Clinical trials: Durability
Vaccinia, Virus Diseases
Evaluating the Human Immune Response to the JYNNEOS Vaccine
This study is designed to evaluate the magnitude and duration of the human adaptive immune response to the JYNNEOS Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine in the blood, lung mucosa, skin and bone marrow.
- Trial name
- NCT06366672
- Testing
- JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) suspension for subcutaneous injection, Phlebotomy, Research bronchoscopy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Syncope, Vasovagal, Neurally-Mediated
Assessment of the Durability of Cardioneuroablation Using Physiological Indices of Heart Rate Reactivity
Cardioneuroablation is a novel treatment option for reflex-mediated syncope. It involves thermal destruction of neural tissue in the close proximity of heart using catheter introduced to the heart through vein in the groin.
- Trial name
- NCT06697145
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 12 people
- Sponsor
- Wroclaw Medical University
Hip Osteoarthritis, Prosthesis Durability
Symax International Study
The uncemented Symax hip stem is developed through optimization of the uncemented Omnifit hip stem. The Symax stem design combines an anatomical anteverted proximal geometry with a straight distal section.
- Trial name
- NCT03469687
- Testing
- Symax uncemented hip stem
- Volunteers
- 80 people
- Sponsor
- Maastricht University Medical Center
Malaria
Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Burkina Faso
The use of insecticide-treated bed nets (ITN) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance commonly used insecticides in mosquito populations.
- Trial name
- NCT04157894
- Testing
- Standard long-lasting insecticidal net, Chlorfenapyr insecticide treated net, Piperonyl butoxide long-lasting insecticidal net
- Where
- Burkina Faso
- Volunteers
- 5,606 people, healthy volunteers welcome
- Sponsor
- PATH
Covid19
Characterization and Durability of COVID-19 Vaccine Induced Immune Responses in Healthcare/Frontline Workers
Rationale: Early in the covid-19 pandemic, it was unclear whether and how individuals and populations would develop protective and enduring immunity against SARS-CoV-2, either after infection or vaccination.
- Trial name
- NCT05049187
- Where
- India
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tuberculosis Research Centre, India
Chronic Hepatitis B
Long-term Follow-up Study to Evaluate Participants With Chronic Hepatitis B (CHB) Previously Treated With AHB-137 Injection
This study is a prospective, open-label, multicenter long-term follow-up study to evaluate the durability of virologic response in subjects with chronic hepatitis B previously treated with AHB-137 injection.
- Trial name
- NCT07146100
- Where
- 37 sites in China
- Volunteers
- 200 people
- Sponsor
- Ausper Biopharma Co., Ltd.
Prosthesis Durability
Effect of Geometric Modifications of Implant Scan Bodies
The aim of this clinical study will be the effect of geometric modifications of implant scan bodies compared to conventional transfer techniques on passivity of all on four mandibular restorations
- Trial name
- NCT06040385
- Testing
- Implant supported hybrid prosthesis
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Obsessive-Compulsive Disorder
Accelerated Rotational Field Deep TMS for Treating OCD
A Prospective Double Blind Randomized Controlled Trial to Evaluate the Efficacy and Durability of the BrainsWay Rotational Field Deep Transcranial Magnetic Stimulation (Deep TMS) in Obsessive-Compulsive Subjects
- Trial name
- NCT07116785
- Testing
- BrainsWay Deep TMS HAC/H7-Coil
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Ben-Gurion University of the Negev
Crohn's Disease
Extended Evaluation of PROCHYMAL® Adult Human Stem Cells for Treatment-Resistant Moderate-to-Severe Crohn's Disease
Protocol 610 is enrolling subjects who successfully achieved clinical benefit (reduction in Crohn's Disease Activity Index (CDAI) of at least 100 points) in Protocol 603.
- Trial name
- NCT00543374
- Testing
- PROCHYMAL adult human mesenchymal stem cells
- Where
- 58 sites in United States, Canada
- Volunteers
- 98 people
- Sponsor
- Mesoblast, Inc.
Testicular Cancer, Testicular Torsion
Prospective Observational Study on SEBBIN Silicone Gel-filled Testicular Implants
To analyze the short and long term postoperative clinical outcome and patient satisfaction of silicone gel-filled testicular implants.
- Conditions
- Testicular Cancer, Testicular Torsion, Gender Dysphoria, Undescended Testes
- Trial name
- NCT05097820
- Testing
- Placement of testicular prosthesis
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Malaria
Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Rwanda
The use of insecticide-treated bed nets (ITNs) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance in mosquito populations to commonly used insecticides.
