Clinical trials: Dupuytren Disease
Dupuytren's Disease
Repurposing Anti-TNF for Treating Dupuytren's Disease
Dupuytren's disease is a very common condition, affecting 4% of the general UK and US population. It causes the fingers to curl irreversibly into the palm and can be extremely disabling.
- Trial name
- RIDD (NCT03180957)
- Testing
- Adalimumab, Saline
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 140 people
- Sponsor
- University of Oxford
Dupuytren Contracture
Evaluating Ultrasound-Guided Needle Knife for Dupuytren's Contracture
This study aims to evaluate the efficacy and safety of ultrasound-guided needle knife dissection in treating Dupuytren's contracture.
- Trial name
- DC-US (NCT06788847)
- Testing
- Ultrasound guided needle knife dissection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mohamed Maher Ismail Ahmed Elashmawy
Dupuytren's Contracture
DEPART Study at Yale
This is a randomized study to determine whether radiation therapy reduces the risk of progression / recurrence of Dupuytren's disease / contracture.
- Trial name
- Dupuytren's (NCT07661342)
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Yale University
Dupuytren's Disease
Splinting for Dupuytren's Contracture Release
This study is comparing two different kinds of splints for patients who have had a surgical contracture release of dupuytren's disease. It compares a static splint and a dynamic splint.
- Trial name
- NCT00575458
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Dupuytren Disease
Percutaneous Aponeurotomy in the Treatment of Dupuytren's Disease
The efficiency of percutaneous aponeurotomy in the treatment of Dupuytrens disease is well known. However, the duration of the clinical improvement after aponeurotomy is not well known.
- Trial name
- APADUP (NCT02474576)
- Testing
- Percutaneous aponeurotomy
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Dupuytren's Contracture
Administration of Two Injections for Multiple Dupuytren's Contractures
The objectives of this study are to assess the safety and efficacy of concurrent administration of two injections of AA4500 into the same hand of subjects with multiple Dupuytren's contractures caused by palpable cords.
- Trial name
- NCT01407068
- Testing
- AA4500 collagenase clostridium histolyticum
- Where
- 8 sites in United States, Australia
- Volunteers
- 60 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Contracture
Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren's Disease
OBJECTIVES: Evaluate the safety and efficacy of collagenase in improving flexion deformity, range of motion, and grip strength in patients with residual Dupuytren's disease.
- Trial name
- NCT00004409
- Testing
- collagenase
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- State University of New York
Dupuytren's Contracture
Real-World Data Study to Understand Participant Treatment Outcomes for Dupuytren's Contracture
This is an observational study, meaning participants will not receive any investigational treatment as part of this study. Researchers will collect real-world data (RWD), based on usual care, to gain a more in-depth knowledge of…
- Trial name
- GRASP-DC (NCT05877066)
- Where
- 7 sites in United States
- Volunteers
- 130 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren Contracture
BOND Study: the Benefit Of Night Splinting in Dupuytrens'
The BOND study is a prospective, randomised single blinded controlled trial to assess the effect of night splinting in patients who have had collagenase injection and manipulation therapy for Dupuytren's Contracture.
- Trial name
- BOND (NCT03031080)
- Testing
- Thermoplastic Hand Splint
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Palmar Fibromatosis
Effect Of Extracorporeal Shock Wave Therapy On Ultrasonography Changes In Patients With Palmar Fibromatosis: A Randomized Controlled Trial
this study will be conducted to investigate the effect of extracorporeal shock wave therapy on ultrasonography chnges In patients with palmar fibromatosis
- Trial name
- ESWT (NCT06248866)
- Testing
- Extracorporeal Shock Wave Therapy, traditional treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Palmar Fibromatosis
Effect of Transfer Energy Capacitive and Resistive Therapy on Palmar Fibromatosis
The objective of the present study is to explore the effect of Transfer Energy Capacitive and Resistive Therapy (TECAR) therapy on pain, range of motion (ROM) and hand function in dupuytren's contracture patients (palmar…
- Trial name
- NCT07443371
- Testing
- Transfer Energy Capacitive and Resistive (TECAR) therapy, Traditional therapy
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Dupuytren Contracture
Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease
Dupuytren's disease results in deformity of the hand and this can lead to trouble with daily activities. Treatment traditionally involves cutting out diseased tissue, however this can cause damage to important structures in the…
- Trial name
- NCT01776892
- Testing
- Collegenase injection, Needle aponeurotomy
- Where
- Canada
- Sponsor
- University of Alberta
Dupuytren Disease of Finger
Can the Number of Skin Tears be Reduced, by Prophylactic Treatment of the Skin in Dupuytrens Contracture Treated With Collagenase?
