Clinical trials: Dual Antiplatelet Therapy
Coronary Artery Disease
3-Month Discontinuation of Dual Antiplatelet Therapy After Ultimaster Sirolimus-Eluting Stent Implantation
To evaluate safety of reduction of dual antiplatelet therapy period to three months after implantation of Ultimaster sirolimus-eluting stent (U-SES).
- Trial name
- MODEL U-SES (NCT02837003)
- Testing
- Aspirin, Thienopyridine
- Where
- Japan
- Volunteers
- 1,500 people
- Sponsor
- Teikyo University
Coronary Artery Disease, Acute Coronary Syndrome
Genotyping Infarct Patients to Adjust and Normalize Thienopyridine Treatment
The objective of GIANT Study is to evaluate the clinical impact of genetic resistance to thienopyridine profile determination (CYP2C19 gene) and the clinical impact of compliance to an adjusted thienopyridine treatment on STEMI…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Genetic Resistance to Clopidogrel, Compliance to Thienopyridine Treatment
- Trial name
- GIANT (NCT01134380)
- Where
- 12 sites in France
- Volunteers
- 1,500 people
- Sponsor
- Biotronik France
Pacemaker Implantation, Pocket Hematoma and Bleeding
Pocket Haematoma Prevention in Patients Who Required Implantation/Replacement of a Pacemaker or Implantable Cardiac Defibrillator. The PHP Study.
The aim of this study is to demonstrate the efficacy of fibrin sealant (Tissucol-Baxter) in preventing pocket haematoma and subsequent complications in patients undergoing pacemaker or ICD implantation/replacement which cannot…
- Conditions
- Pacemaker Implantation, Pocket Hematoma and Bleeding, Antiplatelet Therapy or Oral Anticoagulants
- Trial name
- PHP (NCT01127984)
- Testing
- tissucol, drainage system
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Careggi Hospital
Myocardial Infarction, Coronary Artery Disease
Emulation of Randomized Clinical Trial in Cardiovascular Disease
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- RCT-BigData (NCT06241833)
- Testing
- PPI
- Where
- South Korea
- Volunteers
- 118,420 people
- Sponsor
- Samsung Medical Center
Peripheral Artery Disease
Effects of Prolonged DAPT After Lower Extremity Percutaneous Transluminal Angioplasty (PTA) in Patients With LE-PAD
The objective of the present study was to evaluate the prognostic impact of prolonged dual antiplatelet therapy (DAPT) with acetylsalicylic acid plus clopidogrel on the incidence of major adverse cardiovascular events and major…
- Trial name
- LONGDAPTPAD (NCT02798913)
- Testing
- Short DAPT, Long DAPT
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Federico II University
Ischemic Stroke, Acute, Stent Stenosis
Rescue Stenting in the Severe Atherosclerotic Stenosis After the Failure of Intravenous Thrombolysis
Intravenous (IV) recombinant tissue plasminogen activator is the standard of care for patients with acute ischemic stroke (AIS) who present to the hospital within 4.5 hours of symptom onset.
- Conditions
- Ischemic Stroke, Acute, Stent Stenosis, Thrombosis
- Trial name
- RESFIT (NCT05666388)
- Testing
- Rescue stenting
- Where
- Vietnam
- Volunteers
- 13 people
- Sponsor
- Can Tho Stroke International Services Hospital
Elevated Lipoprotein(a) Level, Coronary Artery Disease
24 Versus 12-Month Dual Antiplatelet Therapy After Drug-Eluting Stent in Patients With Elevated Lipoprotein(a) Levels: A Prospective, Multicenter, Double-Blind, Placebo-Controlled Randomized Trial
1. Main objective Among patients with elevated Lp(a) levels (>30mg/dL) who did not experience cardiovascular events or BARC type 2, 3, or 5 bleeding within 12 months after PCI and DES implantation, was it possible to reduce the…
- Conditions
- Elevated Lipoprotein(a) Level, Coronary Artery Disease, Drug-Eluting Stent, Dual Antiplatelet Therapy
- Trial name
- DAPT-Lp(a) (NCT06014060)
- Testing
- 24 Months DAPT, 12 Months DAPT
- Where
- China
- Volunteers
- 3,300 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease
Recent studies indicate that anti-factor-Xa inhibition with low-dose rivaroxaban may have a role in the reduction of ischemic recurrences in patients with atherosclerotic disease manifestations.
