Clinical trials: Dual Use of Cigarettes and E-cigarettes
Tobacco Use
E-Cigarette and Cigarette Nicotine Delivery and Abuse Liability in Cigarette Smokers and Dual Users
The FDA has shown clear interest in strategies that will reduce the public health burden of tobacco use. One proposed strategy includes banning the sale of fully nicotinized cigarettes and only allowing VLNCs (Very Low Nicotine…
- Trial name
- NCT03943706
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma
Cigarette Smoking, E-Cigarette Use
Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use
The purpose of this research study is to understand whether concurrent treatment for cigarettes and e-cigarettes in which an individual quits both products at the same time (QUIT-C) or sequential treatment in which an individual…
- Conditions
- Cigarette Smoking, E-Cigarette Use, Smoking Cessation
- Trial name
- NCT06027840
- Testing
- Varenicline, Counseling, Guided Self-Change Booklets
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Yale University
Vaping, E-Cig Use
A Study of Cytisinicline for Vaping Cessation in Adult Smokers
This placebo-controlled Phase 2 study is being conducted at sites within the United States to evaluate the efficacy and safety profile of 3 mg cytisinicline administered TID for 12 weeks for vaping cessation.
- Trial name
- ORCA-V1 (NCT05431387)
- Testing
- cytisinicline, Behavioral support
- Where
- 5 sites in United States
- Volunteers
- 160 people
- Sponsor
- Achieve Life Sciences
Smoking Cessation, Smoking, Cigarette
Randomized Trial of Electronic Cigarettes With or Without Nicotine in Smoking Cessation.
Background: Electronic cigarettes (EC) mainly containing nicotine (88-95 % of users) are widely and growingly used worldwide. It is estimated that there were 1.7 million daily users in France in 2016.
- Conditions
- Smoking Cessation, Smoking, Cigarette, Electronic Cigarette
- Trial name
- ECSMOKE (NCT03630614)
- Testing
- Electronic cigarette without nicotine (ECwN) plus active varenicline tablets
- Where
- France
- Volunteers
- 650 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tobacco Products, Cigarettes
Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes
The study is a pilot test of effectiveness of communication campaign ads on interest in quitting combustible cigarettes and e-cigarettes.
- Conditions
- Tobacco Products, Cigarettes, Electronic Cigarettes
- Trial name
- NCT07599462
- Testing
- communication
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cigarette Smoking
Characterization of Biomarkers of Tobacco Exposure, Urge-to-Smoke Following Exclusive and Dual Ad Lib Use of Electronic Cigarettes
This is a randomized, open-label, forced-switch, parallel, proof-of-concept study to assess exposure to biomarkers of tobacco exposure following short-term ad lib use of three blu e-cigarette products.
- Trial name
- NCT02385227
- Testing
- Exclusive blu™ e-cigarette A1, Exclusive blu™ e-cigarette A2, Exclusive blu™ e-cigarette A3
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Lorillard Tobacco Company
Nicotine Addiction, E-Cig Use
Quit Smoking Study for People Who Use E-Cigarettes
The overarching aim of this proposed randomized controlled trial (RCT) is to test nicotine replacement therapy (NRT) with text message support for two smoking cessation approaches among young adult dual users of combustible…
- Conditions
- Nicotine Addiction, E-Cig Use, Quitting Smoking
- Trial name
- NCT04946825
- Testing
- Nicotine replacement therapy patch, Nicotine replacement therapy lozenge, Quit electronic cigarettes
- Where
- United States
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Dual Use of Cigarettes and E-cigarettes, Gestational Weight Gain
Cessation of Dual Use of Cigarettes and E-cigarettes During Pregnancy
We propose a randomized controlled trial to develop and evaluate a cessation program with two different strategies for dual users during pregnancy.
- Conditions
- Dual Use of Cigarettes and E-cigarettes, Gestational Weight Gain, Birth-weight-for-gestational-age z Score
- Trial name
- NCT07124702
- Testing
- Simultaneous cessation intervention, Stepwise cessation intervention, Behavior counseling only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- State University of New York at Buffalo
Smoking Cessation
Smoking Cessation Self-Help for Dual Users of Tobacco Cigarettes and E-Cigarettes
The purpose of this study is to develop and test a series of booklets designed to assist smokers of tobacco cigarettes who are also using e-cigarettes (dual users) in quitting smoking and remaining smoke-free.
- Trial name
- NCT02416011
- Testing
- GENERIC, eTARGET
- Where
- United States
- Volunteers
- 2,896 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Dual Use of Cigarettes and E-cigarettes
DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy
This randomized clinical trial evaluates the effectiveness of augmented-dose combination nicotine replacement therapy (NRT) versus standard-dose NRT and no-NRT control for cessation of dual combustible cigarette (CC) and…
- Trial name
- NCT07754578
- Testing
- Text- and web-based support, Nicotine Replacement Therapy (NRT, nicotine patch), Nicotine replacement therapy lozenge
- Where
- United States
- Volunteers
- 321 people
- Sponsor
- Medical University of South Carolina
Smoking Behaviors, Smoking ( Cigarette)
A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product
This will be a randomized, open-label, 2-way crossover, single-site study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics [PD]), and plasma nicotine…
- Conditions
- Smoking Behaviors, Smoking ( Cigarette), Tobacco Use, Abuse Liability
- Trial name
- NCT07881848
- Testing
- Menthol 5%, Combustible cigarette
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking Cessation, Electronic Cigarette Use
CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes
Many people smoke cigarettes and use e-cigarettes, and have a hard time stopping. Nicotine replacement therapy medications, such as nicotine patches and lozenges, have been shown to help people quit e-cigarette use.
- Conditions
- Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- CAN-DOSE (NCT06087328)
- Testing
- Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Medical University of South Carolina
Smoking, Cigarette, Electronic Cigarette Use
Dual Use of ENDS and Combustible Cigarettes
This study investigates the degree to which shared behavioral processes underlie combustible cigarette (CC) and electronic nicotine delivery system (ENDS) use in young adult dual users of these products in both the laboratory and…
- Trial name
- DUET (NCT05280535)
- Testing
- Cue Reactivity Task, Computerized Visual Dot Probe, Choice Task
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Brown University
Tobacco Use Disorder
Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes
Cigarette smoking remains the leading cause of preventable morbidity and mortality in the US. Use of multiple tobacco products is becoming increasingly prevalent, with dual use of e-cigarettes and cigarettes representing the most…
- Trial name
- RDEC (NCT06614504)
- Testing
- Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes
- Where
- 2 sites in United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Electronic Cigarette Use, Second Hand Smoke
Acute Health Effects of Passive Vape Among COPD Patients
The use of e-cigarettes is often permitted in otherwise smoke-free areas causing passive vape exposure for present individuals. Little is known about the potential adverse health effects of passive vape, and people with…
- Conditions
- Electronic Cigarette Use, Second Hand Smoke, Lung Function
- Trial name
- PASVAP (NCT04316234)
- Testing
- Passive vape
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus