Clinical trials: Dupuytren's Contracture
Dupuytren's Contracture
Collagenase Option for Reduction of Dupuytren's Contracture in Japan
To investigate the efficacy and safety of AK160 in patients with Dupuytren's Contracture. To determine plasma concentration after the first injection of AK160 in patients with Dupuytren's Contracture.
- Trial name
- CORD-J (NCT01588353)
- Testing
- Collagenase Clostridium Histolyticum
- Where
- 20 sites in Japan
- Volunteers
- 104 people
- Sponsor
- Asahi Kasei Therapeutics Corporation
Dupuytren Contracture, Dupuytren Disease of Palm and Finger
Treatment of Dupuytren's Disease With Minimal Invasive Surgery and VIVOSORB® Resorbable Implant Device
Dupuytren's disease is a progressive fibroproliferative condition of the hand which progresses in 20% of patients into a serious condition.
- Trial name
- Vivosorb (NCT03741764)
- Testing
- Vivosorb
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- prof. dr. Ilse Degreef
Dupuytren's Contracture
Real-World Data Study to Understand Participant Treatment Outcomes for Dupuytren's Contracture
This is an observational study, meaning participants will not receive any investigational treatment as part of this study. Researchers will collect real-world data (RWD), based on usual care, to gain a more in-depth knowledge of…
- Trial name
- GRASP-DC (NCT05877066)
- Where
- 7 sites in United States
- Volunteers
- 130 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Contracture
Efficacy and Safety of Xiaflex Injection for Treatment of Dupuytren's Contracture of the Thumb
This study will evaluate the efficacy and safety of clostridial collagenase injections for treatment of Dupuytren's contracture of the thumb and first web space.
- Trial name
- NCT01265420
- Testing
- Injectable clostridial collagenase
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Indiana Hand to Shoulder Center
Hand Surgery, Wrist Surgery
The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery
Patients undergoing hand, wrist, and elbow surgery may experience pain after surgery. The orthopedic surgeon may provide prescription pain medications after surgery to assist with pain control.
- Conditions
- Hand Surgery, Wrist Surgery, Elbow Surgery, Fracture Fixation
- Trial name
- NCT06806410
- Testing
- Liposomal bupivacaine (LB), Dexamethasone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Dupuytren's Contracture
Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren's Disease
OBJECTIVES: Evaluate the safety and efficacy of collagenase in improving flexion deformity, range of motion, and grip strength in patients with residual Dupuytren's disease.
- Trial name
- NCT00004409
- Testing
- collagenase
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- State University of New York
Soft Tissue Injuries, Distal Radius Fracture
Effectiveness of a Tele-Rehabilitation Evidence-based Tablet App for Rehabilitation in Traumatic Bone and Soft Injuries of the Hand, Wrist and Fingers.
Trauma and soft injuries of the wrist, hand and fingers have a high incidence, and large social and healthcare costs are generated, mainly due to productivity loss.
- Conditions
- Soft Tissue Injuries, Distal Radius Fracture, Metacarpal Fracture, Carpal Fracture
- Trial name
- NCT04669704
- Testing
- Experimental: Tablet application, Comparator: Conventional treatment
- Where
- 2 sites in Spain
- Volunteers
- 663 people
- Sponsor
- University of Seville
Dupuytren Contracture
Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release
The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are: Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment…
- Trial name
- NCT06330545
- Testing
- Radiation therapy
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Dupuytren's Disease
Palmaris Longus Muscle and Dupuytren
Dupuytren disease is a medical condition characterized by the painless formation of nodules in the palm of the hand. Cords are formed on the palmar fascia, a connective tissue sheet in the palm of the hand.
- Trial name
- Palmaris (NCT06281509)
- Testing
- Non-invasive tests to determine the presence or absence of the palmaris longus tendon in both hands., Ultrasound
- Where
- Belgium
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren's Contracture
Administration of Two Injections for Multiple Dupuytren's Contractures
The objectives of this study are to assess the safety and efficacy of concurrent administration of two injections of AA4500 into the same hand of subjects with multiple Dupuytren's contractures caused by palpable cords.
