Clinical trials: Drugs of Abuse
Healthy Non-dependent, Recreational Sedative Users
Abuse Potential of Oral Gabapentin in Healthy, Non-Drug-Dependent Individuals With Recreational Sedative Drug Use Experience
The purpose of the present study is to assess prospectively the abuse potential of gabapentin compared to placebo and alprazolam in healthy non-drug-dependent recreational sedative drug users under fasted condition.
- Trial name
- NCT07777965
- Testing
- Alprazolam (Xanax), Gabapentin (Neurontin® (Registered Trademark))
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Viatris Inc.
Drug Abuse, Genotoxicity
Effect of Folic Acid on the Presentation of Nuclear Abnormalities in People With a History Drug Abuse
Background: Multiple studies have pointed to the harmful potential of licit and illicit drugs. as agents associated with neoplastic processes and other non-communicable diseases, for which reason It has become a problem of global…
- Trial name
- NCT05712044
- Testing
- Folic Acid 5 MG
- Where
- Mexico
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centro Universitario de Tonalá
Abuse Potential
An Abuse Potential Study of Orally Administered HORIZANT in Healthy, Non-dependent, Recreational Drug Users
The purpose of this study is to assess the abuse potential of gabapentin enacarbil in healthy adult, non-dependent, recreational drug users.
- Trial name
- NCT06097676
- Testing
- Alprazolam 2 mg, Gabapentin Enacarbil Immediate Release (GE-IR) 200 mg, Gabapentin Enacarbil Immediate Release (GE-IR) 450 mg
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Arbor Pharmaceuticals, Inc.
Substance Use
Drug Abuse Prevention Among Girls Through a Mother-Daughter Intervention
The purpose of this study is to determine a computer- and family-based drug abuse prevention program is able to reduce drug use among early adolescent girls.
- Trial name
- NCT01236248
- Testing
- Prevention
- Where
- United States
- Volunteers
- 916 people, healthy volunteers welcome
- Sponsor
- Columbia University
Drug Abuse, Healthy
Abuse Potential of Single Doses of Lorcaserin in Healthy Recreational Polydrug Users
The purpose of this study is to evaluate the abuse potential of lorcaserin in healthy recreational polydrug users.
- Trial name
- NCT00828659
- Testing
- Active Comparator #1, Active Comparator #2, Active Comparator #3
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Prescription Drug Abuse (Not Dependent)
Influence of Medication on Functional Connectivity
This study will assess the effects of acute low-dose opioid administration on functional neuroimaging measures in healthy individuals
- Trial name
- NCT03612713
- Testing
- Oxycodone Medication First
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy, Drug Abuse
Determination the Abuse Potential of Pitolisant in Healthy, Non-Dependent Recreational Stimulant Users
The purpose of this study is to assess the abuse potential of single doses of pitolisant relative to phentermine HCl and placebo, when administered to healthy, non-dependent, recreational stimulant users.
- Trial name
- NCT03152123
- Testing
- Pitolisant, Phentermine
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Bioprojet
Pain, Chronic, Prescription Drug Abuse (Not Dependent)
Linking Epigenomics With Prescription Opioid Abuse and High Impact Musculoskeletal Pain
Genetic variability from epigenetic modification of genes related to pain physiology and opioid pharmacodynamics may influence susceptibility to high-impact chronic musculoskeletal pain, opioid efficacy, and vulnerability to…
- Trial name
- LEAP (NCT03947749)
- Where
- 2 sites in United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obesity, Adolescent, Healthy Nutrition
Wakaya: Rising Up for Choctaw Youth Health
Investigators will conduct a two-group randomized waitlist-control trial to assess the efficacy of the Wakaya: Rising Up for Choctaw Youth Health program on improving physical activity, reducing sedentary behaviors and improving…
- Conditions
- Obesity, Adolescent, Healthy Nutrition, Sedentary Behavior, Drug Abuse
- Trial name
- Wakaya (NCT05818384)
- Testing
- Wakaya: Rising Up for Choctaw Youth Curriculum
- Where
- 2 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cocaine Dependence
Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse
This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.
