Clinical trials: Durability
Type 2 Diabetes
Glycemic Durability After Metformin Failure
Type 2 diabetes is epidemic and its treatment has become more and more difficult. Consensus algorithms have been developed to help clinicians to select among the numerous medications and their combinations for achieving and…
- Trial name
- AMAZING (NCT02142309)
- Testing
- Glimepiride, Vildagliptin, Pioglitazone
- Where
- 2 sites in Italy
- Volunteers
- 450 people
- Sponsor
- University of Campania Luigi Vanvitelli
Diabetic Macular Edema
South Asian Patients With Diabetic Macular Oedema Treated With Faricimab Assessing the Efficacy, Durability, and Safety (SEAFAR Study)
The YOSEMITE and RHINE trials, which studied DMO treated with faricimab, had a majority Caucasian cohort, and the small Asian cohort was East Asian, with no South Asian representation.
- Trial name
- SEAFAR (NCT07753616)
- Testing
- Intravitreal anti-VEGF injection, Faricimab
- Volunteers
- 120 people
- Sponsor
- Birmingham and Midland Eye Centre Sandwell and west Birmingham NHS trust
Urge Urinary Incontinence
Post Approval Effectiveness and Durability Evaluation of the Altaviva™ Tibial Device
The purpose of this prospective, multicenter study is to assess the long-term safety and effectiveness of the Altaviva™ system for the treatment of UUI
- Trial name
- ENDURANCE™ (NCT07456865)
- Testing
- Altaviva™ system
- Where
- 19 sites in United States
- Volunteers
- 256 people
- Sponsor
- MedtronicNeuro
Influenza
Immune Response Following Seasonal Influenza Vaccination
This is an open-label, single administration dose study in adult healthy male and female subjects. After qualifying for the study, subjects will receive a single intramuscular injection of the FDA approved 2016-2017 quadrivalent…
- Trial name
- NCT03163342
- Testing
- Licensed seasonal influenza vaccine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Altimmune, Inc.
Chronic Pain, Intractable Pain
Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy
The PERSIST study is being conducted within Medtronic's active post-market surveillance platform, the Product Surveillance Registry (PSR).
- Trial name
- PERSIST (NCT07507422)
- Testing
- Commercially available Inceptiv™ neurostimulation systems
- Where
- 6 sites in United States, France
- Volunteers
- 970 people
- Sponsor
- Medtronic
Immune Response, Vaccination
Immune Durability After VSV-EBOV Vaccination
This prospective observational cohort study will follow the roughly 100 adults who received the VSV-ZEBOV vaccine in the Geneva phase 1 randomized controlled trial in 2014-2015 in order to determine their long-term (5-year)…
- Conditions
- Immune Response, Vaccination, Durability
- Trial name
- NCT02933931
- Volunteers
- 95 people
- Sponsor
- University Hospital, Geneva
Kidney Stones
Durability of Flexible Ureteroscopes and Causes of Infection During Flexible Ureterorenoscopy
This is an observational study in which data on consecutive patients who undergo ureterorenoscopy with the use of a flexible ureterorenoscope are collected.
- Trial name
- NCT03087812
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Clinical Research Office of the Endourological Society
Diabetic Macular Edema
A Trial to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Participants With Diabetic Macular Edema (DME)
This Phase 3 study will evaluate the efficacy, durability, and safety of KSI-301 compared to aflibercept in participants with treatment-naïve DME.
- Trial name
- GLEAM (NCT04611152)
- Testing
- KSI-301, Aflibercept
- Where
- 75 sites in United States, Germany and 6 more
- Volunteers
- 460 people
- Sponsor
- Kodiak Sciences Inc
Prosthesis Durability
Hyoid Displacement During Swallowing Function for Completely Edentulous Subjects
To investigate the effect of wearing mandibular implant retained overdentures on superior and anterior hyoid displacement during swallowing process.
