Clinical trials: Dry Eye, completed
Ocular Graft-versus-host Disease
Allogeneic Platelet Lysate Eye Drops for the Treatment of Severe Chronic Ocular Graft-versus-host Disease
The study evaluates the efficacy and safety of allogeneic platelet lysate eye drops in patients with severe ocular graft versus host disease refractory to conventional systemic and local treatments.
- Trial name
- NCT05311514
- Testing
- Allogeneic platelet lysate eye drops
- Where
- Russia
- Volunteers
- 38 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Dry Eye Syndromes
Pharmacokinetics, Safety, and Tolerability of rhEGF Eye Drops in Healthy Male Subjects
A randomized, double-blind, placebo-controlled, single ascending dose and multiple ascending dose study of the Pharmacokinetics, safety, and tolerability of rhEGF eye drops in healthy male subjects
- Trial name
- NCT05219461
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Daewoong Bio Inc.
Dry Eye Syndrome
Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-1
The objective of this study is to compare the safety and efficacy of RGN-259 Ophthalmic Solutions to placebo for the treatment of the signs and symptoms of dry eye.
- Trial name
- NCT02597803
- Testing
- RGN-259
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- ReGenTree, LLC
Dry Eye
A Clinical Evaluation of an Investigational Lubricant Eye Gel (FID 115958D)
The purpose of this study is to estimate the change in sodium fluorescein staining, as a sign of dry eye, during six weeks of treatment with FID 115958D or Refresh Liquigel.
- Trial name
- NCT01294956
- Testing
- Lubricant Eye Drop, Refresh Liquigel
- Volunteers
- 147 people
- Sponsor
- Alcon Research
Dry Eye
Acute Comfort and Blur of Systane and Optive
To evaluate drop comfort, acceptability, preference and blur profile between two marketed artificial tears in both dry eye and non-dry eye patient population.
- Trial name
- NCT00568386
- Testing
- Systane Lubricant Eye Drops, Optive Lubricant Eye Drops
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Neonatal Lupus, Systemic Lupus Erythematosus
The Research Registry for Neonatal Lupus
Women with lupus and other related disorders produce certain antibodies in the blood. Some women have these antibodies even if they have not yet developed symptoms of lupus or Sjogren's syndrome.
- Conditions
- Neonatal Lupus, Systemic Lupus Erythematosus, Sjogren's Syndrome, Congenital Heart Block
- Trial name
- NCT00074373
- Testing
- No intervention; observational
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Dry Eye Disease
Study Evaluating Techniques for Measuring Tear Production
This will be a vehicle-controlled, masked, randomized study conducted at a single site in the United States. All participants enrolled will have Dry Eye Disease (DED). The study will consist of 2 Visits.
- Trial name
- MTP (NCT05497479)
- Testing
- 0.003% AR-15512 to be administered in both eyes, Vehicle to be administered in both eyes
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Aerie Pharmaceuticals
Dry Eye Syndrome
Investigation on Medical Management of Dry Eye Patients
Dry eye is a common complaint in patients encountered by ophthalmologists, which may result from the inflammatory response and can occur in the absence of systemic disease.
- Trial name
- NCT01942226
- Where
- 2 sites in Taiwan
- Volunteers
- 466 people
- Sponsor
- National Cheng Kung University
Dry Eye Syndrome, Ocular Surface Disease
Influencing Factors on Dry Eye Syndrome and Ocular Surface Disease
Dry eye syndrome and ocular surface disease are very important ophthalmologic diseases. It is known that various inducers are involved.
- Trial name
- NCT03364322
- Testing
- Observation
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Dry Eye Syndrome
Study of SkQ1 as Treatment for Dry-eye Syndrome
The purpose of this study is to evaluate whether SkQ1 ophthalmic solutions are safe and effective compared to placebo for the treatment of the signs and symptoms of dry eye syndrome.
- Trial name
- VISTA-1 (NCT03764735)
- Testing
- Low Dose - SkQ1, High dose - SkQ1, SkQ1 (Vehicle)
- Where
- 7 sites in United States
- Volunteers
- 452 people
- Sponsor
- Mitotech, SA
Dry Eye
Acute Comfort of Lubricant Eye Drops FID 112903
To evaluate the acute comfort and blurring profile between two artificial tears in dry eye patients.
