Clinical trials: Dry Eye Symptoms
Ocular Pain, Dry Eye
Study to Evaluate the Ocular Tolerance of SYL1001 in Healthy Volunteers
The purpose of this study is to determine whether SYL1001 is safe for the prevention and treatment of ocular pain and dry eye syndrome.
- Trial name
- NCT01438281
- Testing
- SYL1001
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sylentis, S.A.
Dry Eye
Bilateral, Masked Comparison of PEG-400 Based Artificial Tear and Systane for the Treatment of Dry Eye Signs, Symptoms and Visual Quality
To evaluate and compare the effects of PEG-400 based artificial tear and Systane tears in mild-moderate dry eye patients. TBUT, Visual impact and subjective evaluations will be assessed in this month long trial.
- Trial name
- NCT00622037
- Testing
- PEG-400 based artificial tear, Systane
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Bp Consulting, Inc
Keratoconus, Ocular Surface Disease
Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting
EYEdeal Scanning Technology enables rapid measurement of corneal and scleral topography. By accurately measuring the ocular surface with this imaging technology, the current iterative fitting method required to fit PROSE…
- Conditions
- Keratoconus, Ocular Surface Disease, Pellucid Marginal Corneal Degeneration, Ectasia
- Trial name
- NCT04649177
- Testing
- Ocular surface optical coherence tomography
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston Sight
Dry Eye Disease
Dry Eye Disease in the Vitamin D and Omega-3 Trial (VITAL)
The VITamin D and OmegA-3 Trial (VITAL; NCT 01169259) is a randomized clinical trial in 25,875 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (Omacor fish…
- Trial name
- NCT01880463
- Testing
- Omega-3 fatty acids (fish oil), Vitamin D3
- Volunteers
- 25,875 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Amblyopia, Motion Sickness
Impact of Different Types of Virtual Reality Games on Motion Sickness and Ocular in Adults: A Pilot Study
The research project titled "The Impact of Immersive Virtual Reality Training on Adult: Motion Sickness, and Ocular Surface: A Pilot Study" aimed to evaluate the initial safety impact of head-mounted virtual reality (HMVR)…
- Conditions
- Amblyopia, Motion Sickness, Dry Eye
- Trial name
- NCT06354309
- Testing
- Virtual reality game
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- He Eye Hospital
Dry Eye Disease
IIT Assessing OC-01Nasal Spray on Symptoms of DED Following CXL
A Randomized, Controlled, Double-Masked, Two-Arm Investigator-Initiated study to Assess the Efficacy of OC-01 (varenicline) Nasal Spray on signs and symptoms of Dry Eye Disease in subjects following Corneal Collagen Crosslinking…
- Trial name
- NCT05136924
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision - MT
Dry Eye Syndromes, Hyaluronic Acid
Differences in Dry Eye Symptoms Related to Geographic Location in Spain and Impact of Artificial Tears Use
This study assessed the differences in DED symptomatology measured with the OSDI questionnaire regarding climate data of the geographic location in a large population in Spain, with a special focus on the relative humidity (RH)…
- Conditions
- Dry Eye Syndromes, Hyaluronic Acid, OSDI
- Trial name
- EMO-01 (NCT06499753)
- Testing
- high molecular weight HA-based artificial tears
- Where
- Spain
- Volunteers
- 1,033 people, healthy volunteers welcome
- Sponsor
- University of Valladolid
Dry Eye
Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Following Photorefractive Keratectomy (PRK)
Evaluate the safety and effectiveness of OC-01 (varenicline) nasal spray among subjects suffering from dry eye following photorefractive keratectomy (PRK)
- Trial name
- NCT05045508
- Testing
- OC-01 (varenicline 0.6mg/ml) nasal spray
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brandon Baartman
Dry Eye Syndromes, Computer Vision Syndrome
Evaluation of an Updated Version of the Program "BlinkBlink" for Alleviation of Dry Eye Symptoms Induced by Computer Work
The program "BlinkBlink" was developed to alleviate dry eye symptoms during prolonged computer work. This study aimed to show subjective and objective improvement of dry eye problems in a sample size of office workers
- Trial name
- NCT04637516
- Testing
- Animation program "BlinkBlink"
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts Northwestern Switzerland
Dry Eye
Artificial Tears Study in Mild to Moderate Dry Eye Patients
The mean change in the subjective comfort score from baseline of the test group is at least 2.0 units less than that of the control group.