Collagenase has gained pace in treating Dupuytrens contracture for some years. Thus this treatment is performed routinely in many orthopaedic and or hand surgical department.
- Trial name
- NCT07133945
- Testing
- Silicone plaster or Steristrip or Vaseline
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Zealand University Hospital
Dupuytren's Disease
Phase 2a Dose-Ranging Study to Evaluate Safety and Effectiveness of AA4500 in Treatment of Dupuytren's Disease Nodules
The objectives of this study are to assess the safety and effectiveness of AA4500 in treating palmar Dupuytren's disease nodules.
- Trial name
- NCT02193828
- Testing
- Collagenase clostridium histolyticum
- Where
- 11 sites in United States, Australia
- Volunteers
- 76 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Disease, Surgical Incision
Tolerance and Efficacy Study of Second-line Surgery After Percutaneous Needle Aponeurotomy for Dupuytren's Disease.
As part of a graduated medical-surgical strategy, and in our practice, surgery for Dupuytren's disease appears as a second-line treatment indicated in a situation of failure after treatment with percutaneous needle…
- Trial name
- URAM3 (NCT04164953)
- Testing
- Surgical treatment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Dupuytren Contracture, Dupuytren Disease of Palm and Finger
Treatment of Dupuytren's Disease With Minimal Invasive Surgery and VIVOSORB® Resorbable Implant Device
Dupuytren's disease is a progressive fibroproliferative condition of the hand which progresses in 20% of patients into a serious condition.
- Trial name
- Vivosorb (NCT03741764)
- Testing
- Vivosorb
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- prof. dr. Ilse Degreef
Bullous Pemphigoid
Leflunomide Associated With Topical Corticosteroids for Bullous Pemphigoid
Bullous pemphigoid (BP) is the most common blistering auto-immune disease of skin with an incidence estimated to 400 new cases per year.
- Trial name
- ARABUL (NCT00802243)
- Testing
- leflunomide
- Where
- 3 sites in France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Limoges
Dupuytren Contracture
Comparing the Effectiveness of Two Post-fasciectomy Rehabilitation Protocols in Patients With Dupuytren's Disease
Dupuytren's disease can cause physical impairments that lead to reduced functional performance in personal care, work-related and leisure activities. The prevalence of Dupuytren's disease increases with age.
- Trial name
- NCT03982719
- Testing
- Brief protocol, Intense protocol
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Véronique Flamand
Osteoarthritis, Dislocations
Epidemiology and Outcomes of Upper Limb Surgery: Analysis of Routine Data
Surgery is a common treatment type for damaged joints, tendons and nerves in the upper limb where conservative measures are inappropriate or have failed.
- Conditions
- Osteoarthritis, Dislocations, Inflammatory Arthritis, Rotator Cuff Tear
- Trial name
- NCT03573765
- Testing
- Shoulder arthroplasty, Elbow arthroplasty, Hand and wrist arthroplasty
- Volunteers
- 8,308,821 people
- Sponsor
- University of Oxford
Hand Surgery, Wrist Surgery
The Efficacy of Liposomal Bupivacaine in Ultrasound Guided Supraclavicular Nerve Blocks for Hand and Wrist Surgery
Patients undergoing hand, wrist, and elbow surgery may experience pain after surgery. The orthopedic surgeon may provide prescription pain medications after surgery to assist with pain control.
- Conditions
- Hand Surgery, Wrist Surgery, Elbow Surgery, Fracture Fixation
- Trial name
- NCT06806410
- Testing
- Liposomal bupivacaine (LB), Dexamethasone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania