Clinical trials: Dry Eye, completed
Dry Eye
Loteprednol Etabonate Opthalmic Suspension for the Treatment of Dry Eye
This was a single-center, randomized, double-masked, placebo-controlled, parallel-group, 4-visit, CAE (Controlled Adverse Environment) study lasting approximately 4 weeks.
- Trial name
- NCT00560638
- Testing
- loteprednol etabonate ophthalmic suspension, 0.5%, vehicle of loteprednol etabonate
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye
Safety and Efficacy Study of EGP-437 (Dexamethasone Phosphate Formulated for Ocular Iontophoresis) to Treat Dry Eye
The purpose of this study is to assess the safety and efficacy of EGP-437 (dexamethasone phosphate formulated for ocular iontophoresis) using the EyeGate® II Iontophoresis system in patients with dry eye.
- Trial name
- NCT01129856
- Testing
- Dexamethasone phosphate ophthalmic solution, Sodium citrate buffer solution
- Where
- 5 sites in United States
- Volunteers
- 198 people
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Dry Eye Syndromes
TearLab Refractive Surgery Dry Eye Study
The primary objective of this study is to determine how pre \& post-operative tear osmolarity levels relate to rates of dry eye symptoms related to refractive surgery and if differences exist in patients who are pre-treated with…
- Trial name
- NCT01176045
- Where
- 8 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- TearLab Corporation
Dry Eye, Meibomian Gland Dysfunction (Disorder)
Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery
This randomized, controlled clinical trial investigates the perioperative use of low-level light therapy (LLLT) to prevent or reduce signs and symptoms of dry eye disease (DED) in patients undergoing cataract surgery.
- Conditions
- Dry Eye, Meibomian Gland Dysfunction (Disorder), Ocular Surface Disease
- Trial name
- LLLT-Cataract (NCT07067294)
- Testing
- Low-Level Light Therapy
- Where
- Romania
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Contact Lens Complication, Dry Eye
Correlation Study of Corneal Nerve Changes and Dry Eye in Contact Lens Wearers
This study aims to analyze the changes of corneal nerve morphology and function in contact lens-related dry eye(CLADE) patients and further discuss the role of corneal nerve in the genesis and development of CLADE.
- Trial name
- NCT04663529
- Testing
- contact lens
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Neovascular Age-related Macular Degeneration (nAMD)
Study to Evaluate the Safety and Effectiveness of Intravitreal Injections (IVI) of Brolucizumab in Patients With Neovascular Age-related Macular Degeneration (nAMD)
The purpose of this study was to generate additional safety and effectiveness data in Indian neovascular age-related macular degeneration (nAMD) patients that more closely resemble the real-world population intended to be treated…
- Trial name
- NCT05269966
- Testing
- Injection Brolucizumab
- Where
- 10 sites in India
- Volunteers
- 105 people
- Sponsor
- Novartis Pharmaceuticals
GVHD, Ocular Rosacea
IPL and Meibomian Gland Expression to Treat Ocular Rosacea Ocular GVHD
The purpose of this study was to see if Intense Pulsed Light (IPL) can be used safely and effectively to help treat dry eyes from ocular rosacea after chronic graft-versus-host disease (GVHD).
- Conditions
- GVHD, Ocular Rosacea, Dry Eye Syndrome
- Trial name
- NCT02066051
- Testing
- IPL, Meibomian Gland Expression
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Dry Eye
The Effects of Dietary Supplementation With Omega-3 Fatty Acids on Symptoms of Dry Eye
The aim of this study is to compare ocular symptoms and signs when the test nutraceutical formulation (combination of flaxseed oil, borage oil and fish oil omega-3 fatty acids) is consumed daily over a 3 month period, with a…
- Trial name
- NCT03141931
- Testing
- Supplement
- Where
- Australia
- Volunteers
- 119 people
- Sponsor
- The University of New South Wales
Dry Eye Syndrome
Safety and Tolerability of Artificial Tears in Dry Eye Subjects
The safety and tolerability of two new artificial tears will be compared to a currently-available artificial tear in subjects with dry eye. Each subject will receive all three products in a randomly assigned order.
- Trial name
- NCT00932477
- Testing
- Formulation 1: Carboxymethylcellulose Sodium, Glycerin and Polysorbate 80, based artificial tear, Formulation 2: Carboxymethylcellulose Sodium, Glycerin and Polysorbate 80, based artificial tear, Glycerin and Polysorbate 80 based artificial tear
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Allergan
Dry Eye Disease
Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease
The objective of this study is to assess safety and efficacy of DE-089 ophthalmic solution in patients with dry eye disease in Taiwan.