- Trial name
- NCT00607776
- Testing
- (9587X) Blink Tears, classified as an OTC Drug with the active ingredient being plyethylene glycol 400, Systane
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Primary Sjögren's Syndrome, Xerostomia
Effect of B-cell Depletion in Patients With Primary Sjögren's Syndrome
The primary purpose of the study is to determine whether B-cell depletion with Rituximab has an effect on the oral, ocular and general disease manifestations in patients with primary Sjögren´s syndrome, that is, an effect on the…
- Conditions
- Primary Sjögren's Syndrome, Xerostomia, Hyposalivation, Keratoconjunctivitis Sicca
- Trial name
- NCT00426543
- Testing
- MabThera (rituximab), Rituximab, Mabthera
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Keratoconjunctivitis Sicca
Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK
Purpose: To develop a screening metric by examining both the characteristics of the preoperative tear film and the intracellular signaling pathways of conjunctival goblet cells in order to determine if there are certain…
- Trial name
- NCT00411827
- Testing
- PRK with conjunctival impression cytology before and after surgery, LASIK with conjunctival impression cytology before and after surgery
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Primary Sjogren's Syndrome
Confocal Microscopy and Lacrimal Gland in Sjogren's Syndrome
Traditional methodological clinical and instrumental diagnostics of the lacrimal gland for the study of glandular architecture and functions are limited and include analysis of tear constituents, evaluation of apparent diffusion…
- Trial name
- NCT00920179
- Where
- Japan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Keio University
Dry Eye Syndromes
The Effect of Punctal Plugs on Tear Volume and Osmolality
The purpose of this study is to evaluate the role of tear volume in discomfort and dryness sensations during contact lens wear, and the possible influence on osmolality and ocular surface sensitivity.
- Trial name
- NCT00372034
- Testing
- Temporary Collagen Inserts
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Dry Eye
OC-01 (Varenicline) Nasal Spray and Dry Eye Signs and Symptoms in Daily Disposable Contact Lens Wearers
This study is a single center, prospective, randomized, controlled, double-masked, two-arm investigator-initiated study to investigate the efficacy of OC-01 (varenicline) nasal spray on the signs and symptoms of dry eye disease…
- Trial name
- NCT05161208
- Testing
- OC-01 (varenicline 0.6mg/ml) Nasal Spray
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Center for Ophthalmic and Vision Research, LLC
Dry Eye Disease
Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z®
The purpose of this study is to determine if there is a difference in the ocular signs and symptoms of subjects' eyes using Xalatan® 0.005% versus Travatan Z® 0.004% based on the outcome of subject assessment and clinical…
- Trial name
- NCT00799682
- Testing
- Xalatan, Travatan Z
- Where
- 5 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Long Island
Dry Eye
Single Center, Prospective, Randomized, Controlled, Non-significant Risk
A randomized controlled trial to evaluate the efficiency of serum tears made with Genius PRP for improving signs and symptoms in Dry Eye Disease (DED). Single center, Prospective, Randomized, Controlled, Non-significant risk
- Trial name
- NCT03286166
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Toyos Clinic
Dry Eye, Cataract
Lubricating Eye Drops After Routine Cataract Surgery
Patient satisfaction and dry symptoms in patients undergoing routine uncomplicated cataract surgery in NHS patients treated with prophylactic phosphate-free, preservative-free lubricant eye drops (0.3% cross linked sodium…
- Trial name
- NCT04465071
- Testing
- AEONTM Repair and AEONTM Protect Plus lubricating eye drops
- Where
- United Kingdom
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Dry Eye Syndromes
Computer Screen Properties Study
The purpose of this study is to identify how various popular methods of changing computer screen settings affect dry eye symptoms (eye pain, grittiness, tearing, burning, etc.).
- Trial name
- NCT05042960
- Testing
- Brightness
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Evaporative Dry Eye
Impact of Tear Substitute Use on Dry Eye in Gamers.
Clinical, prospective, comparative, controlled, single-blind study, on the signs and symptoms of dry eye before and after 3 days of playing video games with the use of artificial tears (Hyabak) versus no intervention.
- Trial name
- HYAGAME (NCT05536661)
- Testing
- Preservative free hyaluronic acid artificial tear
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Laboratorios Thea, Spain