Clinical trials: Dry Eye
Nonexudative Age-related Macular Degeneration
Safety Study of a Topical Treatment for Dry Age Related Macular Degeneration
Study to evaluate the safety and tolerability of MC-1101, a potential topical treatment for non-edxudative age Related Macular Degeneration (AMD) in medically stable individuals.
- Trial name
- NCT01922128
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- MacuCLEAR, Inc.
Dry Eye
Randomised Research Comparing Acupuncture, Herbal Treatment and Artificial Tear Eye Drops in Dry Eye
Dry eye is a major, common medical condition with significant health and economic burden in Singapore and worldwide. It is a holistic problem affected by living habits, nutrition and underlying systemic disease, inducing a…
- Trial name
- NCT02219204
- Testing
- Acupuncture, Herbal treatment
- Where
- Singapore
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Sjögren's Syndrome
Modulation of Immunity-related Gene Expression Under the Chinese Herbal Formula SS-1 Treatment for Sjögren's Syndrome
To evaluate the modulation of immunity-related gene expression for the Sjögren's syndrome under Chinese herbal medicine (SS-1) treatment.
- Trial name
- NCT02855658
- Testing
- SS-1
- Where
- 2 sites in Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Dry Eye Syndromes
Comparison Of Blue Light Filter Feature and Blue Blocking Lenses in Digital Device Users With Dry Eye Patients
Comparing Blue Light Filter feature and Blue Blocking Lenses for Dry Eye Patients Prolonged screen time can exacerbate dry eye symptoms.
- Trial name
- NCT06913504
- Testing
- Blue cut filter, blue cut glasses
- Where
- Pakistan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Superior University
Dry Eye, Ametropia
Osmoprotective Containing Lubricants in Dysfunctional Tear Syndrome and Post Refractive Surgery Patients
The purpose of this project is to determine the effectiveness of an eyewash osmoprotective lubricant comparing to castor oil containing and non-osmoprotective lubricants in different types of DTS and post refractive surgery…
- Trial name
- NCT01741987
- Testing
- Optive ®, Fresh Tears ®
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
MGD-Meibomian Gland Dysfunction, Positron-Emission Tomography
PET-CT Imaging Features of Meibomian Glands
Analysis the results of Dry eye analysis results and PET-CT imaging comprehensively
- Conditions
- MGD-Meibomian Gland Dysfunction, Positron-Emission Tomography, Dry Eye
- Trial name
- NCT06324890
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Dry Eye Syndromes
The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients
BAK is one of the most frequent preservatives in eye drops. BAK is a quaternary ammonium salt with surfactant qualities. It can be bacteriostatic or bactericidal depending on the concentrations used.
- Trial name
- NCT01280110
- Testing
- Hydroxypropylmethylcellulose, Carboxymethylcellulose
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Dry Eye Disease
Comparison of Mucin Levels at the Ocular Surface of Visual Display Users With and Without Dry Eye Disease
The study aimed to evaluate 1) if levels of the glycocalyx membrane mucins, including MUC1, MUC4, MUC16 and MUC20, are altered in conjunctival cells of visual display users With and Without Dry Eye Disease, and 2) if mucin levels…
- Trial name
- NCT05604651
- Testing
- no intervention
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Dry Eye
Safety and Efficacy of Optive in Contact Lens Wearers With Dry Eyes
The purpose of this study is to determine if Optive®eye drops are safe for people who wear contact lenses and have dry eyes. The second goal of the study is to determine if using Optive®eye drops can improve my dry eye scores on…
- Trial name
- NCT00469573
- Testing
- 1. Optive
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Dry Eye Syndrome
Evaluation of Factors Affecting the Tear-film Lipid Layer Thickness
In this study, the investigators aim to determine the effects of age, sex, history of ocular surgery and contact lens use, and ocular surface and meibomian gland parameters on the lipid layer thickness (LLT) in normal subjects…
- Trial name
- NCT02645045
- Where
- South Korea
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hemodialysis, Ocular Surface Disease
Evaluation of Ocular Surface in Hemodialysis Patients by Ocular Surface Analyzer
We clinically observed that some hemodialysis patients had corneal epithelial dryness, shedding, edema, and persistent epithelial nonunion after ocular surgery, which seriously affected the effect of surgery, and it is necessary…
- Conditions
- Hemodialysis, Ocular Surface Disease, Dry Eye, OSDI
- Trial name
- NCT04949295
- Testing
- ocular surface analyzer
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- XiaoYong Liu
Dry Eye
A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye
Hyaluronic acid, a natural polymer, helps to maintain ocular surface hydration and can already be found in several artificial tears recommended to alleviate symptoms of dry eye.
