Clinical trials: Dry Eye
Dry Eye Syndrome
Clinical Evaluation Following Use of SYSTANE® ULTRA in the Management of Dry Eye
The purpose of this study is to evaluate the clinical benefits of SYSTANE® ULTRA Lubricant Eye Drops using total ocular surface staining scores in subjects with dry eye administering it either as a scheduled regimen or as-needed…
- Trial name
- NCT02446015
- Testing
- SYSTANE® ULTRA Lubricant Eye Drops
- Volunteers
- 159 people
- Sponsor
- Alcon Research
Dry Eye
Evaluation of Clinical Outcomes After the Use of SYSTANE® HYDRATION
The purpose of this study is to compare SYSTANE® HYDRATION to Hyabak 0.15% based on total ocular surface staining scores (TOSS) at Day 42.
- Trial name
- NCT02470429
- Testing
- SYSTANE HYDRATION lubricant eye drops, Hyabak 0.15% eye drops, 0.9% saline eye drops
- Volunteers
- 114 people
- Sponsor
- Alcon Research
Dry Eye Syndrome, Lipid Deficiency
Evaluation of SYSTANE® BALANCE in Dry Eye Subjects With Lipid Deficiency
The purpose of this study is to evaluate the repeated use of SYSTANE® BALANCE on stabilizing the tear film of dry eye patients with an unstable tear film.
- Trial name
- NCT01688726
- Testing
- SYSTANE® BALANCE eyedrops, Minims® Saline 0.9% eyedrops
- Volunteers
- 91 people
- Sponsor
- Alcon Research
Dry Eye Syndrome
SYSTANE® BALANCE Symptoms (OSDI) & Inflammatory Biomarkers
The purpose of this study is to evaluate the ability of SYSTANE® BALANCE and SYSTANE® Gel to improve comfort in subjects with dry eyes.
- Trial name
- NCT01733732
- Testing
- SYSTANE® BALANCE Lubricant Eye Drops, SYSTANE® Gel
- Volunteers
- 54 people
- Sponsor
- Alcon Research
Dry Eye Syndrome
SYSTANE® Family - Meibomian Deficiency
The purpose of this study was to assess the efficacy of the SYSTANE® family of products (SYSTANE® Lid Wipes, SYSTANE® BALANCE Lubricant Eye Drops, and SYSTANE® Vitamins) on meibomian gland functionality in subjects with lipid…
- Trial name
- M-12-077 (NCT01733745)
- Testing
- SYSTANE® Lid Wipes, SYSTANE® BALANCE, SYSTANE® Vitamins
- Volunteers
- 26 people
- Sponsor
- Alcon Research
Dry Eye
Efficacy and Safety Study of FID 119515A
The purpose of this study was to compare the effect of FID 119515A to Blink® Tears on the integrity of tear film in adults with a history of dry eye in both eyes.
- Trial name
- NCT01833117
- Testing
- FID 119515A, Blink® Tears
- Volunteers
- 75 people
- Sponsor
- Alcon Research
Meibomian Gland Dysfunction, Dry Eye Syndrome
Efficacy of Pulsed Light Therapy for Meibomian Gland Dysfunction and Dry Eye Syndrome
Our primary aim is to determine whether pulsed light therapy (PLT) is effective in reducing symptoms and improving clinical stigmata of dry eye syndrome (DES) associated with meibomian gland dysfunction (MGD) in patients with…
- Trial name
- NCT01917539
- Testing
- Pulsed Light Therapy
- Where
- United States
- Sponsor
- University of Miami
Meibomian Gland Dysfunction, Dry Eye
Comparison of BlephEx to MiBoflo as Treatment Options for Blepharitis
The goal of this study is to compare which treatment - BlephEx or MiBoFlo - will be a better option for patients suffering from dry eye secondary to Meibomian Gland dysfunction.
- Conditions
- Meibomian Gland Dysfunction, Dry Eye, Posterior Blepharitis
- Trial name
- NCT02952079
- Testing
- Blephex, MiboFlo
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of the Incarnate Word
Dry Macular Degeneration
BioCurrent Electrical Stimulation for the Treatment of Dry ARMD
This study evaluates the treatment of Dry Macular Degeneration and the resulting change in vision with a very, very low current that is similar to what occurs in the body naturally.
- Trial name
- NCT02699216
- Testing
- Electrical Stimulation of the Retina
- Volunteers
- healthy volunteers welcome
- Sponsor
- DuBois Vision Clinic
Contact Lens Discomfort, Dry Eye Disease
Pilot Study for Investigating the Effect of the Bruder Eye Hydrating Compress on Contact Lens Discomfort in Contact Lens Wearers
The purpose of this prospective study is to evaluate the benefits of using the Bruder Moist Heat Compress in contact lens wearers who report reduced comfortable wear time.
- Conditions
- Contact Lens Discomfort, Dry Eye Disease, Meibomian Gland Dysfunction
- Trial name
- NCT02848222
- Testing
- Bruder Moist Heat Compress, Washcloth
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Dry Eye Syndromes
Phase 2 Study of a New Ophthalmic Formulation of Cyclosporine (Restasis® X) in Patients With Dry Eye Disease
This study will evaluate a new ophthalmic formulation of cyclosporine (Restasis® X) in patients with moderate to severe dry eye disease in two stages. Up to 3 doses will be studied in Stage 2 based on results from Stage 1.
- Trial name
- NCT02013791
- Testing
- Vehicle, Cyclosporine New Ophthalmic Formulation
- Where
- 8 sites in United States
- Volunteers
- 55 people
- Sponsor
- Allergan
Dry Eye Syndrome
A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome
To determine the effect of Essential Fatty Acids (EFA's) on Meibomian Gland lipids and aqueous tear production in patients with "dry eyes".
- Trial name
- NCT00344721
- Testing
- Omega-3 fatty acid supplement
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Dry Eye
Evaluation of the Efficacy and Safety of DM05 Versus Optive™ on the Treatment of Moderate to Severe Ocular Dryness
This study is a multicentric, comparative, randomized, investigator-blinded, in parallel groups study to demonstrate the non-inferiority of DM05 in comparison with Optive™, in terms of cornea and conjunctiva staining (Oxford…
- Trial name
- NCT03517748
- Testing
- DM05 eye drops, Optive™ eye drops
- Volunteers
- 80 people
- Sponsor
- Horus Pharma
Dry Eye, MGD-Meibomian Gland Dysfunction
Study on Prevention and Treatment of Dry Eye in Patients Using Glaucoma Drops
A multicenter randomized controlled trial on prevention and treatment of ocular surface injury and meibomian gland dysfunction in patients using anti-glaucoma eye drops.
- Trial name
- NCT03515187
- Testing
- 0.3% sodium hyaluronate ophthalmic solution, 0.1% sodium bromide solution, Meibomian gland massage
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shenzhen Hospital of Southern Medical University
Dry Eye Disease
Optical Coherence Tomography of Tear Film Dynamics In-Vivo
The purpose of this study is to evaluate a new instrument that takes digital images of tear film (a thin film that coats the eye that is made up of oil and water).
- Trial name
- NCT02554084
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Dry Eye Syndrome, Photophobia
Functional MRI Study of Cortical Modifications to Light Stimulation in Patients With Photophobia
Photophobia is a common and disabling symptom in patient with dry eye syndrome. The aim of this study is tried to better understand this complain analyzing brain activation during a luminous stimulation to highlight modification…
- Trial name
- NCT03464357
- Testing
- fMRI
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Toulouse
Dry Eye Syndrome
Efficacy and Safety Study of HU00701/HU007 Eye Drops in Patients With Dry Eye Syndrome
A multicenter, Placebo controlled, Restasis® referenced, Randomized, Double blind, Phase II Study to Evaluate the Efficacy and Safety of HU00701/HU007 Eye Drops in Adult Patients with Dry Eye Syndrome
- Trial name
- NCT02917512
- Testing
- HU00701, HU007, Restasis
- Where
- South Korea
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Huons Co., Ltd.
Dry Eye
OTX-14-006: A Phase 2 Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Dry Eye
The objective of the study was to evaluate the efficacy and safety of OTX-DP (dexamethasone insert) 0.4 mg for intracanalicular use when placed in the canaliculus of the eyelid for the treatment of the signs and symptoms of dry…
- Trial name
- NCT02468700
- Testing
- Dexamethasone
- Volunteers
- 43 people
- Sponsor
- Ocular Therapeutix, Inc.
Dry Eye Syndromes
Effects of Sea Buckthorn Oil on Dry Eye
The objective is to study the effect of sea buckthorn oil on dry eye.
- Trial name
- DESB (NCT00739713)
- Testing
- Sea buckthorn (Hippophaë rhamnoides) oil
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Turku
Meibomian Gland Dysfunction, Dry Eye Disease
Investigating the Effect of At Home Thermal Therapy on Dry Eye Patients With Meibomian Gland Dysfunction
The purpose of this pilot study is to determine the feasibility of at home thermal therapy with a wireless, portable device, as an effective management of Meibomian Gland Dysfunction.
- Trial name
- NCT03291704
- Testing
- Thermal therapy device
- Volunteers
- 20 people
- Sponsor
- UMay Care Inc.