- Trial name
- SWAP-AC (NCT04006288)
- Testing
- Clopidogrel, Prasugrel, ticagrelor
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Florida
Ischemic Stroke, Ischemic Stroke, Acute
Tegoprazan for Prevention of Gastrointestinal Complication in Ischemic Stroke Patients on Antiplatelet Therapy (TegoStroke)
Patients with ischemic stroke commonly receive antiplatelet therapy, frequently starting as dual antiplatelet therapy, which is associated with an increased risk of gastrointestinal complications.
- Conditions
- Ischemic Stroke, Ischemic Stroke, Acute, Transient Ischemic Attack (TIA), Cerebrovascular Disease
- Trial name
- TegoStroke (NCT07687706)
- Testing
- Tegoprazan 50 mg
- Where
- 24 sites in South Korea
- Volunteers
- 1,524 people
- Sponsor
- Hanyang University Guri Hospital
Coronary Artery Disease (CAD), Percutaneous Coronary Intervention (PCI)
Safety and Efficacy of Very Short DAPT in Older Patients Undergoing PCI
The goal of this clinical trial is to learn if reducing the duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (short treatment regimen, stopping aspirin at day 7) is as safe and efficient as…
- Conditions
- Coronary Artery Disease (CAD), Percutaneous Coronary Intervention (PCI), Antiplatelet Therapy, Elderly (People Aged 65 or More)
- Trial name
- SOLOPCI (NCT07164859)
- Testing
- short dual antiplatelet therapy (DAPT) duration, Standard DAPT duration
- Where
- France
- Volunteers
- 1,700 people
- Sponsor
- Vincent ROULE
Coronary Disease
Web basEd soCial Media tecHnology to Improvement in Adherence to Dual anTiplatelet Therapy Following Drug-Eluting Stent Implantation
Few studies have attempt to improve DAPT adherence through social media. The investigators will explore the prevalence of DAPT discontinuation and prove the hypothesis that using social media will improve DAPT adherence among…
- Trial name
- WeChat (NCT03732066)
- Testing
- Usual Text Messages, Personalized Reminders, Interactive Responses
- Where
- China
- Volunteers
- 760 people
- Sponsor
- Guangdong Provincial People's Hospital
Tinnitus
A Study on the Effect of Cilostazol in Patients With Chronic Tinnitus
1. Overview of tinnitus Tinnitus is a noisy sound which is perceived without any external sound source. According to the survey of the US, 10-20% of adult have the symptom of tinnitus and 3-5% of tinnitus patients have severe…
- Trial name
- CITI-ESR (NCT01378650)
- Testing
- Cilostazol
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Jong Woo Chung
Stable Coronary Syndrome, Percutaneous Coronary Intervention
A Novel Strategy For Personalized Long-Term Dual Antiplatelet Therapy (RAPID EXTEND PILOT STUDY)
In patients with heart attacks, the current standard of care is to restore blood flow through percutaneous coronary intervention (PCI). This is done using stents (metal meshes) that opens up blockages.
- Conditions
- Stable Coronary Syndrome, Percutaneous Coronary Intervention, Antiplatelet Therapy, Ticagrelor
- Trial name
- NCT03224923
- Testing
- Ticagrelor 60mg, Clopidogrel 75mg, Aspirin 81 mg
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Chronic Total Occlusion
Antiplatelet Therapy After Successful Percutaneous Coronary Intervention for Chronically Occluded Coronary Artery
Coronary arteries are in charge of oxygen supply for the myocardium. When coronary arteries develop stenosis the coronary blood flow (i.e. oxygen flow) is reduced.
