Clinical trials: Dry Eye, completed
Keratoconjunctivitis Sicca, Dry Eye Syndromes
Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye
To investigate and compare the burden of dry eye in Sjögren's syndrome dry eye vs non-Sjögren's syndrome dry eye, as well as investigate the diagnostic potential of tear film mucins and various inflammatory cytokines evaluated by…
- Conditions
- Keratoconjunctivitis Sicca, Dry Eye Syndromes, Ocular Surface Disease, Sjogren's Syndrome
- Trial name
- NCT04493658
- Testing
- Questionnaires, Tear fluid sampling, Impression Cytology
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dry Eye
A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye
Hyaluronic acid, a natural polymer, helps to maintain ocular surface hydration and can already be found in several artificial tears recommended to alleviate symptoms of dry eye.
- Trial name
- NCT02951910
- Testing
- Ophylosa tear supplement
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Dry Eye Symptoms
Dry Eye Under China's Dynamic COVID-zero Strategy
To compare the prevalence of dry eye symptoms and to investigate the association of the risk factors with the dry eye symptomatology among university students in the epidemic and non-epidemic areas of China under the COVID-zero…
- Trial name
- NCT05476068
- Where
- China
- Volunteers
- 1,807 people, healthy volunteers welcome
- Sponsor
- Yifeng Yu
Dry Eye Disease
Physician's Evaluation of Cyclosporine Ophthalmic Emulsion 0.05%
The objective of this retrospective chart review is to evaluate the patient characteristics, treatment variations and efficacy of a second trial of Cyclosporine Ophthalmic Emulsion 0.05% therapy in chronic dry eye patients who…
- Trial name
- NCT00827255
- Testing
- Cyclosporine Ophthalmic Emulsion 0.05%
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Allergan
Dry Eye Syndrome, Healthy
Effect of Olixia Pure® Eye Drops on Tear Film Thickness in Healthy Subjects
Dry eye syndrome (DES) is a common ocular disease, especially in the elderly population. Despite many treatment approaches, instillation of topical lubricants remains the mainstay of therapy.
- Trial name
- NCT01970917
- Testing
- Olixia pure eye drops
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dry Eye Disease
Influence of Perfluorohexyloctane (NovaTears) on Tear Film Thickness in Patients With Mild to Moderate Dry Eye Disease
Patients with mild to moderate dry eye disease will be randomized to receive either NovaTears® or Hydrabak® eye drops as control.
- Trial name
- NCT03048526
- Testing
- NovaTears®, Hydrabak®
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Novaliq GmbH
Dry Eye
Efficacy of Low-Level Light Therapy in Reducing Dry Eye in Patients Undergoing Cataract Surgery
The goal of this clinical trial is to evaluate the effectiveness of Low Level Light Therapy (LLLT) in reducing the incidence or alleviating the severity of DED due to meibomian gland dysfunction in otherwise healthy patients…
- Trial name
- NCT05754437
- Testing
- Low Level Light Therapy
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Azienda Ospedaliera Universitaria Mater Domini, Catanzaro
Dry Eye Syndrome
Effect of an Educational Program on Health-related Outcomes of Patients With Dry Eye Syndrome
Dry eye syndrome (DES) is a widespread ocular disease affecting the general population. It is a complex disorder affecting the surface of the eye, marked by an imbalance in the tear film and ocular symptoms.
- Trial name
- NCT06288945
- Testing
- Educational Program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Dry Eye Symptoms
Evaluation of the Effectiveness of Auricular Acupuncture in Improving Dry Eye Symptoms in University Students
Dry eye symptoms can cause various discomforts in the eyes and/or visual disturbances. This condition not only limits daily personal activities and reduces quality of life and mental health but also has negative economic impacts…
- Trial name
- NCT06876077
- Testing
- Auricular acupuncture, Artificial Tears (AT)
- Where
- Vietnam
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Dry Eye, Contact Lens Complication
Direct Application of Systane Complete to Contact Lenses
A common first line treatment for patients with dryness symptoms or contact lens discomfort is the application of artificial tears or rewetting drops, respectively.
- Trial name
- NCT03848221
- Testing
- Systane Complete, Sensitive Eyes Rewetting Drops
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- University of Alabama at Birmingham
Dry Eye Syndrome
Sodium Hyaluronate Ophthalmic Solution, 0.18% for Treatment of Dry Eye Syndrome
The purpose of this study was to determine if Sodium Hyaluronate, 0.18% is effective in treating the signs and symptoms of dry eye disease.
- Trial name
- NCT01382225
- Testing
- Sodium Hyaluronate Ophthalmic Solution, 0.18%, Vehicle
- Volunteers
- 1,936 people
- Sponsor
- Alcon Research
Eye Dryness
Comparison of Two Marketed Lenses in a Controlled Environment
This study is comparing two silicone hydrogel contact lenses in a controlled environment for identification of characteristics associated to vision.
- Trial name
- NCT02212301
- Testing
- senofilcon A, lotrafilcon B
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Dry Eye Syndrome (DES)
Impact of Filtration on Autologous Serum Eye Drops
Dry eye disease accounts for nearly 25% of ophthalmology consultations, making it a commonly encountered condition. When conventional treatments fail autologous serum in the form of eye drops, have been proposed as a therapeutic…
- Trial name
- IFILCOSA (NCT07407101)
- Testing
- Serum dosage of TGF-β, IGF-1, EGF, Fibronectin and Vitamin A
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Limoges
Evaporative Dry Eye Disease
Safety and Efficacy of NovaTears® + Omega-3 (0.2%) Eye Drops on Signs and Symptoms of Dry Eye
This PMCF study is carried out following successful CE marking of NovaTears® + Omega-3 and is intended to generate systematic clinical data on the safety and performance of the device when used in accordance with the intended…
- Trial name
- NCT04521465
- Testing
- NovaTears® + Omega-3 (Perfluorohexyloctane with 0.2% w/w Omega-3 fatty acid ethyl esters)
- Where
- 2 sites in Germany
- Volunteers
- 36 people
- Sponsor
- Novaliq GmbH
Dry Eye
Study of VVN001 Ophthalmic Solution in Dry Eye Disease
This is a Phase 2a, multi-center, double-masked, randomized, vehicle-controlled, parallel-group study designed to evaluate the safety and tolerability and to explore the efficacy activity of VVN001 ophthalmic solution versus…
- Trial name
- NCT04556838
- Testing
- VVN001 Ophthalmic Solution 1%, VVN001 Ophthalmic Solution 5%, Vehicle
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- VivaVision Biotech, Inc
Dry Eye Syndrome
Study to Assess the Safety and Patients' Satisfaction of Tears Again* in the Treatment of Dry Eye Symptoms
The purpose of this study is to determine safety and patients' satisfaction when using Tears Again to treat Dry Eye Symptoms.
- Trial name
- NCT00535054
- Testing
- Tears Again
- Where
- Israel
- Volunteers
- 125 people
- Sponsor
- Trima, Israel Pharmaceutical Products
Dry Eye
A Study to Assess the Safety and Efficacy of ECF843 vs Vehicle in Subjects With Dry Eye Disease
The study was planned to be conducted in 2 parts: Part 1 to determine the efficacy and safety of ECF843 vs vehicle, followed by Part 2 with additional exploratory assessments of ECF843 vs Vehicle.
- Trial name
- NCT04391894
- Testing
- ECF843, ECF843 vehicle
- Where
- 52 sites in United States
- Volunteers
- 718 people
- Sponsor
- Novartis Pharmaceuticals
Sjogren Syndrome
Two-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome
A randomized, double-blind, placebo controlled, 2-arm multicenter phase 3 study to assess the efficacy and safety of ianalumab in patients with active Sjogren's syndrome (NEPTUNUS-1)
- Trial name
- NEPTUNUS-1 (NCT05350072)
- Testing
- VAY736
- Where
- 77 sites in United States, Austria and 16 more
- Volunteers
- 275 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye
Dry Eye Symptom Mitigation by Oral Intake of Probiotics
This study investigates whether the oral intake of a probiotics capsule product may relieve dry eye symptoms. Participants will be aged between 20 - 65 years of age, with confirmed diagnosis of dry eye status.
- Trial name
- NCT05906381
- Testing
- Probiotics
- Where
- Taiwan
- Volunteers
- 88 people
- Sponsor
- Chung Shan Medical University
Dry Eye Syndromes
NovaTears® Eye Drops Observational Study NT-003
This observational study is intended to collect outcome data from a cohort of 30 patients suffering from dry eye disease due to chronic ocular Graft-versus-Host Disease (GvHD) who are treated with the medical device NovaTears®…
- Trial name
- NCT02356328
- Testing
- NovaTears® Eye Drops
- Where
- 2 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Novaliq GmbH
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