- Trial name
- NCT02951910
- Testing
- Ophylosa tear supplement
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Meibomian Gland Dysfunction, Evaporative Dry Eye
Dextenza With ILUX for Treatment of MGD
To evaluate the benefit of treatment with a physician administered intracanalicular dexamethasone insert in evaporative dry eye disease (DED) patients with meibomian gland disfunction (MGD) and underlying inflammation undergoing…
- Trial name
- NCT04658927
- Testing
- Dexamethasone, 0.4mg, Prednisone acetate, Control
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Warrenville Eyecare
Dry AMD, Geographic Atrophy
Validation of Virtual Reality Tests for the Assessment of Patients With Age-related Macular Degeneration as Clinical Endpoints
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized countries and affects tens of millions of people worldwide, with a rapidly increasing prevalence.
- Conditions
- Dry AMD, Geographic Atrophy, Healhty
- Trial name
- VIRETTA (NCT07433088)
- Testing
- Object recognition and selection task
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Streetlab
Healthy, Dry Eyes
Topical Menthol For Tear Secretion
Tears are the natural way to keep eyes moist, and tears are important for good vision and healthy eyes. Eyes without enought tears get dry and sore.
- Trial name
- TMTS (NCT07109609)
- Testing
- Topical application of 20% menthol solution in MCT oil.
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Reinhold Vieth
Keratoconjunctivitis Sicca
TearLab Core Validation Study to Establish Referent Values for Dry Eye Disease
This is a prospective, observational case series to determine the clinical utility of tear osmolarity and other commonly used objective tests to diagnose dry eye disease, as well as to establish referent values for objective…
- Trial name
- CVS (NCT00848198)
- Where
- 10 sites in United States, France and 3 more
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- TearLab Corporation
Dry Eye Syndrome
Oral Nutrition Impact on Tear Film
Dry eye disease (DED) is a common but often inadequately treated disease of the tears and surface of the eye. It can cause poor vision and chronic pain and is more frequent with increasing age.
- Trial name
- ONIT (NCT01561040)
- Testing
- Omega 3, Vitamins A, D3 and E
- Where
- 4 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Eye and Vision Technologies and Research Institute
Dry Eye
Tear Osmolarity Over Time With Artificial Tears
The effect of artificial tears on tear osmolarity
- Trial name
- NCT01227226
- Testing
- Artificial tears
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hom, Milton M., OD, FAAO
Dry Eye Disease
Ocular Microbiome and Immune System in Dry Eyes
The primary objectives of this study are the characterization of the ocular microbiome as well as of the local immune system in participants with and without dry eye disease.
- Trial name
- NCT04658238
- Testing
- Ocular microbiome, Ocular immune system
- Where
- Switzerland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Healthy, Idiopathic Inflammatory Myopathies
A Phase 1 Open-label Study to Evaluate Safety in Healthy Participants and Participants With Autoimmune Diseases
The purpose of this study is to determine the safety and tolerability of XmAb657 in healthy participants and participants with autoimmune diseases.
- Conditions
- Healthy, Idiopathic Inflammatory Myopathies, Systemic Sclerosis, Sjögren's Disease
- Trial name
- NCT07284797
- Testing
- XmAb657
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xencor, Inc.