- Trial name
- DAPT-CTO (NCT06175377)
- Testing
- Percutaneous coronary intervention, Short dual Aspirin/Clopidogrel therapy, Long dual Aspirin/Clopidogrel therapy
- Volunteers
- 660 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Coronary Syndrome, Coronary Artery Ectasia
Antithrombotic Therapy in Acute Coronary Syndromes and Coronary Artery Ectasia
The optimal anti-thrombotic therapy to prevent recurrent ischemic events in patients with acute coronary syndrome and coronary artery ectasia (CAE) remains unclear.
- Trial name
- OVER-TIME (NCT05233124)
- Testing
- Rivaroxaban 15 MG, Acetylsalicylic acid 100mg, Clopidogrel 75 Mg Oral Tablet
- Where
- 2 sites in Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Acute Coronary Syndrome (ACS), High Bleeding Risk (HBR)
Optimization and Validation of Quality Control Indicators for Coronary Revascularization Based on Antiplatelet Therapy
Study Purpose Coronary heart disease (CAD) is a leading global cause of death, with Acute Coronary Syndrome (ACS) as its acute and life-threatening subtype.
- Conditions
- Acute Coronary Syndrome (ACS), High Bleeding Risk (HBR), Coronary Artery Disease (CAD)
- Trial name
- NCT07354828
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Shenyang Northern Hospital
Atrial Fibrillation, Coronary Artery Disease
LAAO With DAPT Versus Antithrombotic Therapy
This study will retrospectively review and compare clinical outcomes between left atrial appendage occlusion with dual antiplatelet therapy versus conventional antithrombotic therapy in patients with atrial fibrillation…
- Trial name
- NCT03310801
- Testing
- ACP or Watchman
- Volunteers
- 480 people
- Sponsor
- Korea University Anam Hospital
Acute Coronary Syndromes (ACS), Coronary Artery Disease (CAD)
Fexuprazan for Prevention of Upper Gastrointestinal Bleeding in High Bleeding Risk Patients Receiving Dual Antiplatelet Therapy
This study evaluates whether fexuprazan is effective in preventing upper gastrointestinal bleeding and related upper gastrointestinal clinical events in high bleeding risk patients who require dual antiplatelet therapy after…
- Trial name
- SAINT-FEXUDAPT (NCT07479056)
- Testing
- Fexuprazan 40mg, Lansoprazole 30mg
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- SUK MIN SEO
PCI Patients, DAPT(Dual Antiplatelet Therapy)
Comparison of Cardiovascular Risks Between Hip Fracture Surgery With Continued DAPT（Dual Antiplatelet Therapy ） Within 6 Weeks vs After 6 Weeks Post-PCI（Percutaneous Coronary Intervention）: A Prospective Observational Cohort Study
Percutaneous coronary intervention (PCI) is commonly used to treat stable ischemic heart disease. Among patients, 7.5% require surgical treatment, and up to 20% may need noncardiac surgery (NCS) within two years.
- Conditions
- PCI Patients, DAPT(Dual Antiplatelet Therapy), Hip Fracture Surgeries
- Trial name
- NCT07024446
- Testing
- The time interval between PCI and NCS
- Volunteers
- 50 people
- Sponsor
- Fujian Medical University Union Hospital
Aneurysm Cerebral, Endovascular Procedures
Optimal Duration of Dual Antiplatelet Therapy After Stent-assisted Coiling
Comparison of duration of dual antiplatelet therapy after stent-assisted coiling of unruptured intracranial aneurysms
- Trial name
- NCT05257824
- Testing
- Aspirin 100mg, Clopidogrel 75mg
- Where
- 8 sites in South Korea
- Volunteers
- 528 people
- Sponsor
- Seoul National University Bundang Hospital