- Trial name
- NCT04230161
- Testing
- Standard long-lasting insecticidal net, Chlorfenapyr insecticide treated net, Indoor residual spraying
- Where
- Rwanda
- Volunteers
- 3,502 people, healthy volunteers welcome
- Sponsor
- PATH
Corneal Ectasia
Observational Registry to Assess the Durability of Effect of CXL in Patients With Corneal Ectasia After Refractive Surgery
The objectives of this post market registry are to evaluate the safety and durability of treatment effect up to 3 years following cross-linking performed with Photrexa Viscous (riboflavin 5'- phosphate in 20% dextran ophthalmic…
- Trial name
- CXL (NCT03319082)
- Testing
- Corneal Collagen Cross-linking
- Where
- 11 sites in United States
- Volunteers
- 200 people
- Sponsor
- Glaukos Corporation
Edentulous Mouth, Quality of Life
Impact of Retro-molar Pad Demarcation on Complete Denture Wearers' Satisfaction
the retromolar pad is a critical anatomical landmark in the lower edentulous arch marking the posterior end of any removable prosthesis.
- Conditions
- Edentulous Mouth, Quality of Life, Patient Satisfaction, Complete Edentulism
- Trial name
- RMP (NCT07246343)
- Testing
- carving of retromolar pad area (RMP), no carving of the retromolar pad area (RMP)
- Where
- Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samiha Sartawi
Cervical Intraepithelial Neoplasia, Cervical Cancer
The Durability of Protection and Immuno-persistence Study of a Recombinant HPV 16/18 Bivalent Vaccine in Female
The primary objective of this study is to evaluate the durability of protection and immuno-persistence of Recombinant Human Papillomavirus Bivalent (Types 16,18) Vaccine administered in females aged 18-45 years.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT05045755
- Testing
- Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli)
- Where
- China
- Volunteers
- 1,339 people
- Sponsor
- Jun Zhang
Hepatitis C
Long Term Follow-up Study to Assess Durability of Sustained Virologic Response in Alisporivir-treated Hepatitis C Patients
The purpose of this study is to follow-up with participants from feeder studies who achieved sustained virologic response (SVR) over 24 hours posttreatment (SVR24), to assess durability of SVR, and to assess the changes in liver…
- Trial name
- NCT02753699
- Testing
- Alisporivir
- Where
- 119 sites in United States, Argentina and 20 more
- Volunteers
- 723 people
- Sponsor
- Debiopharm International SA
Common Mental Disorders (CMD)
Durability of the Effects of Low-Intensity Cognitive Behavioural Therapy
This exploratory study investigates the relapse condition in Hong Kong adults after low-intensity cognitive behavioural therapy (LICBT) treatment for 18 to 48 months with a 6-month interval.
- Trial name
- NCT07522775
- Testing
- Low-intensity cognitive behavioural therapy
- Where
- Hong Kong
- Volunteers
- 806 people
- Sponsor
- New Life Psychiatric Rehabilitation Association
Macular Edema, Retinal Vein Occlusion
A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Patients With Macular Edema Due to Retinal Vein Occlusion (RVO)
This Phase 3 study will evaluate the efficacy, durability, and safety of KSI-301 compared to aflibercept, in participants with macular edema due to treatment-naïve branch (BRVO) or central retinal vein occlusion (CRVO).
- Trial name
- BEACON (NCT04592419)
- Testing
- KSI-301, Aflibercept
- Where
- 141 sites in United States, Czechia and 10 more
- Volunteers
- 568 people
- Sponsor
- Kodiak Sciences Inc
Cervical Intraepithelial Neoplasia, Cervical Cancer
The Durability of Protection Study of a Recombinant HPV 16/18 Bivalent Vaccine in Female
The primary objective of this study is to evaluate the durability of protection of Recombinant Human Papillomavirus Bivalent (Types 16,18) Vaccine administered in females aged 18-45 years.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT04969445
- Testing
- Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli)
- Where
- China
- Volunteers
- 647 people
- Sponsor
- Jun Zhang
Transcatheter Aortic Valve Replacement, Transcatheter Aortic Valve Implantation
TAVR: The Impact of Prothesis Positioning on Valvular and Coronary Hemodynamics
The aim of this clinical study is to learn more about the effects of TAVR-prosthesis positioning on hemodynamics and the coronary arteries. The main questions it aims to answer are: 1.
- Conditions
- Transcatheter Aortic Valve Replacement, Transcatheter Aortic Valve Implantation, Commissural Alignment, Commissural Misalignment
- Trial name
- NCT06896227
- Testing
- transthoracic echocardiography
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Prostheses Durability
Triple-Scan Protocol to Assess Passivity
Quantification and visualization the internal and marginal gaps by newer digital methods, such as the triple-scan protocol described by Borga Dönmez et al.
- Trial name
- NCT07644689
- Testing
- Conventional Impression Technique, Digital Impression with Nonmodified Scan Body, Digital Impression with Modified Scan Body
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mansoura University