Clinical trials: Dry Eye
Dry Eye Syndromes
A Safety and Efficacy Study of Refresh Optive® Gel Drops in Patients With Dry Eye Disease
This study will evaluate the safety and efficacy o fRefresh Optive® Gel Drops in patients with dry eye disease.
- Trial name
- NCT02280473
- Testing
- Refresh Optive® Gel Drops, REFRESH LIQUIGEL®
- Where
- 10 sites in United States
- Volunteers
- 188 people
- Sponsor
- Allergan
Dry Eye Syndromes, Meibomian Gland Dysfunction
Mechanisms of Light-based Therapies for Dry Eye Disease
Dry eye disease is a common condition affecting millions worldwide and costing millions in healthcare due to reduced work productivity and quality of life.
- Trial name
- MOLT (NCT06004895)
- Testing
- Actual IPL, LLLT
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Aston University
Dry Eye
The Effects of Dietary Supplementation With Omega-3 Fatty Acids on Symptoms of Dry Eye
The aim of this study is to compare ocular symptoms and signs when the test nutraceutical formulation (combination of flaxseed oil, borage oil and fish oil omega-3 fatty acids) is consumed daily over a 3 month period, with a…
- Trial name
- NCT03141931
- Testing
- Supplement
- Where
- Australia
- Volunteers
- 119 people
- Sponsor
- The University of New South Wales
Xerostomia, Sjogren Syndrome
Green Tea Lozenges for the Management of Dry Mouth
The goal of this proposal is to investigate the effectiveness of a Medical College of Georgia patent pending formulation of natural plant extracts on patients with xerostomia.
- Conditions
- Xerostomia, Sjogren Syndrome, Dry Mouth
- Trial name
- NCT01647737
- Testing
- MighTeaFlow, Xylitol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Dry Eye
Clinical Evaluation of a Multidose Preservative-free Lubricating Eye Drops Contained in Novelia® Eye Dropper in Non-Contact Lens Wearing Patients
This is a 30-Day, multi-site, single-masked, bilateral, active- controlled, 2-Arm parallel group study to evaluate the safety and efficacy of an Investigational product.
- Trial name
- NCT05661851
- Testing
- Investigational Lubricating Eye Drop in a Novelia® bottle, Blink® Tears eye Drops
- Where
- 8 sites in United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Dry Eye Disease
A Phase 2b Study Evaluating the Safety and Efficacy of AR-15512 Ophthalmic Solution for the Treatment of Dry Eye Disease
This is a Phase 2b, multicenter, vehicle-controlled, double-masked, randomized study. All subjects enrolled will have dry eye disease.
- Trial name
- COMET-1 (NCT04498182)
- Testing
- AR-15512 Ophthalmic Solution, AR-15512 Ophthalmic Solution Vehicle
- Where
- 15 sites in United States
- Volunteers
- 369 people
- Sponsor
- Aerie Pharmaceuticals
Dry Eye Disease
Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease
Primary Objectives: To compare the efficacy of cenegermin vs vehicle in Schirmer I test (without anaesthesia) > 10 mm/5 min at Week 4 by testing the superiority.
- Trial name
- PROTEGO-2 (NCT05136170)
- Testing
- Cenegermin, Vehicle
- Where
- 10 sites in United States, Italy
- Volunteers
- 85 people
- Sponsor
- Dompé Farmaceutici S.p.A
Dry Eye Syndromes
Clinical Trial to Evaluate the Symptoms in Symptomatic Contact Lens Wearers Following Application of Intranasal Tear Neurostimulator Versus Control
This study will evaluate the increase in comfort and comfortable contact lens (CL) wear time associated with application of TrueTear (active intranasal neurostimulation) compared with application of TrueTear sham control…
- Trial name
- NCT03325673
- Testing
- TrueTear
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Allergan
Dry Eye, Meibomian Gland Dysfunction
TearCare System to Treat Dry Eye Disease
In this study, the TearCare System will be compared with the LipiFlow Thermal Pulsation System in patients with dry eye disease.
- Trial name
- OLYMPIA (NCT03857919)
- Testing
- TearCare, LipiFlow
- Where
- 10 sites in United States
- Volunteers
- 235 people
- Sponsor
- Sight Sciences, Inc.
Dry Eye Syndrome, Keratoconjunctivitis Sicca
A Study to Evaluate the Safety and Effectiveness of Oculeve Intranasal Lacrimal Neurostimulator in Participants With Dry Eye Syndrome
The purpose of this study is to compare acute tear production produced by the Oculeve Intranasal Lacrimal Neurostimulator with two control devices in participants with aqueous tear deficiency.
- Trial name
- NCT02680158
- Testing
- Oculeve Intranasal, Oculeve Extranasal
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Oculeve, Inc.