- Trial name
- NCT01407068
- Testing
- AA4500 collagenase clostridium histolyticum
- Where
- 8 sites in United States, Australia
- Volunteers
- 60 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Disease
Safety and Efficacy of Delayed Manipulation After Xiaflex Treatment in Subjects With Dupuytren's Contracture
The purpose of this study is to determine if of manipulation of digits following collagenase injection for treatment of Dupuytren's contracture is effected by the amount of time between injection and manipulation.
- Trial name
- NCT01226121
- Testing
- Clostridial collagenase injectable
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Indiana Hand to Shoulder Center
Dupuytren's Contracture
Phase III Randomized Study of Collagenase in Patients With Residual Stage Dupuytren's Disease
OBJECTIVES: I. Compare the safety and efficacy of clostridial collagenase vs placebo in terms of improving the degree of flexion deformity, range of finger motion, and grip strength in patients with residual stage Dupuytren's…
- Trial name
- NCT00014742
- Testing
- collagenase
- Volunteers
- 72 people
- Sponsor
- State University of New York
Dupuytren's Disease
Collagenase in the Treatment of Dupuytrens Disease
The purpose of the study is to determine if collagenase will reduce the degree of contracture in the primary joint in subjects with Dupuytren's disease.
- Trial name
- NCT00260429
- Testing
- collagenase clostridium histolyticum
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Stony Brook University
Dupuytren's Disease
Micronerves in Dupuytren and the Impact of Its Dissection on Recurrence
Dupuytren disease (DD) is a highly prevalent disabling hand disease. Spontaneous fibrosis nodules and strands in the palms of the hand cause finger contractures in disturbing positions and movement restrictions.
- Trial name
- Micronerves (NCT06142929)
- Testing
- Microfasciectomy
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren's Disease
Goniometry and Goniometric Measurement on Standardised Images in Dupuytren's Disease
Measuring range of motion (ROM) is essential in detecting musculoskeletal deficits, monitoring the effects of treatment and progression of the disease.
- Trial name
- Goniometry (NCT06263699)
- Testing
- ROM measurement of the MCP and PIP joints in digits 4 and 5
- Where
- Belgium
- Volunteers
- 59 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren Contracture
Is wGRS Associated With DD Recurrence?
Rationale: Retrospectively reviewing the participants of the GODDAF database, revealed a significant association between the weighted genetic risk score and Dupuytren disease recurrence.
- Trial name
- NCT02983162
- Where
- Netherlands
- Volunteers
- 427 people
- Sponsor
- University Medical Center Groningen
Dupuytren Contracture, Dupuytren's Disease
Effectiveness of Splinting After Collagenase Injection
Dupuytren disease is a fibroproliferative condition of the palmar and digital fascia. A collagen containing cord forms which can lead to fixed flexion contracture of one or more fingers.
- Trial name
- NCT04874870
- Testing
- Collagenase Clostridium Histolyticum 0.9 MG [Xiaflex], Xiaflex + Hand-Based Custom Orthosis
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Foundation for Orthopaedic Research and Education
Palmar Fibromatosis
Effect Of Extracorporeal Shock Wave Therapy On Ultrasonography Changes In Patients With Palmar Fibromatosis: A Randomized Controlled Trial
this study will be conducted to investigate the effect of extracorporeal shock wave therapy on ultrasonography chnges In patients with palmar fibromatosis
- Trial name
- ESWT (NCT06248866)
- Testing
- Extracorporeal Shock Wave Therapy, traditional treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Dupuytren Disease of Palm and Finger, With Contracture
Hand Therapy or Not Following Collagenase Treatment for Dupuytren's Contracture?
This study evaluates if hand therapy have an impact on the patients' preformance of and satisfaction with everyday activities or not following collagenase injection treatment for Dupuytren's contracture.
- Trial name
- NCT03580213
- Testing
- Hand therapy MCPJ affected, Hand therapy PIPJ affected
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- Haukeland University Hospital
Dupuytren's Contractures
Ultrasound B Mode Imaging and Elastography
A Pilot Study on Ultrasound B mode Imaging and Elastography during administration of Xiaflex (collagenase clostridium histolyticum) for Dupuytren's contracture.
- Trial name
- UBIEX-DC (NCT04607187)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Theresa Bass-Goldman