- Trial name
- NCT02080819
- Testing
- levodopa/carbidopa 400/100 BID
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cannabis, Drug Effects
The Pharmacokinetic and Pharmacodynamic Effects of Oral Cannabidiol (CBD) Under Acute and Chronic Exposure Conditions
This study will evaluate the pharmacokinetic and pharmacodynamic effects of oral Cannabidiol (with or without low levels of THC), under acute and chronic dosing conditions.
- Trial name
- NCT04283019
- Testing
- CBD, THC
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis, Drug Effect
The Pharmacokinetics and Pharmacodynamics of Hemp-based Topical Cannabinoid Products
This study will evaluate the pharmacokinetic and pharmacodynamic effects of hemp-based Cannabidiol (CBD) topical products (e.g., lotions, creams, patches) that contain low levels of delta-9-tetrahydrocannabinol (THC).
- Trial name
- NCT04741477
- Testing
- CBD, THC
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Use, Alcohol Abuse
Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use- Electronic Spanish Platform
The goal of this study is to validate the TAPS-ESP as a screen and assessment that can be used in primary care for the screening and treatment of substance use.
- Conditions
- Tobacco Use, Alcohol Abuse, Prescription Drug Abuse, Substance Use
- Trial name
- TAPS-ESP (NCT05476588)
- Testing
- Screening
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Medical Education
Online Primary Care Physician (PCP) Training in Screening, Brief Intervention, Referral, and Treatment
This project seeks to develop a comprehensive, computer-based education program for primary care physicians that will improve their skills in structured substance abuse screening, brief interventions, and referral and treatment…
- Trial name
- NCT01326936
- Testing
- Online education
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical Directions, Inc
Marijuana Abuse
Effects of Citicoline on Brain Function and Behavior in Marijuana-Dependent Individuals
The Three Aims of this study are (only studies for Aim 1 were completed) 1. Measure the impact of citicoline on marihuana use patterns in subjects' individualized natural settings and responses to marihuana challenge using…
- Trial name
- NCT00158249
- Testing
- citicoline
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alcohol-Related Disorders, Substance-Related Disorders
"Effectiveness of a Brief Intervention for Substances Consumption Linked to the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST): A Randomized Control Trial in Chilean Primary Care."
Alcohol and drugs consumption are among the highest risk factor for health in Chile and abroad. In Chile, harmful use of alcohol continues to be a major contributor to the burden of disease while lost years of healthy life are…
- Conditions
- Alcohol-Related Disorders, Substance-Related Disorders, Substance Abuse
- Trial name
- NCT01573416
- Testing
- ASSIST-linked brief intervention for hazardous and harmful substance use., Observation
- Where
- 30 sites in Chile
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Drug Abuse
Brief Intervention for Drug Abusing Adolescents
The purpose of this clinical trail is to evaluate the efficacy of a brief, cognitive-behavioral therapeutic intervention for adolescents reporting mild or moderate drug abuse (MMDA).
- Trial name
- NCT00350909
- Testing
- brief intervention (cognitive-behavioral therapy)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pain, Appetite Loss
AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)
This study will assess the analgesic, appetite-stimulating, and subjective effects of cannabigerol (CBG) alone and in combination with THC.
- Conditions
- Pain, Appetite Loss, Abuse, Drug
- Trial name
- ASCENT (NCT04859296)
- Testing
- Low CBG, High CBG, Low THC
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Stigma, Activity Space
Health Outcomes by Neighborhood - Baltimore
Background: Researchers have been studying patterns of mood and drug use in specific neighborhoods. This study will look at environmental factors that may affect drug use, addiction, and treatment seeking in Baltimore…
- Conditions
- Stigma, Activity Space, Social Networks, HIV Status
- Trial name
- NCT01571752
- Where
- United States
- Volunteers
- 1,651 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy Volunteers, Drug Users
A Study to Evaluate the Abuse Potential of EB-1020 Immediate-Release in Healthy Recreational Stimulant Users
This single-center study will be a single-dose, randomized, double-blind, placebo- and active-controlled crossover study with a single inpatient treatment visit.
- Trial name
- NCT02144415
- Testing
- EB-1020 400 mg, EB-1020 800 mg, lisdexamfetamine 150 mg
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.