evaluate whether the Systematic Tool to Reduce Inappropriate Prescribing (STRIP) including STRIP assistant (STRIPA) implemented by an appropriately qualified team will…
- Trial name
- OPERAM (NCT02986425)
- Testing
- STRIP intervention, Control
- Where
- 4 sites in Belgium, Ireland and 2 more
- Volunteers
- 2,009 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diagnostic Imaging
PMS Study Ultravist-IMAGE, IoproMide (UltrAvist) to Gain Further Information on Tolerability and Safety in X-ray Examination
The purpose of this study is to obtain data on the safety and efficacy of Ultravist application in usual daily use.The radiologist will administer the contrast medium to the patient as he/she would have done without the study.
- Trial name
- IMAGE (NCT00876083)
- Testing
- Ultravist (Iopromide, BAY86-4877)
- Where
- 21 sites in Bosnia and Herzegovina, China and 19 more
- Volunteers
- 44,920 people
- Sponsor
- Bayer
Depression, Anxiety, Adherence, Patient
Medication Review in Women With Depression and Anxiety
This study sought to assess the impact of the MMR service on identifying and resolving TRPs, improving adherence, depression and anxiety scores in females diagnosed with depression and anxiety in Jordan
- Trial name
- NCT04082871
- Testing
- Medication management review
- Volunteers
- 73 people
- Sponsor
- Applied Science Private University
Polypharmacy, Deprescribing
Spread and Scale of a Polypharmacy App
Medication overload is an epidemic causing widespread harm, particularly to older Canadians. While most prescriptions are intended to help people live longer and healthier lives, taking multiple medications can increase frailty…
- Conditions
- Polypharmacy, Deprescribing, Adverse Drug Event
- Trial name
- NCT04762303
- Testing
- MedReviewRx
- Where
- 5 sites in Canada
- Volunteers
- 1,000 people
- Sponsor
- Centre for Innovation and Research in Aging, Canada
Drug Resistance, Bacterial
Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailand
The main goal of this retrospective observational study is to understand how stepping down antibiotic treatment (called antibiotic de-escalation) affects patients who receive it compared to those who don't after received a…
- Conditions
- Drug Resistance, Bacterial, Bacteremia
- Trial name
- NCT07082465
- Where
- 4 sites in Thailand
- Volunteers
- 108,000 people
- Sponsor
- University of Oxford
Aging
Studying the Impact of a Medication Use Evaluation by the Community Pharmacist
In this intervention study, 75 Belgian community pharmacies each recruit 12 patients for an intermediate medication review. For each patient, the identified drug-related problems and subsequent interventions are registered using…
- Trial name
- SIMENON (NCT03179722)
- Testing
- Medication review, Additional data collection: questionnaires
- Volunteers
- 453 people, healthy volunteers welcome
- Sponsor
- Joke Wuyts