- Trial name
- NCT00673855
- Testing
- Lubricant Eye Drops FID 112903, Optive Lubricant Eye Drops
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Alcon Research
Dry Eye
Clinical Outcomes Following Treatment With Systane® Balance in Dry Eye Subjects
The purpose of this study is to demonstrate the superior efficacy of Systane® Balance over Preservative-Free 0.9% Saline following 35 days of QID (4 times a day) dosing in treating dry eye subjects with lipid deficiency.
- Trial name
- NCT01967147
- Testing
- Propylene Glycol, 0.6% eye drops, Preservative-free 0.9% Saline solution
- Volunteers
- 279 people
- Sponsor
- Alcon Research
Dry Eye
Validity of Web-Based OSDI-6 Questionnaire in a Chinese Adult Population
This study aimed to evaluate the validity of the Chinese translation version of OSDI-6 (C-OSDI-6) in a theoretical set-up of two questionnaire groups for dry eye
- Trial name
- NCT06158906
- Where
- China
- Volunteers
- 270 people
- Sponsor
- He Eye Hospital
Dry Eye Disease
Effect of Topical Naltrexone Ophthalmic Solution on the Signs and Symptoms of Dry Eye in Diabetic Subjects
The objective of this exploratory study is to determine the safety and efficacy of 0.002% Naltrexone Ophthalmic Solution, compared to placebo for the treatment of the signs and symptoms of dry eye in diabetic subjects.
- Trial name
- NCT03660475
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sassani, Joseph S., MD, MHA
Meibomian Gland Dysfunction, Dry Eye Syndromes
to Evaluate the Effectiveness and Safety of the Tixel® , VS LipiFlow® in the Treatment of Meibomian Gland Dysfunction
A Randomized, Masked (Evaluator), Controlled, Prospective Study Evaluating the Effectiveness and Safety of the Tixel® Medical Device, Versus LipiFlow® in the Treatment of Meibomian Gland Dysfunction
- Conditions
- Meibomian Gland Dysfunction, Dry Eye Syndromes, Dry Eye
- Trial name
- NCT05162261
- Testing
- Tixel C, LipiFlow
- Where
- 5 sites in United States
- Volunteers
- 109 people
- Sponsor
- Novoxel Ltd.
Sjögren's Syndrome
HRR as a Novel Biomarker in Sjögren's Syndrome
Sjögren's syndrome (SS) is an autoimmune disorder characterized by chronic salivary and lacrimal gland dysfunction leading to dry mouth (xerostomia) and dry eye (xerophthalmia) sensation (1).
- Trial name
- NCT05633524
- Testing
- blood sample analysis
- Where
- China
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Allergic Conjunctivitis
Evaluation of the Effect and Tolerance of Preservative Free NAAGA on the Inflammatory Component and Symptoms of Dry Eye Syndrome in Allergic Conjunctivitis Patients
Multicentre, Double blind, Randomized, Comparative Study(comparing N-acetyl-aspartyl-glutamic acid(NAAGA) in Abak preservative free device versus SALINE in Abak preservative free device.
- Trial name
- NCT01203540
- Testing
- NAABAK eyedrops, Saline eyedrops
- Where
- 2 sites in South Korea
- Volunteers
- 21 people
- Sponsor
- Laboratoires Thea
Contact Lens Related Dry Eye Syndrome
Efficacy Study of a New Eyedrop on Silicone Hydrogel Contact Lens Wearers With Dry Eye Complaints
The objectives of the investigation will be to assess the effect of the repeated usage of a new eye drop on the tear film characteristics of silicone hydrogel contact lens wearers with contact lens related comfort problems and to…
- Trial name
- NCT01543061
- Testing
- OPTIVEtm Plus, No treatment, Blink Contacts® Eye Drops
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Optometric Technology Group Ltd
Dry Eye
Electroacupuncture for Mild-to-moderate Dry Eye
To determine if electroacupuncture acts as an dry eye treatment rather than a placebo, and identify if benefits are linked to corneal subbasal nerve changes and neuroimmunomodulatory indicators.
- Trial name
- NCT05552820
- Testing
- Verum Electroacupuncture
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Dry Eye Disease
Evaluation of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease
The objective of this study is to evaluate the safety and effectiveness of OC-01 Nasal Spray as compared to placebo on signs and symptoms of dry eye disease
- Trial name
- NCT03636061
- Testing
- OC-01 (varenicline) nasal spray
- Where
- 3 sites in United States
- Volunteers
- 182 people
- Sponsor
- Oyster Point Pharma, Inc.
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