- Trial name
- NCT06187181
- Testing
- implant overdenture, videofluroscopy
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Diabetic Macular Edema
Suprachoroidal Sustained-Release OXU-001 Compared to Intravitreal Ozurdex® in the Treatment of Diabetic Macular Edema
The purpose of this clinical trial is to compare safety, tolerability, efficacy, and durability of two dose levels of suprachoroidal sustained-release OXU-001 (dexamethasone microspheres; DEXAspheres®) using the Oxulumis®…
- Trial name
- OXEYE (NCT05697809)
- Testing
- OXU-001, Semi-automated suprachoroidal illuminated microcatheter, Ozurdex® Ophthalmic Intravitreal Implant
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 3 people
- Sponsor
- Oxular Limited
Gloves, Surgical
Durability of Double-gloving With Biogel® Surgical Gloves When Used by Clinicians/Surgeons
A prospective open-label study design was chosen because it will provide the most accurate data on the efficacy of four commercially available similar brands of NRL (natural rubber latex) and synthetic latex surgical gloves when…
- Trial name
- InDure (NCT03344354)
- Testing
- Biogel, Ansell, Cardinal
- Where
- United States
- Volunteers
- 3,507 people
- Sponsor
- Molnlycke Health Care AB
HIV Infections
Durability of Adherence in Self-Management of HIV
Adherence to highly active antiretroviral therapy (HAART) is critical to successful treatment of HIV. This study tested an intervention that helps people infected with HIV take all their medications when and how they were…
- Trial name
- DASH (NCT00991302)
- Testing
- CAP-IT
- Where
- 2 sites in United States, Peru
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Penile Girth Enhancement
HYAcorp MLF1 Hyaluronic Acid Filler for Penile Girth Enhancement
The goal of this clinical trial is to learn how well HYAcorp MLF1, a hyaluronic acid filler, works for penile girth enhancement in men aged 25 years or older.
- Trial name
- NCT07877077
- Testing
- cross-linked hyaluronic acid
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Biruni University
Osteoarthritis, Knee
Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans
The aims are to determine whether 1) an incentive based on behaviorally-enhanced gamification and social incentives and 2) health coaching can promote adherence to exercise and physical activity after physical therapy for…
- Trial name
- ReAKTIV (NCT06488144)
- Testing
- Health coach, Remote Incentive Program
- Where
- 5 sites in United States
- Volunteers
- 254 people
- Sponsor
- VA Office of Research and Development
Obsessive-Compulsive Disorder
Evaluation of the Long Term Efficacy and Durability of the BrainsWay Deep TMS in OCD Subjects
A Prospective Double Blind Randomized Controlled Trial to Evaluate the Long Term Efficacy and Durability of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) in Obsessive-Compulsive Subjects
- Trial name
- NCT05404360
- Testing
- BrainsWay Deep TMS HAC/H7-Coil
- Volunteers
- 124 people
- Sponsor
- Brainsway
Diabetic Foot Ulcers (DFU), Foot Ulcer Chronic
Evaluating the Durability of Closure for Diabetic Foot Ulcers Following a Randomized, Controlled, Modified Platform Trial.
Prospective long-term follow-up on durability of closure evaluated by photographic and thermal scanning.
- Conditions
- Diabetic Foot Ulcers (DFU), Foot Ulcer Chronic, Ulcer, Diabetic Foot Ulcer
- Trial name
- SCANX (NCT07360418)
- Testing
- Blue Drop Foot Scanner
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Applied Biologics, LLC
Plantar Fibromatosis
Long-Term Safety, Efficacy, and Durability of EN3835 in the Treatment and Retreatment of Plantar Fibromatosis
Assess the long-term safety and efficacy of EN3835 in participants who have participated in a parent placebo-controlled study of EN3835 (EN3835-222, NCT05152173) and assess the efficacy and safety of EN3835 in the treatment and…
- Trial name
- NCT05254457
- Testing
- EN3835
- Where
- 27 sites in United States
- Volunteers
- 145 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Depression - Major Depressive Disorder, Depression Bipolar
Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - Biomarkers
Despite advances in the effective treatment of major depressive disorder using repetitive transcranial magnetic stimulation (rTMS), the processes that determine a patient's response trajectory remain poorly understood.
- Conditions
- Depression - Major Depressive Disorder, Depression Bipolar, Depression Unipolar
- Trial name
- LONGISTIM-BIO (NCT07684911)
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospital Center Guillaume Régnier
Atrial Fibrillation (AF), Pulsed-field Ablation
Durability of Pulmonary Vein Isolation With Farapulse System Using Minimal Fluoroscopy
Objective: To evaluate the feasibility, acute, and three-month efficacy and safety of near-zero fluoroscopy PVI performed with the Farapulse system (Faravawe catheter, Faradrive sheath, Faraview module).
- Trial name
- Faraview Remap (NCT07752771)
- Testing
- catheter ablation
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Semmelweis University
Prosthesis Durability
Ultrasound Investigation of Tongue Movement for Implant Overdenture
This study aimed to examine the impact of mandibular implant overdentures on tongue movement during mastication.
- Trial name
- NCT06705114
- Testing
- complete denture, implant overdenture
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mansoura University