- Trial name
- NCT03216096
- Where
- 2 sites in Taiwan
- Volunteers
- 20 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Dry Eye Syndromes
Study of Two Formulations of Cyclosporine Ophthalmic Emulsion in Healthy Volunteers and in Patients With Dry Eye
This study will evaluate the safety, tolerability and pharmacokinetics of two formulations of cyclosporine ophthalmic emulsion in healthy adults (parallel-group phase).
- Trial name
- NCT01319773
- Testing
- cyclosporine ophthalmic emulsion Formulation A, cyclosporine ophthalmic emulsion Formulation B, cyclosporine ophthalmic emulsion Formulation A; cyclosporine ophthalmic emulsion 0.05%
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Allergan
Dry Eye, Dry Eye Syndromes
Comparing Efficacy and Safety of TJO-083 in Dry Eye Diseases Patients
In patients with dry eye syndrome, the test drug(TJO-083) or the control drug is administered for 12 weeks, and the corneal staining of each group would be evaluated.
- Trial name
- NCT06427031
- Testing
- TJO-083, Diquafosol ophthalmic sodium solution 3%
- Where
- South Korea
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Taejoon Pharmaceutical Co., Ltd.
Dry Eye
Effect of Povidone-iodine 5% Vs 1% on the Ocular Surface in Intravitreal Injections of Anti-VEGF
Objective and subjective comparison between the use of povidone-iodine 1% vs 5% as antiseptic in patients that need anti-VEGF intravitreal injection
- Trial name
- anti-VEGF (NCT06710951)
- Testing
- Change of normal concentration of povidone-iodine 5% to 1%
- Where
- Mexico
- Volunteers
- 88 people
- Sponsor
- José Gerardo García Aguirre
Keratitis
Effect of IKERVIS® Eye Drops Once Daily on the Quality of Vision in Dry Eye Disease Patients With Severe Keratitis
The proposed 3-month study is a prospective, open-label, multicentre, phase IV, proof of concept study. The study is designed to assess the effect on the quality of vision of IKERVIS® (1mg/mL ciclosporin) eye drops administered…
- Trial name
- FAST (NCT03237936)
- Testing
- 1mg/mL ciclosporin
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Santen SAS
Dry Eye Syndrome
Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Dry Eye
Background: Dry eye disease (DED) is a common condition causing burden on visual function and reducing quality of life. Corticosteroids and/or cyclosporine eye drops are able to improve DED symptoms, however, side effects of…
- Trial name
- DEDCO (NCT03074344)
- Testing
- XLHA+CoQ10, Hyaluronic acid (HA)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Geographic Atrophy, Dry Age Related Macular Degeneration
Subtenon PRP Injection for Geographic Atrophy in Dry Age-Related Macular Degeneration
This study investigates the effects of subtenon autologous platelet-rich plasma (PRP) injections on retinal structure and visual function in patients with advanced dry age-related macular degeneration (AMD).
- Trial name
- GA-PRP (NCT07428798)
- Testing
- Subtenon Autologous Platelet-Rich Plasma Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Lacrimal Apparatus Disease, Salivary Gland Disease
DHEA Treatment for Sjogren's Syndrome
This study will evaluate the effectiveness of the male hormone dehydroepiandrosterone (DHEA) in treating Sjogren's syndrome. This autoimmune disorder, in which the immune system attacks the salivary glands and tear glands…
- Conditions
- Lacrimal Apparatus Disease, Salivary Gland Disease, Sjogren's Syndrome, Xerostomia
- Trial name
- NCT00001598
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dry Eye Syndrome
Evaluation of Factors Affecting the Tear-film Lipid Layer Thickness
In this study, the investigators aim to determine the effects of age, sex, history of ocular surgery and contact lens use, and ocular surface and meibomian gland parameters on the lipid layer thickness (LLT) in normal subjects…
- Trial name
- NCT02645045
- Where
- South Korea
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Dry Eye
Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye
The objective of this study is to compare the safety and efficacy of 1% MIM-D3 and 5% MIM-D3 to placebo for the treatment of the signs and symptoms of dry eye.
- Trial name
- NCT01257607
- Testing
- MIM-D3 Ophthalmic Solution
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mimetogen Pharmaceuticals USA, Inc.
Dry Eye Disease (DED)
SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease
This is a prospective, randomized, double-masked, multi-site clinical trial designed to compare the efficacy of SYSTANE® PRO (Alcon Laboratories, Inc.) to MIEBO™ (Bausch + Lomb) in treating symptoms of evaporative dry eye disease…
- Trial name
- NCT07243275
- Testing
- SYSTANE® PRO, MIEBO™ (Perfluorohexyloctane, PFHO)
- Where
- 4 sites in United States
- Volunteers
- 269 people
- Sponsor
- Indiana University
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