Clinical trials: Drug Withdrawal
Hypnotic Withdrawal
The Impact of a Pharmacist Intervention on Post-discharge Hypnotic Drug Discontinuation in Geriatric Inpatients
This study investigated whether a multifaceted approach was associated with hypnotic drug discontinuation at one month after discharge
- Trial name
- NCT05521971
- Testing
- multifaceted pharmacist-led intervention, Usual care group
- Volunteers
- 173 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
HEADACHE
Efficacy Evaluation Of Great Occipital Nerve Electrical Stimulation On Rebound Headache
SENGO-CAM study is a sham-controlled simple blind trial which aim is to study the efficacy of great occipital nerve stimulation (GONS) associated with medication withdrawal in the treatment of medication overuse headache…
- Trial name
- NCT01184222
- Testing
- great occipital nerve stimulation
- Where
- 4 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Alcohol Withdrawal Syndrome
Assessment of Energetic Resonance by Cutaneous Stimulation on Withdrawal Alcohol Symptoms.
The purpose of RESC study is to assess the efficacy of Energetic Resonance by Cutaneous Stimulation on alcohol withdrawal symptoms measured by CUSHMAN score and in a second time to measure the benzodiazepine amount prescribed…
- Trial name
- RESC (NCT02146716)
- Testing
- Energetic Resonance by Cutaneous Stimulation
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Hospices Civils de Lyon
Alcohol Withdrawal Syndrome
Preventing Alcohol Withdrawal Syndrome With Oral Baclofen
Adult medical/surgical inpatient hospital care is more difficult and more expensive when complicated by alcohol dependency (AD), especially for patients who develop alcohol withdrawal syndrome (AWS).
- Trial name
- NCT02052440
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Denver Health and Hospital Authority
Osteoarthritis of the Knee
A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthritis Pain of the Knee
To evaluate the safety and efficacy of ABT-652 in combination with a Non-steroidal Anti-inflammatory Drug (NSAID) compared to NSAID alone in adults with osteoarthritis (OA) of the knee.
- Trial name
- NCT01444365
- Testing
- ABT-652 NSAID
- Where
- 31 sites in United States
- Volunteers
- 202 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Heroin Dependence, Morphine Dependence
Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1
The purpose of this study is to assess buprenorphine/naloxone versus clonidine for outpatient opiate detoxification.
- Conditions
- Heroin Dependence, Morphine Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00032968
- Testing
- Buprenorphine/naloxone
- Where
- 7 sites in United States
- Volunteers
- 341 people
- Sponsor
- University of California, Los Angeles
Neuralgia, Postherpetic, Diabetic Neuropathy
Neuropathic Pain Syndrome Patient Study (MK-0000-072)
The purpose of this study is to determine the best way to conduct clinical trials in patients with neuropathic pain (nerve pain). This study will see if generic pregabalin has any effect on neuropathic pain.
- Conditions
- Neuralgia, Postherpetic, Diabetic Neuropathy, Painful Small-Fiber Neuropathy, Idiopathic Distal Sensory Polyneuropathy
- Trial name
- NCT00570310
- Testing
- Comparator: pregabalin
- Volunteers
- 104 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic HBV Infection, Drug Withdrawal
Effects of T-bet B Cells in Persistent Virus Control After Discontinuance of NAs in CHB Patients
The immune mechanism of the nucleos(t)ide analogs (NAs) in inhibiting HBV replication effectively while having a low sustained virus control rate after drug withdrawal is unclear.
- Trial name
- NCT06029634
- Testing
- T-bet B cell
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Graves Disease, Relapse
Effects of Different Treatment Schemes on the Regulation and Recurrence of Graves' Disease
In this study, the dose of methimazole was adjusted according to the different states of thyroid function, and the effects of conventional therapy and intensive therapy on the cumulative recurrence of Graves' hyperthyroidism…
- Conditions
- Graves Disease, Relapse, Treatment, Drug Withdrawal
- Trial name
- NCT05461820
- Testing
- Methimazole
- Where
- China
- Volunteers
- 240 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Opiate Use Disorder, Opiate Withdrawal Syndrome
An App to Aid in Transitioning Off Opioid Medication
The investigators propose to develop a smartphone app (called BetterOFF) that will help patients manage opioid withdrawal during opioid medication taper and detoxification.