Dry Eye Syndrome
SYSTANE® Family - Meibomian Deficiency
The purpose of this study was to assess the efficacy of the SYSTANE® family of products (SYSTANE® Lid Wipes, SYSTANE® BALANCE Lubricant Eye Drops, and SYSTANE® Vitamins) on meibomian gland functionality in subjects with lipid…
- Trial name
- M-12-077 (NCT01733745)
- Testing
- SYSTANE® Lid Wipes, SYSTANE® BALANCE, SYSTANE® Vitamins
- Volunteers
- 26 people
- Sponsor
- Alcon Research
Dry Eye
Study to Evaluate a Contact Lens Lubricating and Rewetting Drop
The objective of this study is to evaluate the product performance of investigational lubricating and rewetting drops.
- Trial name
- NCT01267656
- Testing
- Lubricating and Rewetting Drops, AMO Blink Contacts Lubricant Eye Drops
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye
A Study to Evaluate the Performance and Safety of CBL-101 Versus Vismed® Multi Eye Drops in the Management of Dry Eye
The primary objectives of this investigation are to show that the performance of CBL-101 Eye Drops is non-inferior to that of Vismed® Multi eye drops in subjects with moderate to severe keratoconjunctivitis sicca after 28 days…
- Trial name
- NCT02975102
- Testing
- CBL-101 Eye Drops, Vismed® Multi Eye Drops
- Where
- 2 sites in Belgium, France
- Volunteers
- 87 people
- Sponsor
- Laboratoire Chauvin
Dry Eye, Contact Lens Complication
Effects of Supplementation With PUFAs and Antioxidants for Contact Lens Discomfort
HydroEye® is a dietary omega 3 fatty acid supplement that contains both EPA and DHA, as well as GLA and ALA in the form of black currant seed oil.
- Trial name
- NCT04163328
- Testing
- HydroEye®
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Alabama at Birmingham
Dry Eye
The TRANQUILITY 2 Trial: A Phase 3 Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease
The TRANQUILITY 2 Trial: Multi-Center Randomized, Double-Masked, Parallel Design, Vehicle-Controlled Phase 3 Clinical Trial to Assess the Efficacy and Safety of 0.25% Reproxalap Ophthalmic Solution Compared to Vehicle in Subjects…
- Trial name
- NCT05062330
- Testing
- Reproxalap Ophthalmic Solution (0.25%), Vehicle Ophthalmic Solution
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Sjögren's Syndrome, Sjogren's Syndrome
Safety, Tolerability, Pharmacokinetics, and Therapeutic Efficacy of SAR441344 in Primary Sjögren's Syndrome (pSjS)
Primary Objective: To evaluate the therapeutic efficacy of one dose level of SAR441344 versus placebo over 12 weeks in adult patients with primary Sjögren's syndrome (pSjS), assessed by the change of the European League Against…
- Trial name
- phaethuSA (NCT04572841)
- Testing
- SAR441344
- Where
- 36 sites in United States, Argentina and 10 more
- Volunteers
- 84 people
- Sponsor
- Sanofi
Dry Eye
Subjective and Objective Performance of Systane Complete Multi-Dose PF Versus Walgreen's Lubricant Balance
Single site, prospective, double-masked, randomized-controlled, two-arm study of the dry eye symptoms as well as corneal and conjunctival staining in subjects using 2 different eyedrops.
- Trial name
- NCT06219577
- Testing
- Systane Complete Multi-Dose PF, Walgreen's Lubricant Balance
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Scripps Poway Eyecare and Optometry
Dry Eye Syndromes
Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye
The objectives of this study are twofold To evaluate the safety and efficacy of 0.1% AGN-195263 administered twice daily compared to its vehicle in patients with evaporative dry eye (EDE) To evaluate the systemic pharmacokinetics…
- Trial name
- NCT02815293
- Testing
- AGN-195263, Vehicle
- Where
- 29 sites in United States
- Volunteers
- 36 people
- Sponsor
- Allergan
Primary Sjögren Syndrome
A Study Evaluating the Effects of GLPG3970 Given as an Oral Treatment for 12 Weeks in Adults With Active Primary Sjögren's Syndrome (pSS)
This is a first exploration of GLPG3970 in participants with active primary Sjogren's Syndrome (pSS) to evaluate the efficacy, safety and tolerability and to determine its pharmacokinetics (PK) profile compared to placebo.
- Trial name
- GLIDER (NCT04700280)
- Testing
- GLPG3970
- Where
- 10 sites in Germany, Greece and 3 more
- Volunteers
- 31 people
- Sponsor
- Lakefront Biotherapeutics NV
KERATOCONJUNCTIVITIS SICCA, XEROSTOMIA
Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome
This study was designed to test the efficacy and safety of low laser therapy to treat the xerostomia of patients with primary Sjogren's Syndrome.
- Conditions
- KERATOCONJUNCTIVITIS SICCA, XEROSTOMIA, SICCA SYNDROME, PRIMARY SJOGREN SYNDROME
- Trial name
- NCT02066896
- Testing
- Lasertherapy
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Federal University of São Paulo