- Trial name
- BetterOFF (NCT03077932)
- Testing
- App Development and Open Pilot
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Butler Hospital
Topiramate, Lamotrigine
Antiglutamate Anticonvulsants in the Treatment of Alcohol Withdrawal Syndrome
The study is aimed to evaluate the efficacy of antiglutamate anticonvulsants (topiramate, lamotrigine, and memantine) in the treatment of alcohol withdrawal syndrome
- Conditions
- Topiramate, Lamotrigine, Memnatine, Diazepam
- Trial name
- NCT00241995
- Testing
- Anticonvulsants
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Petersburg State Pavlov Medical University
Opiate Dependence
Naloxone Methadone Combination (NAMEKO)
The aim of the study is to examine the tolerability and abuse potential of the diluted methadone solution (5 mg/ml → 2 mg/ml) in combination with naloxone in opioid substitution treatment.
- Trial name
- NAMEKO (NCT01160432)
- Testing
- Methadone, naloxone
- Where
- Finland
- Sponsor
- Kuopio University Hospital
Immune Tolerance
Delayed Blood Stem Transplantation in HLA Matched Kidney Transplant Recipients to Eliminate Immunosuppressive Drugs.
The study will determine whether patients with functioning Human Leukocyte Antigen (HLA) matched kidney transplants for at least one year and who want to discontinue immunosuppressive drugs can be treated with Total Lymphoid…
- Trial name
- NCT03591302
- Testing
- Hematopoietic cell transplantation, Total Lymphoid irradiation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stephan Busque
Alcohol Withdrawal Delirium
Treating Alcohol Withdrawal With Oral Baclofen
The purpose of this study is determine if subjects with alcohol withdrawal who receive oral baclofen, plus standard benzodiazepine therapy, will experience less severe withdrawal symptoms than those who receive placebo plus…
- Trial name
- NCT00597701
- Testing
- Baclofen, Lorazepam
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Essentia Health
Chronic Pain, Opiate Withdrawal Syndrome
Treatment of Withdrawal Symptoms With NADA Acupuncture in Chronic Pain Patients
This project aims at examining the following hypotheses: Treatment with NADA and clonidine reduces intensity of withdrawal symptoms to a greater extent than treatment with clonidine.
- Trial name
- NCT03397212
- Testing
- NADA acupuncture
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
HIV Infections
Interleukin-2 (IL-2) Treatment for HIV Infected Patients Who Have Interrupted Their Anti-HIV Drug Therapy
When an HIV infected person taking strong anti-HIV drugs temporarily stops taking them, viral load rises and the body's immune system is exposed to more HIV.
- Trial name
- NCT00038259
- Testing
- Aldesleukin
- Where
- 10 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Opioid Dependency
Re-Treatment Study of Probuphine in Opioid Addiction
Probuphine (buprenorphine implant) is an investigational implant placed just below the skin containing buprenorphine (BPN). BPN is an approved treatment for opioid dependence.
- Trial name
- NCT01262261
- Testing
- Probuphine (buprenorphine implant)
- Where
- 18 sites in United States
- Volunteers
- 85 people
- Sponsor
- Titan Pharmaceuticals
Chronic Myeloid Leukemia, Chronic Phase, Withdrawal;Drug
Efficacy and Safety of TKIs' Withdrawal After a Two-step Dose Reduction in Patients with Chronic Myeloid Leukemia
Evaluation of the efficacy and safety of withdrawal of tyrosine kinase inhibitors after previous two-step dose reduction in patients with chronic myeloid leukemia in deep molecular remission
- Trial name
- HALF (NCT04147533)
- Testing
- Imatinib withdrawal, Dasatinib, Nilotinib
- Where
- 8 sites in Czechia
- Volunteers
- 150 people
- Sponsor
- Masaryk University
Substance Withdrawal Syndrome, Nicotine Dependence
Electronic Cigarettes in Daily Dependent Smokers
The aim of this study is to measure nicotine cue- and withdrawal-induced craving in current smokers under four distinct conditions: after smoking a conventional cigarette, an electronic cigarette (e-Cigarette) containing…
- Trial name
- NCT02108626
- Testing
- Nicotine
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Centre for Addiction and Mental Health
Withdrawal Syndrome, Iatrogenic Disease
AduLt iatrogEnic withdRawal sTudy in the ICU (ALERT-ICU)
Withdrawal from opioids and sedatives administered for medical purposes (i.e. iatrogenic withdrawal) often goes unrecognized in the critically ill, but its prevalence is high.
- Trial name
- NCT04422808
- Where
- United States
- Volunteers
- 2,437 people
- Sponsor
- Wilkes University